LOCUS       NM_001349608            8244 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens calmodulin binding transcription activator 1 (CAMTA1),
            transcript variant 5, mRNA.
ACCESSION   NM_001349608 XM_017000775
VERSION     NM_001349608.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8244)
  AUTHORS   Al-Kateb,H., Au,P.Y.B., Berland,S., Cogne,B., Demurger,F.,
            Fluss,J., Isidor,B., Frank,L.M., Varvagiannis,K., Koolen,D.A.,
            McDonald,M., Montgomery,S., Moortgat,S., Deprez,M., Karadurmus,D.,
            Paulsen,J., Reis,A., Rieger,M., Vasileiou,G., Willing,M. and
            Shinawi,M.
  TITLE     CAMTA1-related disorder: Phenotypic and molecular characterization
            of 26 new individuals and literature review
  JOURNAL   Clin Genet 105 (3), 294-301 (2024)
   PUBMED   38044714
  REMARK    GeneRIF: CAMTA1-related disorder: Phenotypic and molecular
            characterization of 26 new individuals and literature review.
REFERENCE   2  (bases 1 to 8244)
  AUTHORS   Alves,G., Ornellas,M.H. and Liehr,T.
  TITLE     The role of Calmodulin Binding Transcription Activator 1 (CAMTA1)
            gene and its putative genetic partners in the human nervous system
  JOURNAL   Psychogeriatrics 22 (6), 869-878 (2022)
   PUBMED   35949142
  REMARK    GeneRIF: The role of Calmodulin Binding Transcription Activator 1
            (CAMTA1) gene and its putative genetic partners in the human
            nervous system.
            Review article
REFERENCE   3  (bases 1 to 8244)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 8244)
  AUTHORS   Dzinovic,I., Serranova,T., Prouteau,C., Colin,E., Ziegler,A.,
            Winkelmann,J., Jech,R. and Zech,M.
  TITLE     Myoclonic dystonia phenotype related to a novel calmodulin-binding
            transcription activator 1 sequence variant
  JOURNAL   Neurogenetics 22 (2), 137-141 (2021)
   PUBMED   33677721
  REMARK    GeneRIF: Myoclonic dystonia phenotype related to a novel
            calmodulin-binding transcription activator 1 sequence variant.
            Erratum:[Neurogenetics. 2022 Jan;23(1):77. doi:
            10.1007/s10048-021-00641-w.. PMID: 34859314]
REFERENCE   5  (bases 1 to 8244)
  AUTHORS   Merritt,N., Garcia,K., Rajendran,D., Lin,Z.Y., Zhang,X.,
            Mitchell,K.A., Borcherding,N., Fullenkamp,C., Chimenti,M.S.,
            Gingras,A.C., Harvey,K.F. and Tanas,M.R.
  TITLE     TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by
            recruiting the ATAC histone acetyltransferase complex
  JOURNAL   Elife 10, e62857 (2021)
   PUBMED   33913810
  REMARK    GeneRIF: TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by
            recruiting the ATAC histone acetyltransferase complex.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8244)
  AUTHORS   Henrich,K.O., Claas,A., Praml,C., Benner,A., Mollenhauer,J.,
            Poustka,A., Schwab,M. and Westermann,F.
  TITLE     Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted
            region at 1p36 in neuroblastoma
  JOURNAL   Eur J Cancer 43 (3), 607-616 (2007)
   PUBMED   17222547
  REMARK    GeneRIF: no evidence for somatic mutations in FLJ10737 in
            neuroblastoma
REFERENCE   7  (bases 1 to 8244)
  AUTHORS   Barbashina,V., Salazar,P., Holland,E.C., Rosenblum,M.K. and
            Ladanyi,M.
  TITLE     Allelic losses at 1p36 and 19q13 in gliomas: correlation with
            histologic classification, definition of a 150-kb minimal deleted
            region on 1p36, and evaluation of CAMTA1 as a candidate tumor
            suppressor gene
  JOURNAL   Clin Cancer Res 11 (3), 1119-1128 (2005)
   PUBMED   15709179
REFERENCE   8  (bases 1 to 8244)
  AUTHORS   Nakatani,K., Nishioka,J., Itakura,T., Nakanishi,Y., Horinouchi,J.,
            Abe,Y., Wada,H. and Nobori,T.
  TITLE     Cell cycle-dependent transcriptional regulation of
            calmodulin-binding transcription activator 1 in neuroblastoma cells
  JOURNAL   Int J Oncol 24 (6), 1407-1412 (2004)
   PUBMED   15138581
REFERENCE   9  (bases 1 to 8244)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of FLJ10737 and CAMTA1 genes on
            the commonly deleted region of neuroblastoma at human chromosome
            1p36.31-p36.23
  JOURNAL   Int J Oncol 23 (4), 1219-1224 (2003)
   PUBMED   12964007
  REMARK    GeneRIF: FLJ10737 and CAMTA1 genes on 1p36.31-p36.23 are candidate
            tumor suppressor genes of neuroblastoma
REFERENCE   10 (bases 1 to 8244)
  AUTHORS   Bouche,N., Scharlat,A., Snedden,W., Bouchez,D. and Fromm,H.
  TITLE     A novel family of calmodulin-binding transcription activators in
            multicellular organisms
  JOURNAL   J Biol Chem 277 (24), 21851-21861 (2002)
   PUBMED   11925432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590128.11, Z97635.10,
            Z98052.1, AL365194.15, AL596210.20, AL359881.28, Z98884.11 and
            KF495855.1.
            
            On May 31, 2019 this sequence version replaced NM_001349608.1.
            
            Summary: The protein encoded by this gene contains a CG1
            DNA-binding domain, a transcription factor immunoglobulin domain,
            ankyrin repeats, and calmodulin-binding IQ motifs. The encoded
            protein is thought to be a transcription factor and may be a tumor
            suppressor. However, a translocation event is sometimes observed
            between this gene and the WWTR1 gene, with the resulting
            WWTR1-CAMTA1 oncoprotein leading to epithelioid
            hemangioendothelioma, a malignant vascular cancer. [provided by
            RefSeq, Mar 2017].
            
            Transcript Variant: This variant (5) encodes isoform d.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.118801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               AL590128.11        8839-8960
            123-241             AL590128.11        48477-48595
            242-309             Z97635.10          14059-14126
            310-445             Z98052.1           85246-85381
            446-517             AL365194.15        36142-36213
            518-671             AL596210.20        86653-86806
            672-812             AL359881.28        2867-3007
            813-2659            AL359881.28        4494-6340
            2660-2786           AL359881.28        12052-12178
            2787-2921           AL359881.28        18740-18874
            2922-3073           Z98884.11          9667-9818
            3074-3270           Z98884.11          13563-13759
            3271-3349           Z98884.11          14150-14228
            3350-3665           Z98884.11          14474-14789
            3666-4189           Z98884.11          15178-15701
            4190-4377           Z98884.11          22054-22241
            4378-4624           Z98884.11          23064-23310
            4625-4696           Z98884.11          24929-25000
            4697-4890           Z98884.11          28418-28611
            4891-4965           Z98884.11          29678-29752
            4966-4996           Z98884.11          32857-32887
            4997-7554           Z98884.11          43678-46235
            7555-7845           KF495855.1         1-291
            7846-8244           Z98884.11          46527-46925
FEATURES             Location/Qualifiers
     source          1..8244
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31-p36.23"
     gene            1..8244
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /note="calmodulin binding transcription activator 1"
                     /db_xref="GeneID:23261"
                     /db_xref="HGNC:HGNC:18806"
                     /db_xref="MIM:611501"
     exon            1..122
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..5029
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /note="isoform d is encoded by transcript variant 5"
                     /codon_start=1
                     /product="calmodulin-binding transcription activator 1
                     isoform d"
                     /protein_id="NP_001336537.1"
                     /db_xref="GeneID:23261"
                     /db_xref="HGNC:HGNC:18806"
                     /db_xref="MIM:611501"
                     /translation="MAAENKPEDDHGNSNSSHVKIFLPKKLLECLPKCSSLPKERHRW
                     NTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKT
                     TREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPAIEDCGK
                     PCGPILCSINTDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSGFSVEQLVQQIL
                     DSHQTKPQPRTHNCLCTGSLGAGGSVHHKCNSAKHRIISPKVEPRTGGYGSHSEVQHN
                     DVSEGKHEHSHSKGSSREKRNGKVAKPVLLHQSSTEVSSTNQVEVPDTTQSSPVSISS
                     GLNSDPDMVDSPVVTGVSGMAVASVMGSLSQSATVFMSEVTNEAVYTMSPTAGPNHHL
                     LSPDASQGLVLAVSSDGHKFAFPTTGSSESLSMLPTNVSEELVLSTTLDGGRKIPETT
                     MNFDPDCFLNNPKQGQTYGGGGLKAEMVSSNIRHSPPGERSFSFTTVLTKEIKTEDTS
                     FEQQMAKEAYSSSAAAVAASSLTLTAGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYT
                     SSFSQTGHSPHIHQTPSPSFFLQDASKPLPVEQNTHSSLSDSGGTFVMPTVKTEASSQ
                     TSSCSGHVETRIESTSSLHLMQFQANFQAMTAEGEVTMETSQAAEGSEVLLKSGELQA
                     CSSEHYLQPETNGVIRSAGGVPILPGNVVQGLYPVAQPSLGNASNMELSLDHFDISFS
                     NQFSDLINDFISVEGGSSTIYGHQLVSGDSTALSQSEDGARAPFTQAEMCLPCCSPQQ
                     GSLQLSSSEGGASTMAYMHVAEVVSAASAQGTLGMLQQSGRVFMVTDYSPEWSYPEGG
                     VKVLITGPWQEASNNYSCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQII
                     SNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMTGSQQHKQA
                     SGGGSSGGGSGSGNGGSQAQCASGTGALGSCFESRVVVVCEKMMSRACWAKSKHLIHS
                     KTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWAC
                     ALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQLGQ
                     NPRIHCPASEEPSTESWMAQWHSEAISSPEIPKGVTVIASTNPELRRPRSEPSNYYSS
                     ESHKDYPAPKKHKLNPEYFQTRQEKLLPTALSLEEPNIRKQSPSSKQSVPETLSPSEG
                     VRDFSRELSPPTPETAAFQASGSQPVGKWNSKDLYIGVSTVQVTGNPKGTSVGKEAAP
                     SQVRPREPMSVLMMANREVVNTELGSYRDSAENEECGQPMDDIQVNMMTLAEHIIEAT
                     PDRIKQENFVPMESSGLERTDPATISSTMSWLASYLADADCLPSAAQIRSAYNEPLTP
                     SSNTSLSPVGSPVSEIAFEKPNLPSAADWSEFLSASTSEKVENEFAQLTLSDHEQREL
                     YEAARLVQTAFRKYKGRPLREQQEVAAAVIQRCYRKYKQYALYKKMTQAAILIQSKFR
                     SYYEQKKFQQSRRAAVLIQKYYRSYKKCGKRRQARRTAVIVQQKLRSSLLTKKQDQAA
                     RKIMRFLRRCRHSPLVDHRLYKRSERIEKGQGT"
     exon            123..241
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            242..309
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            310..445
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            446..517
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            518..671
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            672..812
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            813..2659
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2786
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2921
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3073
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3270
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            3271..3349
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3665
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            3666..4189
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            4190..4377
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            4378..4624
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            4625..4696
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            4697..4890
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            4891..4965
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            4966..4996
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     exon            4997..8244
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8218..8223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /note="hexamer: ATTAAA"
     polyA_site      8244
                     /gene="CAMTA1"
                     /gene_synonym="CANPMR; CECBA"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcgggg tggctgggcc ggcggcggcg gcggtacgag gcgcgcgctc ggggtcccgg
       61 tcgcgaggag gaggaggatg tggcgcgcgg aggggaaatg gctgccgaaa acaagccgga
      121 agatgatcat gggaacagca atagtagtca tgtaaaaatc tttttaccga aaaagctgct
      181 tgaatgtctg ccgaaatgtt caagtttacc aaaagagagg caccgctgga acactaatga
      241 ggaaattgca gcttatttaa taacatttga gaaacacgaa gaatggctaa ccacctcccc
      301 taagacaaga ccacagaatg gctcaatgat actctacaac aggaagaaag tgaaatacag
      361 gaaagatggg tattgctgga aaaagaggaa agatgggaaa acgaccagag aggaccacat
      421 gaaactcaag gtccagggag tggagtgctt gtacggctgc tatgtccatt cctccatcat
      481 ccccaccttc caccggaggt gctactggct ccttcagaac cccgacatcg tcctggtgca
      541 ctacctgaac gtgccggcca tcgaggactg cggcaagcct tgcggcccca tcctctgctc
      601 catcaacacc gacaagaagg agtgggcgaa atggacgaaa gaagagctca tcgggcagct
      661 gaaacccatg ttccatggca tcaagtggac ctgcagcaat gggaacagca gctcaggctt
      721 ctcggtggaa cagctggtgc agcagatcct cgacagccac cagaccaagc cccagccgcg
      781 gacccacaac tgcctctgca ccggcagcct gggagctggc ggcagcgtgc atcacaagtg
      841 taacagcgcc aaacaccgca tcatctcgcc caaggtggag ccacggacag gggggtacgg
      901 gagccactcg gaggtgcagc acaatgacgt gtcggagggc aagcacgagc acagccacag
      961 caagggctcc agccgtgaga agaggaacgg caaggtggcc aagcccgtgc tcctgcacca
     1021 gagcagcacc gaggtctcct ccaccaacca ggtggaagtc cccgacacca cccagagctc
     1081 ccctgtgtcc atcagcagcg ggctcaacag cgacccggac atggtggaca gcccggtggt
     1141 cacaggtgtg tccggtatgg cggtggcctc tgtgatgggg agcttgtccc agagcgccac
     1201 ggtgttcatg tcagaggtca ccaatgaggc cgtgtacacc atgtccccca ccgctggccc
     1261 caaccaccac ctcctctcac ctgacgcctc tcagggcctc gtcctggccg tgagctctga
     1321 tggccacaag ttcgcctttc ccaccacggg cagctcggag agcctgtcca tgctgcccac
     1381 caacgtgtcc gaagagctgg tcctctccac caccctcgac ggtggccgga agattccaga
     1441 aaccaccatg aactttgacc ccgactgttt ccttaataac ccaaagcagg gccagacgta
     1501 cgggggtgga ggcctgaaag ccgagatggt cagctccaac atccggcact cgccacccgg
     1561 ggagcggagc ttcagcttta ccaccgtcct caccaaggag atcaagaccg aggacacctc
     1621 cttcgagcag cagatggcca aagaagcgta ctcctcctcc gcggcggctg tggcagccag
     1681 ctccctcacc ctgaccgccg gctccagcct cctgccgtcg ggcggcggcc tgagtcccag
     1741 caccaccctg gagcagatgg acttcagcgc catcgactcc aacaaggact acacgtccag
     1801 cttcagccag acgggccaca gcccccacat ccaccagacc ccctccccga gcttcttcct
     1861 gcaggacgcc agcaaacccc tccccgtcga gcagaacacc cacagcagcc tgagtgactc
     1921 tgggggcacc ttcgtgatgc ccacggtgaa aacggaggcc tcgtcccaaa ccagctcctg
     1981 cagcggtcac gtggagacgc ggatcgagtc cacttcctcc ctccacctca tgcagttcca
     2041 ggccaacttc caggccatga cggcagaagg ggaggtcacc atggagacct cgcaggcggc
     2101 ggaagggagc gaggtcctgc tcaagtctgg ggagctgcag gcttgcagct ctgagcacta
     2161 cctgcagccg gagaccaacg gggtaatccg aagcgccggc ggcgtcccca tcctcccggg
     2221 caacgtggtg cagggactct accccgtggc ccagcccagc ctcggcaacg cctccaacat
     2281 ggagctcagc ctggaccact ttgacatctc cttcagcaac cagttctccg acctgatcaa
     2341 cgacttcatc tccgtggagg ggggcagcag caccatctat gggcaccagc tggtgtcggg
     2401 ggacagcacg gcgctctcac agtcagagga cggggcgcgg gcccccttca cccaggcaga
     2461 gatgtgcctc ccctgctgta gcccccagca gggtagcctg cagctgagca gctcggaggg
     2521 cggggccagc accatggcct acatgcacgt cgccgaggtg gtctcggccg cctcggccca
     2581 gggcacccta ggcatgctgc agcagagcgg acgggtgttc atggtgaccg actactcccc
     2641 agagtggtct tacccagagg gaggagtgaa ggtcctcatc acaggcccgt ggcaagaagc
     2701 cagcaataac tacagctgcc tgtttgacca gatctcagtg cctgcatccc tgattcagcc
     2761 tggggtgctg cgctgctact gcccagccca tgacactggt cttgtgaccc tacaagttgc
     2821 cttcaacaac cagatcatct ccaactcggt ggtgtttgag tacaaagccc gggctctgcc
     2881 cacgctccct tcctcccagc acgactggct gtcgttggac gataaccagt tcaggatgtc
     2941 catcctggaa cgactggagc agatggagag gaggatggcc gagatgacgg ggtcccagca
     3001 gcacaaacag gcgagcggag gcggcagcag tggaggcggc agcgggagcg ggaatggagg
     3061 gagccaggca cagtgtgctt ctgggactgg ggccttgggg agctgctttg agagccgtgt
     3121 ggtcgtggta tgcgagaaga tgatgagccg agcctgctgg gcgaagtcca agcacttgat
     3181 ccactcaaag actttccgcg gaatgaccct actccacctg gccgctgccc agggctatgc
     3241 caccctaatc cagaccctca tcaaatggcg tacaaagcac gcggatagca ttgacctgga
     3301 actggaagtt gaccccttga atgtggacca cttctcctgt actcctctga tgtgggcgtg
     3361 tgccctaggg cacttggaag ctgccgtcgt gctgtacaag tgggaccgtc gggccatctc
     3421 gattcccgac tctctaggaa ggctgccttt gggaattgcc aggtcacggg gtcatgtgaa
     3481 attagcagag tgtctggagc acctgcagag agatgagcag gctcagctgg gacagaaccc
     3541 cagaatccac tgtcctgcaa gcgaagagcc cagcacagag agctggatgg cccagtggca
     3601 cagcgaagcc atcagctctc cagaaatacc caagggagtc actgttattg caagcaccaa
     3661 cccagagctg agaagacctc gttctgaacc ctctaattac tacagcagtg agagccacaa
     3721 agattatccg gctcccaaaa agcataaatt gaaccctgag tacttccaga caaggcagga
     3781 gaagctgctt cccactgcac tgagtctgga agagccaaat atcaggaagc aaagccctag
     3841 ttctaagcag tctgtccccg agacactcag ccccagtgaa ggagtgaggg acttcagccg
     3901 ggaactctcc cctcccactc cagagactgc agcatttcaa gcctctggat ctcagcctgt
     3961 aggaaagtgg aattccaaag atctttacat tggtgtgtct acagtacagg tgactggaaa
     4021 tccgaagggg accagtgtag gaaaggaggc agcaccttca caggtgcgtc cacgggaacc
     4081 aatgagtgtc ctgatgatgg ctaacagaga ggtggtgaat acagagctgg ggtcctaccg
     4141 tgatagtgca gaaaatgaag aatgcggcca gcccatggat gacatacagg tgaacatgat
     4201 gaccttggca gaacacatta ttgaagccac acctgaccga atcaagcagg agaattttgt
     4261 gcccatggag tcctcaggat tggaaagaac agaccctgcc accattagca gtacaatgag
     4321 ctggctggcc agttatctag cggatgctga ctgccttccc agtgctgccc agatccgaag
     4381 tgcatataac gagcctctaa ccccttcttc taataccagc ttgagccctg ttggctctcc
     4441 cgtcagtgaa atcgctttcg agaaacctaa ccttccctcc gccgcggatt ggtcagaatt
     4501 cctgagtgca tctaccagtg agaaggtaga gaatgagttt gctcagctca ctctgtctga
     4561 tcatgaacag agagaactct atgaggctgc caggcttgtc cagacagctt tccggaaata
     4621 caagggccga cccttgcggg aacagcaaga agtagctgct gctgttattc agcgttgtta
     4681 cagaaaatat aaacagtacg cactttataa aaagatgaca caggctgcca tccttatcca
     4741 gagcaaattc cgaagttact atgaacaaaa aaaattccag cagagccgac gggctgctgt
     4801 gctcatccaa aagtactacc gaagttataa gaaatgtggc aaaagacggc aggctcgccg
     4861 gacggctgtg attgtacaac agaaactcag gagcagtttg ctaaccaaaa agcaggatca
     4921 agctgctcga aaaataatga ggtttcttcg ccgctgtcgc cacagccccc tggtggacca
     4981 taggctgtac aaaaggagtg aaagaattga aaaaggccaa ggaacttgaa gacatacagc
     5041 agcatccctt agcaatgtga cattgctttt cagactgttt tcatttctgt ttttagcaga
     5101 gacatgcaac aacaacacac acgcacacac gcacacacac acacgtacac acacatacaa
     5161 aatccctctg cagttttggg gagatcagct gcaggatttt aacaggaatg ttttggtcat
     5221 tgcatttgca ctttcatgga caacttttaa tttgatcagc aagacatctt ggaactcaat
     5281 cttctgttgg atcacgggaa atcaagacac ccaggaggaa ttgaaagagg cttcctcttc
     5341 tcaggaagaa gccatttcct tctcatatag ggctgtattc aaacatcgtg tggaactgta
     5401 caaatattta taccaaaaat atagataaga aaaggtgggg ctatactagc aacaaaaaaa
     5461 gaatgctgtt cctgcacctg ccggttattt ccaagaagct gaatctttgg gactgattct
     5521 cagtggaggg cttagatcat acaaaaatct ttattgggtc cgtgtgttct catttccttc
     5581 actgtttatt tttgtttgtt tgtttgtttg ttttaatctc tacagcacat ttaatgcaac
     5641 ttttgaaatc tgcaggtttt taatgtcttg tggaaatttg cagaggggca ggtgtgtggt
     5701 aaacgggtaa tgcatgggaa ataatgagaa gcagctcaca gagtttaaac tattttcttg
     5761 tccccaccac cttccaagaa cctgcgaggg tagtaatcat cttgtcccct ttttcatgtt
     5821 cagcacttta atttttttgc cttactttca tgtgcaatga gaattactta agaattggta
     5881 acgcatgtag ccttttttag taaccttgga agctgtagta attctaagga atcatgaacc
     5941 ttgcctggac atttgccacc taaacgatca gtgtggtgct gcgttctggc cagtaaattc
     6001 catgtttttg gctatatctc atccaaactg agcagtttct gtgtatatat agaaggtaga
     6061 aatgaaaagt gagaaaatat ttgaaaggga ttatattaat tgctaaatat tttattcaca
     6121 aaggtcaata acatggcaag ataaaattat ttgtatagtt ttgtctgaat gagcgagaaa
     6181 aatgtggatg tactgtttgt atatattgta tatattaaaa cagagatatg tgcatgaaat
     6241 caagaaaaaa gaaatgaaca aaagcaaagc attagtggct atggtctgta aaatgaaaca
     6301 aaaaaacttt atttcactat aagagtactt tattttaaat gttctttagg agaacatttt
     6361 gctaaagcat gactaaactg caaaaaaaaa aaaagagcta ctgtatttag acttaggaaa
     6421 aaaggcagag taacattact taaaaaaaaa aggatatgtt tacatttaat tttggctacc
     6481 aggagtttag tttattttat ttaaaatttt tttgccaatg gtgccaagta atgtgaatgc
     6541 taatactgct taagaaaatt aagttacttt tgcaaaacag ataatcataa gatgaatcag
     6601 tatgtagctt aacaccatcc actcactcca acaaagaaca cttagaatga taaaaaaaaa
     6661 aaaaaaaaac ctgacaaaag aaatagtatg aaaagtagaa aaatgtcacg tttccatatc
     6721 tcctgctgga aatcagaaaa tataataaaa ttgcacaaaa aaaaaaatga aaaagatgca
     6781 gactggtctt ttagagacgg catggtatat tactatttcc acataatgag gagccaaaga
     6841 aatctgatgt ttttaacaat taaactgcta atgttaaatt gagagaataa agttcgtatt
     6901 tgctgatgcc agtttaaaat tcccaggtta cgtctgagga tcagttggtg taaagctgag
     6961 atgttttttc ttggttctgg ctgccaactg tgagttaaaa ctcaaggctt gttgtgaagc
     7021 ctaaaaatat tcacaaataa gcttttaaac tggtgtcttt ggaaggaagg tagatacaaa
     7081 aagattgtgg taaaaactgg ggtcagtgct cttggtgcct tttctataat tgtacttgtt
     7141 ttttaattac ttcctttcac tgccaacctc gaattactgt acagtatatg tctttctgct
     7201 tgtgatcagc tttgacaaca gtgacagccc cacaactagt agccacctgt acatttgtaa
     7261 actgacctga ctccattttg tttttaaatg tgtgggttat gttgcagctg ttgcagtccc
     7321 ccagatacct attattttac acaatttgac ctataggagg acactgagta atttacaaac
     7381 acaactgcat tcataaatgg gaatagaacg tgaaagccag ctctttcaga atatcctcta
     7441 ttaatactga atttagatat ctttattcca tttattatgg tacaaataac tgatgtttta
     7501 accagagtaa tgacctcagt ggatttgctt taaccctcac attttttttt taatgtttca
     7561 catgttacat tattagctga atacgttaga aaatgacaga tggtagagac ttccatagaa
     7621 ttaagagggt tctcatggag gggataggaa gtaggtttaa agcctaccag tgtaacctac
     7681 cagtacaact gtgaatccta ggcgaggcaa aaatgcactt ccactgaaac gaagcatttc
     7741 tgaccgcttt ttcttggtta tgaatcttaa tttcgaatat aagatgatag gtaagcgcag
     7801 ctttcttgga taatctgaat tcccaagtgc caggagtagg atttcattat aaaattaata
     7861 gctaatctta ttctatctcc tgaagattta attgctattg ttacccattc gaaatcagct
     7921 gtactgtgtg aacgaaataa agacaataat acgaacccct ctctggctgc acggtcgctt
     7981 atggcagttc cacacagtag ttggcgccca atggggggtc cctgagactt gcatgtaaaa
     8041 ctagtctaga tgtcttcttt ttttgtaagt tttatttttg taattgtgca tgtaaagcat
     8101 cattgaatca atggatctgt tgaagaactc agctgctgga aaccatgcaa aatgttttga
     8161 attgccctta aaatatggaa aatgttttct gaatgcttta tattctttct gctgtaaatt
     8221 aaaaatgaag aaaatttccc cata
//
