LOCUS       NM_020902               4137 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens calmodulin regulated spectrin associated protein
            family member 3 (CAMSAP3), transcript variant 2, mRNA.
ACCESSION   NM_020902 XM_940427
VERSION     NM_020902.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4137)
  AUTHORS   Kobori,M., Abe,J., Saito,R. and Hirai,Y.
  TITLE     CAMSAP3, a microtubule orientation regulator, plays a vital role in
            manifesting differentiation-dependent characteristics in
            keratinocytes
  JOURNAL   Exp Cell Res 435 (1), 113927 (2024)
   PUBMED   38190868
  REMARK    GeneRIF: CAMSAP3, a microtubule orientation regulator, plays a
            vital role in manifesting differentiation-dependent characteristics
            in keratinocytes.
REFERENCE   2  (bases 1 to 4137)
  AUTHORS   Zhang,R., Gu,L., Chen,W., Tanaka,N., Zhou,Z., Xu,H., Xu,T., Ji,W.,
            Liang,X. and Meng,W.
  TITLE     CAMSAP2 and CAMSAP3 localize at microtubule intersections to
            regulate the spatial distribution of microtubules
  JOURNAL   J Mol Cell Biol 15 (8) (2024)
   PUBMED   37567766
  REMARK    GeneRIF: CAMSAP2 and CAMSAP3 localize at microtubule intersections
            to regulate the spatial distribution of microtubules.
REFERENCE   3  (bases 1 to 4137)
  AUTHORS   Seephan,S., Sasaki,S.I., Wattanathamsan,O., Singharajkomron,N.,
            He,K., Ucche,S., Kungsukool,S., Petchjorm,S., Chantaravisoot,N.,
            Wongkongkathep,P., Hayakawa,Y. and Pongrakhananon,V.
  TITLE     CAMSAP3 negatively regulates lung cancer cell invasion and
            angiogenesis through nucleolin/HIF-1alpha mRNA complex
            stabilization
  JOURNAL   Life Sci 322, 121655 (2023)
   PUBMED   37019300
  REMARK    GeneRIF: CAMSAP3 negatively regulates lung cancer cell invasion and
            angiogenesis through nucleolin/HIF-1alpha mRNA complex
            stabilization.
REFERENCE   4  (bases 1 to 4137)
  AUTHORS   Gibieza,P., Peterman,E., Hoffman,H.K., Van Engeleburg,S.,
            Skeberdis,V.A. and Prekeris,R.
  TITLE     Rab14/MACF2 complex regulates endosomal targeting during
            cytokinesis
  JOURNAL   Mol Biol Cell 32 (7), 554-566 (2021)
   PUBMED   33566684
  REMARK    GeneRIF: Rab14/MACF2 complex regulates endosomal targeting during
            cytokinesis.
REFERENCE   5  (bases 1 to 4137)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4137)
  AUTHORS   Meng,W., Mushika,Y., Ichii,T. and Takeichi,M.
  TITLE     Anchorage of microtubule minus ends to adherens junctions regulates
            epithelial cell-cell contacts
  JOURNAL   Cell 135 (5), 948-959 (2008)
   PUBMED   19041755
  REMARK    GeneRIF: KIAA1543 is a non-centrosomal minus end binding protein.
            It is termed Nezha(a character in Chinese mythic novel (Journey to
            the West)).
REFERENCE   7  (bases 1 to 4137)
  AUTHORS   Akhmanova,A. and Yap,A.S.
  TITLE     Organizing junctions at the cell-cell interface
  JOURNAL   Cell 135 (5), 791-793 (2008)
   PUBMED   19041742
REFERENCE   8  (bases 1 to 4137)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   9  (bases 1 to 4137)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 4137)
  AUTHORS   Acierno,J.S. Jr., Kennedy,J.C., Falardeau,J.L., Leyne,M.,
            Bromley,M.C., Colman,M.W., Sun,M., Bove,C., Ashworth,L.K.,
            Chadwick,L.H., Schiripo,T., Ma,S., Goldin,E., Schiffmann,R. and
            Slaugenhaupt,S.A.
  TITLE     A physical and transcript map of the MCOLN1 gene region on human
            chromosome 19p13.3-p13.2
  JOURNAL   Genomics 73 (2), 203-210 (2001)
   PUBMED   11318610
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008763.9, BC035808.1, BC020431.1 and BU733578.1.
            
            On Jun 2, 2019 this sequence version replaced NM_020902.1.
            
            Transcript Variant: This variant (2) lacks two exons in the 5'
            coding region, compared to variant 1. The encoded isoform (2) is
            shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035808.1, SRR9304717.572230.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000160298.9/ ENSP00000160298.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC008763.9         26675-26713
            40-2499             BC035808.1         1-2460
            2500-2810           BC020431.1         2385-2695
            2811-3928           BC035808.1         2772-3889
            3929-4137           BU733578.1         23-231              c
FEATURES             Location/Qualifiers
     source          1..4137
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..4137
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /note="calmodulin regulated spectrin associated protein
                     family member 3"
                     /db_xref="GeneID:57662"
                     /db_xref="HGNC:HGNC:29307"
                     /db_xref="MIM:612685"
     exon            1..288
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..3890
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /note="isoform 2 is encoded by transcript variant 2;
                     calmodulin-regulated spectrin-associated protein 3;
                     protein phosphatase 1, regulatory subunit 80"
                     /codon_start=1
                     /product="calmodulin-regulated spectrin-associated protein
                     3 isoform 2"
                     /protein_id="NP_065953.1"
                     /db_xref="CCDS:CCDS42489.1"
                     /db_xref="GeneID:57662"
                     /db_xref="HGNC:HGNC:29307"
                     /db_xref="MIM:612685"
                     /translation="MVEAAPPGPGPLRRTFLVPEIKSLDQYDFSRAKAAASLAWVLRA
                     AFGGAEHVPPELWEPFYTDQYAQEHVKPPVTRLLLSAELYCRAWRQALPQLETPPNPS
                     ALLALLARRGTVPALPERPVREADLRHQPILMGAHLAVIDALMAAFAFEWTKTLPGPL
                     ALTSLEHKLLFWVDTTVRRLQEKTEQEAAQRASPAAPADGAAPAQPSIRYRKDRVVAR
                     RAPCFPTVTSLQDLASGAALAATIHCYCPQLLRLEEVCLKDPMSVADSLYNLQLVQDF
                     CASRLPRGCPLSLEDLLYVPPPLKVNLVVMLAELFMCFEVLKPDFVQVKDLPDGHAAS
                     PRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLKSSPSMSHMEALGKA
                     WNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPPRPAPARTPTQPP
                     PEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSLASPYLPEGTSKP
                     LSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASSPAATNSEVKMTS
                     FAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEKRRAIEAQKRRIEAI
                     FAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAV
                     TFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPP
                     AAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPLTRVL
                     TPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAA
                     EDEGDGSPAGAEDSLEEEASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRA
                     EEARRRKQWQEVEKEQRREEAARLAQEEAPGPAPLVSAVPMATPAPAARAPAEEEVGP
                     RKGDFTRQEYERRAQLKLMDDLDKVLRPRAAGSGGPGRGGRRATRPRSGCCDDSALAR
                     SPARGLLGSRLSKIYSQSTLSLSTVANEAHNNLGVKRPTSRAPSPSGLMSPSRLPGSR
                     ERDWENGSNASSPASVPEYTGPRLYKEPSAKSNKFIIHNALSHCCLAGKVNEPQKNRI
                     LEEIEKSKANHFLILFRDSSCQFRALYTLSGETEELSRLAGYGPRTVTPAMVEGIYKY
                     NSDRKRFTQIPAKTMSMSVDAFTIQGHLWQGKKPTTPKKGGGTPK"
     exon            289..542
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /inference="alignment:Splign:2.1.0"
     exon            543..665
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /inference="alignment:Splign:2.1.0"
     exon            666..761
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /inference="alignment:Splign:2.1.0"
     exon            762..900
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1040
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1134
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1189
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1263
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1333
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..2810
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2950
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3252
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3352
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..3465
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /inference="alignment:Splign:2.1.0"
     exon            3466..3584
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /inference="alignment:Splign:2.1.0"
     exon            3585..4137
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4117..4122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /note="hexamer: AATAAA"
     polyA_site      4137
                     /gene="CAMSAP3"
                     /gene_synonym="KIAA1543; NEZHA; PPP1R80"
                     /note="major polyA site"
ORIGIN      
        1 gcacctggct cagcagcggc ggcggcggcg gcggcggcag cggcggtagc agcagcgggc
       61 ccggctgggg cgcgagcgcg gcgcagccca gcccagccca gtccgagcgc ggacccggcg
      121 cccgcagccc cggcgccgcc atggtggagg cggcgccccc cgggcccggg ccgctgcgga
      181 ggacctttct agtgcccgag atcaagtcgc tggaccagta cgatttctcg cgggccaagg
      241 cggcggccag cctggcgtgg gtgctgcggg ccgcgttcgg gggcgcagag cacgtgcccc
      301 cggagctgtg ggagcccttc tataccgacc agtacgcgca ggagcatgtg aagcccccgg
      361 tgacacggct gctgctctca gccgagctct actgcagagc ctggcgccag gcactgccac
      421 agcttgaaac accccccaac ccctctgcac tgctggccct gctggcgcgg aggggcacag
      481 tgcctgcttt gcccgagcgc ccggtgcgcg aggccgacct gaggcaccag cccattctca
      541 tgggagccca cctagctgtc attgatgccc tcatggctgc ctttgccttc gagtggacaa
      601 agaccctgcc aggtcccttg gccctgacca gcttggagca caagctgctt ttctgggtgg
      661 acacgaccgt ccggcggctg caggagaaga ccgagcagga agcggcccag cgagcctctc
      721 cagcagcccc tgcagacggg gcggccccgg cgcagccctc gatccgatac cgcaaggacc
      781 gtgtggtggc gcgacgtgcc ccctgcttcc cgacggtgac cagcctccag gacctggcca
      841 gtggggccgc gctggccgcc accatccact gctattgtcc ccagctgctt cgacttgagg
      901 aggtgtgctt gaaggacccc atgtctgtgg cggacagcct gtacaacctc cagctcgtgc
      961 aggatttctg tgcctctcgc cttcctcgtg gctgccccct gtcccttgag gacttgctgt
     1021 acgtcccacc gccactcaag gtcaacttgg tggtgatgct ggccgagttg ttcatgtgtt
     1081 ttgaggtgct caagcccgac tttgtgcaag tgaaggactt gcccgatggt cacgctgcct
     1141 ccccccgggg cactgaggcc tccccacctc agaacaacag cggcagtagt tctcctgtct
     1201 tcaccttccg ccacccgctt ctgtcatctg gtggccccca gtccccactc cgaggatcca
     1261 caggctccct gaagtcttcc ccgtccatgt cccatatgga ggccctgggc aaggcctgga
     1321 accggcagct cagccgtccc ctctcccagg ctgtgtcatt cagcaccccc tttggcctgg
     1381 acagcgacgt ggatgtcgtc atgggagacc ctgtgctcct ccgctctgtg agctcggaca
     1441 gcctgggccc cccgcgtccc gcgccggcca ggacccccac ccagccaccc ccggagcctg
     1501 gtgacctgcc caccatcgag gaagctctgc agatcatcca cagtgccgag ccccggctcc
     1561 tcccagatgg ggcggccgac ggcagcttct acctccactc ccctgagggg ccctccaagc
     1621 catccctggc ctccccctac ctgcccgagg ggacctccaa accactgtcc gacaggccca
     1681 ccaaagcacc agtgtacatg ccacaccccg agaccccctc gaaaccatct ccctgtctgg
     1741 tgggggaggc atcgaaaccg ccagccccat ccgaggggtc cccgaaggcg gtggcttcgt
     1801 ccccagcagc caccaactcc gaggtgaaaa tgaccagctt tgcagaacgc aagaaacagc
     1861 tggtgaaggc agaggctgag gccggagcgg ggtcccccac gtccactccg gccccgccgg
     1921 aggccctgag ctcggagatg agtgagctca gcgcccggct ggaggagaaa cgcagagcca
     1981 tcgaggctca gaagcgacgg attgaggcca tattcgccaa gcaccgccag cggctgggca
     2041 aaagcgcctt cctgcaggtg cagccgcggg aagcctctgg ggaggcggaa gcagaggcgg
     2101 aggaggccga ttccggtcca gtccctggtg gggagcggcc cgcaggcgag ggccagggtg
     2161 agccaacctc acggcccaag gcagtgacct tctcgccaga cctgggcccg gtgccccacg
     2221 aggggctggg ggaatacaat cgagcggtca gcaagctgag tgccgccttg agctcgctgc
     2281 agcgggacat gcagaggctc acggaccagc agcagcggct cctggccccg cccgaggccc
     2341 ccggatccgc cccaccacct gctgcgtggg tcatccctgg ccccacgacg gggcccaaag
     2401 ctgcatcccc cagccccgcc cggcgagtcc cggccacccg gcgcagccct gggcccgggc
     2461 ccagccagtc accccgcagc ccgaaacaca cgcggccagc ggagctgcgg ctggcaccct
     2521 tgaccagggt gcttacgcca ccccacgacg tagacagcct cccccacctg cgcaagttct
     2581 cgccgagcca ggtgcccgtg cagacgcgct cttccatcct cctggcggag gagacgcccc
     2641 ccgaggagcc agccgcccgg ccgggcctca tcgagatccc gctgggcagc ctggcagatc
     2701 ccgccgccga ggacgaggga gacgggagcc ccgctggtgc tgaggattcc ttggaggagg
     2761 aggcgtcttc ggagggggag ccccgggtgg ggctggggtt cttctacaag gatgaagaca
     2821 agcctgagga cgagatggcc caaaagcggg ccagcctgct ggagcggcag cagcggcgag
     2881 cagaggaggc gcggcggcgc aagcagtggc aggaggtgga gaaggaacag cggagggagg
     2941 aggccgcgag gctggcccaa gaggaggccc cgggcccagc cccgcttgtg tccgcagtcc
     3001 cgatggcgac tccagcccct gctgcccggg ctccagccga ggaggaggtg ggcccccgga
     3061 agggggactt cacgcggcag gagtacgagc gccgggccca gctgaagctg atggacgacc
     3121 tcgataaggt gctgcggccc cgggctgcgg ggtccggggg tccaggtcgg ggcgggcgga
     3181 gggccacccg gcctcgctcg ggttgctgtg acgactcagc cctggcacga agcccagccc
     3241 gcggcctgct gggctctcgg ctgagcaaaa tctattccca gtccaccctg tcactgtcca
     3301 ctgtggccaa cgaggcccac aataacctcg gggtgaagag gcccacgtct cgggctccct
     3361 ccccgtcagg tctcatgtcc ccaagccgcc tgcctggaag ccgcgaacgg gactgggaaa
     3421 atggcagcaa tgcctcctcc ccagcgtcag tgcccgagta cacaggtcca cggctgtaca
     3481 aagaacccag cgccaagtcc aacaagttca tcatccacaa tgccctatca cactgctgcc
     3541 tggcgggcaa ggtgaacgaa ccgcagaaga atcgcattct ggaggaaatt gagaaaagca
     3601 aggccaacca cttcctgatc ctctttcgcg actcgagctg ccagttccgg gcgctctaca
     3661 cgctgtcggg ggagacagag gagctgtcgc ggctggcagg gtatgggccc cggaccgtca
     3721 cgcccgccat ggtggaaggc atctacaagt acaactcgga ccgcaagcgc ttcacccaga
     3781 tccccgccaa gaccatgtcc atgagcgtcg atgccttcac catccaggga cacctctggc
     3841 agggcaagaa acccaccact cccaagaagg gcggcggcac ccccaaatag ccccacccgg
     3901 gcggtccacg ggccgggccc tgtgtgctgc ggccgccatc ccctggagga cagtcagtcg
     3961 gtattcctgg gtcctgtctg tccccaaccg tgtctgggtg gggctggagt ctccaccctc
     4021 tgactttgag tccagtcctg ctgtgggggc tgagctggga ggttcaggga ctcagggctc
     4081 agctcagtcc ccttgtctgt cctcccccac ttcttgaata aaataattta aagagaa
//
