LOCUS       NM_203459               8017 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens calmodulin regulated spectrin associated protein
            family member 2 (CAMSAP2), transcript variant 2, mRNA.
ACCESSION   NM_203459 XM_036589
VERSION     NM_203459.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8017)
  AUTHORS   Singharajkomron,N., Yodsurang,V., Limprasutr,V., Wattanathamsan,O.,
            Iksen,I., Hayakawa,Y. and Pongrakhananon,V.
  TITLE     CAMSAP2 enhances lung cancer cell metastasis by mediating RASAL2
            degradation
  JOURNAL   Life Sci 338, 122391 (2024)
   PUBMED   38159595
  REMARK    GeneRIF: CAMSAP2 enhances lung cancer cell metastasis by mediating
            RASAL2 degradation.
REFERENCE   2  (bases 1 to 8017)
  AUTHORS   Zhang,R., Gu,L., Chen,W., Tanaka,N., Zhou,Z., Xu,H., Xu,T., Ji,W.,
            Liang,X. and Meng,W.
  TITLE     CAMSAP2 and CAMSAP3 localize at microtubule intersections to
            regulate the spatial distribution of microtubules
  JOURNAL   J Mol Cell Biol 15 (8) (2024)
   PUBMED   37567766
  REMARK    GeneRIF: CAMSAP2 and CAMSAP3 localize at microtubule intersections
            to regulate the spatial distribution of microtubules.
REFERENCE   3  (bases 1 to 8017)
  AUTHORS   Zuo,L., Wang,L., Yang,Z., Li,J., Wang,W., Li,J., Wang,Y., Song,X.,
            Zhnag,X. and Geng,Z.
  TITLE     [High expression of CAMSAP2 promotes invasion and metastasis of
            gastric cancer cells by upregulating TGF-beta signaling]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (9), 1460-1468 (2023)
   PUBMED   37814859
  REMARK    GeneRIF: [High expression of CAMSAP2 promotes invasion and
            metastasis of gastric cancer cells by upregulating TGF-beta
            signaling].
REFERENCE   4  (bases 1 to 8017)
  AUTHORS   Lv,C., Hu,Y., Zhou,X., Zhu,Y., Wang,J. and Zhou,F.
  TITLE     CircRNA SOD2 motivates non-small cell lungs cancer advancement with
            EMT via acting as microRNA-2355-5p's competing endogenous RNA to
            mediate calmodulin regulated spectrin associated proteins-2
  JOURNAL   Bioengineered 13 (3), 5756-5768 (2022)
   PUBMED   35188072
  REMARK    GeneRIF: CircRNA SOD2 motivates non-small cell lungs cancer
            advancement with EMT via acting as microRNA-2355-5p's competing
            endogenous RNA to mediate calmodulin regulated spectrin associated
            proteins-2.
REFERENCE   5  (bases 1 to 8017)
  AUTHORS   Cupido,T., Jones,N.H., Grasso,M.J., Pisa,R. and Kapoor,T.M.
  TITLE     A chemical genetics approach to examine the functions of AAA
            proteins
  JOURNAL   Nat Struct Mol Biol 28 (4), 388-397 (2021)
   PUBMED   33782614
  REMARK    GeneRIF: A chemical genetics approach to examine the functions of
            AAA proteins.
REFERENCE   6  (bases 1 to 8017)
  AUTHORS   Zhang,S., Kwan,P. and Baum,L.
  TITLE     The potential role of CAMSAP1L1 in symptomatic epilepsy
  JOURNAL   Neurosci Lett 556, 146-151 (2013)
   PUBMED   24148305
  REMARK    GeneRIF: the rs2292096 G allele of CAMSAP1L1, which was associated
            with reduced risk of symptomatic epilepsy, tended to associate with
            increased expression of CAMSAP1L1, which represses neurite
            outgrowth.
REFERENCE   7  (bases 1 to 8017)
  AUTHORS   Tanaka,N., Meng,W., Nagae,S. and Takeichi,M.
  TITLE     Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific
            organization of noncentrosomal microtubules
  JOURNAL   Proc Natl Acad Sci U S A 109 (49), 20029-20034 (2012)
   PUBMED   23169647
REFERENCE   8  (bases 1 to 8017)
  AUTHORS   Guo,Y., Baum,L.W., Sham,P.C., Wong,V., Ng,P.W., Lui,C.H., Sin,N.C.,
            Tsoi,T.H., Tang,C.S., Kwan,J.S., Yip,B.H., Xiao,S.M., Thomas,G.N.,
            Lau,Y.L., Yang,W., Cherny,S.S. and Kwan,P.
  TITLE     Two-stage genome-wide association study identifies variants in
            CAMSAP1L1 as susceptibility loci for epilepsy in Chinese
  JOURNAL   Hum Mol Genet 21 (5), 1184-1189 (2012)
   PUBMED   22116939
  REMARK    GeneRIF: in a two-stage GWAS to identify common susceptibility
            variants of epilepsy in Chinese, the strongest signals were
            observed with two highly correlated variants, rs2292096 and
            rs6660197, with the former reaching genome-wide significance, on
            1q32.1 in the CAMSAP1L gene
REFERENCE   9  (bases 1 to 8017)
  AUTHORS   Miyamoto-Sato,E., Fujimori,S., Ishizaka,M., Hirai,N., Masuoka,K.,
            Saito,R., Ozawa,Y., Hino,K., Washio,T., Tomita,M., Yamashita,T.,
            Oshikubo,T., Akasaka,H., Sugiyama,J., Matsumoto,Y. and Yanagawa,H.
  TITLE     A comprehensive resource of interacting protein regions for
            refining human transcription factor networks
  JOURNAL   PLoS One 5 (2), e9289 (2010)
   PUBMED   20195357
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 8017)
  AUTHORS   Baines,A.J., Bignone,P.A., King,M.D., Maggs,A.M., Bennett,P.M.,
            Pinder,J.C. and Phillips,G.W.
  TITLE     The CKK domain (DUF1781) binds microtubules and defines the
            CAMSAP/ssp4 family of animal proteins
  JOURNAL   Mol Biol Evol 26 (9), 2005-2014 (2009)
   PUBMED   19508979
  REMARK    GeneRIF: The CKK domain binds microtubules and represents a domain
            that evolved with the metazoa.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450104.14.
            
            On Jan 7, 2021 this sequence version replaced NM_203459.3.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon, compared to variant 1. The encoded isoform (2) is shorter
            than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2362277.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358823.7/ ENSP00000351684.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1074              AL450104.14        30057-31130
            1075-1334           AL450104.14        52003-52262
            1335-1496           AL450104.14        98540-98701
            1497-1580           AL450104.14        106725-106808
            1581-1722           AL450104.14        123364-123505
            1723-1862           AL450104.14        123870-124009
            1863-1956           AL450104.14        133158-133251
            1957-2044           AL450104.14        135946-136033
            2045-2127           AL450104.14        138374-138456
            2128-2197           AL450104.14        138804-138873
            2198-4400           AL450104.14        139196-141398
            4401-4537           AL450104.14        143705-143841
            4538-4758           AL450104.14        144439-144659
            4759-4831           AL450104.14        145981-146053
            4832-4947           AL450104.14        147174-147289
            4948-5066           AL450104.14        148470-148588
            5067-8017           AL450104.14        148918-151868
FEATURES             Location/Qualifiers
     source          1..8017
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..8017
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /note="calmodulin regulated spectrin associated protein
                     family member 2"
                     /db_xref="GeneID:23271"
                     /db_xref="HGNC:HGNC:29188"
                     /db_xref="MIM:613775"
     exon            1..1074
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             936..5372
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     calmodulin-regulated spectrin-associated protein 2;
                     calmodulin-regulated spectrin-associated protein 1-like
                     protein 1"
                     /codon_start=1
                     /product="calmodulin-regulated spectrin-associated protein
                     2 isoform 2"
                     /protein_id="NP_982284.1"
                     /db_xref="CCDS:CCDS1404.1"
                     /db_xref="GeneID:23271"
                     /db_xref="HGNC:HGNC:29188"
                     /db_xref="MIM:613775"
                     /translation="MGDAADPREMRKTFIVPAIKPFDHYDFSRAKIACNLAWLVAKAF
                     GTENVPEELQEPFYTDQYDQEHIKPPVVNLLLSAELYCRAGSLILKSDAAKPLLGHDA
                     VIQALAQKGLYVTDQEKLVTERDLHKKPIQMSAHLAMIDTLMMAYTVEMVSIEKVIAC
                     AQQYSAFFQATDLPYDIEDAVMYWINKVNEHLKDIMEQEQKLKEHHTVEAPGGQKARY
                     RKEQTLLKQLPCIPLVENLLKDGTDGCALAALIHFYCPDVVRLEDICLKETMSLADSL
                     YNLQLIQEFCQEYLNQCCHFTLEDMLYAASSIKSNYLVFMAELFWWFEVVKPSFVQPR
                     VVRPQGAEPVKDMPSIPVLNAAKRNVLDSSSDFPSSGEGATFTQSHHHLPSRYSRPQA
                     HSSASGGIRRSSSMSYVDGFIGTWPKEKRSSVHGVSFDISFDKEDSVQRSTPNRGITR
                     SISNEGLTLNNSHVSKHIRKNLSFKPINGEEEAESIEEELNIDSHSDLKSCVPLNTNE
                     LNSNENIHYKLPNGALQNRILLDEFGNQIETPSIEEALQIIHDTEKSPHTPQPDQIAN
                     GFFLHSQEMSILNSNIKLNQSSPDNVTDTKGALSPITDNTEVDTGIHVPSEDIPETMD
                     EDSSLRDYTVSLDSDMDDASKFLQDYDIRTGNTREALSPCPSTVSTKSQPGSSASSSS
                     GVKMTSFAEQKFRKLNHTDGKSSGSSSQKTTPEGSELNIPHVVAWAQIPEETGLPQGR
                     DTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGI
                     SPLREEAAGAEDEKVYTDRAKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPI
                     DPEKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQ
                     QSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSV
                     KSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGEPQL
                     KESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNED
                     QLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQ
                     KVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKT
                     EEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDH
                     IESPKTPIKGPPVSSLSLASLNTGDNESVHSGKRTPRSESVEGFLSPSRCGSRNGEKD
                     WENASTTSSVASGTEYTGPKLYKEPSAKSNKHIIQNALAHCCLAGKVNEGQKKKILEE
                     MEKSDANNFLILFRDSGCQFRSLYTYCPETEEINKLTGIGPKSITKKMIEGLYKYNSD
                     RKQFSHIPAKTLSASVDAITIHSHLWQTKRPVTPKKLLPTKA"
     exon            1075..1334
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1496
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1580
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1722
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1862
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1956
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2044
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2127
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2197
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..4400
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            4401..4537
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            4538..4758
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            4759..4831
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            4832..4947
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            4948..5066
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            5067..8017
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7998..8003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /note="hexamer: AATAAA"
     polyA_site      8017
                     /gene="CAMSAP2"
                     /gene_synonym="CAMSAP1L1"
                     /note="major polyA site"
ORIGIN      
        1 agtctccgca tctgctcctt catccagtgc cgcagccgga aaaccgcagc ggcggcggcg
       61 gcggctgagg gggaacgatc cagcgagctg cagaaagggg ggcaggaaaa aattacaagg
      121 acattactga taagacagga actgagagct tgggattcgc ggcctctccc cggccaccac
      181 cttcgccgtc agcaagggag gaagacccgg gagacggcag cggcgacggc ggcaggggaa
      241 ggaggagacg gcgacgggag ggagcacaga ggaggggacg ggccggcggc ggcctgtgag
      301 ccgcagtgat tttgacgttt tccgctgctg cgtctccggc gggcaggggc cgggctgcgc
      361 tgggtgggcc agctcgcccc gcgcttcccc ctcgtcctgc tcgtccctcc gcccacccgg
      421 ggcctgaggg gtctccccgc tccgagggaa ggggagaggg aggcgagggc gtgcgggcat
      481 cgcgatggcg gggacatttt ccacaacgtg attgttgaag gctcccccca tcccccctcc
      541 cttaaaattc cgggcccttc cagcctccac cctcccccaa gcccgtgtga ctaaaccgag
      601 acaaagggga ggcggcctcg ctcacacgcg ggctcgcggg gcgggtggct cggaggggcg
      661 cgggcacggg gcggacctcg cgcggacgga cggacggaga cggcgccgcc acattcctat
      721 gcccgggagc ggcggcggcg gcggcggcgg ctcccgcggg aggcggcagg cgcgcggcgc
      781 ggacagctga gcttctcctc cgtcggcgcc cgggcggaca tcgcccgggc cccgatggtt
      841 tgagcttgct tctccctccc tcccgacccc cgtggtggcg aggccacgcc atgtgaaggt
      901 tagggccggg acatcccgag gagccgcggt gaaagatggg ggatgctgca gaccccaggg
      961 agatgagaaa gacgttcatt gttccagcca tcaagccttt tgaccactat gatttctcca
     1021 gggccaaaat cgcctgcaat ctggcctggc tggtggccaa agcctttggg acagaaaatg
     1081 tgccagagga acttcaagaa ccattttaca cagatcagta tgaccaggaa cacatcaaac
     1141 cacctgttgt taatttgctt ctatcggctg aactatactg tcgtgctggg agtctcattc
     1201 tcaagagtga tgctgcaaaa ccccttttgg gccatgatgc tgtaatccag gctttagcac
     1261 agaaaggtct ttatgtcact gaccaggaaa aattggtaac tgaacgagat ctccacaaga
     1321 aacccataca gatgagtgca catttggcca tgatcgatac cctcatgatg gcttatactg
     1381 tagaaatggt cagtatagaa aaagtaattg cgtgtgctca gcagtattca gctttttttc
     1441 aagccacaga tctgccctat gatattgagg acgctgtcat gtactggata aataaggtaa
     1501 atgaacattt gaaagacata atggaacaag aacaaaaact gaaagaacat cacacagttg
     1561 aagctccagg aggtcaaaag gctcgttatc ggaaagagca aacattgctt aagcaactgc
     1621 cttgcattcc attggtagaa aatttgttga aggatgggac agatggctgt gcattagctg
     1681 cccttattca tttttactgt cctgatgttg tcagattaga ggatatttgt ttgaaagaaa
     1741 ctatgtcttt ggctgatagc ctgtataatc tgcagctgat tcaagaattt tgccaagaat
     1801 acttgaacca gtgttgccat ttcactctgg aagatatgct ctatgctgct tcatccataa
     1861 agagtaatta tttggtgttc atggcggaac tgttctggtg gtttgaagtg gtgaagccgt
     1921 cttttgtaca gcctcgtgtt gttcgtccac aaggagctga acctgtaaaa gatatgcctt
     1981 caattcctgt cttgaatgct gccaaaagaa atgtcttaga tagtagttct gacttccctt
     2041 caagtgggga aggagctaca tttacacagt ctcatcatca tttgccttct aggtattcac
     2101 gtccccaggc tcattcttca gcctcaggag gaattagaag gtcttcatct atgtcttatg
     2161 ttgatggctt catagggaca tggcccaaag agaaaagatc atcagtgcat ggcgtatcat
     2221 ttgatatttc ttttgataaa gaagatagtg tacagagatc cactccaaac cgaggaatca
     2281 ctcgttctat tagtaatgaa ggacttactc tgaacaacag tcatgtatct aaacacatta
     2341 ggaaaaattt gtccttcaag ccaataaatg gagaagagga agcagagagc attgaagaag
     2401 aacttaatat agattctcac agtgacctca aatcttgtgt gccccttaac acaaatgaac
     2461 taaattctaa tgagaatatt cattacaagc ttccaaatgg agctttacaa aatagaatac
     2521 ttcttgacga gtttggcaat cagatcgaga caccaagcat tgaagaagca ttacaaataa
     2581 ttcatgatac tgaaaaatct cctcatacac ctcagccaga ccaaattgct aatggcttct
     2641 ttcttcatag tcaagaaatg agtatcttaa attcaaatat caagttaaat caatctagtc
     2701 ctgataatgt aactgatacg aaaggtgcct tgagtcccat aactgacaat actgaagtag
     2761 acactggaat tcacgttcct tcagaagata ttcctgaaac tatggacgaa gattcttcgt
     2821 tgagagatta tactgtaagc ttggactctg acatggatga tgcatctaaa tttcttcagg
     2881 attatgatat tcgaactggc aacaccaggg aagctttgag tccttgtcca agtactgtaa
     2941 gtaccaagtc tcagccaggc agcagtgctt cttctagttc tggagttaaa atgaccagct
     3001 ttgctgaaca aaaattcagg aaactgaatc ataccgatgg aaaaagtagt ggaagcagtt
     3061 ctcaaaaaac tacaccagaa ggctctgaac ttaatattcc tcatgtggtt gcttgggcac
     3121 aaattccaga agaaacaggg cttccacagg gacgggacac tacccagctg ttggcctctg
     3181 aaatggtgca tcttaggatg aaactagaag aaaagaggcg tgctatagaa gcccagaaaa
     3241 agaaaatgga agctgctttt accaaacaga gacagaaaat gggaaggaca gcattcctta
     3301 ctgtagtgaa aaagaaaggg gatgggatat ctcctctacg agaggaagcg gcgggtgcag
     3361 aagatgagaa agtatatact gatcgagcaa aagaaaagga atcacaaaaa actgatggac
     3421 aaaggagcaa gtcactggca gatataaaag agagcatgga gaatcctcaa gccaaatggc
     3481 taaagtctcc aactacacct attgatcctg agaagcagtg gaacctggca agcccctcag
     3541 aagaaacttt aaatgaagga gagattttag aatataccaa atccattgaa aagttaaatt
     3601 catccctgca ttttctacaa caagaaatgc aacgcttgtc acttcagcag gagatgttaa
     3661 tgcagatgag agagcaacaa tcttgggtga tttcacctcc acaaccctct ccacagaaac
     3721 agattcgaga ttttaagcct tctaagcagg caggcctgtc atcagccatt gcaccattct
     3781 cctcagactc ccctcgtcct actcacccat ctccacagtc ttctaacagg aaaagtgcat
     3841 ctttttctgt taaaagtcaa aggactccta ggccaaatga gttaaaaata acacctttga
     3901 atcgaacctt gacacctcct cggtctgtgg atagccttcc tcggttaagg aggttttcac
     3961 caagtcaagt tcctattcaa actaggtcat ttgtatgttt tggggatgat ggagaacctc
     4021 agttaaagga atccaaacct aaagaggaag ttaaaaagga ggaattggaa tccaaaggga
     4081 ctttggaaca gcgtggacat aatccagaag aaaaggaaat caaacctttt gagtcaacag
     4141 tctctgaagt cctatcactg cctgtcacag agactgtatg tctgacacca aatgaggacc
     4201 aattgaatca acccacagaa ccccctccta aacccgtttt cccacccact gctccaaaaa
     4261 atgttaatct gattgaagtt tccctctcag atttgaaacc ccctgaaaag gctgatgtac
     4321 ctgttgaaaa atatgatgga gaaagtgata aagaacaatt tgatgatgac cagaaagtat
     4381 gctgtggatt cttttttaag gatgatcaaa aagcagaaaa tgatatggca atgaaacggg
     4441 cagctttgtt ggagaaaaga ttaagaaggg aaaaggaaac tcagctccgg aaacaacagt
     4501 tggaagcaga aatggagcat aagaaggagg aaacaaggcg taaaactgag gaagaacgtc
     4561 agaagaaaga agatgagaga gcacgcagag aatttattag gcaagaatat atgaggcgga
     4621 aacaactgaa actaatggaa gatatggata cagtaattaa accccgtcct caagtagtaa
     4681 aacaaaaaaa acagcgacca aaatctattc acagagatca tattgaatcc cccaaaacac
     4741 caataaaggg tcctccagtc tctagccttt ctttggcatc gctgaacacg ggtgataacg
     4801 agagtgtaca ttcaggcaag aggacgccaa gatcagagtc tgtagaaggc ttcttatctc
     4861 caagtcgttg tggcagtcga aatggagaaa aagactggga gaatgcatca acaacttctt
     4921 cagtggcttc tggaacagaa tatacaggac caaagctcta caaagaaccc agtgcaaaat
     4981 ccaataagca cataatacaa aatgctttag ctcattgctg tttggctgga aaagtaaatg
     5041 aaggtcagaa gaaaaaaata ctggaggaaa tggagaaatc agatgccaac aacttcttaa
     5101 tcttgttccg ggattcagga tgccagttca gatctttata cacttattgc ccagaaactg
     5161 aagaaatcaa taaactgact gggataggcc ctaaatctat cactaaaaaa atgattgaag
     5221 gactttacaa atataattct gacaggaaac agtttagcca catacccgct aaaactttat
     5281 ctgccagtgt tgatgcaatt accattcata gccatttatg gcagaccaaa agaccagtaa
     5341 cacccaaaaa acttttaccc actaaggcat agaagttggg aaatacttgc ttcagaacat
     5401 tcatggtaaa tttgcacttc atctttcctg cctatagaaa atctttctaa ttgccaacaa
     5461 gacttttatt aattaaaact ggacattaag ctctgttgtc atgaacaact ggaatgtaaa
     5521 ccacagtatt ttggagtgca gaacattctc aattaagtga taagtccaaa tgatgaagga
     5581 aatgttttaa ttcacaaatg gagatttgta tgtgttatca ggttcacctg cttgatatta
     5641 gatacattaa agcactgaat tttcatggat attagttgga tttatcattg aaatatggtt
     5701 aagattacaa attatgtgtt ttatttgttg ctttttttta accttttaat gtatattctt
     5761 gtcttcagat ggtttgctat ttttctctcc tgggggttta ttctaagata cctttgtatt
     5821 ttatttcatg tggagatcat gaaagtagga aatatacctt tagaagtaac tcgcaccttt
     5881 cttatgatgt taagagaaac actagtgttt agttttacag taaccctcat attttaatgg
     5941 tgttacagca tttgcaaaaa ttattctgct aagtatttac aactctattt attattcact
     6001 caagtattaa cattctctat taaataagag gaggtgttgt aaagagctgc tagtaggttc
     6061 gctttaaacc acatgagctt aaccaagaat atgttatgag aagttgctga ttaaatcagt
     6121 gctgttttta caccacttct ggccaactca gaataattta gattgttctt ttaacaaaaa
     6181 aggctttcta tctcttttaa agtaagtcac tttataagtt ggcagaagtg aatgacactt
     6241 tgagagtagt ctttcaatct gaagatgtaa gacttcctga aacaagttct caagaagtct
     6301 ttacattata tttataactc atataaaaat tatatttaga atttttaaac atgtacaaag
     6361 ggctacattt taattttaaa atagcttcac attattttac ttatattggg tttttcttca
     6421 ttttaatcct tttcaagtgg aatggcttag aataagtata cacttgaaat ctcctctaca
     6481 tgatctttgt tctttaacag tgtataccag agggttagtt ggggaaaaac ttcattctca
     6541 ggaaaagact tgaatgatta tgtgaccctg ttatatttca gtgttgtgac aaatgtgtaa
     6601 actagcgggg gaagacagta ttgtatcata aatgagatgc gtagtttgtt ttctttcatg
     6661 ggaagtagag ataaaaatat atacatttct ctaattgagt tgtttagaga aagaactaat
     6721 gtctcatatg atgtatttac ttattttaaa aaaaagaata ggaatgagat gtccctgagc
     6781 tgtacttttc tattattata aggcctttag gcatcagtgc atctgggtta tcaacatttt
     6841 ctcaaatgct gtcaatattt tactgtaatt tatgttctta tatttatgta tatttgttaa
     6901 aactgtaaaa aaatttcaca gatttttttc caatacctgt gcaagataca tgtgtagctc
     6961 aaaactattt gtgatctact gtttgcatgt aagagaccag gatatgtaac tcttatattt
     7021 taagtgtata catattgtgt atataacata tggatattaa aaatggggaa ttgcacattt
     7081 taccttttgg acagtaattt ctatcacagt tagaaggaaa tgatagtcaa atacacgttt
     7141 agattaaaac tagtttaaaa aattataaat gaatctaatc aaaatgtgaa tagtagtcaa
     7201 aaggataatt taataagcat tttacgttac taaatttgtt catttcaata ttaactaaat
     7261 ttccctcatc aaagcaatct ttgtgatatt acttcgctat taaataaaga aaattggatg
     7321 caagacaatg gagaaacttt aaaactaaac aggaccaccc tttattctta aatttgtgtg
     7381 tgtccaacag ttgaattgaa tgtctataag gtctaaaggt agaatgtgaa tattgccaca
     7441 gagttcattg ctctcagtat aagattttac tttattaatg cagaaggaat atggatatat
     7501 ttctttaagt ctgcagattt ttttattatg gtgcagcttt tttttaatta tgtttttaaa
     7561 attatacagt tgaaaaatat gccatttcat aaagtctgag gattttcgtc aaccttactg
     7621 aaacacactg gtgctttcat catcagaggt caaattatta tgataactat tccattaagt
     7681 ttgccaaaca tttgtcgtgg ttaccagtgc agcctgtcaa attctgctat ttgacacagc
     7741 tttggaaaga tttagttctt ggtttttccg ttttgtatta gaatgactgt tacagtttta
     7801 tttggctgtt taaagccaaa ttcagctatt taattatggt ttcatggaca ctgttgagca
     7861 atgtacagtg tatggtgtgc ttacctgtcc actctagagc attgcttaca ggttttttgt
     7921 tttttaagat gctgtgctgt aaaatactgt catacttgct atttcctggt acagtgtagt
     7981 ttttcccctt tcatttgaat aaaagcatgg caccaaa
//
