LOCUS       NM_004345                591 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens cathelicidin antimicrobial peptide (CAMP), mRNA.
ACCESSION   NM_004345
VERSION     NM_004345.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 591)
  AUTHORS   Hernandez-Sarmiento,L.J., Valdes-Lopez,J.F. and Urcuqui-Inchima,S.
  TITLE     Zika virus infection suppresses CYP24A1 and CAMP expression in
            human monocytes
  JOURNAL   Arch Virol 169 (7), 135 (2024)
   PUBMED   38839691
  REMARK    GeneRIF: Zika virus infection suppresses CYP24A1 and CAMP
            expression in human monocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 591)
  AUTHORS   Lou,J. and He,X.
  TITLE     [Progress of researches on the antiparasitic activity of
            antimicrobial peptide LL-37]
  JOURNAL   Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 36 (1), 98-104 (2024)
   PUBMED   38604693
  REMARK    GeneRIF: [Progress of researches on the antiparasitic activity of
            antimicrobial peptide LL-37].
            Review article
REFERENCE   3  (bases 1 to 591)
  AUTHORS   Wang,Q., Wen,W., Zhou,L., Liu,F., Ren,X., Yu,L., Chen,H. and
            Jiang,Z.
  TITLE     LL-37 improves sepsis-induced acute lung injury by suppressing
            pyroptosis in alveolar epithelial cells
  JOURNAL   Int Immunopharmacol 129, 111580 (2024)
   PUBMED   38310763
  REMARK    GeneRIF: LL-37 improves sepsis-induced acute lung injury by
            suppressing pyroptosis in alveolar epithelial cells.
REFERENCE   4  (bases 1 to 591)
  AUTHORS   Hopfinger,A., Schmid,A., Karrasch,T., Pankuweit,S., Schaffler,A.
            and Grote,K.
  TITLE     Cathelicidin Antimicrobial Peptide Levels in Atherosclerosis and
            Myocardial Infarction in Mice and Human
  JOURNAL   Int J Mol Sci 25 (5), 2909 (2024)
   PUBMED   38474156
  REMARK    GeneRIF: Cathelicidin Antimicrobial Peptide Levels in
            Atherosclerosis and Myocardial Infarction in Mice and Human.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 591)
  AUTHORS   Altieri,A., Marshall,C.L., Ramotar,P., Lloyd,D., Hemshekhar,M.,
            Spicer,V., van der Does,A.M. and Mookherjee,N.
  TITLE     Human Host Defense Peptide LL-37 Suppresses TNFalpha-Mediated
            Matrix Metalloproteinases MMP9 and MMP13 in Human Bronchial
            Epithelial Cells
  JOURNAL   J Innate Immun 16 (1), 203-215 (2024)
   PUBMED   38471488
  REMARK    GeneRIF: Human Host Defense Peptide LL-37 Suppresses
            TNFalpha-Mediated Matrix Metalloproteinases MMP9 and MMP13 in Human
            Bronchial Epithelial Cells.
REFERENCE   6  (bases 1 to 591)
  AUTHORS   Vandamme,D., Landuyt,B., Luyten,W. and Schoofs,L.
  TITLE     A comprehensive summary of LL-37, the factotum human cathelicidin
            peptide
  JOURNAL   Cell Immunol 280 (1), 22-35 (2012)
   PUBMED   23246832
  REMARK    GeneRIF: Besides its antimicrobial activity against bacteria,
            fungi, and viruses, LL-37 plays a role in chemotaxis,
            immunomodulation, wound healing, angiogenesis, apoptosis, & tumor
            surveillance.
            Review article
REFERENCE   7  (bases 1 to 591)
  AUTHORS   Gudmundsson,G.H., Magnusson,K.P., Chowdhary,B.P., Johansson,M.,
            Andersson,L. and Boman,H.G.
  TITLE     Structure of the gene for porcine peptide antibiotic PR-39, a
            cathelin gene family member: comparative mapping of the locus for
            the human peptide antibiotic FALL-39
  JOURNAL   Proc Natl Acad Sci U S A 92 (15), 7085-7089 (1995)
   PUBMED   7624374
REFERENCE   8  (bases 1 to 591)
  AUTHORS   Cowland,J.B., Johnsen,A.H. and Borregaard,N.
  TITLE     hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil
            specific granules
  JOURNAL   FEBS Lett 368 (1), 173-176 (1995)
   PUBMED   7615076
REFERENCE   9  (bases 1 to 591)
  AUTHORS   Larrick,J.W., Hirata,M., Balint,R.F., Lee,J., Zhong,J. and
            Wright,S.C.
  TITLE     Human CAP18: a novel antimicrobial lipopolysaccharide-binding
            protein
  JOURNAL   Infect Immun 63 (4), 1291-1297 (1995)
   PUBMED   7890387
REFERENCE   10 (bases 1 to 591)
  AUTHORS   Agerberth,B., Gunne,H., Odeberg,J., Kogner,P., Boman,H.G. and
            Gudmundsson,G.H.
  TITLE     FALL-39, a putative human peptide antibiotic, is cysteine-free and
            expressed in bone marrow and testis
  JOURNAL   Proc Natl Acad Sci U S A 92 (1), 195-199 (1995)
   PUBMED   7529412
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X89658.1.
            
            On Dec 27, 2018 this sequence version replaced NM_004345.4.
            
            Summary: This gene encodes a member of an antimicrobial peptide
            family, characterized by a highly conserved N-terminal signal
            peptide containing a cathelin domain and a structurally variable
            cationic antimicrobial peptide, which is produced by extracellular
            proteolysis from the C-terminus. The protein plays an important
            role in innate immunity defense against viruses. In addition to its
            antibacterial, antifungal, and antiviral activities, the encoded
            protein functions in cell chemotaxis, immune mediator induction,
            and inflammatory response regulation. [provided by RefSeq, Sep
            2021].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ891396.1, X89658.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG   :: upstream AUG and CDS
                                                  extension is not conserved
            coronavirus related                :: involved in immune response
                                                  or antiviral activity
            MANE Ensembl match                 :: ENST00000652295.2/
                                                  ENSP00000498425.1
            Protein has antimicrobial activity :: PMID: 23246832
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-591               X89658.1           19-609
FEATURES             Location/Qualifiers
     source          1..591
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..591
                     /gene="CAMP"
                     /gene_synonym="CAP-18; CAP18; CRAMP; FALL-39; FALL39;
                     HSD26; LL37"
                     /note="cathelicidin antimicrobial peptide"
                     /db_xref="GeneID:820"
                     /db_xref="HGNC:HGNC:1472"
                     /db_xref="MIM:600474"
     exon            1..218
                     /gene="CAMP"
                     /gene_synonym="CAP-18; CAP18; CRAMP; FALL-39; FALL39;
                     HSD26; LL37"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..530
                     /gene="CAMP"
                     /gene_synonym="CAP-18; CAP18; CRAMP; FALL-39; FALL39;
                     HSD26; LL37"
                     /note="18 kDa cationic antimicrobial protein; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="cathelicidin antimicrobial peptide
                     preproprotein"
                     /protein_id="NP_004336.4"
                     /db_xref="CCDS:CCDS2762.3"
                     /db_xref="GeneID:820"
                     /db_xref="HGNC:HGNC:1472"
                     /db_xref="MIM:600474"
                     /translation="MKTQRDGHSLGRWSLVLLLLGLVMPLAIIAQVLSYKEAVLRAID
                     GINQRSSDANLYRLLDLDPRPTMDGDPDTPKPVSFTVKETVCPRTTQQSPEDCDFKKD
                     GLVKRCMGTVTLNQARGSFDISCDKDNKRFALLGDFFRKSKEKIGKEFKRIVQRIKDF
                     LRNLVPRTES"
     exon            219..326
                     /gene="CAMP"
                     /gene_synonym="CAP-18; CAP18; CRAMP; FALL-39; FALL39;
                     HSD26; LL37"
                     /inference="alignment:Splign:2.1.0"
     exon            327..398
                     /gene="CAMP"
                     /gene_synonym="CAP-18; CAP18; CRAMP; FALL-39; FALL39;
                     HSD26; LL37"
                     /inference="alignment:Splign:2.1.0"
     exon            399..591
                     /gene="CAMP"
                     /gene_synonym="CAP-18; CAP18; CRAMP; FALL-39; FALL39;
                     HSD26; LL37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      570..575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMP"
                     /gene_synonym="CAP-18; CAP18; CRAMP; FALL-39; FALL39;
                     HSD26; LL37"
                     /note="hexamer: AATAAA"
     polyA_site      591
                     /gene="CAMP"
                     /gene_synonym="CAP-18; CAP18; CRAMP; FALL-39; FALL39;
                     HSD26; LL37"
                     /note="major polyA site"
ORIGIN      
        1 aggcagacat ggggaccatg aagacccaaa gggatggcca ctccctgggg cggtggtcac
       61 tggtgctcct gctgctgggc ctggtgatgc ctctggccat cattgcccag gtcctcagct
      121 acaaggaagc tgtgcttcgt gctatagatg gcatcaacca gcggtcctcg gatgctaacc
      181 tctaccgcct cctggacctg gaccccaggc ccacgatgga tggggaccca gacacgccaa
      241 agcctgtgag cttcacagtg aaggagacag tgtgccccag gacgacacag cagtcaccag
      301 aggattgtga cttcaagaag gacgggctgg tgaagcggtg tatggggaca gtgaccctca
      361 accaggccag gggctccttt gacatcagtt gtgataagga taacaagaga tttgccctgc
      421 tgggtgattt cttccggaaa tctaaagaga agattggcaa agagtttaaa agaattgtcc
      481 agagaatcaa ggattttttg cggaatcttg tacccaggac agagtcctag tgtgtgccct
      541 accctggctc aggcttctgg gctctgagaa ataaactatg agagcaattt c
//
