LOCUS       NM_001745               2171 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens calcium modulating ligand (CAMLG), mRNA.
ACCESSION   NM_001745
VERSION     NM_001745.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2171)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2171)
  AUTHORS   McDowell,M.A., Heimes,M., Fiorentino,F., Mehmood,S., Farkas,A.,
            Coy-Vergara,J., Wu,D., Bolla,J.R., Schmid,V., Heinze,R., Wild,K.,
            Flemming,D., Pfeffer,S., Schwappach,B., Robinson,C.V. and
            Sinning,I.
  TITLE     Structural Basis of Tail-Anchored Membrane Protein Biogenesis by
            the GET Insertase Complex
  JOURNAL   Mol Cell 80 (1), 72-86 (2020)
   PUBMED   32910895
REFERENCE   3  (bases 1 to 2171)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2171)
  AUTHORS   Inglis,A.J., Page,K.R., Guna,A. and Voorhees,R.M.
  TITLE     Differential Modes of Orphan Subunit Recognition for the WRB/CAML
            Complex
  JOURNAL   Cell Rep 30 (11), 3691-3698 (2020)
   PUBMED   32187542
REFERENCE   5  (bases 1 to 2171)
  AUTHORS   Kennedy,S.A., Jarboui,M.A., Srihari,S., Raso,C., Bryan,K.,
            Dernayka,L., Charitou,T., Bernal-Llinares,M., Herrera-Montavez,C.,
            Krstic,A., Matallanas,D., Kotlyar,M., Jurisica,I., Curak,J.,
            Wong,V., Stagljar,I., LeBihan,T., Imrie,L., Pillai,P., Lynn,M.A.,
            Fasterius,E., Al-Khalili Szigyarto,C., Breen,J., Kiel,C.,
            Serrano,L., Rauch,N., Rukhlenko,O., Kholodenko,B.N.,
            Iglesias-Martinez,L.F., Ryan,C.J., Pilkington,R., Cammareri,P.,
            Sansom,O., Shave,S., Auer,M., Horn,N., Klose,F., Ueffing,M.,
            Boldt,K., Lynn,D.J. and Kolch,W.
  TITLE     Extensive rewiring of the EGFR network in colorectal cancer cells
            expressing transforming levels of KRASG13D
  JOURNAL   Nat Commun 11 (1), 499 (2020)
   PUBMED   31980649
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2171)
  AUTHORS   Tovey,S.C., Bootman,M.D., Lipp,P., Berridge,M.J. and Bram,R.J.
  TITLE     Calcium-modulating cyclophilin ligand desensitizes hormone-evoked
            calcium release
  JOURNAL   Biochem Biophys Res Commun 276 (1), 97-100 (2000)
   PUBMED   11006089
REFERENCE   7  (bases 1 to 2171)
  AUTHORS   Holloway,M.P. and Bram,R.J.
  TITLE     Co-localization of calcium-modulating cyclophilin ligand with
            intracellular calcium pools
  JOURNAL   J Biol Chem 273 (26), 16346-16350 (1998)
   PUBMED   9632697
REFERENCE   8  (bases 1 to 2171)
  AUTHORS   von Bulow,G.U. and Bram,R.J.
  TITLE     NF-AT activation induced by a CAML-interacting member of the tumor
            necrosis factor receptor superfamily
  JOURNAL   Science 278 (5335), 138-141 (1997)
   PUBMED   9311921
REFERENCE   9  (bases 1 to 2171)
  AUTHORS   Bram,R.J., Valentine,V., Shapiro,D.N., Jenkins,N.A., Gilbert,D.J.
            and Copeland,N.G.
  TITLE     The gene for calcium-modulating cyclophilin ligand (CAMLG) is
            located on human chromosome 5q23 and a syntenic region of mouse
            chromosome 13
  JOURNAL   Genomics 31 (2), 257-260 (1996)
   PUBMED   8824814
REFERENCE   10 (bases 1 to 2171)
  AUTHORS   Bram,R.J. and Crabtree,G.R.
  TITLE     Calcium signalling in T cells stimulated by a cyclophilin B-binding
            protein
  JOURNAL   Nature 371 (6495), 355-358 (1994)
   PUBMED   7522304
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA727548.1, U18242.1,
            AC010301.7 and BX111055.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001745.3.
            
            Summary: The immunosuppressant drug cyclosporin A blocks a
            calcium-dependent signal from the T-cell receptor (TCR) that
            normally leads to T-cell activation. When bound to cyclophilin B,
            cyclosporin A binds and inactivates the key signaling intermediate
            calcineurin. The protein encoded by this gene functions similarly
            to cyclosporin A, binding to cyclophilin B and acting downstream of
            the TCR and upstream of calcineurin by causing an influx of
            calcium. This integral membrane protein appears to be a new
            participant in the calcium signal transduction pathway, implicating
            cyclophilin B in calcium signaling, even in the absence of
            cyclosporin. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.480092.1,
                                           SRR3476690.273731.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297156.4/ ENSP00000297156.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                DA727548.1         78-114
            38-994              U18242.1           1-957
            995-1670            AC010301.7         72675-73350
            1671-2171           BX111055.1         17-517              c
FEATURES             Location/Qualifiers
     source          1..2171
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..2171
                     /gene="CAMLG"
                     /gene_synonym="CAML; CDG2Z; GET2"
                     /note="calcium modulating ligand"
                     /db_xref="GeneID:819"
                     /db_xref="HGNC:HGNC:1471"
                     /db_xref="MIM:601118"
     exon            1..245
                     /gene="CAMLG"
                     /gene_synonym="CAML; CDG2Z; GET2"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..964
                     /gene="CAMLG"
                     /gene_synonym="CAML; CDG2Z; GET2"
                     /note="cyclophilin B-binding protein; calcium-modulating
                     cyclophilin ligand; calcium signal-modulating cyclophilin
                     ligand"
                     /codon_start=1
                     /product="guided entry of tail-anchored proteins factor
                     CAMLG"
                     /protein_id="NP_001736.1"
                     /db_xref="CCDS:CCDS4178.1"
                     /db_xref="GeneID:819"
                     /db_xref="HGNC:HGNC:1471"
                     /db_xref="MIM:601118"
                     /translation="MESMAVATDGGERPGVPAGSGLSASQRRAELRRRKLLMNSEQRI
                     NRIMGFHRPGSGAEEESQTKSKQQDSDKLNSLSVPSVSKRVVLGDSVSTGTTDQQGGV
                     AEVKGTQLGDKLDSFIKPPECSSDVNLELRQRNRGDLTADSVQRGSRHGLEQYLSRFE
                     EAMKLRKQLISEKPSQEDGNTTEEFDSFRIFRLVGCALLALGVRAFVCKYLSIFAPFL
                     TLQLAYMGLYKYFPKSEKKIKTTVLTAALLLSGIPAEVINRSMDTYSKMGEVFTDLCV
                     YFFTFIFCHELLDYWGSEVP"
     exon            246..706
                     /gene="CAMLG"
                     /gene_synonym="CAML; CDG2Z; GET2"
                     /inference="alignment:Splign:2.1.0"
     exon            707..772
                     /gene="CAMLG"
                     /gene_synonym="CAML; CDG2Z; GET2"
                     /inference="alignment:Splign:2.1.0"
     exon            773..2171
                     /gene="CAMLG"
                     /gene_synonym="CAML; CDG2Z; GET2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1371..1376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMLG"
                     /gene_synonym="CAML; CDG2Z; GET2"
                     /note="hexamer: AATAAA"
     regulatory      1381..1386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMLG"
                     /gene_synonym="CAML; CDG2Z; GET2"
                     /note="hexamer: AAGAAA"
     polyA_site      1391
                     /gene="CAMLG"
                     /gene_synonym="CAML; CDG2Z; GET2"
                     /note="major polyA site"
     polyA_site      1405
                     /gene="CAMLG"
                     /gene_synonym="CAML; CDG2Z; GET2"
     regulatory      1511..1516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMLG"
                     /gene_synonym="CAML; CDG2Z; GET2"
                     /note="hexamer: TATAAA"
     polyA_site      1538
                     /gene="CAMLG"
                     /gene_synonym="CAML; CDG2Z; GET2"
     regulatory      2144..2149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMLG"
                     /gene_synonym="CAML; CDG2Z; GET2"
                     /note="hexamer: ATTAAA"
     polyA_site      2171
                     /gene="CAMLG"
                     /gene_synonym="CAML; CDG2Z; GET2"
ORIGIN      
        1 ctctagtcat cgccctcgca gcggcggcca acatcaccgc cactgccacc cctcccagac
       61 tgtggacggg aggatggagt cgatggccgt cgctaccgac ggcggggaga ggccgggggt
      121 cccagcgggc tcaggtctgt cggcttccca gcgtcgggcg gagctgcgtc ggagaaagct
      181 gctcatgaac tcggaacagc gcatcaaccg gatcatgggc tttcacaggc ccgggagcgg
      241 cgcggaagaa gaaagtcaaa caaaatcaaa gcagcaggac agtgataaac tgaactccct
      301 cagcgttcct tccgtttcaa agcgagtagt gctgggtgat tcagtcagta caggaacaac
      361 tgaccagcag ggtggtgtgg ccgaggtaaa ggggacccaa ctgggagaca aattggactc
      421 gttcattaaa ccacctgagt gcagtagtga tgtcaacctt gagctccggc agcggaacag
      481 aggggacctg acagcggact cggtccagag gggttcccgc catggcctag agcagtacct
      541 ttccagattc gaagaagcaa tgaagctaag gaaacagctg attagtgaaa aacccagtca
      601 agaggatgga aatacaacag aagaatttga ctcttttcga atatttagat tggtgggatg
      661 tgctcttctt gctcttggag tcagagcttt tgtttgcaaa tacttgtcca tatttgctcc
      721 atttcttact ttacaacttg cgtacatggg attatacaaa tattttccca agagtgaaaa
      781 gaagataaag acaacagtac taacagctgc acttctattg tcgggaattc ctgccgaagt
      841 gataaatcga tcaatggata cctatagcaa aatgggcgaa gtcttcacag atctctgtgt
      901 ctactttttc acttttatct tttgtcatga actgcttgat tattggggct ctgaagtacc
      961 atgaagcctg tagaactgag aaggagaagc ttacaaaaaa aaaaaaatcc tcttctatat
     1021 tgcagtgtct ctaaaggagg caaattggtt tacaccttca tgtaattctt ttactttagg
     1081 ggttgtaaag ctactttatt agatatagaa tggcagattc tctgatttaa aagggctgag
     1141 tttgtattat tactgatatg aagaatagag taccaatgtc attaattgat ttttcttgtt
     1201 aatcagaatt cctattctgt acctttcctc taacttctca gatttgtaat tcttcttttg
     1261 ggagctgagc tagtgctttt aggagaacag ataaatgtgg tctcagccag ccctagagac
     1321 tgcttcttgt gtttgtgtca ttctgtcctg agaaatgaag tcatctgaaa aataaaatga
     1381 aagaaactga attgtctaat gttaactctg cacattgtaa cttttcttgt tgagttagta
     1441 tcttaatttt tactccagca caagtattta atcaaagaaa agattcatac atgtgaaatt
     1501 ggaaggtatt tataaaattt ttattgctgt ataccaaact cagaattgga actttttaca
     1561 tttgagtttc actttttaga agtatgtttt aagcaagcaa aaacaaaatg ggatgtgaag
     1621 aattgaggca tgcaacccaa tagcataaat gtcctttttc cccccaaata tggtctagat
     1681 gagttattat aaacattgtt tttatttttt tgagacagag tttcgctctt gttgcccagg
     1741 ctagagtgca atggcgccat ctcggctcac cgcaacctcc accttcctgg ttcaagggat
     1801 tctcctgcct cagcctccca agtagctggg attacaggca tgcaccacca cgcccagcta
     1861 atttttatat tctttagtaa agacagggtt tctccatgtt ggtcaggctg gtctcgaact
     1921 tctgacctca ggtgatctgc ccacctcggc ctcccaaagt gctgggatta caggcgtgag
     1981 ccactgcacc tggccttata aatatccttt taactaactc agtaactgcc atattttgtt
     2041 gggttgtctt cttaaaagaa tataagacta aagtgttaat gtcacttggt gttacatttc
     2101 cttacagatt tttgtatagt ctaatttggt taatccttgt gacattaaaa acacatacac
     2161 tttttaaaaa a
//
