LOCUS       NM_024046               2998 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens CaM kinase like vesicle associated (CAMKV), transcript
            variant 1, mRNA.
ACCESSION   NM_024046
VERSION     NM_024046.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2998)
  AUTHORS   Liang,Z., Zhan,Y., Shen,Y., Wong,C.C., Yates,J.R. 3rd, Plattner,F.,
            Lai,K.O. and Ip,N.Y.
  TITLE     The pseudokinase CaMKv is required for the activity-dependent
            maintenance of dendritic spines
  JOURNAL   Nat Commun 7, 13282 (2016)
   PUBMED   27796283
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2998)
  AUTHORS   So,H.C., Fong,P.Y., Chen,R.Y., Hui,T.C., Ng,M.Y., Cherny,S.S.,
            Mak,W.W., Cheung,E.F., Chan,R.C., Chen,E.Y., Li,T. and Sham,P.C.
  TITLE     Identification of neuroglycan C and interacting partners as
            potential susceptibility genes for schizophrenia in a Southern
            Chinese population
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 153B (1), 103-113 (2010)
   PUBMED   19367581
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   3  (bases 1 to 2998)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   4  (bases 1 to 2998)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   5  (bases 1 to 2998)
  AUTHORS   Godbout,M., Erlander,M.G., Hasel,K.W., Danielson,P.E., Wong,K.K.,
            Battenberg,E.L., Foye,P.E., Bloom,F.E. and Sutcliffe,J.G.
  TITLE     1G5: a calmodulin-binding, vesicle-associated, protein kinase-like
            protein enriched in forebrain neurites
  JOURNAL   J Neurosci 14 (1), 1-13 (1994)
   PUBMED   8283228
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK074856.1 and BC017363.2.
            
            On Nov 23, 2018 this sequence version replaced NM_024046.4.
            
            Transcript Variant: This variant (1)  represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.137079.1,
                                           SRR1660807.102109.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000477224.6/ ENSP00000419195.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1016              AK074856.1         31-1046
            1017-2998           BC017363.2         1004-2985
FEATURES             Location/Qualifiers
     source          1..2998
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..2998
                     /gene="CAMKV"
                     /gene_synonym="1G5; VACAMKL"
                     /note="CaM kinase like vesicle associated"
                     /db_xref="GeneID:79012"
                     /db_xref="HGNC:HGNC:28788"
                     /db_xref="MIM:614993"
     exon            1..149
                     /gene="CAMKV"
                     /gene_synonym="1G5; VACAMKL"
                     /inference="alignment:Splign:2.1.0"
     exon            150..258
                     /gene="CAMKV"
                     /gene_synonym="1G5; VACAMKL"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1669
                     /gene="CAMKV"
                     /gene_synonym="1G5; VACAMKL"
                     /note="isoform 1 is encoded by transcript variant 1;
                     vesicle-associated calmodulin-binding protein; caM
                     kinase-like vesicle-associated protein; testis tissue
                     sperm-binding protein Li 52e"
                     /codon_start=1
                     /product="caM kinase-like vesicle-associated protein
                     isoform 1"
                     /protein_id="NP_076951.2"
                     /db_xref="CCDS:CCDS33762.1"
                     /db_xref="GeneID:79012"
                     /db_xref="HGNC:HGNC:28788"
                     /db_xref="MIM:614993"
                     /translation="MPFGCVTLGDKKNYNQPSEVTDRYDLGQVIKTEEFCEIFRAKDK
                     TTGKLHTCKKFQKRDGRKVRKAAKNEIGILKMVKHPNILQLVDVFVTRKEYFIFLELA
                     TGREVFDWILDQGYYSERDTSNVVRQVLEAVAYLHSLKIVHRNLKLENLVYYNRLKNS
                     KIVISDFHLAKLENGLIKEPCGTPEYLAPEVVGRQRYGRPVDCWAIGVIMYILLSGNP
                     PFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWDDISQAAKDLVTRLMEVEQDQRIT
                     AEEAISHEWISGNAASDKNIKDGVCAQIEKNFARAKWKKAVRVTTLMKRLRAPEQSST
                     AAAQSASATDTATPGAAGGATAAAASGATSAPEGDAARAAKSDNVAPADRSATPATDG
                     SATPATDGSVTPATDGSITPATDGSVTPATDRSATPATDGRATPATEESTVPTTQSSA
                     MLATKAAATPEPAMAQPDSTAPEGATGQAPPSSKGEEAAGYAQESQREEAS"
     exon            259..390
                     /gene="CAMKV"
                     /gene_synonym="1G5; VACAMKL"
                     /inference="alignment:Splign:2.1.0"
     exon            391..465
                     /gene="CAMKV"
                     /gene_synonym="1G5; VACAMKL"
                     /inference="alignment:Splign:2.1.0"
     exon            466..604
                     /gene="CAMKV"
                     /gene_synonym="1G5; VACAMKL"
                     /inference="alignment:Splign:2.1.0"
     exon            605..725
                     /gene="CAMKV"
                     /gene_synonym="1G5; VACAMKL"
                     /inference="alignment:Splign:2.1.0"
     exon            726..801
                     /gene="CAMKV"
                     /gene_synonym="1G5; VACAMKL"
                     /inference="alignment:Splign:2.1.0"
     exon            802..938
                     /gene="CAMKV"
                     /gene_synonym="1G5; VACAMKL"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1017
                     /gene="CAMKV"
                     /gene_synonym="1G5; VACAMKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1105
                     /gene="CAMKV"
                     /gene_synonym="1G5; VACAMKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..2998
                     /gene="CAMKV"
                     /gene_synonym="1G5; VACAMKL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2976..2981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMKV"
                     /gene_synonym="1G5; VACAMKL"
                     /note="hexamer: AATAAA"
     polyA_site      2998
                     /gene="CAMKV"
                     /gene_synonym="1G5; VACAMKL"
                     /note="major polyA site"
ORIGIN      
        1 gatgctggag gttcgctagc cgaagcggct gcatctggcg ccgcgtctgc cccgcgtgct
       61 cggagcggat tctgcccgcc gtccccggag ccctcggcgc cccgctgagc ccgcgatcac
      121 ttcctccctg tgaccaaccg gcgctgcagg ttagagcctg gcaatgccgt ttgggtgtgt
      181 gactctgggc gacaagaaga actataacca gccatcggag gtgactgaca gatatgattt
      241 gggacaggtc atcaagactg aggagttttg tgaaatcttc cgggccaagg acaagacgac
      301 aggcaagctg cacacctgca agaagttcca gaagcgggac ggccgcaagg tgcggaaagc
      361 tgccaagaac gagataggca tcctcaagat ggtgaagcat cccaacatcc tacagctggt
      421 ggatgtgttt gtgacccgca aggagtactt tatcttcctg gagctggcca cggggaggga
      481 ggtgtttgac tggatcctgg accagggcta ctactcggag cgagacacaa gcaacgtggt
      541 acggcaagtc ctggaggccg tggcctattt gcactcactc aagatcgtgc acaggaatct
      601 caagctggag aacctggttt actacaaccg gctgaagaac tcgaagattg tcatcagtga
      661 cttccatctg gctaagctag aaaatggcct catcaaggag ccctgtggga cccccgagta
      721 tctggcccca gaggtggtag gccggcagcg gtatggacgc cctgtggact gctgggccat
      781 tggagtcatc atgtacatcc tgctttcagg caatccacct ttctatgagg aggtggaaga
      841 agatgattat gagaaccatg ataagaatct cttccgcaag atcctggctg gtgactatga
      901 gtttgactct ccatattggg atgatatttc gcaggcagcc aaagacctgg tcacaaggct
      961 gatggaggtg gagcaagacc agcggatcac tgcagaagag gccatctccc atgagtggat
     1021 ttctggcaat gctgcttctg ataagaacat caaggatggt gtctgtgccc agattgaaaa
     1081 gaactttgcc agggccaagt ggaagaaggc tgtccgagtg accaccctca tgaaacggct
     1141 ccgggcacca gagcagtcca gcacggctgc agcccagtcg gcctcagcca cagacactgc
     1201 cacccccggg gctgcaggtg gggccacagc tgcagctgcg agtggagcta cctcagcccc
     1261 tgagggtgat gctgctcgtg ctgcaaagag tgataatgtg gcccccgcag accgtagtgc
     1321 caccccagcc acagatggaa gtgccacccc agccactgat ggcagtgtca ccccagccac
     1381 cgatggaagc atcactccag ccactgatgg gagtgtcacc ccagccactg acaggagcgc
     1441 tactccagcc actgatggga gagccacacc agccacagaa gagagcactg tgcccaccac
     1501 ccaaagcagt gccatgctgg ccaccaaggc agctgccacc cctgagccgg ctatggccca
     1561 gccggacagc acagccccag agggcgccac aggccaggct ccaccctcta gtaaagggga
     1621 agaggctgct ggttatgccc aggagtctca aagggaggag gccagctgag taggcagcct
     1681 ggtgaggggg ggcaggggat gggcaggagg gtgggagagt ggatgagggg cttctcactg
     1741 tacatagagt cactggcatg atgccctcgc tcccccatgc ccccacatcc cagtggggca
     1801 taactagggg tcacgggaga gcagtctcgt ctcctgtgtg tatgtgtgtg agtggtgggc
     1861 aggccagtgg cagggccggc cccagcccct gcatggattc cttgtggctt ttctgtcttt
     1921 tgctagcttc accagtttct gttccttgtg ggatgctgct ctagggatac tcagggggct
     1981 cctgctctcc ttccccttcc cttcttgcct caccattccc ctaggcaggc cctgcaggtc
     2041 ccacactctc ccaggcccta aacttgggcg gccttgccct gagagctggt cctccagcga
     2101 ggccctgtca gcggtcttag gctcctgcac atgaaggtgt gtgcctgtgg tgtgtgggct
     2161 gctctaggag cagatacagg ctggtataga ggatgcagaa aggtagggca gtatgtttaa
     2221 gtccagactt ggcacatggc tagggatact gctcactagc tgtggaggtc ctcaggagtg
     2281 gagagaatga gtaggagggc agaagcttcc atttttgtcc ttcctaagac cctgttattt
     2341 gtgttatttc ctgcctttcc gagtcctgca gtgggctgcc ctgtaccctg aacctcatga
     2401 gcctctaagg gaaaggagga acaattagga cgtggcaatg agacctggca gggcagagta
     2461 caagcccagc acccagtgtc ccagccttac tgggtcctta ccctgggcca aacagggagg
     2521 gctgatacct ccttgctctt cctagatgcc cacctcctac aatctcagcc cacaagtcct
     2581 ctccacccta gggggcttgc tgcatggcaa taactcataa tctgatttgg aggtttgccc
     2641 tttacagggg cagattttct gctcagttca acaatgaaat gaagaggaac tccctctttc
     2701 tacagctcac ttctatcaga ggcccaggtg cctcagagcc acattgagtt gctttttctg
     2761 ggatgaggaa gtagggttaa actccccagt ttcctgaggg aggctcctga caggtgccct
     2821 ttgtcagacc ctaccacagc ctggataggc agccacattg gtcctcgccc ttgctcggca
     2881 ctccgtggtg gtcctgccct tctccctgca tgcctgtggg tctgctctgg tgtgtgaagg
     2941 tcggtgggtt aactgtgtgc ctactgaacc tggcaaataa acatcaccct gcaaagcc
//
