LOCUS       NM_032294               3572 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens calcium/calmodulin dependent protein kinase kinase 1
            (CAMKK1), transcript variant 1, mRNA.
ACCESSION   NM_032294
VERSION     NM_032294.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3572)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 3572)
  AUTHORS   Beghi,S., Cavaliere,F., Manfredini,M., Ferrarese,S., Corazzari,C.,
            Beghi,C. and Buschini,A.
  TITLE     Polymorphism rs7214723 in CAMKK1: a new genetic variant associated
            with cardiovascular diseases
  JOURNAL   Biosci Rep 41 (7) (2021)
   PUBMED   34165505
  REMARK    GeneRIF: Polymorphism rs7214723 in CAMKK1: a new genetic variant
            associated with cardiovascular diseases.
REFERENCE   3  (bases 1 to 3572)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3572)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3572)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   6  (bases 1 to 3572)
  AUTHORS   Matsushita,M. and Nairn,A.C.
  TITLE     Inhibition of the Ca2+/calmodulin-dependent protein kinase I
            cascade by cAMP-dependent protein kinase
  JOURNAL   J Biol Chem 274 (15), 10086-10093 (1999)
   PUBMED   10187789
REFERENCE   7  (bases 1 to 3572)
  AUTHORS   Matsushita,M. and Nairn,A.C.
  TITLE     Characterization of the mechanism of regulation of Ca2+/
            calmodulin-dependent protein kinase I by calmodulin and by
            Ca2+/calmodulin-dependent protein kinase kinase
  JOURNAL   J Biol Chem 273 (34), 21473-21481 (1998)
   PUBMED   9705275
REFERENCE   8  (bases 1 to 3572)
  AUTHORS   Tokumitsu,H. and Soderling,T.R.
  TITLE     Requirements for calcium and calmodulin in the calmodulin kinase
            activation cascade
  JOURNAL   J Biol Chem 271 (10), 5617-5622 (1996)
   PUBMED   8621423
REFERENCE   9  (bases 1 to 3572)
  AUTHORS   Tokumitsu,H., Enslen,H. and Soderling,T.R.
  TITLE     Characterization of a Ca2+/calmodulin-dependent protein kinase
            cascade. Molecular cloning and expression of
            calcium/calmodulin-dependent protein kinase kinase
  JOURNAL   J Biol Chem 270 (33), 19320-19324 (1995)
   PUBMED   7642608
REFERENCE   10 (bases 1 to 3572)
  AUTHORS   Selbert,M.A., Anderson,K.A., Huang,Q.H., Goldstein,E.G., Means,A.R.
            and Edelman,A.M.
  TITLE     Phosphorylation and activation of Ca(2+)-calmodulin-dependent
            protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia
            kinase. Phosphorylation of threonine 196 is essential for
            activation
  JOURNAL   J Biol Chem 270 (29), 17616-17621 (1995)
   PUBMED   7615569
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005940.3.
            
            On May 17, 2019 this sequence version replaced NM_032294.2.
            
            Summary: The product of this gene belongs to the Serine/Threonine
            protein kinase family, and to the Ca(2+)/calmodulin-dependent
            protein kinase subfamily. This protein plays a role in the
            calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript
            variants encoding two distinct isoforms have been identified for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136576.1, AF425232.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000348335.7/ ENSP00000323118.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AC005940.3         87194-87308
            116-518             AC005940.3         94517-94919
            519-566             AC005940.3         95820-95867
            567-620             AC005940.3         96310-96363
            621-672             AC005940.3         96767-96818
            673-806             AC005940.3         97072-97205
            807-843             AC005940.3         97683-97719
            844-865             AC005940.3         98599-98620
            866-954             AC005940.3         99813-99901
            955-1154            AC005940.3         103825-104024
            1155-1208           AC005940.3         106785-106838
            1209-1282           AC005940.3         107620-107693
            1283-1370           AC005940.3         110359-110446
            1371-1499           AC005940.3         110632-110760
            1500-1603           AC005940.3         114236-114339
            1604-3572           AC005940.3         117964-119932
FEATURES             Location/Qualifiers
     source          1..3572
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..3572
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /note="calcium/calmodulin dependent protein kinase kinase
                     1"
                     /db_xref="GeneID:84254"
                     /db_xref="HGNC:HGNC:1469"
                     /db_xref="MIM:611411"
     exon            1..115
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /inference="alignment:Splign:2.1.0"
     exon            116..518
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1676
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /EC_number="2.7.11.17"
                     /note="isoform a is encoded by transcript variant 1; CAMKK
                     alpha protein; caMKK 1; caM-KK 1; caM-KK alpha; caM-kinase
                     kinase 1; caM-kinase IV kinase; caM-kinase kinase alpha;
                     calcium/calmodulin-dependent protein kinase kinase alpha;
                     calcium/calmodulin-dependent protein kinase kinase 1,
                     alpha"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase
                     kinase 1 isoform a"
                     /protein_id="NP_115670.1"
                     /db_xref="CCDS:CCDS11038.1"
                     /db_xref="GeneID:84254"
                     /db_xref="HGNC:HGNC:1469"
                     /db_xref="MIM:611411"
                     /translation="MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDP
                     PPRARAASVIPGSTSRLLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPR
                     AWRRPTIESHHVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLS
                     KKKLLKQYGFPRRPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVL
                     DDPAEDNLYLVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDI
                     KPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKAL
                     DVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDK
                     NPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILV
                     KSMLRKRSFGNPFEPQARREERSMSAPGNLLVKEGFGEGGKSPELPGVQEDEAAS"
     exon            519..566
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /inference="alignment:Splign:2.1.0"
     exon            567..620
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /inference="alignment:Splign:2.1.0"
     exon            621..672
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /inference="alignment:Splign:2.1.0"
     exon            673..806
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /inference="alignment:Splign:2.1.0"
     exon            807..843
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /inference="alignment:Splign:2.1.0"
     exon            844..865
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /inference="alignment:Splign:2.1.0"
     exon            866..954
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1154
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1208
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1282
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1370
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1499
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1603
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..3572
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3144..3149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /note="hexamer: AATACA"
     polyA_site      3162
                     /gene="CAMKK1"
                     /gene_synonym="CAMKKA"
                     /note="major polyA site"
ORIGIN      
        1 gctcggcgat ctgggcccca gcgaggcggt ggggcggggc ggggcggggc ggggcgcgca
       61 gcaggagcga gtggggccgc ccgccgggcc gcggacactg tcgcccggcg cccaggttcc
      121 caacaaggct acgcagaaga acccccttga ctgaagcaat ggaggggggt ccagctgtct
      181 gctgccagga tcctcgggca gagctggtag aacgggtggc agccatcgat gtgactcact
      241 tggaggaggc agatggtggc ccagagccta ctagaaacgg tgtggacccc ccaccacggg
      301 ccagagctgc ctctgtgatc cctggcagta cttcaagact gctcccagcc cggcctagcc
      361 tctcagccag gaagctttcc ctacaggagc ggccagcagg aagctatctg gaggcgcagg
      421 ctgggcctta tgccacgggg cctgccagcc acatctcccc ccgggcctgg cggaggccca
      481 ccatcgagtc ccaccacgtg gccatctcag atgcagagga ctgcgtgcag ctgaaccagt
      541 acaagctgca gagtgagatt ggcaagggtg cctacggtgt ggtgaggctg gcctacaacg
      601 aaagtgaaga cagacactat gcaatgaaag tcctttccaa aaagaagtta ctgaagcagt
      661 atggctttcc acgtcgccct cccccgagag ggtcccaggc tgcccaggga ggaccagcca
      721 agcagctgct gcccctggag cgggtgtacc aggagattgc catcctgaag aagctggacc
      781 acgtgaatgt ggtcaaactg atcgaggtcc tggatgaccc agctgaggac aacctctatt
      841 tggtgtttga cctcctgaga aaggggcccg tcatggaagt gccctgtgac aagcccttct
      901 cggaggagca agctcgcctc tacctgcggg acgtcatcct gggcctcgag tacttgcact
      961 gccagaagat cgtccacagg gacatcaagc catccaacct gctcctgggg gatgatgggc
     1021 acgtgaagat cgccgacttt ggcgtcagca accagtttga ggggaacgac gctcagctgt
     1081 ccagcacggc gggaacccca gcattcatgg cccccgaggc catttctgat tccggccaga
     1141 gcttcagtgg gaaggccttg gatgtatggg ccactggcgt cacgttgtac tgctttgtct
     1201 atgggaagtg cccattcatc gacgatttca tcctggccct ccacaggaag atcaagaatg
     1261 agcccgtggt gtttcctgag gagccagaaa tcagcgagga gctcaaggac ctgatcctga
     1321 agatgttaga caagaatccc gagacgagaa ttggggtgcc agacatcaag ttgcaccctt
     1381 gggtgaccaa gaacggggag gagccccttc cttcggagga ggagcactgc agcgtggtgg
     1441 aggtgacaga ggaggaggtt aagaactcag tcaggctcat ccccagctgg accacggtga
     1501 tcctggtgaa gtccatgctg aggaagcgtt cctttgggaa cccgtttgag ccccaagcac
     1561 ggagggaaga gcgatccatg tctgctccag gaaacctact ggtgaaagaa gggtttggtg
     1621 aagggggcaa gagcccagag ctccccggcg tccaggaaga cgaggctgca tcctgagccc
     1681 ctgcatgcac ccagggccac ccggcagcac actcatcccg cgcctccaga ggcccacccc
     1741 tcatgcaaca gccgcccccg caggcagggg gctggggact gcagccccac tcccgcccct
     1801 cccccatcgt gctgcatgac ctccacgcac gcacgtccag ggacagactg gaatgtatgt
     1861 catttggggt cttgggggca gggctcccac gaggccatcc tcctcttctt ggacctcctt
     1921 ggcctgaccc attctgtggg gaaaccgggt gcccatggag cctcagaaat gccacccggc
     1981 tggttggcat ggcctggggc aggaggcaga ggcaggagac caagatggca ggtggaggcc
     2041 aggcttacca caacggaaga gacctcccgc tggggccggg caggcctggc tcagctgcca
     2101 caggcatatg gtggagaggg gggtaccctg cccaccttgg ggtggtggca ccagagctct
     2161 tgtctattca gacgctggta tgggggctcg gacccctcac tggggacagg gccagtgttg
     2221 gagaattctg attccttttt tgttgtcttt tacttttgtt tttaacctgg gggttcgggg
     2281 agaggccctg cttgggaaca tctcacgagc tttcctacat cttccgtggt tcccagcaca
     2341 gcccaagatt atttggcagc caagtggatg gaactaactt tcctggactg tgtttcgcat
     2401 tcggcgttat ctggaaagtg gactgaacgg aatcaagctc tgagcagagg cctgaagcgg
     2461 aagcaccaca tcgtccctgc ccatctcact ctctcccttg atgatgcccc tagagctgag
     2521 gctggagaag acaccagggc tgactttgac cgagggccat ggacgcgaca ggcctgtggc
     2581 cctgcgcatg ctgaaataac tggaacccag cctctcctcc tacaccggcc tacccatctg
     2641 ggcccaagag ctgcactcac actcctacaa cgaaggacaa actgtccagg tcggagggat
     2701 cacgagacac agaacctgga ggggtgtgca cgctggcagg tggcctctgc ggcaattgcc
     2761 tcaccctgag gacatcagca gtcagcctgc tcagagcggg ggtgctggag cgcgtgcaga
     2821 cacagctctt ccggagcagc cttcaccttc tctctgggat cagtgtccgg ctggccgacg
     2881 tggcatttgc tgaccgaatg ctcatagagg ttgaccccca cagggtcacg caggactcgg
     2941 acactgccct ggaaacatgg atggacaagg gcttttggcc acaggtgtgg gtgtcctgtt
     3001 ggaggagggc ttgtttggag aagggaggct ggctggggga gaaacccgga tcccgctgca
     3061 tctccgcgcc tgtgggtgca tgtcgcgtgc tcatctgttg cacacagctc actcgtatgt
     3121 cctgcactgg tacatgcatc tgtaatacag tttctacgtc tatttaaggc taggagccga
     3181 atgtgcccca ttgtcagtgg gtccacgttt ctccccggct cctctgggct aaggcagtgt
     3241 ggcccgaagc ttaaaaagtt actcggtact gtttttaaga acacttttat agagttagtg
     3301 gaaggcaagt taagagccaa tcactgatcc ccaagtgttt cttgagcatc tggtctgggg
     3361 ggaccacttt gatcggaccc acccttggaa agctcagggg taggcccagg tgggatgctc
     3421 accctgtcac tgagggtttt ggttggcatc gttgtttttg aatgtagcac aagcgatgag
     3481 caaactctat aagagtgttt taaaaattaa cttcccagga agtgagttaa aaacaataaa
     3541 agccctttct tgagttaaaa agaaaaaaaa aa
//
