LOCUS       NM_001744              11942 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens calcium/calmodulin dependent protein kinase IV
            (CAMK4), transcript variant 1, mRNA.
ACCESSION   NM_001744
VERSION     NM_001744.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11942)
  AUTHORS   Scherlinger,M., Li,H., Pan,W., Li,W., Karino,K., Vichos,T.,
            Boulougoura,A., Yoshida,N., Tsokos,M.G. and Tsokos,G.C.
  TITLE     CaMK4 controls follicular helper T cell expansion and function
            during normal and autoimmune T-dependent B cell responses
  JOURNAL   Nat Commun 15 (1), 840 (2024)
   PUBMED   38287012
  REMARK    GeneRIF: CaMK4 controls follicular helper T cell expansion and
            function during normal and autoimmune T-dependent B cell responses.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11942)
  AUTHORS   Zhang,Y., Daniel,E.A., Metcalf,J., Dai,Y., Reif,G.A. and
            Wallace,D.P.
  TITLE     CaMK4 overexpression in polycystic kidney disease promotes
            mTOR-mediated cell proliferation
  JOURNAL   J Mol Cell Biol 14 (7) (2022)
   PUBMED   36002021
  REMARK    GeneRIF: CaMK4 overexpression in polycystic kidney disease promotes
            mTOR-mediated cell proliferation.
REFERENCE   3  (bases 1 to 11942)
  AUTHORS   Bhargava,R., Lehoux,S., Maeda,K., Tsokos,M.G., Krishfield,S.,
            Ellezian,L., Pollak,M., Stillman,I.E., Cummings,R.D. and
            Tsokos,G.C.
  TITLE     Aberrantly glycosylated IgG elicits pathogenic signaling in
            podocytes and signifies lupus nephritis
  JOURNAL   JCI Insight 6 (9), 147789 (2021)
   PUBMED   33784256
  REMARK    GeneRIF: Aberrantly glycosylated IgG elicits pathogenic signaling
            in podocytes and signifies lupus nephritis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11942)
  AUTHORS   Chang,S., Yin,T., He,F., Ding,J., Shang,Y. and Yang,J.
  TITLE     CaMK4 promotes abortion-related Th17 cell imbalance by activating
            AKT/mTOR signaling pathway
  JOURNAL   Am J Reprod Immunol 84 (6), e13315 (2020)
   PUBMED   32738170
  REMARK    GeneRIF: CaMK4 promotes abortion-related Th17 cell imbalance by
            activating AKT/mTOR signaling pathway.
REFERENCE   5  (bases 1 to 11942)
  AUTHORS   Selbert,M.A., Anderson,K.A., Huang,Q.H., Goldstein,E.G., Means,A.R.
            and Edelman,A.M.
  TITLE     Phosphorylation and activation of Ca(2+)-calmodulin-dependent
            protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia
            kinase. Phosphorylation of threonine 196 is essential for
            activation
  JOURNAL   J Biol Chem 270 (29), 17616-17621 (1995)
   PUBMED   7615569
REFERENCE   6  (bases 1 to 11942)
  AUTHORS   Bland,M.M., Monroe,R.S. and Ohmstede,C.A.
  TITLE     The cDNA sequence and characterization of the
            Ca2+/calmodulin-dependent protein kinase-Gr from human brain and
            thymus
  JOURNAL   Gene 142 (2), 191-197 (1994)
   PUBMED   8194751
REFERENCE   7  (bases 1 to 11942)
  AUTHORS   Kitani,T., Okuno,S. and Fujisawa,H.
  TITLE     cDNA cloning and expression of human calmodulin-dependent protein
            kinase IV
  JOURNAL   J Biochem 115 (4), 637-640 (1994)
   PUBMED   8089075
REFERENCE   8  (bases 1 to 11942)
  AUTHORS   Bredt,D.S., Ferris,C.D. and Snyder,S.H.
  TITLE     Nitric oxide synthase regulatory sites. Phosphorylation by cyclic
            AMP-dependent protein kinase, protein kinase C, and
            calcium/calmodulin protein kinase; identification of flavin and
            calmodulin binding sites
  JOURNAL   J Biol Chem 267 (16), 10976-10981 (1992)
   PUBMED   1375933
REFERENCE   9  (bases 1 to 11942)
  AUTHORS   Jensen,K.F., Ohmstede,C.A., Fisher,R.S. and Sahyoun,N.
  TITLE     Nuclear and axonal localization of Ca2+/calmodulin-dependent
            protein kinase type Gr in rat cerebellar cortex
  JOURNAL   Proc Natl Acad Sci U S A 88 (7), 2850-2853 (1991)
   PUBMED   2011593
REFERENCE   10 (bases 1 to 11942)
  AUTHORS   Sikela,J.M., Law,M.L., Kao,F.T., Hartz,J.A., Wei,Q. and Hahn,W.E.
  TITLE     Chromosomal localization of the human gene for brain
            Ca2+/calmodulin-dependent protein kinase type IV
  JOURNAL   Genomics 4 (1), 21-27 (1989)
   PUBMED   2536634
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA396146.1, BC025687.1,
            AC011422.2 and BQ018740.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001744.5.
            
            Summary: The product of this gene belongs to the serine/threonine
            protein kinase family, and to the Ca(2+)/calmodulin-dependent
            protein kinase subfamily. This enzyme is a multifunctional
            serine/threonine protein kinase with limited tissue distribution,
            that has been implicated in transcriptional regulation in
            lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.161163.1,
                                           SRR1660803.26251.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282356.9/ ENSP00000282356.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA396146.1         136-146
            12-1110             BC025687.1         1-1099
            1111-1111           AC011422.2         42259-42259         c
            1112-2107           BC025687.1         1101-2096
            2108-11338          AC011422.2         32032-41262         c
            11339-11942         BQ018740.1         15-618              c
FEATURES             Location/Qualifiers
     source          1..11942
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.1"
     gene            1..11942
                     /gene="CAMK4"
                     /gene_synonym="caMK; CaMK IV; CaMK-GR; CaMKIV"
                     /note="calcium/calmodulin dependent protein kinase IV"
                     /db_xref="GeneID:814"
                     /db_xref="HGNC:HGNC:1464"
                     /db_xref="MIM:114080"
     exon            1..261
                     /gene="CAMK4"
                     /gene_synonym="caMK; CaMK IV; CaMK-GR; CaMKIV"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1522
                     /gene="CAMK4"
                     /gene_synonym="caMK; CaMK IV; CaMK-GR; CaMKIV"
                     /EC_number="2.7.11.17"
                     /note="isoform 1 is encoded by transcript variant 1; brain
                     Ca++-calmodulin-dependent protein kinase type IV; brain
                     Ca(2+)-calmodulin-dependent protein kinase type IV;
                     calcium/calmodulin-dependent protein kinase type IV
                     catalytic chain; CAM kinase IV; CAM kinase- GR"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     IV isoform 1"
                     /protein_id="NP_001735.1"
                     /db_xref="CCDS:CCDS4103.1"
                     /db_xref="GeneID:814"
                     /db_xref="HGNC:HGNC:1464"
                     /db_xref="MIM:114080"
                     /translation="MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSD
                     FFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNII
                     KLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGI
                     VHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAY
                     GPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDL
                     VRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVV
                     ASSRLGSASSSHGSIQESHKASRDPSPIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQA
                     ELMKVQALEKVKGADINAEEAPKMVPKAVEDGIKVADLELEEGLAEEKLKTVEEAAAP
                     REGQGSSAVGFEVPQQDVILPEY"
     exon            262..340
                     /gene="CAMK4"
                     /gene_synonym="caMK; CaMK IV; CaMK-GR; CaMKIV"
                     /inference="alignment:Splign:2.1.0"
     exon            341..403
                     /gene="CAMK4"
                     /gene_synonym="caMK; CaMK IV; CaMK-GR; CaMKIV"
                     /inference="alignment:Splign:2.1.0"
     exon            404..486
                     /gene="CAMK4"
                     /gene_synonym="caMK; CaMK IV; CaMK-GR; CaMKIV"
                     /inference="alignment:Splign:2.1.0"
     exon            487..559
                     /gene="CAMK4"
                     /gene_synonym="caMK; CaMK IV; CaMK-GR; CaMKIV"
                     /inference="alignment:Splign:2.1.0"
     exon            560..650
                     /gene="CAMK4"
                     /gene_synonym="caMK; CaMK IV; CaMK-GR; CaMKIV"
                     /inference="alignment:Splign:2.1.0"
     exon            651..725
                     /gene="CAMK4"
                     /gene_synonym="caMK; CaMK IV; CaMK-GR; CaMKIV"
                     /inference="alignment:Splign:2.1.0"
     exon            726..801
                     /gene="CAMK4"
                     /gene_synonym="caMK; CaMK IV; CaMK-GR; CaMKIV"
                     /inference="alignment:Splign:2.1.0"
     exon            802..928
                     /gene="CAMK4"
                     /gene_synonym="caMK; CaMK IV; CaMK-GR; CaMKIV"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1081
                     /gene="CAMK4"
                     /gene_synonym="caMK; CaMK IV; CaMK-GR; CaMKIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..11942
                     /gene="CAMK4"
                     /gene_synonym="caMK; CaMK IV; CaMK-GR; CaMKIV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11916..11921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK4"
                     /gene_synonym="caMK; CaMK IV; CaMK-GR; CaMKIV"
                     /note="hexamer: AATAAA"
     polyA_site      11942
                     /gene="CAMK4"
                     /gene_synonym="caMK; CaMK IV; CaMK-GR; CaMKIV"
                     /note="major polyA site"
ORIGIN      
        1 ctctctcgct cctgcgttcg caggcggcgg ctggcggccg gcttctcgct cgggcagcgg
       61 cggcggcggc ggcggcggct tccggagtcc cgctgcgaag atgctcaaag tcacggtgcc
      121 ctcctgctcc gcctcgtcct gctcttcggt caccgccagt gcggccccgg ggaccgcgag
      181 cctcgtcccg gattactgga tcgacggctc caacagggat gcgctgagcg atttcttcga
      241 ggtggagtcg gagctgggac ggggtgctac atccattgtg tacagatgca aacagaaggg
      301 gacccagaag ccttatgctc tcaaagtgtt aaagaaaaca gtggacaaaa aaatcgtaag
      361 aactgagata ggagttcttc ttcgcctctc acatccaaac attataaaac ttaaagagat
      421 atttgaaacc cctacagaaa tcagtctggt cctagaactc gtcacaggag gagaactgtt
      481 tgataggatt gtggaaaagg gatattacag tgagcgagat gctgcagatg ccgttaaaca
      541 aatcctggag gcagttgctt atctacatga aaatgggatt gtccatcgtg atctcaaacc
      601 agagaatctt ctttatgcaa ctccagcccc agatgcacca ctcaaaatcg ctgattttgg
      661 actctctaaa attgtggaac atcaagtgct catgaagaca gtatgtggaa ccccagggta
      721 ctgcgcacct gaaattctta gaggttgtgc ctatggacct gaggtggaca tgtggtctgt
      781 aggaataatc acctacatct tactttgtgg atttgaacca ttctatgatg aaagaggcga
      841 tcagttcatg ttcaggagaa ttctgaattg tgaatattac tttatctccc cctggtggga
      901 tgaagtatct ctaaatgcca aggacttggt cagaaaatta attgttttgg atccaaagaa
      961 acggctgact acatttcaag ctctccagca tccgtgggtc acaggtaaag cagccaattt
     1021 tgtacacatg gataccgctc aaaagaagct ccaagaattc aatgcccggc gtaagcttaa
     1081 ggcagcggtg aaggctgtgg tggcctcttc gcgcctggga agtgccagca gcagccatgg
     1141 cagcatccag gagagccaca aggctagccg agacccttct ccaatccaag atggcaacga
     1201 ggacatgaaa gctattccag aaggagagaa aattcaaggc gatggggccc aagccgcagt
     1261 taagggggca caggctgagc tgatgaaggt gcaagcctta gagaaagtta aaggtgcaga
     1321 tataaatgct gaagaggccc ccaaaatggt gcccaaggca gtggaggatg ggataaaggt
     1381 ggctgacctg gaactagagg agggcctagc agaggagaag ctgaagactg tggaggaggc
     1441 agcagctccc agagaagggc aaggaagctc tgctgtgggt tttgaagttc cacagcaaga
     1501 tgtgatcctg ccagagtact aaacagcttc cttcagatct ggaagccaaa caccggcatt
     1561 ttatgtactt tgtccttcag caagaaaggt gtggaagcat gatatgtact atagtgattc
     1621 tgtttttgag gtgcaaaaaa catacatata taccagttgg taattctaac ttcaatgcat
     1681 gtgactgctt tatgaaaata atagtgtctt ctatggcatg taatggatac ctaataccga
     1741 tgagttaaat cttgcaagtt aacacaacgt aacacttaaa agcatacatt ttcagcaacc
     1801 agtggcacat atttgaagtg aatagtagca aattgttttt gctttgaaaa tctagccatc
     1861 ctacatcctt tggatttctt cacaaggcag taattccttt gaactactgc ttagctaata
     1921 ctaggtagtg ctaaaagaca tgttcccata acttttacaa cattttactt tttatcattg
     1981 atgtgttcaa actgtttaca aggagatgct tatagatgat agttgtacat atgtgcaaaa
     2041 aaaaatccac ttgcaatggt aagaaattga agtatcctta aaggccatga agccatatgt
     2101 ccctaaagcc tgtgtggaga atgctttatt ttattcttat ttatatacac tatattaata
     2161 ataaccaaaa tgttctaaga ttctgccatt ttacaaccct ggaggaagta atttacaaac
     2221 tcacgctgag ttccattctt tccttcacct gctctccaat aagatgactt tctgatagac
     2281 aaagcttagg gtgtaataaa cagggaagaa aagaaggtaa gactgtactt aaactgatga
     2341 agataagatt gattcctttt cattttccag ataaaattgt atttactcat gaatttatac
     2401 aactttacag ataagaacat tttaatggat aaactctata attaccaagt tgcaaatatt
     2461 tagaaaattc tatttcacag gttagtgcca aaatgtcttc atagagtagg aataatattc
     2521 cattttaaga ttattcatta ttgactttaa tagagtaaga aaacattatt gtttatcaaa
     2581 gctctttttt tatccaattg atggttatct acacatatca cttataaact aaagttattt
     2641 atgaaaagct agtatgtctt tttctcgtat ttggaatgaa agtacccaca ttttacaatg
     2701 tagtgttgag aatgtggctg ccaataaatt tagcacaatg caatttattt accttaaaaa
     2761 acaaacaaaa acaaaaataa agaaaaatac tgatttcaaa tcagactctt aaaaagctgg
     2821 aacattagac ctgatatttt attatgattt ttcccagaat aagtttaatt tctctttgac
     2881 tttcatagaa acactttccc cttatagaaa ttgcactatc tccaatttat ttctagtttg
     2941 agttgaaatg aatattttat cagattaatt atgtgtcaca tttttggtgg gttttctcaa
     3001 ttttaaaaaa gaattcattt taaaaaataa ttattttcag agaccaaata aagacaataa
     3061 aaatgactat cacataaaaa tccttgttaa aaaagagatc ttaaattatg ttggctctcc
     3121 ctcaaaacta ttaaattaga aaacgaaact aaagctccag tttgtagagg ctgttggacc
     3181 tcagtagaca ttcttctttt caatcacaaa tctctctcta ctactgttct catgggaaga
     3241 aaacaaggta ggacttctta tctttcatag tttaagaatc tgacaggtca ctgatatgga
     3301 gcccctgaag aagcacatca tctgggctca gaagattatt ttttgttttg ttttatttgt
     3361 actatctagt agagagcact tttcttattc cctctttcct tccttcctca tttaattatt
     3421 ccctctcaga attcccatgt tgtccattat aaggggctcg ctatttttaa cctttaagaa
     3481 tgtcttcttt gttaagcatt aagatttcca tttaagagga tcaatttcct gttgtacttt
     3541 ttaccatgag actgaaacac acacacacac acacacacac acacacacac acacacacgt
     3601 gttggaagag caaagagagg gaagggggtc tttttagaaa gtggcacttg gcgcttagct
     3661 gaaagatcag aacacatcat tcctccctgc ccacccccat attgttccaa gggcagttgt
     3721 tacattattt caacactaga gtagggcgga ctgcattgtt tggccctgag aactatagaa
     3781 acaacgttgc aaataccatg cccaatgtgt attttagaat ttactcattt aaatgagtgc
     3841 atattaccat tcctccatgt gagtactcga gttgataatt ccctctatct ttttaaaccc
     3901 ataaactaca tttttaaaaa aatcaatggg agttttaaat tttgactcat gttaaagata
     3961 agattctgat aatgactata tagtgactaa tttcattgtt tcagtaggaa acaaatcaaa
     4021 ctttcaaaaa tgttggtcat ttcagtcaaa ttattcaaag atttcatata catacatcct
     4081 aagttaggat aattatgtta acatttttga aagaacagcc aatgtttata ttgcttgtta
     4141 aaatggaatg tattgtctat ctcaaagatt acttagctaa ataatagtag acaaatggag
     4201 atttaatttc acaaaatact tcataacatc actcctaatt ggcaatatag tcacaaagca
     4261 aaagaattca aatttcagca aacaataaat tacattttac attttagagc taacacttat
     4321 cacattacat tatgggtttt tattttgaga taagttcagc tacatagcat aaactaggtt
     4381 tttttttata accatgaagg acagtcttga attatttccc ccattaacaa agtctaattg
     4441 gaatccagta ttttttctca aactgtaatt tcacttgtcc caggacacat aaataggtaa
     4501 aaattagaat aatatcgtgg tagaagttaa ttgtccagaa caagtgcatt atataaatat
     4561 aatgcaagca catgtcattt aagattttct attagtcaca ttttaagaaa aatagatgaa
     4621 agtatagtat ttttaatcca attcatccaa attattctat cgatatatag tcaatattaa
     4681 aatttaatgt gatattttga attctttatt tttatactgt tttcaaaatc aagagtgtat
     4741 gttaggcctt tgggacatca agtgctcaat agtcacatgt ggctagtggc taccatatta
     4801 gacagcacta gtctagagta ctttttattt taagcaaagt gacacttgaa gttctatgct
     4861 tagatttaag tggcctcagt tttcacattg aggagctggt gggaggccac aaagaaagtg
     4921 tttcagaaat gttacacact gagtaaaagc ttattgacca ctcctgccca ttcatttact
     4981 tcagaggaga aatgattcct aacatgactt caaagaacgg gcattactaa attatctact
     5041 gaccaatccc tctgattcct gatgggccct ggagtcttga ctacagccta gagtctcctg
     5101 agtactgcca tgatgccaat agcattcttg cttaccaaaa tctactctca gccaactatg
     5161 tgtcttcatt caggaagaac tgcacataga atctgatttt gaggcctgga ttaagcttca
     5221 tgccatcctt gtatcacagg caatatgtct ttctggaaat ctaatgaacc ataccaaatc
     5281 tgcatgatga agattgtgta atgatggtga tatcatgcca gttatcctca aagtgggaat
     5341 atgaccatta gctggcattt tttaagattt ccttagaagg gtttaatcaa cactgccatt
     5401 acacatggat ttaacaaaag acttttgaaa attttttaca tactgatttt agaataatcc
     5461 tcaaggttct atagtcattt ttagtggaag acttaaaaag aaaggaacaa tttttactgt
     5521 gacttcaatt tcatagtatt ttaaacatat tttgtaattc agaatgttta gcaatcccta
     5581 tgtcctgttt cacatgcatg gtaactgatg gtgggttgcc tacaggctga agatttggag
     5641 agagccattt tgtttcataa atcagttttt attgcacaga agcagctggt tgtatttcaa
     5701 gttggaaaaa gaaaagtaaa tgccagaaaa ggcaaaggat aaacttagta agccatttat
     5761 tttgttttag aattgttttt gcaaagcaaa tttttttaaa aaaaggtcaa caaagtgaat
     5821 cagcactagc attttcttga tggttgactc aatgtataat taacaaatat acatagcaga
     5881 gtcaattaat catagtgcca ttatgtcact tatttgtcat tgcaaagtat tcagtcatgt
     5941 tgtctagatt tactttagat ggtgcaaaat ttccagatag taacctatgt aaaaggattt
     6001 gtaatttcct tgtaattcct gcctattagt ccatattctg atttccttat gttcatcact
     6061 gatatgttcc tgatcagggt cattgctagt agttgagcat ttactggttg aacattgttt
     6121 aatggttaga tgttatgtgt gtctgcattt aaaaaaattg tgtacatgtt atttcactat
     6181 tggtattaca atattcataa ccacatgata aacagaaatg tacccaataa tttcctataa
     6241 aatttttcaa agtcctttta ttcccctgac acactcaggg tgaatttttg tctccttggc
     6301 aaataagaaa aaaaaggaga gagaccactg gagagatatc agcaaaccac ccacagtaac
     6361 caagttcagt atttcctctt tctatatttt gaccaatata ttaagagcaa attttgtcat
     6421 tattactcct tgtggctatt acctgagatc agataatata atctcagctc ataaagcttg
     6481 gccatgtcta tacttatctt ggagagcaat aacaaacttg attaatttgt ttggttattt
     6541 aaaattccaa ctttcataaa tgctctgtga tgtactcaag acgattgggt tgtgtgatac
     6601 taacttcctt caagaactca gtctgttccc tgttgtctgg ttcagaggtc caccagggca
     6661 aaatagaagc cttgccgaga aagtgaactg tcttactcct tcaaaggaat cagatgttgc
     6721 tctagagaag actccaggca tctacctggt tgagctcaaa tgaggcaagt gggagaaaac
     6781 ctcttctcat cctctgattg aaagtgatac aatttgaata ttggtatatt gtcattggtc
     6841 agtaatggaa aaatgagatt ccaccagtgg gttactcttt tcttgtcttg gtttgctatg
     6901 ccttatccca gatcagtgtt ttgttccatc cctatggtca tctctaaagc cctgacagga
     6961 gcatcccaga ctggagaaat gcagcgtatc tgtggcccag aattttgttt gatactctaa
     7021 acagcaatgc aaagactgca aaatcacact attctaaaca gttgttttca gctcattttg
     7081 aagattgacc tggaaaacat atagatacag aatatataca tttaatcgtt gcttgtgatt
     7141 cattgtgtca aaataacatt taattttcac tctgattaat ctttattttc catttaaaag
     7201 attatttcag gctacttaaa tacaagacct tgcattctaa tttttgaaag cggttgtttt
     7261 ccctgagctc tctctcaact ttgacagttt gtgaatgata aaaagttact aggtttgtcc
     7321 tttccttgat agatgtagag cagttcatct gttttgtaaa ggtacagtta agcataacta
     7381 taggctgggc gtgatagttc atgcctgtaa tcccaacact ttgggaggcc gaggttggca
     7441 gatcacctga ggtcaggagt ttgagaccag cctggccaac gtggtgaaac ccctaataca
     7501 aaaattagct gggcatggtg gcacgctcct gtaatctcag ctactcagga ggctgaggca
     7561 ggagaatctc ttgaacccgg gaggcagagg ttgcagtgag ccaagatcat gccactgcac
     7621 tccagcctgg acaacaagag cgaaactccg tcaaaaaaaa atatatatat atgaccataa
     7681 attgaaaact atcatctcat actgcctcct tttaacctga cctattttat atacctacaa
     7741 tacagttaat atgcagcagc gtagagaaca aatagcatat tcataatttg taattttgtt
     7801 tttcttttta cggcaccctt aagtctcagt aatattttaa aagtcctcta taagccaaaa
     7861 gaacgttgta acatatccat ttattaagga gttaggccta aacatagtaa tagtagtcca
     7921 ttccatgtcc aacagatgtt gctgtgtttc tttcaacatt tttcaatgtc ttgtgagttt
     7981 agtgagtggg tacagctgag ttggggttta ggtgatttct tatgcccaat gaactaaagg
     8041 tatcagtaaa agattattag taaacaaatt agttatttat gctcttactt gaatgtcagt
     8101 cattcatttt atctctcgtc tttgagatac acacattaaa acttatgtgc atattttttt
     8161 aaagagtaat ttccacataa ttccccaaga actgaactca aatctccaaa aatttttcag
     8221 aactcaagca accaatgatt cacagagcaa atctaccaaa gccccatttt tattggaaca
     8281 caggcatgct catttatgta catattgttt gtggctgctt ttatgttgtc aaggcagagt
     8341 tgagtacttt caacagagac catatggact gcaaagccta aaatgtgtat ctggaccctt
     8401 acagtaaaac aatgaccctg ggttttcatg gcaccccaat gcctttttgg tgacttgcag
     8461 gaatacagat tcctatattc cagtttgttt tttttttttt ctccttagct taaggttcgt
     8521 attcccattt gcttctgaga aagttaggaa aattttgttt tatgttgcag atgctctcac
     8581 aacaataatt gtgctggaga tagatacaac ttagtgaaat tttcctacag aactaaaaac
     8641 gcaaaattgc atcactcctg aagaaaagaa atttagagta tgaattgagt tggttgagag
     8701 tagaattaaa aagatttcta gcactttgag catgttttag aaatttgatc cttacattta
     8761 aaattatgta aatgacatct ttcactggca tttgctcaca tttaagtcaa tctacagctg
     8821 ttacttacta agctaagaaa taagaagatc cctatggttc tgaatctctc ataatattct
     8881 gaagtaattt atatcaattg aattttcatt aatcatttta ggaaatatta tgttttattt
     8941 tgtggcatta tatgacaatg actttctcaa caatagctca gggaatacgc aaacagccag
     9001 ctcttttatg taagaaagcc attttctaat ccccacgctt tcctgagtgt tacgtatttt
     9061 atttctttga aaagagaggg ccttgagtaa atgctttcgt ttgctttcct tacatattta
     9121 gaaatccaag aagggccctt gtcttagtct atttctgtca cagagaaatt gttcattcca
     9181 aaatatccac cttaagggaa gctagtgacc gagatatgga gaaaaacata ggcattcatg
     9241 acctttgtgt ttccgtttga ctttcaacat ctgtaaccaa aaggtcacaa atgaaatatt
     9301 tagtagaaag tgcaatatca atttattagg agtacctaaa attataactc taaataatat
     9361 acagcaatat tattgctcta ttattacagc aatcaataat ataatatagc cactaggata
     9421 cactcgctgt agaactcaga acaaaagata tcaatcttct gccagtccgc atcattatgt
     9481 gtagcagaga ctttactgga atgagtgagg ggaaagataa caaaatgtag attaggattc
     9541 cacattctcc cctgcccatc ttcttgattg ctcagtttga agacgatcat tgatggacaa
     9601 atactttaga aatgaatgaa gtcaatagct aatgtttctc ccagaaacta aacaacatag
     9661 tttaggggat attaggccta cattctaatc acattgtaag gaagtgattt tctaattttg
     9721 aagcttccca ggagcagccc cctccaggaa caattttccc tgtgaacttt cactgagaaa
     9781 ctattatatg ccatggagga gtcaaagatg aattaaatcc aatgctatcc tccaggagtg
     9841 agctttgtag ttggagagaa aagccaacct tatagataca acctgtacat atataaccta
     9901 tgctgcattt aggcagatga taagccctag gaatggaaag agggaaaagc tcccttttgc
     9961 caggaatgat gaaggaaagc tttatggaaa cacaggctgt atgtgaaaga tgggtgaatc
    10021 tttgcaggta gggaagaagt agggggcatg tctggctgag aaccggcctg atcatagagt
    10081 ggaaaaatga aaggcagagg tgaaggaaga atactaaatg tgaaaggctg aaatacacag
    10141 ggaagtgttg ccagtgtgca acagaatctc atctcgtgca aaattgaatt agacttcctt
    10201 actccttcct tactctgggt aggtccatgt gcagcctttc ctcagagcat ctagcctgac
    10261 atacttggct catctgctgt gcttctaagc caaataaaaa tcatcaaaca catcgaagat
    10321 atttttggga gtcaccaggt taaagcaaag cctcagtcac tgaaagcaaa aactgaattg
    10381 gccaggtctc cactgacaaa acagagtaaa tgatagtatg acagataatt tcaagttttc
    10441 caagactcca atttctgaaa aatgtctcat gactccaaaa aatcacgtac ttcctaaaat
    10501 gttgccagtg gaggaccgaa tcaaggttat tgctgacctc attttttcaa ccttttcagt
    10561 tatttgacct gaataggcaa tcccccagga tttctgattg aattctacct gaaagtttag
    10621 attttaaaag acaacctgta ggaagctaag tctcaggcaa caaaatttaa aaccatcaga
    10681 acttgtttct ccaaacatca acctgctcct gtcaagtcct ttttcatctc tcccttttgt
    10741 ccctttacat actgttttgt aagttccttt tgatatcatt tattgcaggc agtattttta
    10801 catccatctt caagaaactt gggagacatt tagacattta gtatgtgtac ttttagttgt
    10861 cttgcctctt tatttcagat aatgcctgtg attagtgaat ggcggcatta ttcctgaaga
    10921 caaatgaagg aagataggga gcaagattga ctgtcatttg aatgatggaa gagaagtaga
    10981 attactgtga ggttacaaaa atcgtaagtt agcagacatt gagaaaggaa aacttcctac
    11041 ttgggctttt caggcttatg tgacattatc tggatgtgtt ttctagtctt tcctaaagga
    11101 gaaattttta ttcctgggtt gctgaaagct ttctggacta aaaggatata agcagctcaa
    11161 tagcagcata gaggattaga ttaatggaac agcactgcat acaggaaagc tacatctcca
    11221 atagtttagg ctgcaagtca gtagccaaac acaagagcat gtaagatttg gaggacaaag
    11281 tataaatatt ttaagtttac acaaccaaga ttataggcta ccttcccaac ttctaatttg
    11341 aagagcactg aaaatggagc tgtgaacact tcatttttaa aacctgacaa tatggtgcta
    11401 ttgactactt aatacaaaga tatattacaa tatttttagg taaatgtatt aagtctggcc
    11461 tgggcataaa tgtacataca gaaaatgttt gtagagaatt catcaaaatc atgcccattt
    11521 gctgttgtag agctacagta ttcttcaatg gtggtgactg accagtgagt ttctacttct
    11581 tacagatggg acacaacagt catgggctgt ctcagctgcc caaagcctga ggcagaccac
    11641 atgagagctg tggcttcttc ttggattcag gttggataac ccaattcagt aattaaatat
    11701 gtaaattttg gggggggttg gggggtgttt tctaggaact tgaagagtac gtgacattat
    11761 aaaaaatggg tgttggaaga ctaattgtag aaatttgacc tgagggccaa tgttacttgg
    11821 tgtaagttca ctcagacaga catgtcagaa catgcccaaa gaagcctata tcttgctgct
    11881 gggaaatgta aagcagttgg catgtagaat acgataataa atcatttaag aaaccaccaa
    11941 aa
//
