LOCUS       NM_033259               1452 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens calcium/calmodulin dependent protein kinase II
            inhibitor 2 (CAMK2N2), mRNA.
ACCESSION   NM_033259
VERSION     NM_033259.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1452)
  AUTHORS   Convertini,P., Zhang,J., de la Grange,P., Hayward,L.J., Zhu,H. and
            Stamm,S.
  TITLE     Genome wide array analysis indicates that an amyotrophic lateral
            sclerosis mutation of FUS causes an early increase of CAMK2N2 in
            vitro
  JOURNAL   Biochim Biophys Acta 1832 (8), 1129-1135 (2013)
   PUBMED   23545117
  REMARK    GeneRIF: Mutant FUS-DeltaNLS increased calcium/calmodulin-dependent
            protein kinase II inhibitor 2 (CAMK2N2) at both mRNA and protein
            levels.
REFERENCE   2  (bases 1 to 1452)
  AUTHORS   Esteras,N., Alquezar,C., Bermejo-Pareja,F., Bialopiotrowicz,E.,
            Wojda,U. and Martin-Requero,A.
  TITLE     Downregulation of extracellular signal-regulated kinase 1/2
            activity by calmodulin KII modulates p21Cip1 levels and survival of
            immortalized lymphocytes from Alzheimer's disease patients
  JOURNAL   Neurobiol Aging 34 (4), 1090-1100 (2013)
   PUBMED   23153928
  REMARK    GeneRIF: Murine double minute 2 (MDM2) protein levels were
            decreased in AD cells relative to control lymphoblasts, suggesting
            an impairment of FOXO3a degradation.
REFERENCE   3  (bases 1 to 1452)
  AUTHORS   Ripke,S., Wray,N.R., Lewis,C.M., Hamilton,S.P., Weissman,M.M.,
            Breen,G., Byrne,E.M., Blackwood,D.H., Boomsma,D.I., Cichon,S.,
            Heath,A.C., Holsboer,F., Lucae,S., Madden,P.A., Martin,N.G.,
            McGuffin,P., Muglia,P., Noethen,M.M., Penninx,B.P., Pergadia,M.L.,
            Potash,J.B., Rietschel,M., Lin,D., Muller-Myhsok,B., Shi,J.,
            Steinberg,S., Grabe,H.J., Lichtenstein,P., Magnusson,P.,
            Perlis,R.H., Preisig,M., Smoller,J.W., Stefansson,K., Uher,R.,
            Kutalik,Z., Tansey,K.E., Teumer,A., Viktorin,A., Barnes,M.R.,
            Bettecken,T., Binder,E.B., Breuer,R., Castro,V.M., Churchill,S.E.,
            Coryell,W.H., Craddock,N., Craig,I.W., Czamara,D., De Geus,E.J.,
            Degenhardt,F., Farmer,A.E., Fava,M., Frank,J., Gainer,V.S.,
            Gallagher,P.J., Gordon,S.D., Goryachev,S., Gross,M., Guipponi,M.,
            Henders,A.K., Herms,S., Hickie,I.B., Hoefels,S., Hoogendijk,W.,
            Hottenga,J.J., Iosifescu,D.V., Ising,M., Jones,I., Jones,L.,
            Jung-Ying,T., Knowles,J.A., Kohane,I.S., Kohli,M.A., Korszun,A.,
            Landen,M., Lawson,W.B., Lewis,G., Macintyre,D., Maier,W.,
            Mattheisen,M., McGrath,P.J., McIntosh,A., McLean,A.,
            Middeldorp,C.M., Middleton,L., Montgomery,G.M., Murphy,S.N.,
            Nauck,M., Nolen,W.A., Nyholt,D.R., O'Donovan,M., Oskarsson,H.,
            Pedersen,N., Scheftner,W.A., Schulz,A., Schulze,T.G., Shyn,S.I.,
            Sigurdsson,E., Slager,S.L., Smit,J.H., Stefansson,H., Steffens,M.,
            Thorgeirsson,T., Tozzi,F., Treutlein,J., Uhr,M., van den Oord,E.J.,
            Van Grootheest,G., Volzke,H., Weilburg,J.B., Willemsen,G.,
            Zitman,F.G., Neale,B., Daly,M., Levinson,D.F. and Sullivan,P.F.
  CONSRTM   Major Depressive Disorder Working Group of the Psychiatric GWAS
            Consortium
  TITLE     A mega-analysis of genome-wide association studies for major
            depressive disorder
  JOURNAL   Mol Psychiatry 18 (4), 497-511 (2013)
   PUBMED   22472876
REFERENCE   4  (bases 1 to 1452)
  AUTHORS   Radwanska,K., Tudor-Jones,A.A., Mizuno,K., Pereira,G.S.,
            Lucchesi,W., Alfano,I., Lach,A., Kaczmarek,L., Knapp,S. and
            Giese,K.P.
  TITLE     Differential regulation of CaMKII inhibitor beta protein expression
            after exposure to a novel context and during contextual fear memory
            formation
  JOURNAL   Genes Brain Behav 9 (6), 648-657 (2010)
   PUBMED   20487031
  REMARK    GeneRIF: We show that CaMKII N beta expression is differentially
            regulated by novelty and contextual fear conditioning, providing
            further insight into molecular basis of fear LTM.
REFERENCE   5  (bases 1 to 1452)
  AUTHORS   Okabe,T., Nakamura,T., Nishimura,Y.N., Kohu,K., Ohwada,S.,
            Morishita,Y. and Akiyama,T.
  TITLE     RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is
            involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate
            receptor signaling
  JOURNAL   J Biol Chem 278 (11), 9920-9927 (2003)
   PUBMED   12531901
REFERENCE   6  (bases 1 to 1452)
  AUTHORS   Zhang,J., Li,N., Yu,J., Zhang,W. and Cao,X.
  TITLE     Molecular cloning and characterization of a novel
            calcium/calmodulin-dependent protein kinase II inhibitor from human
            dendritic cells
  JOURNAL   Biochem Biophys Res Commun 285 (2), 229-234 (2001)
   PUBMED   11444830
REFERENCE   7  (bases 1 to 1452)
  AUTHORS   Chang,B.H., Mukherji,S. and Soderling,T.R.
  TITLE     Characterization of a calmodulin kinase II inhibitor protein in
            brain
  JOURNAL   Proc Natl Acad Sci U S A 95 (18), 10890-10895 (1998)
   PUBMED   9724800
  REMARK    GeneRIF: Functional study of the rat homolog
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC078797.20, AY037149.1 and
            AC061705.16.
            
            On Nov 22, 2018 this sequence version replaced NM_033259.2.
            
            Summary: This gene encodes a protein that is highly similar to the
            rat CaM-KII inhibitory protein, an inhibitor of
            calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII
            regulates numerous physiological functions, including neuronal
            synaptic plasticity through the phosphorylation of
            alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type
            glutamate (AMPA) receptors. Studies of the similar protein in rat
            suggest that this protein may function as a negative regulator of
            CaM-KII and may act to inhibit the phosphorylation of AMPA
            receptors. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY037149.1, BC105077.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437, SAMN03465403
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296238.4/ ENSP00000296238.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AC078797.20        2829-2918           c
            91-681              AY037149.1         1-591
            682-1450            AC061705.16        653-1421
            1451-1452           AC061705.16        1422-1423
FEATURES             Location/Qualifiers
     source          1..1452
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.1"
     gene            1..1452
                     /gene="CAMK2N2"
                     /gene_synonym="CAM-KIIN; CAMKIIN"
                     /note="calcium/calmodulin dependent protein kinase II
                     inhibitor 2"
                     /db_xref="GeneID:94032"
                     /db_xref="HGNC:HGNC:24197"
                     /db_xref="MIM:608721"
     exon            1..437
                     /gene="CAMK2N2"
                     /gene_synonym="CAM-KIIN; CAMKIIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..508
                     /gene="CAMK2N2"
                     /gene_synonym="CAM-KIIN; CAMKIIN"
                     /note="CaM-KII inhibitory protein"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase II
                     inhibitor 2"
                     /protein_id="NP_150284.1"
                     /db_xref="CCDS:CCDS3257.1"
                     /db_xref="GeneID:94032"
                     /db_xref="HGNC:HGNC:24197"
                     /db_xref="MIM:608721"
                     /translation="MSEILPYSEDKMGRFGADPEGSDLSFSCRLQDTNSFFAGNQAKR
                     PPKLGQIGRAKRVVIEDDRIDDVLKGMGEKPPSGV"
     exon            438..1452
                     /gene="CAMK2N2"
                     /gene_synonym="CAM-KIIN; CAMKIIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1430..1435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK2N2"
                     /gene_synonym="CAM-KIIN; CAMKIIN"
                     /note="hexamer: AATAAA"
     polyA_site      1452
                     /gene="CAMK2N2"
                     /gene_synonym="CAM-KIIN; CAMKIIN"
                     /note="major polyA site"
ORIGIN      
        1 attccgctct tgccgccgcc gccgccaccc ccgccccccg cccccgcccc cgcccggtcc
       61 ccgccaccgc cgccgccgcc gcctgcccag cggcccggga ggcggaggcg cgggggagga
      121 ggccccgctt ggctcctcag ccccggatgc tgcatgactt catccttccg ccggctcccc
      181 tgctgaggta gggccggtcc ggcagcaagc ccgccgcccg cgccccgccg cagtcccgct
      241 cccgccccgc gcccaccccg cgcccgccat gtccgagatc ctgccctaca gcgaagacaa
      301 gatgggccgc ttcggcgcag accccgaggg ctccgacctc tccttcagct gccgcctgca
      361 ggacaccaac tccttcttcg cgggcaacca ggccaagcga ccccccaagc tgggccagat
      421 cggccgagcc aagcgagtgg tgatcgagga tgaccggata gacgacgtgc tgaaggggat
      481 gggggagaag ccgccgtccg gagtgtagac gcgccggctc gggcggcggg ctccgggccc
      541 agcctcgcag cggccaggag cgcgggccgg cgatgcggct gccggcgccc ccccgccccg
      601 gcccaggcgc ccgcgggcgg gggctgcagg gccgtgccgc cgccgccgcc aggcactccg
      661 gagctgtccg cttcagcacc acggcggccg cggtagcggc ggcgcggacc cgcccggaac
      721 ccgccgccgc gctcatgcac tttaaaacct cgggccgcag ccccaccccg cacaccggaa
      781 cggacacgga gacccgcggc ccccagcccc cggcccgccc cctcccgcac ggctcccctg
      841 ccccgccccc ctccggccag tctggtctgc agaccgggcg gccgccggtg tcggaccgcg
      901 cgcggccagg gatgtttggc tgcgtacttg catgagcttt ccacccactt gagcccagtc
      961 ctccgggccg ttcctcgccc ccacccctgt ctggcgtgac cccagcctca gcctctttct
     1021 aagggacttc ctcagcacat ttgtattttt atatccgact ctttgtttac tggctctgct
     1081 catggttcct gccctcccct cagtctcggc cacgctcttc tgcgcctggc agataggatg
     1141 ggtgttgagg ctgggatgag acaagccccc gacacggtta ccaaccacat ggccagtctg
     1201 cccaggcctg accccaggag gctttctggc agaccccttc tccccaaggt atcatcacct
     1261 tccaagggcc cagatccgat tttaccttgg acccctgcgt cttgcccctg ggaacccaaa
     1321 tggggactgc tctgaacctt tggatgacat ctgtggcccc ggagatgttc tcaacccagg
     1381 ggtgcccttc gtaaatgttc ctccatcctc actgtaccag gagtgtgtga ataaacacag
     1441 accccctctg tg
//
