LOCUS       NM_018584               2326 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens calcium/calmodulin dependent protein kinase II
            inhibitor 1 (CAMK2N1), mRNA.
ACCESSION   NM_018584
VERSION     NM_018584.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2326)
  AUTHORS   Bao,J., Xu,T., Wang,W., Xu,H., Chen,X. and Xia,R.
  TITLE     N6-methyladenosine-induced miR-182-5p promotes multiple myeloma
            tumorigenesis by regulating CAMK2N1
  JOURNAL   Mol Cell Biochem 479 (11), 3077-3089 (2024)
   PUBMED   38180718
  REMARK    GeneRIF: N6-methyladenosine-induced miR-182-5p promotes multiple
            myeloma tumorigenesis by regulating CAMK2N1.
REFERENCE   2  (bases 1 to 2326)
  AUTHORS   Tang,J.Y., Yang,L., Wu,Q.J., Yang,Y., Su,Y.Y., Chen,Y.R. and Mu,J.
  TITLE     Circ-IP6K2 suppresses tumor progression by modulating the
            miR-1292-5p/CAMK2N1 signal in clear cell renal cell carcinoma
  JOURNAL   Funct Integr Genomics 24 (4), 122 (2024)
   PUBMED   38980439
  REMARK    GeneRIF: Circ-IP6K2 suppresses tumor progression by modulating the
            miR-1292-5p/CAMK2N1 signal in clear cell renal cell carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2326)
  AUTHORS   Zhang,X., Tian,L., Li,Z., Liu,R., Yu,J. and Liu,B.
  TITLE     CAMK2N1 has a cancer-suppressive function in colorectal carcinoma
            via effects on the Wnt/beta-catenin pathway
  JOURNAL   Biochem Biophys Res Commun 626, 220-228 (2022)
   PUBMED   35998547
  REMARK    GeneRIF: CAMK2N1 has a cancer-suppressive function in colorectal
            carcinoma via effects on the Wnt/beta-catenin pathway.
REFERENCE   4  (bases 1 to 2326)
  AUTHORS   Peng,J.M., Tseng,R.H., Shih,T.C. and Hsieh,S.Y.
  TITLE     CAMK2N1 suppresses hepatoma growth through inhibiting E2F1-mediated
            cell-cycle signaling
  JOURNAL   Cancer Lett 497, 66-76 (2021)
   PUBMED   33068700
  REMARK    GeneRIF: CAMK2N1 suppresses hepatoma growth through inhibiting
            E2F1-mediated cell-cycle signaling.
REFERENCE   5  (bases 1 to 2326)
  AUTHORS   Karandur,D., Bhattacharyya,M., Xia,Z., Lee,Y.K., Muratcioglu,S.,
            McAffee,D., McSpadden,E.D., Qiu,B., Groves,J.T., Williams,E.R. and
            Kuriyan,J.
  TITLE     Breakage of the oligomeric CaMKII hub by the regulatory segment of
            the kinase
  JOURNAL   Elife 9, e57784 (2020)
   PUBMED   32902386
  REMARK    GeneRIF: Breakage of the oligomeric CaMKII hub by the regulatory
            segment of the kinase.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2326)
  AUTHORS   Hafner,N., Steinbach,D., Jansen,L., Diebolder,H., Durst,M. and
            Runnebaum,I.B.
  TITLE     RUNX3 and CAMK2N1 hypermethylation as prognostic marker for
            epithelial ovarian cancer
  JOURNAL   Int J Cancer 138 (1), 217-228 (2016)
   PUBMED   26175272
  REMARK    GeneRIF: Hypermethylation of RUNX3/CAMK2N1 is associated with poor
            clinical outcome in Type II EOC, also after macroscopic complete
            resection.
REFERENCE   7  (bases 1 to 2326)
  AUTHORS   Wang,T., Guo,S., Liu,Z., Wu,L., Li,M., Yang,J., Chen,R., Liu,X.,
            Xu,H., Cai,S., Chen,H., Li,W., Xu,S., Wang,L., Hu,Z., Zhuang,Q.,
            Wang,L., Wu,K., Liu,J., Ye,Z., Ji,J.Y., Wang,C. and Chen,K.
  TITLE     CAMK2N1 inhibits prostate cancer progression through androgen
            receptor-dependent signaling
  JOURNAL   Oncotarget 5 (21), 10293-10306 (2014)
   PUBMED   25296973
  REMARK    GeneRIF: contributes to prostate cancer growth and survival through
            androgen receptor-dependent signaling
REFERENCE   8  (bases 1 to 2326)
  AUTHORS   Wang,T., Liu,Z., Guo,S., Wu,L., Li,M., Yang,J., Chen,R., Xu,H.,
            Cai,S., Chen,H., Li,W., Wang,L., Hu,Z., Zhuang,Q., Xu,S., Wang,L.,
            Liu,J., Ye,Z., Ji,J.Y., Wang,C. and Chen,K.
  TITLE     The tumor suppressive role of CAMK2N1 in castration-resistant
            prostate cancer
  JOURNAL   Oncotarget 5 (11), 3611-3621 (2014)
   PUBMED   25003983
  REMARK    GeneRIF: Analyses suggest that CAMK2N1 plays a tumor suppressive
            role in prostate cancer cells. Reduced CAMK2N1 expression
            correlates to human prostate cancer progression and predicts poor
            clinical outcome.
REFERENCE   9  (bases 1 to 2326)
  AUTHORS   Meng,F., Guo,J., Zhang,Q., Song,B. and Zhang,G.
  TITLE     Autophosphorylated calcium/calmodulin-dependent protein kinase II
            alpha (CaMKII alpha) reversibly targets to and phosphorylates
            N-methyl-D-aspartate receptor subunit 2B (NR2B) in cerebral
            ischemia and reperfusion in hippocampus of rats
  JOURNAL   Brain Res 967 (1-2), 161-169 (2003)
   PUBMED   12650977
REFERENCE   10 (bases 1 to 2326)
  AUTHORS   Sedelnikova,A. and Weiss,D.S.
  TITLE     Phosphorylation of the recombinant rho1 GABA receptor
  JOURNAL   Int J Dev Neurosci 20 (3-5), 237-246 (2002)
   PUBMED   12175859
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB475389.1, AY204901.1, AL391357.20 and BI820748.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018584.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.822171.1,
                                           ERR279868.2182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375078.4/ ENSP00000364219.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-445               DB475389.1         28-472
            446-1278            AY204901.1         15-847
            1279-1893           AL391357.20        4631-5245           c
            1894-2326           BI820748.1         1-433
FEATURES             Location/Qualifiers
     source          1..2326
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..2326
                     /gene="CAMK2N1"
                     /gene_synonym="PRO1489"
                     /note="calcium/calmodulin dependent protein kinase II
                     inhibitor 1"
                     /db_xref="GeneID:55450"
                     /db_xref="HGNC:HGNC:24190"
                     /db_xref="MIM:614986"
     exon            1..997
                     /gene="CAMK2N1"
                     /gene_synonym="PRO1489"
                     /inference="alignment:Splign:2.1.0"
     CDS             832..1068
                     /gene="CAMK2N1"
                     /gene_synonym="PRO1489"
                     /note="CaMKIINalpha; caMKIIN-alpha; caMKII inhibitory
                     protein alpha"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase II
                     inhibitor 1"
                     /protein_id="NP_061054.2"
                     /db_xref="CCDS:CCDS207.1"
                     /db_xref="GeneID:55450"
                     /db_xref="HGNC:HGNC:24190"
                     /db_xref="MIM:614986"
                     /translation="MSEVLPYGDEKLSPYGDGGDVGQIFSCRLQDTNNFFGAGQNKRP
                     PKLGQIGRSKRVVIEDDRIDDVLKNMTDKAPPGV"
     exon            998..2326
                     /gene="CAMK2N1"
                     /gene_synonym="PRO1489"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1343..1348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK2N1"
                     /gene_synonym="PRO1489"
                     /note="hexamer: AATAAA"
     polyA_site      1365
                     /gene="CAMK2N1"
                     /gene_synonym="PRO1489"
     regulatory      2301..2306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK2N1"
                     /gene_synonym="PRO1489"
                     /note="hexamer: AATAAA"
     polyA_site      2326
                     /gene="CAMK2N1"
                     /gene_synonym="PRO1489"
                     /note="major polyA site"
ORIGIN      
        1 atttctcctc gcagctcgct gcctcctcta tccctgcctc cctctccccc ctctgttttt
       61 ctcccttcct tccctctccg accctcttcc tctccctccc gatcctttcc ctcctcctct
      121 catctttccc ctgtctctcc gttctagctc gtcccccacc ccaccttttc ttctttctcc
      181 tcctctcctt cctctccccc tctcctctgt ctccttccac cgtctcccct gcctccctgt
      241 ctttcagtcc ctgtttttca gccccgtctc cctctcggtt tctctccccc accctccctc
      301 cgggtttcct ccccggtgcc ctccctcctc tctccctccc ctccccctcc gcccctcgca
      361 gccccgccgc tcgcagctcc cagtctgcct ccccgaaccg gcgccgccgc ccgcactcgc
      421 cgcaggaccg gcccgcccgg ctcccggggt gcgccctcct cggtcccgcg ccctccgggc
      481 tcgcagggac gtctcctccc tcccggctcg cggccccgcc cggcccggcc cccgcccaga
      541 gccccagcgc gccgaggatg tgagtcctgc tcgcctctgg cggagcagca gccactcgcg
      601 cgcggagccg gagcgcagcg cagcgcagcc gcgggcgctc tccgggccgc tcgcgcgagt
      661 gccgcgctct tgccctagcg gcgtcccccg gcctctcgcc ggcgccaccg ccgcagcagc
      721 ccgcgggccg tccccggccg gccgcccccg gccccagcgc cgctgaccct gtccgccgcg
      781 ggcggggacg cgggcggagg aggcgccgcg gcggagcccc cggacgcgac catgtcggag
      841 gtgctgccct acggcgacga gaagctgagc ccctacggcg acggcggcga cgtgggccag
      901 atcttctcct gccgcctgca ggacaccaac aacttcttcg gcgccgggca gaacaagcgg
      961 ccgcccaagc tgggccagat cggccggagc aagcgggttg ttattgaaga tgataggatt
     1021 gatgacgtgc tgaaaaatat gaccgacaag gcacctcctg gtgtctaact cccccaaaga
     1081 caatgagtta agggagagaa taagaacggc ggtaacagtt attggcaaaa agcatgaaaa
     1141 gagaaagcac tttgaaattt attactagct tgctacccac gatgaaatca acaacctgta
     1201 tctggtatca ggccgggaga cagatgaggc gagaggagga ggaggaggag gagaaggctc
     1261 tgggctcctc tgcaaaaata aaaataaaaa aataaataaa attttaaaaa taataaaaat
     1321 tcactatata cacatataaa gaaataaaaa gaagtctcag ttgcagctat ttgtcaaaat
     1381 taatatccat ttctttttat atacggtgaa tattgcgcaa ttatagatct ggattttgaa
     1441 ccacttaatg aagcggcaac accaggtgtt ttgaggtgtt ggcattcttc gctgatttgg
     1501 ctgttcccaa tgtttacatt atttaatctt gcaaaaatgg ttctgtgcac ttggatgtga
     1561 aatgctgtcc agttttattt tttttatgtt gttatccttg gatgtacaaa aaattcagaa
     1621 aatgatctct gtagatattc tgttttattt tggtcatctt tagaagttat caggaatgtg
     1681 tttaaaacaa gaagagaact tttctaagga atgatacata gaaaagattt tattttaaaa
     1741 tgagttgtaa agcttgtgtt tctttgttgc tgcaagctat ctgcccaagt taatgcaaat
     1801 ggacacattt tttatgtcag aaaaacacac acacacacac acacacacac acacacacac
     1861 gaaaaacaaa gaaaaaaatg cttgagcttt ttctaacttc cccttgcagt ctgttgtgtg
     1921 agcagcctgt ttatttctct aatattatgt cagtttattc tctttaatgg actgtaaaaa
     1981 aatgtaatca caagagtgcc aaatatcttg aaatgccaaa aggcatttta gtttcttttc
     2041 tctgtgctct gagtccacgt acaggaatgc ttggagtgtc ttttctgtta tttataggga
     2101 ttctcttaag gcacaccagc tgcctgtttt gcatggtatt tgcaaaaatg cctcttgcgt
     2161 gaggaaatct tttaccattt tttgtttgca actttggacc tcaagaggtt tcccttccct
     2221 tccccgttcc ctcttttctt aattcaatat tctgtatgtt gcaccttgaa ccagcacaca
     2281 gggctatttc tccaatgtac aataaaagaa ttgttcctgt gtctca
//
