LOCUS       NM_001367534            3878 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens calcium/calmodulin dependent protein kinase II gamma
            (CAMK2G), transcript variant 27, mRNA.
ACCESSION   NM_001367534 XM_006717993
VERSION     NM_001367534.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3878)
  AUTHORS   Gurd,B.J., Menezes,E.S., Arhen,B.B. and Islam,H.
  TITLE     Impacts of altered exercise volume, intensity, and duration on the
            activation of AMPK and CaMKII and increases in PGC-1alpha mRNA
  JOURNAL   Semin Cell Dev Biol 143, 17-27 (2023)
   PUBMED   35680515
  REMARK    GeneRIF: Impacts of altered exercise volume, intensity, and
            duration on the activation of AMPK and CaMKII and increases in
            PGC-1alpha mRNA.
            Review article
REFERENCE   2  (bases 1 to 3878)
  AUTHORS   Koren,D.T., Shrivastava,R. and Ghosh,S.
  TITLE     Ca2+/Calmodulin-Dependent Protein Kinase II Disrupts the Voltage
            Dependency of the Voltage-Dependent Anion Channel on the Lipid
            Bilayer Membrane
  JOURNAL   J Phys Chem B 127 (15), 3372-3381 (2023)
   PUBMED   37040575
  REMARK    GeneRIF: Ca[2+]/Calmodulin-Dependent Protein Kinase II Disrupts the
            Voltage Dependency of the Voltage-Dependent Anion Channel on the
            Lipid Bilayer Membrane.
REFERENCE   3  (bases 1 to 3878)
  AUTHORS   Zhu,S., Zhang,X., Guo,Y., Tang,L., Zhou,Z., Chen,X. and Peng,C.
  TITLE     NETO2 promotes melanoma progression via activation of the
            Ca2+/CaMKII signaling pathway
  JOURNAL   Front Med 17 (2), 263-274 (2023)
   PUBMED   36738427
  REMARK    GeneRIF: NETO2 promotes melanoma progression via activation of the
            Ca[2+]/CaMKII signaling pathway.
REFERENCE   4  (bases 1 to 3878)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 3878)
  AUTHORS   Miyauchi,M., Sasaki,K., Kagoya,Y., Taoka,K., Masamoto,Y.,
            Yamazaki,S., Arai,S., Mizuno,H. and Kurokawa,M.
  TITLE     CAMK2G is identified as a novel therapeutic target for
            myelofibrosis
  JOURNAL   Blood Adv 6 (5), 1585-1597 (2022)
   PUBMED   34521112
  REMARK    GeneRIF: CAMK2G is identified as a novel therapeutic target for
            myelofibrosis.
REFERENCE   6  (bases 1 to 3878)
  AUTHORS   Wen,Z., Zhong,Z. and Darnell,J.E. Jr.
  TITLE     Maximal activation of transcription by Stat1 and Stat3 requires
            both tyrosine and serine phosphorylation
  JOURNAL   Cell 82 (2), 241-250 (1995)
   PUBMED   7543024
REFERENCE   7  (bases 1 to 3878)
  AUTHORS   Countaway,J.L., Nairn,A.C. and Davis,R.J.
  TITLE     Mechanism of desensitization of the epidermal growth factor
            receptor protein-tyrosine kinase
  JOURNAL   J Biol Chem 267 (2), 1129-1140 (1992)
   PUBMED   1309762
REFERENCE   8  (bases 1 to 3878)
  AUTHORS   Ikebe,M. and Reardon,S.
  TITLE     Phosphorylation of smooth myosin light chain kinase by smooth
            muscle Ca2+/calmodulin-dependent multifunctional protein kinase
  JOURNAL   J Biol Chem 265 (16), 8975-8978 (1990)
   PUBMED   2160950
REFERENCE   9  (bases 1 to 3878)
  AUTHORS   Czernik,A.J., Pang,D.T. and Greengard,P.
  TITLE     Amino acid sequences surrounding the cAMP-dependent and
            calcium/calmodulin-dependent phosphorylation sites in rat and
            bovine synapsin I
  JOURNAL   Proc Natl Acad Sci U S A 84 (21), 7518-7522 (1987)
   PUBMED   3118371
REFERENCE   10 (bases 1 to 3878)
  AUTHORS   Vulliet,P.R., Woodgett,J.R. and Cohen,P.
  TITLE     Phosphorylation of tyrosine hydroxylase by calmodulin-dependent
            multiprotein kinase
  JOURNAL   J Biol Chem 259 (22), 13680-13683 (1984)
   PUBMED   6150037
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL596247.22, AL713896.9 and
            AC022400.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 5, 2018 this sequence version replaced XM_006717993.1.
            
            Summary: The product of this gene is one of the four subunits of an
            enzyme which belongs to the serine/threonine protein kinase family,
            and to the Ca(2+)/calmodulin-dependent protein kinase subfamily.
            Calcium signaling is crucial for several aspects of plasticity at
            glutamatergic synapses. In mammalian cells the enzyme is composed
            of four different chains: alpha, beta, gamma, and delta. The
            product of this gene is a gamma chain. Many alternatively spliced
            transcripts encoding different isoforms have been described but the
            full-length nature of all the variants has not been
            determined.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.779364.1,
                                           SRR1803611.17573.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000423381.6/ ENSP00000410298.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AL596247.22        23297-23455         c
            160-254             AL596247.22        21889-21983         c
            255-314             AL596247.22        9730-9789           c
            315-369             AL596247.22        2092-2146           c
            370-435             AL713896.9         3168-3233           c
            436-508             AC022400.9         181972-182044       c
            509-611             AC022400.9         181724-181826       c
            612-695             AC022400.9         181237-181320       c
            696-790             AC022400.9         180699-180793       c
            791-913             AC022400.9         179936-180058       c
            914-997             AC022400.9         175169-175252       c
            998-1040            AC022400.9         174880-174922       c
            1041-1103           AC022400.9         172250-172312       c
            1104-1147           AC022400.9         170179-170222       c
            1148-1180           AC022400.9         160800-160832       c
            1181-1249           AC022400.9         157990-158058       c
            1250-1294           AC022400.9         156751-156795       c
            1295-1343           AC022400.9         154393-154441       c
            1344-1457           AC022400.9         152243-152356       c
            1458-1533           AC022400.9         150190-150265       c
            1534-1628           AC022400.9         149734-149828       c
            1629-1873           AC022400.9         147714-147958       c
            1874-3878           AC022400.9         145212-147216       c
FEATURES             Location/Qualifiers
     source          1..3878
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2"
     gene            1..3878
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /note="calcium/calmodulin dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:818"
                     /db_xref="HGNC:HGNC:1463"
                     /db_xref="MIM:602123"
     exon            1..159
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1861
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /EC_number="2.7.11.17"
                     /note="isoform 27 is encoded by transcript variant 27;
                     calcium/calmodulin-dependent protein kinase (CaM kinase)
                     II gamma; calcium/calmodulin-dependent protein kinase type
                     II subunit gamma; caMK-II subunit gamma"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 27"
                     /protein_id="NP_001354463.1"
                     /db_xref="CCDS:CCDS91269.1"
                     /db_xref="GeneID:818"
                     /db_xref="HGNC:HGNC:1463"
                     /db_xref="MIM:602123"
                     /translation="MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGL
                     AIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDED
                     QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRS
                     TVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQSSAPASPAASAAGLA
                     GQAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVV
                     HNATDGIKGSTESCNTTTEDEDLKAAPLRTGNGSSVPEGRSSRDRTAPSAGMQPQPSL
                     CSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFY
                     FENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWH
                     RRDGKWLNVHYHCSGAPAAPLQ"
     exon            160..254
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            255..314
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            315..369
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            370..435
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            436..508
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            509..611
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            612..695
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            696..790
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            791..913
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            914..997
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1040
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1103
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1147
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1180
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1249
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1294
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1343
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1457
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1533
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1628
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1873
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..3878
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3856..3861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /note="hexamer: AATAAA"
     polyA_site      3878
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /note="major polyA site"
ORIGIN      
        1 ccccgtctcc tcctcttgct ccctcggccg ggcggcggtg actgtgcacc gacgtcggcg
       61 cgggctgcac cgccgcgtcc gcccgcccgc cagcatggcc accaccgcca cctgcacccg
      121 tttcaccgac gactaccagc tcttcgagga gcttggcaag ggtgctttct ctgtggtccg
      181 caggtgtgtg aagaaaacct ccacgcagga gtacgcagca aaaatcatca ataccaagaa
      241 gttgtctgcc cgggatcacc agaaactaga acgtgaggct cggatatgtc gacttctgaa
      301 acatccaaac atcgtgcgcc tccatgacag tatttctgaa gaagggtttc actacctcgt
      361 gtttgacctt gttaccggcg gggagctgtt tgaagacatt gtggccagag agtactacag
      421 tgaagcagat gccagccact gtatacatca gattctggag agtgttaacc acatccacca
      481 gcatgacatc gtccacaggg acctgaagcc tgagaacctg ctgctggcga gtaaatgcaa
      541 gggtgccgcc gtcaagctgg ctgattttgg cctagccatc gaagtacagg gagagcagca
      601 ggcttggttt ggttttgctg gcaccccagg ttacttgtcc cctgaggtct tgaggaaaga
      661 tccctatgga aaacctgtgg atatctgggc ctgcggggtc atcctgtata tcctcctggt
      721 gggctatcct cccttctggg atgaggatca gcacaagctg tatcagcaga tcaaggctgg
      781 agcctatgat ttcccatcac cagaatggga cacggtaact cctgaagcca agaacttgat
      841 caaccagatg ctgaccataa acccagcaaa gcgcatcacg gctgaccagg ctctcaagca
      901 cccgtgggtc tgtcaacgat ccacggtggc atccatgatg catcgtcagg agactgtgga
      961 gtgtttgcgc aagttcaatg cccggagaaa actgaagggt gccatcctca cgaccatgct
     1021 tgtctccagg aacttctcag ttggcaggca gagctccgcc cccgcctcgc ctgccgcgag
     1081 cgccgccggc ctggccgggc aagctgccaa aagcctattg aacaagaagt cggatggcgg
     1141 tgtcaagaaa aggaagtcga gttccagcgt gcacctaatg ccacagagca acaacaaaaa
     1201 cagtctcgta agcccagccc aagagcccgc gcccttgcag acggccatgg agccacaaac
     1261 cactgtggta cacaacgcta cagatgggat caagggctcc acagagagct gcaacaccac
     1321 cacagaagat gaggacctca aagctgcccc gctccgcact gggaatggca gctcggtgcc
     1381 tgaaggacgg agctcccggg acagaacagc cccctctgca ggcatgcagc cccagccttc
     1441 tctctgctcc tcagccatgc gaaaacagga gatcattaag attacagaac agctgattga
     1501 agccatcaac aatggggact ttgaggccta cacgaagatt tgtgatccag gcctcacttc
     1561 ctttgagcct gaggcccttg gtaacctcgt ggaggggatg gatttccata agttttactt
     1621 tgagaatctc ctgtccaaga acagcaagcc tatccatacc accatcctaa acccacacgt
     1681 ccacgtgatt ggggaggacg cagcgtgcat cgcctacatc cgcctcaccc agtacatcga
     1741 cgggcagggt cggcctcgca ccagccagtc agaagagacc cgggtctggc accgtcggga
     1801 tggcaagtgg ctcaatgtcc actatcactg ctcaggggcc cctgccgcac cgctgcagtg
     1861 agctcagcca caggggcttt aggagattcc agccggaggt ccaaccttcg cagccagtgg
     1921 ctctggaggg cctgagtgac agcggcagtc ctgtttgttt gaggtttaaa acaattcaat
     1981 tacaaaagcg gcagcagcca atgcacgccc ctgcatgcag ccctcccgcc cgcccttcgt
     2041 gtctgtctct gctgtaccga ggtgtttttt acatttaaga aaaaaaaaaa agaaaaaaag
     2101 attgtttaaa aaaaaaagga atccatacca tgatgcgttt taaaaccacc gacagccctt
     2161 gggttggcaa gaaggcagga gtatgtatga ggtccatcct ggcatgagca gtggctcacc
     2221 caccggcctt gaagaggtga gcttggcctc tctggtcccc atggacttag ggggaccagg
     2281 caagaactct gacagagctt tgggggccgt gatgtgattg cagctcctga ggtggcctgc
     2341 ttaccccagg tctaggaatg aacttctttg gaacttgcat aggcgcctag aatggggctg
     2401 atgagaacat cgtgaccatc agacctactt gggagagaac gcagagctcc cagcctgctg
     2461 tggaggcagc tgagaagtgg tggcctcagg actgagagcc cggacgttgc tgtactgtct
     2521 tgtttagtgt agaagggaag agaattggtg ctgcagaagt gtacccgcca tgaagccgat
     2581 gagaaacctc gtgttagtct gacatgcact cactcatcca tttctatagg atgcacaatg
     2641 catgtgggcc ctaatattga ggccttatcc ctgcagctag gagggggagg ggttgttgct
     2701 gctttgcttc gtgttttctt ctaacctggc aaggagagag ccaggccctg gtcagggctc
     2761 ccgtgccgcc tttggcggtt ctgtttctgt gctgatctgg accatctttg tcttgccttt
     2821 tcacggtagt ggtccccatg ctgaccctca tctgggcctg ggccctctgc caagtgcccc
     2881 tgtgggatgg gaggagtgag gcagtgggag aagaggtggt ggtcgtttct atgcattcag
     2941 gctgcctttg gggctgcctc ccttcttatt cttccttgct gcacgtccat ctcttttcct
     3001 gtctttgaga ttgacctgac tgctctggca agaagaagag gtgtccttac agaggcctct
     3061 ttactgacca actgaagtat agacttactg ctggacaatc tgcatgggca tcacccctcc
     3121 ccgcatgtaa cccaaaagag gtgtccagag ccaaggcttc taccttcatt gtccctctct
     3181 gtgctcaagg agttccattc caggaggaag agatctatac cctaagcaga tagcaaagaa
     3241 gataatggag gagcaattgg tcatggcctt ggtttccctc aaaacaacgc tgcagattta
     3301 tctgcacaaa catctccact tttgggggaa aggtgggtag attccagttc cctggactac
     3361 cttcaggagg cacgagagct gggagaagag gcaaagctac aggtttactt gggagccagc
     3421 tgagaagaga gcagactcac aggtgctggt gcttggattt agccaggctc ctccgagcac
     3481 ctcatgcatg tcccagcccc tgggccctag ccctttcctg ccctgcagtc tgcagtgcca
     3541 gcacgcaaat cccttcacca cagggtttcg ttttgctggc ttgaagacaa atggtcttag
     3601 aattcattga gacccatagc ttcatatggc tgctccagcc ccacttctta gcattcttac
     3661 tcctcttctg gggctaatgt cagcatctat agacaataga ctattaaaaa atcacctttt
     3721 aaacaagaaa cggaaggcat ttgatgcaga atttttgcat gacaacatag aaataattta
     3781 aaaatagtgt ttgttctgaa tgttggtaga cccttcatag ctttgttaca atgaaacctt
     3841 gaactgaaaa tatttaataa aataaccttt aaacagtc
//
