LOCUS       NM_001367530            3632 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens calcium/calmodulin dependent protein kinase II gamma
            (CAMK2G), transcript variant 23, mRNA.
ACCESSION   NM_001367530 XM_017016735
VERSION     NM_001367530.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3632)
  AUTHORS   Gurd,B.J., Menezes,E.S., Arhen,B.B. and Islam,H.
  TITLE     Impacts of altered exercise volume, intensity, and duration on the
            activation of AMPK and CaMKII and increases in PGC-1alpha mRNA
  JOURNAL   Semin Cell Dev Biol 143, 17-27 (2023)
   PUBMED   35680515
  REMARK    GeneRIF: Impacts of altered exercise volume, intensity, and
            duration on the activation of AMPK and CaMKII and increases in
            PGC-1alpha mRNA.
            Review article
REFERENCE   2  (bases 1 to 3632)
  AUTHORS   Koren,D.T., Shrivastava,R. and Ghosh,S.
  TITLE     Ca2+/Calmodulin-Dependent Protein Kinase II Disrupts the Voltage
            Dependency of the Voltage-Dependent Anion Channel on the Lipid
            Bilayer Membrane
  JOURNAL   J Phys Chem B 127 (15), 3372-3381 (2023)
   PUBMED   37040575
  REMARK    GeneRIF: Ca[2+]/Calmodulin-Dependent Protein Kinase II Disrupts the
            Voltage Dependency of the Voltage-Dependent Anion Channel on the
            Lipid Bilayer Membrane.
REFERENCE   3  (bases 1 to 3632)
  AUTHORS   Zhu,S., Zhang,X., Guo,Y., Tang,L., Zhou,Z., Chen,X. and Peng,C.
  TITLE     NETO2 promotes melanoma progression via activation of the
            Ca2+/CaMKII signaling pathway
  JOURNAL   Front Med 17 (2), 263-274 (2023)
   PUBMED   36738427
  REMARK    GeneRIF: NETO2 promotes melanoma progression via activation of the
            Ca[2+]/CaMKII signaling pathway.
REFERENCE   4  (bases 1 to 3632)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 3632)
  AUTHORS   Miyauchi,M., Sasaki,K., Kagoya,Y., Taoka,K., Masamoto,Y.,
            Yamazaki,S., Arai,S., Mizuno,H. and Kurokawa,M.
  TITLE     CAMK2G is identified as a novel therapeutic target for
            myelofibrosis
  JOURNAL   Blood Adv 6 (5), 1585-1597 (2022)
   PUBMED   34521112
  REMARK    GeneRIF: CAMK2G is identified as a novel therapeutic target for
            myelofibrosis.
REFERENCE   6  (bases 1 to 3632)
  AUTHORS   Wen,Z., Zhong,Z. and Darnell,J.E. Jr.
  TITLE     Maximal activation of transcription by Stat1 and Stat3 requires
            both tyrosine and serine phosphorylation
  JOURNAL   Cell 82 (2), 241-250 (1995)
   PUBMED   7543024
REFERENCE   7  (bases 1 to 3632)
  AUTHORS   Countaway,J.L., Nairn,A.C. and Davis,R.J.
  TITLE     Mechanism of desensitization of the epidermal growth factor
            receptor protein-tyrosine kinase
  JOURNAL   J Biol Chem 267 (2), 1129-1140 (1992)
   PUBMED   1309762
REFERENCE   8  (bases 1 to 3632)
  AUTHORS   Ikebe,M. and Reardon,S.
  TITLE     Phosphorylation of smooth myosin light chain kinase by smooth
            muscle Ca2+/calmodulin-dependent multifunctional protein kinase
  JOURNAL   J Biol Chem 265 (16), 8975-8978 (1990)
   PUBMED   2160950
REFERENCE   9  (bases 1 to 3632)
  AUTHORS   Czernik,A.J., Pang,D.T. and Greengard,P.
  TITLE     Amino acid sequences surrounding the cAMP-dependent and
            calcium/calmodulin-dependent phosphorylation sites in rat and
            bovine synapsin I
  JOURNAL   Proc Natl Acad Sci U S A 84 (21), 7518-7522 (1987)
   PUBMED   3118371
REFERENCE   10 (bases 1 to 3632)
  AUTHORS   Vulliet,P.R., Woodgett,J.R. and Cohen,P.
  TITLE     Phosphorylation of tyrosine hydroxylase by calmodulin-dependent
            multiprotein kinase
  JOURNAL   J Biol Chem 259 (22), 13680-13683 (1984)
   PUBMED   6150037
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL596247.22, AL713896.9 and
            AC022400.9.
            
            On Dec 5, 2018 this sequence version replaced XM_017016735.1.
            
            Summary: The product of this gene is one of the four subunits of an
            enzyme which belongs to the serine/threonine protein kinase family,
            and to the Ca(2+)/calmodulin-dependent protein kinase subfamily.
            Calcium signaling is crucial for several aspects of plasticity at
            glutamatergic synapses. In mammalian cells the enzyme is composed
            of four different chains: alpha, beta, gamma, and delta. The
            product of this gene is a gamma chain. Many alternatively spliced
            transcripts encoding different isoforms have been described but the
            full-length nature of all the variants has not been
            determined.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1150351.1,
                                           SRR3476690.370411.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AL596247.22        23297-23455         c
            160-254             AL596247.22        21889-21983         c
            255-314             AL596247.22        9730-9789           c
            315-369             AL596247.22        2092-2146           c
            370-435             AL713896.9         3168-3233           c
            436-508             AC022400.9         181972-182044       c
            509-611             AC022400.9         181724-181826       c
            612-695             AC022400.9         181237-181320       c
            696-790             AC022400.9         180699-180793       c
            791-913             AC022400.9         179936-180058       c
            914-997             AC022400.9         175169-175252       c
            998-1040            AC022400.9         174880-174922       c
            1041-1084           AC022400.9         170179-170222       c
            1085-1117           AC022400.9         160800-160832       c
            1118-1162           AC022400.9         156751-156795       c
            1163-1211           AC022400.9         154393-154441       c
            1212-1287           AC022400.9         150190-150265       c
            1288-1382           AC022400.9         149734-149828       c
            1383-1627           AC022400.9         147714-147958       c
            1628-3632           AC022400.9         145212-147216       c
FEATURES             Location/Qualifiers
     source          1..3632
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2"
     gene            1..3632
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /note="calcium/calmodulin dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:818"
                     /db_xref="HGNC:HGNC:1463"
                     /db_xref="MIM:602123"
     exon            1..159
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1615
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /EC_number="2.7.11.17"
                     /note="isoform 23 is encoded by transcript variant 23;
                     calcium/calmodulin-dependent protein kinase (CaM kinase)
                     II gamma; calcium/calmodulin-dependent protein kinase type
                     II subunit gamma; caMK-II subunit gamma"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 23"
                     /protein_id="NP_001354459.1"
                     /db_xref="GeneID:818"
                     /db_xref="HGNC:HGNC:1463"
                     /db_xref="MIM:602123"
                     /translation="MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGL
                     AIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDED
                     QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRS
                     TVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKS
                     SSSVHLMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNG
                     DFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVI
                     GEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ"
     exon            160..254
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            255..314
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            315..369
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            370..435
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            436..508
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            509..611
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            612..695
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            696..790
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            791..913
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            914..997
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1040
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1084
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1117
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1162
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1211
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1287
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1382
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1627
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..3632
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3610..3615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /note="hexamer: AATAAA"
     polyA_site      3632
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /note="major polyA site"
ORIGIN      
        1 ccccgtctcc tcctcttgct ccctcggccg ggcggcggtg actgtgcacc gacgtcggcg
       61 cgggctgcac cgccgcgtcc gcccgcccgc cagcatggcc accaccgcca cctgcacccg
      121 tttcaccgac gactaccagc tcttcgagga gcttggcaag ggtgctttct ctgtggtccg
      181 caggtgtgtg aagaaaacct ccacgcagga gtacgcagca aaaatcatca ataccaagaa
      241 gttgtctgcc cgggatcacc agaaactaga acgtgaggct cggatatgtc gacttctgaa
      301 acatccaaac atcgtgcgcc tccatgacag tatttctgaa gaagggtttc actacctcgt
      361 gtttgacctt gttaccggcg gggagctgtt tgaagacatt gtggccagag agtactacag
      421 tgaagcagat gccagccact gtatacatca gattctggag agtgttaacc acatccacca
      481 gcatgacatc gtccacaggg acctgaagcc tgagaacctg ctgctggcga gtaaatgcaa
      541 gggtgccgcc gtcaagctgg ctgattttgg cctagccatc gaagtacagg gagagcagca
      601 ggcttggttt ggttttgctg gcaccccagg ttacttgtcc cctgaggtct tgaggaaaga
      661 tccctatgga aaacctgtgg atatctgggc ctgcggggtc atcctgtata tcctcctggt
      721 gggctatcct cccttctggg atgaggatca gcacaagctg tatcagcaga tcaaggctgg
      781 agcctatgat ttcccatcac cagaatggga cacggtaact cctgaagcca agaacttgat
      841 caaccagatg ctgaccataa acccagcaaa gcgcatcacg gctgaccagg ctctcaagca
      901 cccgtgggtc tgtcaacgat ccacggtggc atccatgatg catcgtcagg agactgtgga
      961 gtgtttgcgc aagttcaatg cccggagaaa actgaagggt gccatcctca cgaccatgct
     1021 tgtctccagg aacttctcag ctgccaaaag cctattgaac aagaagtcgg atggcggtgt
     1081 caagaaaagg aagtcgagtt ccagcgtgca cctaatggag ccacaaacca ctgtggtaca
     1141 caacgctaca gatgggatca agggctccac agagagctgc aacaccacca cagaagatga
     1201 ggacctcaaa gtgcgaaaac aggagatcat taagattaca gaacagctga ttgaagccat
     1261 caacaatggg gactttgagg cctacacgaa gatttgtgat ccaggcctca cttcctttga
     1321 gcctgaggcc cttggtaacc tcgtggaggg gatggatttc cataagtttt actttgagaa
     1381 tctcctgtcc aagaacagca agcctatcca taccaccatc ctaaacccac acgtccacgt
     1441 gattggggag gacgcagcgt gcatcgccta catccgcctc acccagtaca tcgacgggca
     1501 gggtcggcct cgcaccagcc agtcagaaga gacccgggtc tggcaccgtc gggatggcaa
     1561 gtggctcaat gtccactatc actgctcagg ggcccctgcc gcaccgctgc agtgagctca
     1621 gccacagggg ctttaggaga ttccagccgg aggtccaacc ttcgcagcca gtggctctgg
     1681 agggcctgag tgacagcggc agtcctgttt gtttgaggtt taaaacaatt caattacaaa
     1741 agcggcagca gccaatgcac gcccctgcat gcagccctcc cgcccgccct tcgtgtctgt
     1801 ctctgctgta ccgaggtgtt ttttacattt aagaaaaaaa aaaaagaaaa aaagattgtt
     1861 taaaaaaaaa aggaatccat accatgatgc gttttaaaac caccgacagc ccttgggttg
     1921 gcaagaaggc aggagtatgt atgaggtcca tcctggcatg agcagtggct cacccaccgg
     1981 ccttgaagag gtgagcttgg cctctctggt ccccatggac ttagggggac caggcaagaa
     2041 ctctgacaga gctttggggg ccgtgatgtg attgcagctc ctgaggtggc ctgcttaccc
     2101 caggtctagg aatgaacttc tttggaactt gcataggcgc ctagaatggg gctgatgaga
     2161 acatcgtgac catcagacct acttgggaga gaacgcagag ctcccagcct gctgtggagg
     2221 cagctgagaa gtggtggcct caggactgag agcccggacg ttgctgtact gtcttgttta
     2281 gtgtagaagg gaagagaatt ggtgctgcag aagtgtaccc gccatgaagc cgatgagaaa
     2341 cctcgtgtta gtctgacatg cactcactca tccatttcta taggatgcac aatgcatgtg
     2401 ggccctaata ttgaggcctt atccctgcag ctaggagggg gaggggttgt tgctgctttg
     2461 cttcgtgttt tcttctaacc tggcaaggag agagccaggc cctggtcagg gctcccgtgc
     2521 cgcctttggc ggttctgttt ctgtgctgat ctggaccatc tttgtcttgc cttttcacgg
     2581 tagtggtccc catgctgacc ctcatctggg cctgggccct ctgccaagtg cccctgtggg
     2641 atgggaggag tgaggcagtg ggagaagagg tggtggtcgt ttctatgcat tcaggctgcc
     2701 tttggggctg cctcccttct tattcttcct tgctgcacgt ccatctcttt tcctgtcttt
     2761 gagattgacc tgactgctct ggcaagaaga agaggtgtcc ttacagaggc ctctttactg
     2821 accaactgaa gtatagactt actgctggac aatctgcatg ggcatcaccc ctccccgcat
     2881 gtaacccaaa agaggtgtcc agagccaagg cttctacctt cattgtccct ctctgtgctc
     2941 aaggagttcc attccaggag gaagagatct ataccctaag cagatagcaa agaagataat
     3001 ggaggagcaa ttggtcatgg ccttggtttc cctcaaaaca acgctgcaga tttatctgca
     3061 caaacatctc cacttttggg ggaaaggtgg gtagattcca gttccctgga ctaccttcag
     3121 gaggcacgag agctgggaga agaggcaaag ctacaggttt acttgggagc cagctgagaa
     3181 gagagcagac tcacaggtgc tggtgcttgg atttagccag gctcctccga gcacctcatg
     3241 catgtcccag cccctgggcc ctagcccttt cctgccctgc agtctgcagt gccagcacgc
     3301 aaatcccttc accacagggt ttcgttttgc tggcttgaag acaaatggtc ttagaattca
     3361 ttgagaccca tagcttcata tggctgctcc agccccactt cttagcattc ttactcctct
     3421 tctggggcta atgtcagcat ctatagacaa tagactatta aaaaatcacc ttttaaacaa
     3481 gaaacggaag gcatttgatg cagaattttt gcatgacaac atagaaataa tttaaaaata
     3541 gtgtttgttc tgaatgttgg tagacccttc atagctttgt tacaatgaaa ccttgaactg
     3601 aaaatattta ataaaataac ctttaaacag tc
//
