LOCUS       NM_001367524            2660 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens calcium/calmodulin dependent protein kinase II gamma
            (CAMK2G), transcript variant 17, mRNA.
ACCESSION   NM_001367524 XM_017016734
VERSION     NM_001367524.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2660)
  AUTHORS   Gurd,B.J., Menezes,E.S., Arhen,B.B. and Islam,H.
  TITLE     Impacts of altered exercise volume, intensity, and duration on the
            activation of AMPK and CaMKII and increases in PGC-1alpha mRNA
  JOURNAL   Semin Cell Dev Biol 143, 17-27 (2023)
   PUBMED   35680515
  REMARK    GeneRIF: Impacts of altered exercise volume, intensity, and
            duration on the activation of AMPK and CaMKII and increases in
            PGC-1alpha mRNA.
            Review article
REFERENCE   2  (bases 1 to 2660)
  AUTHORS   Koren,D.T., Shrivastava,R. and Ghosh,S.
  TITLE     Ca2+/Calmodulin-Dependent Protein Kinase II Disrupts the Voltage
            Dependency of the Voltage-Dependent Anion Channel on the Lipid
            Bilayer Membrane
  JOURNAL   J Phys Chem B 127 (15), 3372-3381 (2023)
   PUBMED   37040575
  REMARK    GeneRIF: Ca[2+]/Calmodulin-Dependent Protein Kinase II Disrupts the
            Voltage Dependency of the Voltage-Dependent Anion Channel on the
            Lipid Bilayer Membrane.
REFERENCE   3  (bases 1 to 2660)
  AUTHORS   Zhu,S., Zhang,X., Guo,Y., Tang,L., Zhou,Z., Chen,X. and Peng,C.
  TITLE     NETO2 promotes melanoma progression via activation of the
            Ca2+/CaMKII signaling pathway
  JOURNAL   Front Med 17 (2), 263-274 (2023)
   PUBMED   36738427
  REMARK    GeneRIF: NETO2 promotes melanoma progression via activation of the
            Ca[2+]/CaMKII signaling pathway.
REFERENCE   4  (bases 1 to 2660)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2660)
  AUTHORS   Miyauchi,M., Sasaki,K., Kagoya,Y., Taoka,K., Masamoto,Y.,
            Yamazaki,S., Arai,S., Mizuno,H. and Kurokawa,M.
  TITLE     CAMK2G is identified as a novel therapeutic target for
            myelofibrosis
  JOURNAL   Blood Adv 6 (5), 1585-1597 (2022)
   PUBMED   34521112
  REMARK    GeneRIF: CAMK2G is identified as a novel therapeutic target for
            myelofibrosis.
REFERENCE   6  (bases 1 to 2660)
  AUTHORS   Wen,Z., Zhong,Z. and Darnell,J.E. Jr.
  TITLE     Maximal activation of transcription by Stat1 and Stat3 requires
            both tyrosine and serine phosphorylation
  JOURNAL   Cell 82 (2), 241-250 (1995)
   PUBMED   7543024
REFERENCE   7  (bases 1 to 2660)
  AUTHORS   Countaway,J.L., Nairn,A.C. and Davis,R.J.
  TITLE     Mechanism of desensitization of the epidermal growth factor
            receptor protein-tyrosine kinase
  JOURNAL   J Biol Chem 267 (2), 1129-1140 (1992)
   PUBMED   1309762
REFERENCE   8  (bases 1 to 2660)
  AUTHORS   Ikebe,M. and Reardon,S.
  TITLE     Phosphorylation of smooth myosin light chain kinase by smooth
            muscle Ca2+/calmodulin-dependent multifunctional protein kinase
  JOURNAL   J Biol Chem 265 (16), 8975-8978 (1990)
   PUBMED   2160950
REFERENCE   9  (bases 1 to 2660)
  AUTHORS   Czernik,A.J., Pang,D.T. and Greengard,P.
  TITLE     Amino acid sequences surrounding the cAMP-dependent and
            calcium/calmodulin-dependent phosphorylation sites in rat and
            bovine synapsin I
  JOURNAL   Proc Natl Acad Sci U S A 84 (21), 7518-7522 (1987)
   PUBMED   3118371
REFERENCE   10 (bases 1 to 2660)
  AUTHORS   Vulliet,P.R., Woodgett,J.R. and Cohen,P.
  TITLE     Phosphorylation of tyrosine hydroxylase by calmodulin-dependent
            multiprotein kinase
  JOURNAL   J Biol Chem 259 (22), 13680-13683 (1984)
   PUBMED   6150037
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL596247.22, AL713896.9 and
            AC022400.9.
            
            On Dec 5, 2018 this sequence version replaced XM_017016734.1.
            
            Summary: The product of this gene is one of the four subunits of an
            enzyme which belongs to the serine/threonine protein kinase family,
            and to the Ca(2+)/calmodulin-dependent protein kinase subfamily.
            Calcium signaling is crucial for several aspects of plasticity at
            glutamatergic synapses. In mammalian cells the enzyme is composed
            of four different chains: alpha, beta, gamma, and delta. The
            product of this gene is a gamma chain. Many alternatively spliced
            transcripts encoding different isoforms have been described but the
            full-length nature of all the variants has not been
            determined.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.93845.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AL596247.22        23297-23455         c
            160-254             AL596247.22        21889-21983         c
            255-314             AL596247.22        9730-9789           c
            315-380             AL713896.9         3168-3233           c
            381-453             AC022400.9         181972-182044       c
            454-556             AC022400.9         181724-181826       c
            557-640             AC022400.9         181237-181320       c
            641-735             AC022400.9         180699-180793       c
            736-858             AC022400.9         179936-180058       c
            859-942             AC022400.9         175169-175252       c
            943-985             AC022400.9         174880-174922       c
            986-1048            AC022400.9         172250-172312       c
            1049-1092           AC022400.9         170179-170222       c
            1093-1125           AC022400.9         160800-160832       c
            1126-1170           AC022400.9         156751-156795       c
            1171-1219           AC022400.9         154393-154441       c
            1220-1333           AC022400.9         152243-152356       c
            1334-1409           AC022400.9         150190-150265       c
            1410-2660           AC022400.9         148578-149828       c
FEATURES             Location/Qualifiers
     source          1..2660
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2"
     gene            1..2660
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /note="calcium/calmodulin dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:818"
                     /db_xref="HGNC:HGNC:1463"
                     /db_xref="MIM:602123"
     exon            1..159
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            160..254
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            255..314
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..1818
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /EC_number="2.7.11.17"
                     /note="isoform 17 is encoded by transcript variant 17;
                     calcium/calmodulin-dependent protein kinase (CaM kinase)
                     II gamma; calcium/calmodulin-dependent protein kinase type
                     II subunit gamma; caMK-II subunit gamma"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 17"
                     /protein_id="NP_001354453.1"
                     /db_xref="GeneID:818"
                     /db_xref="HGNC:HGNC:1463"
                     /db_xref="MIM:602123"
                     /translation="MSTSETSKHRVTGGELFEDIVAREYYSEADASHCIHQILESVNH
                     IHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPE
                     VLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVT
                     PEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKL
                     KGAILTTMLVSRNFSVGRQSSAPASPAASAAGLAGQAAKSLLNKKSDGGVKKRKSSSS
                     VHLMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKAAPLRTGNGSSVPEGRSSRDRTA
                     PSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGN
                     LVEGMDFHKFYFENREWVRAADILLPAPLPLCLCLLLTFSSQLPTFPLFDLRAALLLC
                     MLVPLCPDGCRQAPLKALLLSSKCHSFCSCFVAVPVTTIKLTYFLPGAVAYACNPNTL
                     GG"
     exon            315..380
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            381..453
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            454..556
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            557..640
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            641..735
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            736..858
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            859..942
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            943..985
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1048
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1092
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1125
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1170
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1219
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1333
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1409
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..2660
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2634..2639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /note="hexamer: AATAAA"
     polyA_site      2660
                     /gene="CAMK2G"
                     /gene_synonym="CAMK; CAMK-II; CAMKG; MRD59"
                     /note="major polyA site"
ORIGIN      
        1 ccccgtctcc tcctcttgct ccctcggccg ggcggcggtg actgtgcacc gacgtcggcg
       61 cgggctgcac cgccgcgtcc gcccgcccgc cagcatggcc accaccgcca cctgcacccg
      121 tttcaccgac gactaccagc tcttcgagga gcttggcaag ggtgctttct ctgtggtccg
      181 caggtgtgtg aagaaaacct ccacgcagga gtacgcagca aaaatcatca ataccaagaa
      241 gttgtctgcc cgggatcacc agaaactaga acgtgaggct cggatatgtc gacttctgaa
      301 acatccaaac atcgtgttac cggcggggag ctgtttgaag acattgtggc cagagagtac
      361 tacagtgaag cagatgccag ccactgtata catcagattc tggagagtgt taaccacatc
      421 caccagcatg acatcgtcca cagggacctg aagcctgaga acctgctgct ggcgagtaaa
      481 tgcaagggtg ccgccgtcaa gctggctgat tttggcctag ccatcgaagt acagggagag
      541 cagcaggctt ggtttggttt tgctggcacc ccaggttact tgtcccctga ggtcttgagg
      601 aaagatccct atggaaaacc tgtggatatc tgggcctgcg gggtcatcct gtatatcctc
      661 ctggtgggct atcctccctt ctgggatgag gatcagcaca agctgtatca gcagatcaag
      721 gctggagcct atgatttccc atcaccagaa tgggacacgg taactcctga agccaagaac
      781 ttgatcaacc agatgctgac cataaaccca gcaaagcgca tcacggctga ccaggctctc
      841 aagcacccgt gggtctgtca acgatccacg gtggcatcca tgatgcatcg tcaggagact
      901 gtggagtgtt tgcgcaagtt caatgcccgg agaaaactga agggtgccat cctcacgacc
      961 atgcttgtct ccaggaactt ctcagttggc aggcagagct ccgcccccgc ctcgcctgcc
     1021 gcgagcgccg ccggcctggc cgggcaagct gccaaaagcc tattgaacaa gaagtcggat
     1081 ggcggtgtca agaaaaggaa gtcgagttcc agcgtgcacc taatggagcc acaaaccact
     1141 gtggtacaca acgctacaga tgggatcaag ggctccacag agagctgcaa caccaccaca
     1201 gaagatgagg acctcaaagc tgccccgctc cgcactggga atggcagctc ggtgcctgaa
     1261 ggacggagct cccgggacag aacagccccc tctgcaggca tgcagcccca gccttctctc
     1321 tgctcctcag ccatgcgaaa acaggagatc attaagatta cagaacagct gattgaagcc
     1381 atcaacaatg gggactttga ggcctacacg aagatttgtg atccaggcct cacttccttt
     1441 gagcctgagg cccttggtaa cctcgtggag gggatggatt tccataagtt ttactttgag
     1501 aatcgtgagt gggttcgtgc tgctgatata ctcctgcctg cccctttacc cctttgtctc
     1561 tgtctcctgc tcaccttctc atcccagttg cccacttttc ccttatttga ccttcgtgct
     1621 gcactcctac tctgtatgct tgtccccttg tgccccgatg gttgtagaca ggcacctttg
     1681 aaggccctgc tcctgagctc caagtgccat tcattctgca gctgctttgt ggcagtgcca
     1741 gtcaccacaa tcaagctcac ttatttcttg ccgggcgcgg tggcttacgc ctgtaatccc
     1801 aacactttgg gaggctgagg ctggcggatc acgaggtcag gagatcgagg ccatcctggc
     1861 taacacggtg aaaccccatc tctactaaaa atacaaaaaa ttagccgggc gtggtggcgg
     1921 tgcctgtagt cccagctact cgggtggctg aggcaggaga atgatgtgaa cctgggaggc
     1981 agagcttgca gtgagccaag atcaggccac tgcactccag cctgggcaac agagcaagac
     2041 tccatctcaa aaaaaaagaa aaaattattt aagcctcacc tctttccaag acggattgga
     2101 aggaaaccct ttgagattag gttgagatga tctcagcaca taagaactaa gctctgtgtc
     2161 tgcaggtttc acaatagagg aaattaaaac caggataaga atgtgcaaac cagggcactg
     2221 ttggtgattt gcgagatcgg aagttgtggc tagaatcttc ctgactatgg aggaaggcag
     2281 acgtcttgta tagggggtgg ggtgtacatt ctggacagtt catggaaaat aaggggataa
     2341 gaagctgaat catcaccccc tcccatcttt ctctctgctc tatgagaccc tccccttcct
     2401 tatttttatc tcttcccact ttatgctggg ccttccctat cctgccctga gttatagtta
     2461 gtcactaact tctccgctgg ctcccaccct tatcacatct cagctacata tataaactct
     2521 ctgttatcta agtaattcta ttagccagaa gcaattccag agtttatatt agtactagga
     2581 aggtgtcatg tagcccctgt ctaacatttg aattgaacta aaatgtgaat ctcaataaaa
     2641 gcaacacagt tttcacagca
//
