LOCUS       NM_001399859            5784 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens calcium/calmodulin dependent protein kinase II delta
            (CAMK2D), transcript variant 42, mRNA.
ACCESSION   NM_001399859
VERSION     NM_001399859.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5784)
  AUTHORS   Rigter,P.M.F., de Konink,C., Dunn,M.J., Proietti Onori,M.,
            Humberson,J.B., Thomas,M., Barnes,C., Prada,C.E., Weaver,K.N.,
            Ryan,T.D., Caluseriu,O., Conway,J., Calamaro,E., Fong,C.T.,
            Wuyts,W., Meuwissen,M., Hordijk,E., Jonkers,C.N., Anderson,L.,
            Yuseinova,B., Polonia,S., Beysen,D., Stark,Z., Savva,E.,
            Poulton,C., McKenzie,F., Bhoj,E., Bupp,C.P., Bezieau,S.,
            Mercier,S., Blevins,A., Wentzensen,I.M., Xia,F., Rosenfeld,J.A.,
            Hsieh,T.C., Krawitz,P.M., Elbracht,M., Veenma,D.C.M., Schulman,H.,
            Stratton,M.M., Kury,S. and van Woerden,G.M.
  TITLE     Role of CAMK2D in neurodevelopment and associated conditions
  JOURNAL   Am J Hum Genet 111 (2), 364-382 (2024)
   PUBMED   38272033
  REMARK    GeneRIF: Role of CAMK2D in neurodevelopment and associated
            conditions.
REFERENCE   2  (bases 1 to 5784)
  AUTHORS   Chuah,Y.H., Tay,E.X.Y., Grinchuk,O.V., Yoon,J., Feng,J., Kannan,S.,
            Robert,M., Jakhar,R., Liang,Y., Lee,B.W.L., Wang,L.C., Lim,Y.T.,
            Zhao,T., Sobota,R.M., Lu,G., Low,B.C., Crasta,K.C., Verma,C.S.,
            Lin,Z. and Ong,D.S.T.
  TITLE     CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to
            induce mitotic checkpoint in glioma
  JOURNAL   Cell Death Differ 30 (8), 1973-1987 (2023)
   PUBMED   37468549
  REMARK    GeneRIF: CAMK2D serves as a molecular scaffold for RNF8-MAD2
            complex to induce mitotic checkpoint in glioma.
REFERENCE   3  (bases 1 to 5784)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 5784)
  AUTHORS   Saddouk,F.Z., Ginnan,R. and Singer,H.A.
  TITLE     Ca2+/Calmodulin-Dependent Protein Kinase II in Vascular Smooth
            Muscle
  JOURNAL   Adv Pharmacol 78, 171-202 (2017)
   PUBMED   28212797
  REMARK    Review article
REFERENCE   5  (bases 1 to 5784)
  AUTHORS   Bhattacharyya,M., Stratton,M.M., Going,C.C., McSpadden,E.D.,
            Huang,Y., Susa,A.C., Elleman,A., Cao,Y.M., Pappireddi,N.,
            Burkhardt,P., Gee,C.L., Barros,T., Schulman,H., Williams,E.R. and
            Kuriyan,J.
  TITLE     Molecular mechanism of activation-triggered subunit exchange in
            Ca(2+)/calmodulin-dependent protein kinase II
  JOURNAL   Elife 5, e13405 (2016)
   PUBMED   26949248
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5784)
  AUTHORS   Hudmon,A. and Schulman,H.
  TITLE     Neuronal CA2+/calmodulin-dependent protein kinase II: the role of
            structure and autoregulation in cellular function
  JOURNAL   Annu Rev Biochem 71, 473-510 (2002)
   PUBMED   12045104
  REMARK    Review article
REFERENCE   7  (bases 1 to 5784)
  AUTHORS   Soderling,T.R. and Stull,J.T.
  TITLE     Structure and regulation of calcium/calmodulin-dependent protein
            kinases
  JOURNAL   Chem Rev 101 (8), 2341-2352 (2001)
   PUBMED   11749376
  REMARK    Review article
REFERENCE   8  (bases 1 to 5784)
  AUTHORS   Williams,C.L., Phelps,S.H. and Porter,R.A.
  TITLE     Expression of Ca2+/calmodulin-dependent protein kinase types II and
            IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent
            protein kinase inhibitor KN-62
            (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl
            piperazine) in small cell lung carcinoma
  JOURNAL   Biochem Pharmacol 51 (5), 707-715 (1996)
   PUBMED   8615909
REFERENCE   9  (bases 1 to 5784)
  AUTHORS   de Groot,R.P., den Hertog,J., Vandenheede,J.R., Goris,J. and
            Sassone-Corsi,P.
  TITLE     Multiple and cooperative phosphorylation events regulate the CREM
            activator function
  JOURNAL   EMBO J 12 (10), 3903-3911 (1993)
   PUBMED   8404858
REFERENCE   10 (bases 1 to 5784)
  AUTHORS   Sakagami,H. and Kondo,H.
  TITLE     Differential expression of mRNAs encoding gamma and delta subunits
            of Ca2+/calmodulin-dependent protein kinase type II (CaM kinase II)
            in the mature and postnatally developing rat brain
  JOURNAL   Brain Res Mol Brain Res 20 (1-2), 51-63 (1993)
   PUBMED   8255181
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004168.2, AC004056.1 and
            AC093900.3.
            
            Summary: The product of this gene belongs to the serine/threonine
            protein kinase family and to the Ca(2+)/calmodulin-dependent
            protein kinase subfamily. Calcium signaling is crucial for several
            aspects of plasticity at glutamatergic synapses. In mammalian
            cells, the enzyme is composed of four different chains: alpha,
            beta, gamma, and delta. The product of this gene is a delta chain.
            Alternative splicing results in multiple transcript variants
            encoding distinct isoforms. Distinct isoforms of this chain have
            different expression patterns.[provided by RefSeq, Nov 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.2403369.1,
                                           SRR14038193.2786476.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-735               AC004168.2         162048-162782       c
            736-830             AC004168.2         160364-160458       c
            831-931             AC004168.2         78552-78652         c
            932-991             AC004168.2         62757-62816         c
            992-1046            AC004168.2         10196-10250         c
            1047-1112           AC004056.1         93238-93303         c
            1113-1185           AC004056.1         89864-89936         c
            1186-1288           AC004056.1         78548-78650         c
            1289-1372           AC004056.1         72423-72506         c
            1373-1467           AC004056.1         58770-58864         c
            1468-1590           AC004056.1         56276-56398         c
            1591-1674           AC004056.1         55037-55120         c
            1675-1717           AC004056.1         54535-54577         c
            1718-1755           AC004056.1         50845-50882         c
            1756-1804           AC004056.1         41670-41718         c
            1805-1880           AC004056.1         6736-6811           c
            1881-1975           AC004056.1         1354-1448           c
            1976-2204           AC093900.3         149129-149357       c
            2205-2300           AC093900.3         147520-147615       c
            2301-5784           AC093900.3         142826-146309       c
FEATURES             Location/Qualifiers
     source          1..5784
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q26"
     gene            1..5784
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /note="calcium/calmodulin dependent protein kinase II
                     delta"
                     /db_xref="GeneID:817"
                     /db_xref="HGNC:HGNC:1462"
                     /db_xref="MIM:607708"
     exon            1..735
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            736..830
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            831..931
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     CDS             889..2271
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /EC_number="2.7.11.17"
                     /note="isoform 39 is encoded by transcript variant 42;
                     calcium/calmodulin-dependent protein kinase (CaM kinase)
                     II delta; calcium/calmodulin-dependent protein kinase type
                     II delta chain; CaM-kinase II delta chain; CaM kinase II
                     delta subunit; CaMK-II delta subunit;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit delta"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit delta isoform 39"
                     /protein_id="NP_001386788.1"
                     /db_xref="GeneID:817"
                     /db_xref="HGNC:HGNC:1462"
                     /db_xref="MIM:607708"
                     /translation="MSDGSKTSKFLQEGNHQKLEREARICRLLKHPNIVRLHDSISEE
                     GFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPEN
                     LLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWA
                     CGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP
                     AKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFS
                     AAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKIC
                     DPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAY
                     IRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPPCIPNGKENF
                     SGGTSLWQNI"
     exon            932..991
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1046
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1112
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1185
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1288
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1372
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1467
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1590
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1674
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1717
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1755
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1804
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1880
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1975
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2204
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2300
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..5784
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4378..4383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /note="hexamer: AATAAA"
     polyA_site      4400
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
     regulatory      5759..5764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /note="hexamer: AATAAA"
     polyA_site      5784
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /note="major polyA site"
ORIGIN      
        1 ctttctctcg ccgcgccgtc ttgaagccgc gcgggctcgt gagcagcgcg aggccgccaa
       61 ggtgcctcgc ttcgccggag ccgctgccgc ccgccggagg gaagccggcc tcgggcgcgc
      121 acgctcgtcg gagccccggc gcgccccgcg cctgagcctg ctgacagcgg ccgctgggct
      181 caggctgtcc gctctgggct ccgcggcctc ggccccgctg cactccacct ccgccccctc
      241 ggactccctc ccctctgctt ctactcctcc tgctccagtg cggatcgttt cgcaactgct
      301 tgccactcgt cccgtgcctg gctgtttttc catttcccgg ccccctcttc ttgagtactt
      361 taccccctgc atttggggac agggactgga aaaggggcgg gtggagcgtc cagtggagaa
      421 gaaggaagcg aggcccgcag gaggaggagg atcggcggac tgtggggagg agaccccacg
      481 ccaccctttc tggtcatctc ccctcccgcc ccgcccctgc gcacactccc tcgcgggcga
      541 gctactttcg gaccaggaaa gtaagagcgg ccctgggtga cagcgccgcg gggccagtcc
      601 cggggttagc cgcgcgtctg ctcgcttctg gtccgtcgcg ctcccagcca gggcacagcc
      661 cggaccgagg atggcttcga ccacaacctg caccaggttc acggacgagt atcagctttt
      721 cgaggagctt ggaaaggggg cattctcagt ggtgagaaga tgtatgaaaa ttcctactgg
      781 acaagaatat gctgccaaaa ttatcaacac caaaaagctt tctgctaggg atggtattgc
      841 atcgcttgac tcttagagaa ggctctggat gattgacaga ttatcctcat gtctgacgga
      901 agtaagacga gcaagttcct tcaagaagga aatcatcaga aactagaaag agaagctaga
      961 atctgccgtc ttttgaagca ccctaatatt gtgcgacttc atgatagcat atcagaagag
     1021 ggctttcact acttggtgtt tgatttagtt actggaggtg aactgtttga agacatagtg
     1081 gcaagagaat actacagtga agctgatgcc agtcattgta tacagcagat tctagaaagt
     1141 gttaatcatt gtcacctaaa tggcatagtt cacagggacc tgaagcctga gaatttgctt
     1201 ttagctagca aatccaaggg agcagctgtg aaattggcag actttggctt agccatagaa
     1261 gttcaagggg accagcaggc gtggtttggt tttgctggca cacctggata tctttctcca
     1321 gaagttttac gtaaagatcc ttatggaaag ccagtggata tgtgggcatg tggtgtcatt
     1381 ctctatattc tacttgtggg gtatccaccc ttctgggatg aagaccaaca cagactctat
     1441 cagcagatca aggctggagc ttatgatttt ccatcaccag aatgggacac ggtgactcct
     1501 gaagccaaag acctcatcaa taaaatgctt actatcaacc ctgccaaacg catcacagcc
     1561 tcagaggcac tgaagcaccc atggatctgt caacgttcta ctgttgcttc catgatgcac
     1621 agacaggaga ctgtagactg cttgaagaaa tttaatgcta gaagaaaact aaagggtgcc
     1681 atcttgacaa ctatgctggc tacaaggaat ttctcagcag ccaagagttt gttgaagaaa
     1741 ccagatggag taaaggagtc aactgagagt tcaaatacaa caattgagga tgaagatgtg
     1801 aaagcacgaa agcaagagat tatcaaagtc actgaacaac tgatcgaagc tatcaacaat
     1861 ggggactttg aagcctacac aaaaatctgt gacccaggcc ttactgcttt tgaacctgaa
     1921 gctttgggta atttagtgga agggatggat tttcaccgat tctactttga aaatgctttg
     1981 tccaaaagca ataaaccaat ccacactatt attctaaacc ctcatgtaca tctggtaggg
     2041 gatgatgccg cctgcatagc atatattagg ctcacacagt acatggatgg cagtggaatg
     2101 ccaaagacaa tgcagtcaga agagactcgt gtgtggcacc gccgggatgg aaagtggcag
     2161 aatgttcatt ttcatcgctc ggggtcacca acagtaccca tcaagccacc ctgtattcca
     2221 aatgggaaag aaaacttctc aggaggcacc tctttgtggc aaaacatcta aggcctgaaa
     2281 accattcaca tatgggtctt ctaaatttca acagtgccac ttctgcattc tctgttctca
     2341 aggcacctgg atggtgaccc tgggccgtcc tctcctcctc ttcatgcatg tttctgagtg
     2401 catgaagttg tgaaggtcct acatgtaatg catatgtgat gcatcatctt atcatatatt
     2461 ccttcctata cattgtttac acttcaacta cggggatgtt ccacacaaac ttaaattact
     2521 gttggcaaaa caataggggg agattagaca aaaaaaaaaa tccacaatat tccaagtaca
     2581 actcttcatc aagtttctct gttaatgcca agatttaaca gacttaagaa ctattgttct
     2641 ctgaatgaca gttgtaagag aaatgtaaat tttttagaac tctttgctgt taatctgttt
     2701 tggtttgttt ggtttttttt ttttttttta aggtaaaaaa aaaatacacc ttcagtttcc
     2761 tggtgtgatc ctggttaaaa tggatgattt ttcattgaaa gttttgctga ttaacaatta
     2821 aagtgggatg atatgtgggc aaaatcactt atgaaagtag aagcaagaat cagttggttt
     2881 gctaccacat aaagccatgc tgtttttggt caaactgtgt aaactggaaa aattcacatc
     2941 atttctgagt ttaatcactt taggatatat tcacattgtt ttggtgaatt tgctgaattg
     3001 aattgttttt ctttctcaaa tctgtgatct cttttcttta tcctgtttct ttgttccttt
     3061 cgtttgcttt cttatttttc ttttgttcca ttcttttctt acttttttcc cttttccttt
     3121 tttggggagg ctggctagta gtgtgtgaga aaagaataga agtgaaattt gcataatgaa
     3181 tgtaaaaggg aaataaaagt cttttgaagg tagctatact agcacttttg atcatcttca
     3241 gggcccacaa aaatgttgtc aagattttaa aggtttataa ttctgcttaa gctctagttt
     3301 ggacttaggt atcctaacta tgttggaggt atttgcattg tttaaagtta ggataaaagc
     3361 aagttcctcc tgtgactgca acgtcttact gattgggaca gttgccagga ggataccaac
     3421 ttgatagcag agggggtttt atgcaaacgc actcacctcc gccttgggga atgaaagggt
     3481 cacttctgca tcatcactag ctagttttct agtgttagag aggcttacaa atgtttgcca
     3541 ttctcataag tgttttgaac ttgatctttg tgacttgtgc ttttttagct tctctcttga
     3601 atcagagtat cattgtcttc ctccaaggag ttagaatttc ccagtttaaa acaaaaaggg
     3661 aaatgtccta ggttttcttt gtgcttctca tttttccttt gttgattcaa ttcctgtgat
     3721 ttttgttctc ttccctgaag tgctttacag tgcatggaat ctccatcatt gttattttaa
     3781 cgatagtaat tcacagtcct cagaagccta tttttaaagc agaagcaaaa aagaaaaaca
     3841 aaataacaaa aacaaccctt cctcttttct ctcatctcac ctctctgtgt tgattactaa
     3901 tcatcttaga tattattgct agtggatgta tggtagatgg gttgaagctt ttctgataat
     3961 tattacacaa tttaaaacaa catatatatt taaaataaat atatacagta aatatattga
     4021 gccatgttaa cctgccaatg agatctgtga aaaaataatg gcctcatttt tctcttttta
     4081 atttctttta cccttttgtg aagcagctat acgtggcata catgtattta aagaaaaaaa
     4141 aatagatgta gagtgttttt tttacacttt taacttagca tgtggtgttg aagtattact
     4201 gtagatcaag tttgtcttcc gcactaagat gtgaggaaat tgtgatttgt tctctccacc
     4261 acaaatgaat tacacattta ttatcttcta tcattttgaa acactgcagt ttaccatggg
     4321 acactgtata tatttcttgc cataatggta aaggactgat tgatatattt aagagttaat
     4381 aaatttgtga tttctgctga cagtgcgtcc atctttattt cttcagaaga ggtactgtat
     4441 gtatgcctgc atagtgctgg ccagtgtcaa gggcagtgtg tcctactctg gtctcattta
     4501 gtacataaca atttgcactt ggtgagaatg gcaagttaat tgttctctgt gagcaaaaca
     4561 atggtctctt ctgggaaaat gttgctgaga acaatatagt taacaactaa gactcctaaa
     4621 agcttctcta aactgtaccc tccaatccag ccttcacatg gctgcttttt tttttttttt
     4681 ttaatacgaa cctgtccttg taacactttg atgttatcat ttctgggata caggcaagca
     4741 ccccagctcc tgctactccc cagcttgaac ttgagcatac atggatgctc agcttctttt
     4801 gatttgctaa aaacatcaca cttgctcaca tgcctgttta tgctgttcat gttgtttatg
     4861 tttcttacct agaataaata gtctcttccc ctacttcttt tcccgacttc ttactttttc
     4921 ctaagattca gtgtacagca tcatgctcca cagcaaacct tcctaggccc tattctgggc
     4981 ttgccttccc tctcaaaacc tacataatag attgtattta cctctcctgt caaccacatt
     5041 gttttgaaaa tatatttcta tttgtgtctc ctctactgca gtataatgtc tccatgggca
     5101 agaactgtgt attcatcatt gcattcctaa acccaaacca aggccaggaa tggagatatc
     5161 attgataaat agttgttgaa ttgaggccaa gcccttttga taacagaagc ctcaaggggt
     5221 acccagatag tccttgtttt aatgatgggt tctctcacca ctgtcttgat gctctgagca
     5281 agttacctct tccctctgac cctcagtttc catatttgta aaatgagaat aaacatacca
     5341 acttaataaa gatattgtga ggattaatgg gtacagagtg actagaatga tatttgatag
     5401 aaattaaatg gtagcagtat aactattctg atcactgaca ttaatattcc tattgttatt
     5461 attctttgct cacgagggta tacaactctt gttttgctgt tgggctgccc tctttatgta
     5521 ggtttactgt taatgctgag gatatactcg gactcaaatg tctcagcaga aggctgagag
     5581 acaccaaatg aagtggtcat ctagctgaat gtaggaaaaa tgaaatgtag tagcaaatca
     5641 gtatattcta aggaaatttt caaggaatat taatcttcac ccaaattttg aatttttatg
     5701 taaaaaatta taatttaagg gtaaacatag atgacacagc tttcgagtga tttcattgaa
     5761 taaaattcta ctgacttcta tgaa
//
