LOCUS       NM_001399858            5587 bp    mRNA    linear   PRI 07-AUG-2024
DEFINITION  Homo sapiens calcium/calmodulin dependent protein kinase II delta
            (CAMK2D), transcript variant 41, mRNA.
ACCESSION   NM_001399858
VERSION     NM_001399858.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5587)
  AUTHORS   Rigter,P.M.F., de Konink,C., Dunn,M.J., Proietti Onori,M.,
            Humberson,J.B., Thomas,M., Barnes,C., Prada,C.E., Weaver,K.N.,
            Ryan,T.D., Caluseriu,O., Conway,J., Calamaro,E., Fong,C.T.,
            Wuyts,W., Meuwissen,M., Hordijk,E., Jonkers,C.N., Anderson,L.,
            Yuseinova,B., Polonia,S., Beysen,D., Stark,Z., Savva,E.,
            Poulton,C., McKenzie,F., Bhoj,E., Bupp,C.P., Bezieau,S.,
            Mercier,S., Blevins,A., Wentzensen,I.M., Xia,F., Rosenfeld,J.A.,
            Hsieh,T.C., Krawitz,P.M., Elbracht,M., Veenma,D.C.M., Schulman,H.,
            Stratton,M.M., Kury,S. and van Woerden,G.M.
  TITLE     Role of CAMK2D in neurodevelopment and associated conditions
  JOURNAL   Am J Hum Genet 111 (2), 364-382 (2024)
   PUBMED   38272033
  REMARK    GeneRIF: Role of CAMK2D in neurodevelopment and associated
            conditions.
REFERENCE   2  (bases 1 to 5587)
  AUTHORS   Chuah,Y.H., Tay,E.X.Y., Grinchuk,O.V., Yoon,J., Feng,J., Kannan,S.,
            Robert,M., Jakhar,R., Liang,Y., Lee,B.W.L., Wang,L.C., Lim,Y.T.,
            Zhao,T., Sobota,R.M., Lu,G., Low,B.C., Crasta,K.C., Verma,C.S.,
            Lin,Z. and Ong,D.S.T.
  TITLE     CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to
            induce mitotic checkpoint in glioma
  JOURNAL   Cell Death Differ 30 (8), 1973-1987 (2023)
   PUBMED   37468549
  REMARK    GeneRIF: CAMK2D serves as a molecular scaffold for RNF8-MAD2
            complex to induce mitotic checkpoint in glioma.
REFERENCE   3  (bases 1 to 5587)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 5587)
  AUTHORS   Saddouk,F.Z., Ginnan,R. and Singer,H.A.
  TITLE     Ca2+/Calmodulin-Dependent Protein Kinase II in Vascular Smooth
            Muscle
  JOURNAL   Adv Pharmacol 78, 171-202 (2017)
   PUBMED   28212797
  REMARK    Review article
REFERENCE   5  (bases 1 to 5587)
  AUTHORS   Bhattacharyya,M., Stratton,M.M., Going,C.C., McSpadden,E.D.,
            Huang,Y., Susa,A.C., Elleman,A., Cao,Y.M., Pappireddi,N.,
            Burkhardt,P., Gee,C.L., Barros,T., Schulman,H., Williams,E.R. and
            Kuriyan,J.
  TITLE     Molecular mechanism of activation-triggered subunit exchange in
            Ca(2+)/calmodulin-dependent protein kinase II
  JOURNAL   Elife 5, e13405 (2016)
   PUBMED   26949248
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5587)
  AUTHORS   Hudmon,A. and Schulman,H.
  TITLE     Neuronal CA2+/calmodulin-dependent protein kinase II: the role of
            structure and autoregulation in cellular function
  JOURNAL   Annu Rev Biochem 71, 473-510 (2002)
   PUBMED   12045104
  REMARK    Review article
REFERENCE   7  (bases 1 to 5587)
  AUTHORS   Soderling,T.R. and Stull,J.T.
  TITLE     Structure and regulation of calcium/calmodulin-dependent protein
            kinases
  JOURNAL   Chem Rev 101 (8), 2341-2352 (2001)
   PUBMED   11749376
  REMARK    Review article
REFERENCE   8  (bases 1 to 5587)
  AUTHORS   Williams,C.L., Phelps,S.H. and Porter,R.A.
  TITLE     Expression of Ca2+/calmodulin-dependent protein kinase types II and
            IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent
            protein kinase inhibitor KN-62
            (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl
            piperazine) in small cell lung carcinoma
  JOURNAL   Biochem Pharmacol 51 (5), 707-715 (1996)
   PUBMED   8615909
REFERENCE   9  (bases 1 to 5587)
  AUTHORS   de Groot,R.P., den Hertog,J., Vandenheede,J.R., Goris,J. and
            Sassone-Corsi,P.
  TITLE     Multiple and cooperative phosphorylation events regulate the CREM
            activator function
  JOURNAL   EMBO J 12 (10), 3903-3911 (1993)
   PUBMED   8404858
REFERENCE   10 (bases 1 to 5587)
  AUTHORS   Sakagami,H. and Kondo,H.
  TITLE     Differential expression of mRNAs encoding gamma and delta subunits
            of Ca2+/calmodulin-dependent protein kinase type II (CaM kinase II)
            in the mature and postnatally developing rat brain
  JOURNAL   Brain Res Mol Brain Res 20 (1-2), 51-63 (1993)
   PUBMED   8255181
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004168.2, AC004056.1 and
            AC093900.3.
            
            Summary: The product of this gene belongs to the serine/threonine
            protein kinase family and to the Ca(2+)/calmodulin-dependent
            protein kinase subfamily. Calcium signaling is crucial for several
            aspects of plasticity at glutamatergic synapses. In mammalian
            cells, the enzyme is composed of four different chains: alpha,
            beta, gamma, and delta. The product of this gene is a delta chain.
            Alternative splicing results in multiple transcript variants
            encoding distinct isoforms. Distinct isoforms of this chain have
            different expression patterns.[provided by RefSeq, Nov 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2263143.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-735               AC004168.2         162048-162782       c
            736-830             AC004168.2         160364-160458       c
            831-890             AC004168.2         62757-62816         c
            891-945             AC004168.2         10196-10250         c
            946-1011            AC004056.1         93238-93303         c
            1012-1084           AC004056.1         88851-88923         c
            1085-1187           AC004056.1         78548-78650         c
            1188-1271           AC004056.1         72423-72506         c
            1272-1366           AC004056.1         58770-58864         c
            1367-1489           AC004056.1         56276-56398         c
            1490-1573           AC004056.1         55037-55120         c
            1574-1616           AC004056.1         54535-54577         c
            1617-1654           AC004056.1         50845-50882         c
            1655-1703           AC004056.1         41670-41718         c
            1704-1779           AC004056.1         6736-6811           c
            1780-1874           AC004056.1         1354-1448           c
            1875-2103           AC093900.3         149129-149357       c
            2104-5587           AC093900.3         142826-146309       c
FEATURES             Location/Qualifiers
     source          1..5587
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q26"
     gene            1..5587
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /note="calcium/calmodulin dependent protein kinase II
                     delta"
                     /db_xref="GeneID:817"
                     /db_xref="HGNC:HGNC:1462"
                     /db_xref="MIM:607708"
     exon            1..735
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     CDS             671..2107
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /EC_number="2.7.11.17"
                     /note="isoform 38 is encoded by transcript variant 41;
                     calcium/calmodulin-dependent protein kinase (CaM kinase)
                     II delta; calcium/calmodulin-dependent protein kinase type
                     II delta chain; CaM-kinase II delta chain; CaM kinase II
                     delta subunit; CaMK-II delta subunit;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit delta"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit delta isoform 38"
                     /protein_id="NP_001386787.1"
                     /db_xref="GeneID:817"
                     /db_xref="HGNC:HGNC:1462"
                     /db_xref="MIM:607708"
                     /translation="MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKSKGAAVKLADFGL
                     AIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDED
                     QHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRS
                     TVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESS
                     NTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGM
                     DFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSE
                     ETRVWHRRDGKWQNVHFHRSGSPTVPIN"
     exon            736..830
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            831..890
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            891..945
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1011
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1084
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1187
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1271
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1366
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1489
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1573
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1616
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1654
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1703
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1779
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1874
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2103
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..5587
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4181..4186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /note="hexamer: AATAAA"
     polyA_site      4203
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
     regulatory      5562..5567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /note="hexamer: AATAAA"
     polyA_site      5587
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /note="major polyA site"
ORIGIN      
        1 ctttctctcg ccgcgccgtc ttgaagccgc gcgggctcgt gagcagcgcg aggccgccaa
       61 ggtgcctcgc ttcgccggag ccgctgccgc ccgccggagg gaagccggcc tcgggcgcgc
      121 acgctcgtcg gagccccggc gcgccccgcg cctgagcctg ctgacagcgg ccgctgggct
      181 caggctgtcc gctctgggct ccgcggcctc ggccccgctg cactccacct ccgccccctc
      241 ggactccctc ccctctgctt ctactcctcc tgctccagtg cggatcgttt cgcaactgct
      301 tgccactcgt cccgtgcctg gctgtttttc catttcccgg ccccctcttc ttgagtactt
      361 taccccctgc atttggggac agggactgga aaaggggcgg gtggagcgtc cagtggagaa
      421 gaaggaagcg aggcccgcag gaggaggagg atcggcggac tgtggggagg agaccccacg
      481 ccaccctttc tggtcatctc ccctcccgcc ccgcccctgc gcacactccc tcgcgggcga
      541 gctactttcg gaccaggaaa gtaagagcgg ccctgggtga cagcgccgcg gggccagtcc
      601 cggggttagc cgcgcgtctg ctcgcttctg gtccgtcgcg ctcccagcca gggcacagcc
      661 cggaccgagg atggcttcga ccacaacctg caccaggttc acggacgagt atcagctttt
      721 cgaggagctt ggaaaggggg cattctcagt ggtgagaaga tgtatgaaaa ttcctactgg
      781 acaagaatat gctgccaaaa ttatcaacac caaaaagctt tctgctaggg atcatcagaa
      841 actagaaaga gaagctagaa tctgccgtct tttgaagcac cctaatattg tgcgacttca
      901 tgatagcata tcagaagagg gctttcacta cttggtgttt gatttagtta ctggaggtga
      961 actgtttgaa gacatagtgg caagagaata ctacagtgaa gctgatgcca gtcattgcat
     1021 tcagcagatc ctggaggctg tgctacactg ccatcagatg ggcgtggtcc atcgggacct
     1081 gaagcctgag aatttgcttt tagctagcaa atccaaggga gcagctgtga aattggcaga
     1141 ctttggctta gccatagaag ttcaagggga ccagcaggcg tggtttggtt ttgctggcac
     1201 acctggatat ctttctccag aagttttacg taaagatcct tatggaaagc cagtggatat
     1261 gtgggcatgt ggtgtcattc tctatattct acttgtgggg tatccaccct tctgggatga
     1321 agaccaacac agactctatc agcagatcaa ggctggagct tatgattttc catcaccaga
     1381 atgggacacg gtgactcctg aagccaaaga cctcatcaat aaaatgctta ctatcaaccc
     1441 tgccaaacgc atcacagcct cagaggcact gaagcaccca tggatctgtc aacgttctac
     1501 tgttgcttcc atgatgcaca gacaggagac tgtagactgc ttgaagaaat ttaatgctag
     1561 aagaaaacta aagggtgcca tcttgacaac tatgctggct acaaggaatt tctcagcagc
     1621 caagagtttg ttgaagaaac cagatggagt aaaggagtca actgagagtt caaatacaac
     1681 aattgaggat gaagatgtga aagcacgaaa gcaagagatt atcaaagtca ctgaacaact
     1741 gatcgaagct atcaacaatg gggactttga agcctacaca aaaatctgtg acccaggcct
     1801 tactgctttt gaacctgaag ctttgggtaa tttagtggaa gggatggatt ttcaccgatt
     1861 ctactttgaa aatgctttgt ccaaaagcaa taaaccaatc cacactatta ttctaaaccc
     1921 tcatgtacat ctggtagggg atgatgccgc ctgcatagca tatattaggc tcacacagta
     1981 catggatggc agtggaatgc caaagacaat gcagtcagaa gagactcgtg tgtggcaccg
     2041 ccgggatgga aagtggcaga atgttcattt tcatcgctcg gggtcaccaa cagtacccat
     2101 caactaaatt tcaacagtgc cacttctgca ttctctgttc tcaaggcacc tggatggtga
     2161 ccctgggccg tcctctcctc ctcttcatgc atgtttctga gtgcatgaag ttgtgaaggt
     2221 cctacatgta atgcatatgt gatgcatcat cttatcatat attccttcct atacattgtt
     2281 tacacttcaa ctacggggat gttccacaca aacttaaatt actgttggca aaacaatagg
     2341 gggagattag acaaaaaaaa aaatccacaa tattccaagt acaactcttc atcaagtttc
     2401 tctgttaatg ccaagattta acagacttaa gaactattgt tctctgaatg acagttgtaa
     2461 gagaaatgta aattttttag aactctttgc tgttaatctg ttttggtttg tttggttttt
     2521 tttttttttt ttaaggtaaa aaaaaaatac accttcagtt tcctggtgtg atcctggtta
     2581 aaatggatga tttttcattg aaagttttgc tgattaacaa ttaaagtggg atgatatgtg
     2641 ggcaaaatca cttatgaaag tagaagcaag aatcagttgg tttgctacca cataaagcca
     2701 tgctgttttt ggtcaaactg tgtaaactgg aaaaattcac atcatttctg agtttaatca
     2761 ctttaggata tattcacatt gttttggtga atttgctgaa ttgaattgtt tttctttctc
     2821 aaatctgtga tctcttttct ttatcctgtt tctttgttcc tttcgtttgc tttcttattt
     2881 ttcttttgtt ccattctttt cttacttttt tcccttttcc ttttttgggg aggctggcta
     2941 gtagtgtgtg agaaaagaat agaagtgaaa tttgcataat gaatgtaaaa gggaaataaa
     3001 agtcttttga aggtagctat actagcactt ttgatcatct tcagggccca caaaaatgtt
     3061 gtcaagattt taaaggttta taattctgct taagctctag tttggactta ggtatcctaa
     3121 ctatgttgga ggtatttgca ttgtttaaag ttaggataaa agcaagttcc tcctgtgact
     3181 gcaacgtctt actgattggg acagttgcca ggaggatacc aacttgatag cagagggggt
     3241 tttatgcaaa cgcactcacc tccgccttgg ggaatgaaag ggtcacttct gcatcatcac
     3301 tagctagttt tctagtgtta gagaggctta caaatgtttg ccattctcat aagtgttttg
     3361 aacttgatct ttgtgacttg tgctttttta gcttctctct tgaatcagag tatcattgtc
     3421 ttcctccaag gagttagaat ttcccagttt aaaacaaaaa gggaaatgtc ctaggttttc
     3481 tttgtgcttc tcatttttcc tttgttgatt caattcctgt gatttttgtt ctcttccctg
     3541 aagtgcttta cagtgcatgg aatctccatc attgttattt taacgatagt aattcacagt
     3601 cctcagaagc ctatttttaa agcagaagca aaaaagaaaa acaaaataac aaaaacaacc
     3661 cttcctcttt tctctcatct cacctctctg tgttgattac taatcatctt agatattatt
     3721 gctagtggat gtatggtaga tgggttgaag cttttctgat aattattaca caatttaaaa
     3781 caacatatat atttaaaata aatatataca gtaaatatat tgagccatgt taacctgcca
     3841 atgagatctg tgaaaaaata atggcctcat ttttctcttt ttaatttctt ttaccctttt
     3901 gtgaagcagc tatacgtggc atacatgtat ttaaagaaaa aaaaatagat gtagagtgtt
     3961 ttttttacac ttttaactta gcatgtggtg ttgaagtatt actgtagatc aagtttgtct
     4021 tccgcactaa gatgtgagga aattgtgatt tgttctctcc accacaaatg aattacacat
     4081 ttattatctt ctatcatttt gaaacactgc agtttaccat gggacactgt atatatttct
     4141 tgccataatg gtaaaggact gattgatata tttaagagtt aataaatttg tgatttctgc
     4201 tgacagtgcg tccatcttta tttcttcaga agaggtactg tatgtatgcc tgcatagtgc
     4261 tggccagtgt caagggcagt gtgtcctact ctggtctcat ttagtacata acaatttgca
     4321 cttggtgaga atggcaagtt aattgttctc tgtgagcaaa acaatggtct cttctgggaa
     4381 aatgttgctg agaacaatat agttaacaac taagactcct aaaagcttct ctaaactgta
     4441 ccctccaatc cagccttcac atggctgctt tttttttttt tttttaatac gaacctgtcc
     4501 ttgtaacact ttgatgttat catttctggg atacaggcaa gcaccccagc tcctgctact
     4561 ccccagcttg aacttgagca tacatggatg ctcagcttct tttgatttgc taaaaacatc
     4621 acacttgctc acatgcctgt ttatgctgtt catgttgttt atgtttctta cctagaataa
     4681 atagtctctt cccctacttc ttttcccgac ttcttacttt ttcctaagat tcagtgtaca
     4741 gcatcatgct ccacagcaaa ccttcctagg ccctattctg ggcttgcctt ccctctcaaa
     4801 acctacataa tagattgtat ttacctctcc tgtcaaccac attgttttga aaatatattt
     4861 ctatttgtgt ctcctctact gcagtataat gtctccatgg gcaagaactg tgtattcatc
     4921 attgcattcc taaacccaaa ccaaggccag gaatggagat atcattgata aatagttgtt
     4981 gaattgaggc caagcccttt tgataacaga agcctcaagg ggtacccaga tagtccttgt
     5041 tttaatgatg ggttctctca ccactgtctt gatgctctga gcaagttacc tcttccctct
     5101 gaccctcagt ttccatattt gtaaaatgag aataaacata ccaacttaat aaagatattg
     5161 tgaggattaa tgggtacaga gtgactagaa tgatatttga tagaaattaa atggtagcag
     5221 tataactatt ctgatcactg acattaatat tcctattgtt attattcttt gctcacgagg
     5281 gtatacaact cttgttttgc tgttgggctg ccctctttat gtaggtttac tgttaatgct
     5341 gaggatatac tcggactcaa atgtctcagc agaaggctga gagacaccaa atgaagtggt
     5401 catctagctg aatgtaggaa aaatgaaatg tagtagcaaa tcagtatatt ctaaggaaat
     5461 tttcaaggaa tattaatctt cacccaaatt ttgaattttt atgtaaaaaa ttataattta
     5521 agggtaaaca tagatgacac agctttcgag tgatttcatt gaataaaatt ctactgactt
     5581 ctatgaa
//
