LOCUS       NM_001321584            5626 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens calcium/calmodulin dependent protein kinase II delta
            (CAMK2D), transcript variant 25, mRNA.
ACCESSION   NM_001321584
VERSION     NM_001321584.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5626)
  AUTHORS   Rigter,P.M.F., de Konink,C., Dunn,M.J., Proietti Onori,M.,
            Humberson,J.B., Thomas,M., Barnes,C., Prada,C.E., Weaver,K.N.,
            Ryan,T.D., Caluseriu,O., Conway,J., Calamaro,E., Fong,C.T.,
            Wuyts,W., Meuwissen,M., Hordijk,E., Jonkers,C.N., Anderson,L.,
            Yuseinova,B., Polonia,S., Beysen,D., Stark,Z., Savva,E.,
            Poulton,C., McKenzie,F., Bhoj,E., Bupp,C.P., Bezieau,S.,
            Mercier,S., Blevins,A., Wentzensen,I.M., Xia,F., Rosenfeld,J.A.,
            Hsieh,T.C., Krawitz,P.M., Elbracht,M., Veenma,D.C.M., Schulman,H.,
            Stratton,M.M., Kury,S. and van Woerden,G.M.
  TITLE     Role of CAMK2D in neurodevelopment and associated conditions
  JOURNAL   Am J Hum Genet 111 (2), 364-382 (2024)
   PUBMED   38272033
  REMARK    GeneRIF: Role of CAMK2D in neurodevelopment and associated
            conditions.
REFERENCE   2  (bases 1 to 5626)
  AUTHORS   Chuah,Y.H., Tay,E.X.Y., Grinchuk,O.V., Yoon,J., Feng,J., Kannan,S.,
            Robert,M., Jakhar,R., Liang,Y., Lee,B.W.L., Wang,L.C., Lim,Y.T.,
            Zhao,T., Sobota,R.M., Lu,G., Low,B.C., Crasta,K.C., Verma,C.S.,
            Lin,Z. and Ong,D.S.T.
  TITLE     CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to
            induce mitotic checkpoint in glioma
  JOURNAL   Cell Death Differ 30 (8), 1973-1987 (2023)
   PUBMED   37468549
  REMARK    GeneRIF: CAMK2D serves as a molecular scaffold for RNF8-MAD2
            complex to induce mitotic checkpoint in glioma.
REFERENCE   3  (bases 1 to 5626)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 5626)
  AUTHORS   Saddouk,F.Z., Ginnan,R. and Singer,H.A.
  TITLE     Ca2+/Calmodulin-Dependent Protein Kinase II in Vascular Smooth
            Muscle
  JOURNAL   Adv Pharmacol 78, 171-202 (2017)
   PUBMED   28212797
  REMARK    Review article
REFERENCE   5  (bases 1 to 5626)
  AUTHORS   Bhattacharyya,M., Stratton,M.M., Going,C.C., McSpadden,E.D.,
            Huang,Y., Susa,A.C., Elleman,A., Cao,Y.M., Pappireddi,N.,
            Burkhardt,P., Gee,C.L., Barros,T., Schulman,H., Williams,E.R. and
            Kuriyan,J.
  TITLE     Molecular mechanism of activation-triggered subunit exchange in
            Ca(2+)/calmodulin-dependent protein kinase II
  JOURNAL   Elife 5, e13405 (2016)
   PUBMED   26949248
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5626)
  AUTHORS   Hudmon,A. and Schulman,H.
  TITLE     Neuronal CA2+/calmodulin-dependent protein kinase II: the role of
            structure and autoregulation in cellular function
  JOURNAL   Annu Rev Biochem 71, 473-510 (2002)
   PUBMED   12045104
  REMARK    Review article
REFERENCE   7  (bases 1 to 5626)
  AUTHORS   Soderling,T.R. and Stull,J.T.
  TITLE     Structure and regulation of calcium/calmodulin-dependent protein
            kinases
  JOURNAL   Chem Rev 101 (8), 2341-2352 (2001)
   PUBMED   11749376
  REMARK    Review article
REFERENCE   8  (bases 1 to 5626)
  AUTHORS   Williams,C.L., Phelps,S.H. and Porter,R.A.
  TITLE     Expression of Ca2+/calmodulin-dependent protein kinase types II and
            IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent
            protein kinase inhibitor KN-62
            (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl
            piperazine) in small cell lung carcinoma
  JOURNAL   Biochem Pharmacol 51 (5), 707-715 (1996)
   PUBMED   8615909
REFERENCE   9  (bases 1 to 5626)
  AUTHORS   de Groot,R.P., den Hertog,J., Vandenheede,J.R., Goris,J. and
            Sassone-Corsi,P.
  TITLE     Multiple and cooperative phosphorylation events regulate the CREM
            activator function
  JOURNAL   EMBO J 12 (10), 3903-3911 (1993)
   PUBMED   8404858
REFERENCE   10 (bases 1 to 5626)
  AUTHORS   Sakagami,H. and Kondo,H.
  TITLE     Differential expression of mRNAs encoding gamma and delta subunits
            of Ca2+/calmodulin-dependent protein kinase type II (CaM kinase II)
            in the mature and postnatally developing rat brain
  JOURNAL   Brain Res Mol Brain Res 20 (1-2), 51-63 (1993)
   PUBMED   8255181
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004168.2, AC004056.1 and
            AC093900.3.
            
            On May 31, 2019 this sequence version replaced NM_001321584.1.
            
            Summary: The product of this gene belongs to the serine/threonine
            protein kinase family and to the Ca(2+)/calmodulin-dependent
            protein kinase subfamily. Calcium signaling is crucial for several
            aspects of plasticity at glutamatergic synapses. In mammalian
            cells, the enzyme is composed of four different chains: alpha,
            beta, gamma, and delta. The product of this gene is a delta chain.
            Alternative splicing results in multiple transcript variants
            encoding distinct isoforms. Distinct isoforms of this chain have
            different expression patterns.[provided by RefSeq, Nov 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.17788.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-735               AC004168.2         162048-162782       c
            736-830             AC004168.2         160364-160458       c
            831-890             AC004168.2         62757-62816         c
            891-945             AC004168.2         10196-10250         c
            946-1011            AC004056.1         93238-93303         c
            1012-1084           AC004056.1         89864-89936         c
            1085-1187           AC004056.1         78548-78650         c
            1188-1271           AC004056.1         72423-72506         c
            1272-1366           AC004056.1         58770-58864         c
            1367-1489           AC004056.1         56276-56398         c
            1490-1573           AC004056.1         55037-55120         c
            1574-1616           AC004056.1         54535-54577         c
            1617-1651           AC004056.1         50845-50879         c
            1652-1693           AC004056.1         44143-44184         c
            1694-1742           AC004056.1         41670-41718         c
            1743-1818           AC004056.1         6736-6811           c
            1819-1913           AC004056.1         1354-1448           c
            1914-2142           AC093900.3         149129-149357       c
            2143-5626           AC093900.3         142826-146309       c
FEATURES             Location/Qualifiers
     source          1..5626
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q26"
     gene            1..5626
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /note="calcium/calmodulin dependent protein kinase II
                     delta"
                     /db_xref="GeneID:817"
                     /db_xref="HGNC:HGNC:1462"
                     /db_xref="MIM:607708"
     exon            1..735
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     CDS             671..2146
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /EC_number="2.7.11.17"
                     /note="isoform 24 is encoded by transcript variant 25;
                     calcium/calmodulin-dependent protein kinase (CaM kinase)
                     II delta; calcium/calmodulin-dependent protein kinase type
                     II delta chain; CaM-kinase II delta chain; CaM kinase II
                     delta subunit; CaMK-II delta subunit;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit delta"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit delta isoform 24"
                     /protein_id="NP_001308513.1"
                     /db_xref="CCDS:CCDS93604.1"
                     /db_xref="GeneID:817"
                     /db_xref="HGNC:HGNC:1462"
                     /db_xref="MIM:607708"
                     /translation="MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGL
                     AIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDED
                     QHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRS
                     TVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAKSLLKKPDGVKEPQTTVI
                     HNPDGNKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTA
                     FEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQY
                     MDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIN"
     exon            736..830
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            831..890
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            891..945
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1011
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1084
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1187
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1271
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1366
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1489
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1573
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1616
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1651
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1693
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1742
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1818
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1913
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2142
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..5626
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4220..4225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /note="hexamer: AATAAA"
     polyA_site      4242
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
     regulatory      5601..5606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /note="hexamer: AATAAA"
     polyA_site      5626
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /note="major polyA site"
ORIGIN      
        1 ctttctctcg ccgcgccgtc ttgaagccgc gcgggctcgt gagcagcgcg aggccgccaa
       61 ggtgcctcgc ttcgccggag ccgctgccgc ccgccggagg gaagccggcc tcgggcgcgc
      121 acgctcgtcg gagccccggc gcgccccgcg cctgagcctg ctgacagcgg ccgctgggct
      181 caggctgtcc gctctgggct ccgcggcctc ggccccgctg cactccacct ccgccccctc
      241 ggactccctc ccctctgctt ctactcctcc tgctccagtg cggatcgttt cgcaactgct
      301 tgccactcgt cccgtgcctg gctgtttttc catttcccgg ccccctcttc ttgagtactt
      361 taccccctgc atttggggac agggactgga aaaggggcgg gtggagcgtc cagtggagaa
      421 gaaggaagcg aggcccgcag gaggaggagg atcggcggac tgtggggagg agaccccacg
      481 ccaccctttc tggtcatctc ccctcccgcc ccgcccctgc gcacactccc tcgcgggcga
      541 gctactttcg gaccaggaaa gtaagagcgg ccctgggtga cagcgccgcg gggccagtcc
      601 cggggttagc cgcgcgtctg ctcgcttctg gtccgtcgcg ctcccagcca gggcacagcc
      661 cggaccgagg atggcttcga ccacaacctg caccaggttc acggacgagt atcagctttt
      721 cgaggagctt ggaaaggggg cattctcagt ggtgagaaga tgtatgaaaa ttcctactgg
      781 acaagaatat gctgccaaaa ttatcaacac caaaaagctt tctgctaggg atcatcagaa
      841 actagaaaga gaagctagaa tctgccgtct tttgaagcac cctaatattg tgcgacttca
      901 tgatagcata tcagaagagg gctttcacta cttggtgttt gatttagtta ctggaggtga
      961 actgtttgaa gacatagtgg caagagaata ctacagtgaa gctgatgcca gtcattgtat
     1021 acagcagatt ctagaaagtg ttaatcattg tcacctaaat ggcatagttc acagggacct
     1081 gaagcctgag aatttgcttt tagctagcaa atccaaggga gcagctgtga aattggcaga
     1141 ctttggctta gccatagaag ttcaagggga ccagcaggcg tggtttggtt ttgctggcac
     1201 acctggatat ctttctccag aagttttacg taaagatcct tatggaaagc cagtggatat
     1261 gtgggcatgt ggtgtcattc tctatattct acttgtgggg tatccaccct tctgggatga
     1321 agaccaacac agactctatc agcagatcaa ggctggagct tatgattttc catcaccaga
     1381 atgggacacg gtgactcctg aagccaaaga cctcatcaat aaaatgctta ctatcaaccc
     1441 tgccaaacgc atcacagcct cagaggcact gaagcaccca tggatctgtc aacgttctac
     1501 tgttgcttcc atgatgcaca gacaggagac tgtagactgc ttgaagaaat ttaatgctag
     1561 aagaaaacta aagggtgcca tcttgacaac tatgctggct acaaggaatt tctcagccaa
     1621 gagtttgttg aagaaaccag atggagtaaa ggagccccaa actactgtaa tccacaaccc
     1681 tgatggaaac aaggagtcaa ctgagagttc aaatacaaca attgaggatg aagatgtgaa
     1741 agcacgaaag caagagatta tcaaagtcac tgaacaactg atcgaagcta tcaacaatgg
     1801 ggactttgaa gcctacacaa aaatctgtga cccaggcctt actgcttttg aacctgaagc
     1861 tttgggtaat ttagtggaag ggatggattt tcaccgattc tactttgaaa atgctttgtc
     1921 caaaagcaat aaaccaatcc acactattat tctaaaccct catgtacatc tggtagggga
     1981 tgatgccgcc tgcatagcat atattaggct cacacagtac atggatggca gtggaatgcc
     2041 aaagacaatg cagtcagaag agactcgtgt gtggcaccgc cgggatggaa agtggcagaa
     2101 tgttcatttt catcgctcgg ggtcaccaac agtacccatc aactaaattt caacagtgcc
     2161 acttctgcat tctctgttct caaggcacct ggatggtgac cctgggccgt cctctcctcc
     2221 tcttcatgca tgtttctgag tgcatgaagt tgtgaaggtc ctacatgtaa tgcatatgtg
     2281 atgcatcatc ttatcatata ttccttccta tacattgttt acacttcaac tacggggatg
     2341 ttccacacaa acttaaatta ctgttggcaa aacaataggg ggagattaga caaaaaaaaa
     2401 aatccacaat attccaagta caactcttca tcaagtttct ctgttaatgc caagatttaa
     2461 cagacttaag aactattgtt ctctgaatga cagttgtaag agaaatgtaa attttttaga
     2521 actctttgct gttaatctgt tttggtttgt ttggtttttt tttttttttt taaggtaaaa
     2581 aaaaaataca ccttcagttt cctggtgtga tcctggttaa aatggatgat ttttcattga
     2641 aagttttgct gattaacaat taaagtggga tgatatgtgg gcaaaatcac ttatgaaagt
     2701 agaagcaaga atcagttggt ttgctaccac ataaagccat gctgtttttg gtcaaactgt
     2761 gtaaactgga aaaattcaca tcatttctga gtttaatcac tttaggatat attcacattg
     2821 ttttggtgaa tttgctgaat tgaattgttt ttctttctca aatctgtgat ctcttttctt
     2881 tatcctgttt ctttgttcct ttcgtttgct ttcttatttt tcttttgttc cattcttttc
     2941 ttactttttt cccttttcct tttttgggga ggctggctag tagtgtgtga gaaaagaata
     3001 gaagtgaaat ttgcataatg aatgtaaaag ggaaataaaa gtcttttgaa ggtagctata
     3061 ctagcacttt tgatcatctt cagggcccac aaaaatgttg tcaagatttt aaaggtttat
     3121 aattctgctt aagctctagt ttggacttag gtatcctaac tatgttggag gtatttgcat
     3181 tgtttaaagt taggataaaa gcaagttcct cctgtgactg caacgtctta ctgattggga
     3241 cagttgccag gaggatacca acttgatagc agagggggtt ttatgcaaac gcactcacct
     3301 ccgccttggg gaatgaaagg gtcacttctg catcatcact agctagtttt ctagtgttag
     3361 agaggcttac aaatgtttgc cattctcata agtgttttga acttgatctt tgtgacttgt
     3421 gcttttttag cttctctctt gaatcagagt atcattgtct tcctccaagg agttagaatt
     3481 tcccagttta aaacaaaaag ggaaatgtcc taggttttct ttgtgcttct catttttcct
     3541 ttgttgattc aattcctgtg atttttgttc tcttccctga agtgctttac agtgcatgga
     3601 atctccatca ttgttatttt aacgatagta attcacagtc ctcagaagcc tatttttaaa
     3661 gcagaagcaa aaaagaaaaa caaaataaca aaaacaaccc ttcctctttt ctctcatctc
     3721 acctctctgt gttgattact aatcatctta gatattattg ctagtggatg tatggtagat
     3781 gggttgaagc ttttctgata attattacac aatttaaaac aacatatata tttaaaataa
     3841 atatatacag taaatatatt gagccatgtt aacctgccaa tgagatctgt gaaaaaataa
     3901 tggcctcatt tttctctttt taatttcttt tacccttttg tgaagcagct atacgtggca
     3961 tacatgtatt taaagaaaaa aaaatagatg tagagtgttt tttttacact tttaacttag
     4021 catgtggtgt tgaagtatta ctgtagatca agtttgtctt ccgcactaag atgtgaggaa
     4081 attgtgattt gttctctcca ccacaaatga attacacatt tattatcttc tatcattttg
     4141 aaacactgca gtttaccatg ggacactgta tatatttctt gccataatgg taaaggactg
     4201 attgatatat ttaagagtta ataaatttgt gatttctgct gacagtgcgt ccatctttat
     4261 ttcttcagaa gaggtactgt atgtatgcct gcatagtgct ggccagtgtc aagggcagtg
     4321 tgtcctactc tggtctcatt tagtacataa caatttgcac ttggtgagaa tggcaagtta
     4381 attgttctct gtgagcaaaa caatggtctc ttctgggaaa atgttgctga gaacaatata
     4441 gttaacaact aagactccta aaagcttctc taaactgtac cctccaatcc agccttcaca
     4501 tggctgcttt tttttttttt ttttaatacg aacctgtcct tgtaacactt tgatgttatc
     4561 atttctggga tacaggcaag caccccagct cctgctactc cccagcttga acttgagcat
     4621 acatggatgc tcagcttctt ttgatttgct aaaaacatca cacttgctca catgcctgtt
     4681 tatgctgttc atgttgttta tgtttcttac ctagaataaa tagtctcttc ccctacttct
     4741 tttcccgact tcttactttt tcctaagatt cagtgtacag catcatgctc cacagcaaac
     4801 cttcctaggc cctattctgg gcttgccttc cctctcaaaa cctacataat agattgtatt
     4861 tacctctcct gtcaaccaca ttgttttgaa aatatatttc tatttgtgtc tcctctactg
     4921 cagtataatg tctccatggg caagaactgt gtattcatca ttgcattcct aaacccaaac
     4981 caaggccagg aatggagata tcattgataa atagttgttg aattgaggcc aagccctttt
     5041 gataacagaa gcctcaaggg gtacccagat agtccttgtt ttaatgatgg gttctctcac
     5101 cactgtcttg atgctctgag caagttacct cttccctctg accctcagtt tccatatttg
     5161 taaaatgaga ataaacatac caacttaata aagatattgt gaggattaat gggtacagag
     5221 tgactagaat gatatttgat agaaattaaa tggtagcagt ataactattc tgatcactga
     5281 cattaatatt cctattgtta ttattctttg ctcacgaggg tatacaactc ttgttttgct
     5341 gttgggctgc cctctttatg taggtttact gttaatgctg aggatatact cggactcaaa
     5401 tgtctcagca gaaggctgag agacaccaaa tgaagtggtc atctagctga atgtaggaaa
     5461 aatgaaatgt agtagcaaat cagtatattc taaggaaatt ttcaaggaat attaatcttc
     5521 acccaaattt tgaattttta tgtaaaaaat tataatttaa gggtaaacat agatgacaca
     5581 gctttcgagt gatttcattg aataaaattc tactgacttc tatgaa
//
