LOCUS       NM_001321571            5785 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens calcium/calmodulin dependent protein kinase II delta
            (CAMK2D), transcript variant 12, mRNA.
ACCESSION   NM_001321571 XM_005263252
VERSION     NM_001321571.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5785)
  AUTHORS   Rigter,P.M.F., de Konink,C., Dunn,M.J., Proietti Onori,M.,
            Humberson,J.B., Thomas,M., Barnes,C., Prada,C.E., Weaver,K.N.,
            Ryan,T.D., Caluseriu,O., Conway,J., Calamaro,E., Fong,C.T.,
            Wuyts,W., Meuwissen,M., Hordijk,E., Jonkers,C.N., Anderson,L.,
            Yuseinova,B., Polonia,S., Beysen,D., Stark,Z., Savva,E.,
            Poulton,C., McKenzie,F., Bhoj,E., Bupp,C.P., Bezieau,S.,
            Mercier,S., Blevins,A., Wentzensen,I.M., Xia,F., Rosenfeld,J.A.,
            Hsieh,T.C., Krawitz,P.M., Elbracht,M., Veenma,D.C.M., Schulman,H.,
            Stratton,M.M., Kury,S. and van Woerden,G.M.
  TITLE     Role of CAMK2D in neurodevelopment and associated conditions
  JOURNAL   Am J Hum Genet 111 (2), 364-382 (2024)
   PUBMED   38272033
  REMARK    GeneRIF: Role of CAMK2D in neurodevelopment and associated
            conditions.
REFERENCE   2  (bases 1 to 5785)
  AUTHORS   Chuah,Y.H., Tay,E.X.Y., Grinchuk,O.V., Yoon,J., Feng,J., Kannan,S.,
            Robert,M., Jakhar,R., Liang,Y., Lee,B.W.L., Wang,L.C., Lim,Y.T.,
            Zhao,T., Sobota,R.M., Lu,G., Low,B.C., Crasta,K.C., Verma,C.S.,
            Lin,Z. and Ong,D.S.T.
  TITLE     CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to
            induce mitotic checkpoint in glioma
  JOURNAL   Cell Death Differ 30 (8), 1973-1987 (2023)
   PUBMED   37468549
  REMARK    GeneRIF: CAMK2D serves as a molecular scaffold for RNF8-MAD2
            complex to induce mitotic checkpoint in glioma.
REFERENCE   3  (bases 1 to 5785)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 5785)
  AUTHORS   Saddouk,F.Z., Ginnan,R. and Singer,H.A.
  TITLE     Ca2+/Calmodulin-Dependent Protein Kinase II in Vascular Smooth
            Muscle
  JOURNAL   Adv Pharmacol 78, 171-202 (2017)
   PUBMED   28212797
  REMARK    Review article
REFERENCE   5  (bases 1 to 5785)
  AUTHORS   Bhattacharyya,M., Stratton,M.M., Going,C.C., McSpadden,E.D.,
            Huang,Y., Susa,A.C., Elleman,A., Cao,Y.M., Pappireddi,N.,
            Burkhardt,P., Gee,C.L., Barros,T., Schulman,H., Williams,E.R. and
            Kuriyan,J.
  TITLE     Molecular mechanism of activation-triggered subunit exchange in
            Ca(2+)/calmodulin-dependent protein kinase II
  JOURNAL   Elife 5, e13405 (2016)
   PUBMED   26949248
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5785)
  AUTHORS   Hudmon,A. and Schulman,H.
  TITLE     Neuronal CA2+/calmodulin-dependent protein kinase II: the role of
            structure and autoregulation in cellular function
  JOURNAL   Annu Rev Biochem 71, 473-510 (2002)
   PUBMED   12045104
  REMARK    Review article
REFERENCE   7  (bases 1 to 5785)
  AUTHORS   Soderling,T.R. and Stull,J.T.
  TITLE     Structure and regulation of calcium/calmodulin-dependent protein
            kinases
  JOURNAL   Chem Rev 101 (8), 2341-2352 (2001)
   PUBMED   11749376
  REMARK    Review article
REFERENCE   8  (bases 1 to 5785)
  AUTHORS   Williams,C.L., Phelps,S.H. and Porter,R.A.
  TITLE     Expression of Ca2+/calmodulin-dependent protein kinase types II and
            IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent
            protein kinase inhibitor KN-62
            (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl
            piperazine) in small cell lung carcinoma
  JOURNAL   Biochem Pharmacol 51 (5), 707-715 (1996)
   PUBMED   8615909
REFERENCE   9  (bases 1 to 5785)
  AUTHORS   de Groot,R.P., den Hertog,J., Vandenheede,J.R., Goris,J. and
            Sassone-Corsi,P.
  TITLE     Multiple and cooperative phosphorylation events regulate the CREM
            activator function
  JOURNAL   EMBO J 12 (10), 3903-3911 (1993)
   PUBMED   8404858
REFERENCE   10 (bases 1 to 5785)
  AUTHORS   Sakagami,H. and Kondo,H.
  TITLE     Differential expression of mRNAs encoding gamma and delta subunits
            of Ca2+/calmodulin-dependent protein kinase type II (CaM kinase II)
            in the mature and postnatally developing rat brain
  JOURNAL   Brain Res Mol Brain Res 20 (1-2), 51-63 (1993)
   PUBMED   8255181
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004168.2, AC004056.1 and
            AC093900.3.
            
            On Nov 22, 2018 this sequence version replaced NM_001321571.1.
            
            Summary: The product of this gene belongs to the serine/threonine
            protein kinase family and to the Ca(2+)/calmodulin-dependent
            protein kinase subfamily. Calcium signaling is crucial for several
            aspects of plasticity at glutamatergic synapses. In mammalian
            cells, the enzyme is composed of four different chains: alpha,
            beta, gamma, and delta. The product of this gene is a delta chain.
            Alternative splicing results in multiple transcript variants
            encoding distinct isoforms. Distinct isoforms of this chain have
            different expression patterns.[provided by RefSeq, Nov 2008].
            
            Transcript Variant: This variant (12) encodes isoform (11, also
            known as delta 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.39452.1,
                                           SRR1803616.94415.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000511664.6/ ENSP00000425824.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-735               AC004168.2         162048-162782       c
            736-830             AC004168.2         160364-160458       c
            831-890             AC004168.2         62757-62816         c
            891-945             AC004168.2         10196-10250         c
            946-1011            AC004056.1         93238-93303         c
            1012-1084           AC004056.1         88851-88923         c
            1085-1187           AC004056.1         78548-78650         c
            1188-1271           AC004056.1         72423-72506         c
            1272-1366           AC004056.1         58770-58864         c
            1367-1489           AC004056.1         56276-56398         c
            1490-1573           AC004056.1         55037-55120         c
            1574-1616           AC004056.1         54535-54577         c
            1617-1654           AC004056.1         50845-50882         c
            1655-1714           AC004056.1         46183-46242         c
            1715-1756           AC004056.1         44143-44184         c
            1757-1805           AC004056.1         41670-41718         c
            1806-1881           AC004056.1         6736-6811           c
            1882-1976           AC004056.1         1354-1448           c
            1977-2205           AC093900.3         149129-149357       c
            2206-2301           AC093900.3         147520-147615       c
            2302-5785           AC093900.3         142826-146309       c
FEATURES             Location/Qualifiers
     source          1..5785
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q26"
     gene            1..5785
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /note="calcium/calmodulin dependent protein kinase II
                     delta"
                     /db_xref="GeneID:817"
                     /db_xref="HGNC:HGNC:1462"
                     /db_xref="MIM:607708"
     exon            1..735
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     CDS             671..2272
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /EC_number="2.7.11.17"
                     /note="isoform 11 is encoded by transcript variant 12;
                     calcium/calmodulin-dependent protein kinase (CaM kinase)
                     II delta; calcium/calmodulin-dependent protein kinase type
                     II delta chain; CaM-kinase II delta chain; CaM kinase II
                     delta subunit; CaMK-II delta subunit;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit delta"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit delta isoform 11"
                     /protein_id="NP_001308500.1"
                     /db_xref="CCDS:CCDS82949.1"
                     /db_xref="GeneID:817"
                     /db_xref="HGNC:HGNC:1462"
                     /db_xref="MIM:607708"
                     /translation="MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKSKGAAVKLADFGL
                     AIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDED
                     QHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRS
                     TVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKINNKAN
                     VVTSPKENIPTPALEPQTTVIHNPDGNKESTESSNTTIEDEDVKARKQEIIKVTEQLI
                     EAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILN
                     PHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPT
                     VPIKPPCIPNGKENFSGGTSLWQNI"
     exon            736..830
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            831..890
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            891..945
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1011
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1084
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1187
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1271
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1366
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1489
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1573
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1616
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1654
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1714
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1756
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1805
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1881
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1976
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2205
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2301
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..5785
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4379..4384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /note="hexamer: AATAAA"
     polyA_site      4401
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
     regulatory      5760..5765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /note="hexamer: AATAAA"
     polyA_site      5785
                     /gene="CAMK2D"
                     /gene_synonym="CAMKD"
                     /note="major polyA site"
ORIGIN      
        1 ctttctctcg ccgcgccgtc ttgaagccgc gcgggctcgt gagcagcgcg aggccgccaa
       61 ggtgcctcgc ttcgccggag ccgctgccgc ccgccggagg gaagccggcc tcgggcgcgc
      121 acgctcgtcg gagccccggc gcgccccgcg cctgagcctg ctgacagcgg ccgctgggct
      181 caggctgtcc gctctgggct ccgcggcctc ggccccgctg cactccacct ccgccccctc
      241 ggactccctc ccctctgctt ctactcctcc tgctccagtg cggatcgttt cgcaactgct
      301 tgccactcgt cccgtgcctg gctgtttttc catttcccgg ccccctcttc ttgagtactt
      361 taccccctgc atttggggac agggactgga aaaggggcgg gtggagcgtc cagtggagaa
      421 gaaggaagcg aggcccgcag gaggaggagg atcggcggac tgtggggagg agaccccacg
      481 ccaccctttc tggtcatctc ccctcccgcc ccgcccctgc gcacactccc tcgcgggcga
      541 gctactttcg gaccaggaaa gtaagagcgg ccctgggtga cagcgccgcg gggccagtcc
      601 cggggttagc cgcgcgtctg ctcgcttctg gtccgtcgcg ctcccagcca gggcacagcc
      661 cggaccgagg atggcttcga ccacaacctg caccaggttc acggacgagt atcagctttt
      721 cgaggagctt ggaaaggggg cattctcagt ggtgagaaga tgtatgaaaa ttcctactgg
      781 acaagaatat gctgccaaaa ttatcaacac caaaaagctt tctgctaggg atcatcagaa
      841 actagaaaga gaagctagaa tctgccgtct tttgaagcac cctaatattg tgcgacttca
      901 tgatagcata tcagaagagg gctttcacta cttggtgttt gatttagtta ctggaggtga
      961 actgtttgaa gacatagtgg caagagaata ctacagtgaa gctgatgcca gtcattgcat
     1021 tcagcagatc ctggaggctg tgctacactg ccatcagatg ggcgtggtcc atcgggacct
     1081 gaagcctgag aatttgcttt tagctagcaa atccaaggga gcagctgtga aattggcaga
     1141 ctttggctta gccatagaag ttcaagggga ccagcaggcg tggtttggtt ttgctggcac
     1201 acctggatat ctttctccag aagttttacg taaagatcct tatggaaagc cagtggatat
     1261 gtgggcatgt ggtgtcattc tctatattct acttgtgggg tatccaccct tctgggatga
     1321 agaccaacac agactctatc agcagatcaa ggctggagct tatgattttc catcaccaga
     1381 atgggacacg gtgactcctg aagccaaaga cctcatcaat aaaatgctta ctatcaaccc
     1441 tgccaaacgc atcacagcct cagaggcact gaagcaccca tggatctgtc aacgttctac
     1501 tgttgcttcc atgatgcaca gacaggagac tgtagactgc ttgaagaaat ttaatgctag
     1561 aagaaaacta aagggtgcca tcttgacaac tatgctggct acaaggaatt tctcagcagc
     1621 caagagtttg ttgaagaaac cagatggagt aaagataaac aacaaagcca acgtggtaac
     1681 cagccccaaa gaaaatattc ctaccccagc gctggagccc caaactactg taatccacaa
     1741 ccctgatgga aacaaggagt caactgagag ttcaaataca acaattgagg atgaagatgt
     1801 gaaagcacga aagcaagaga ttatcaaagt cactgaacaa ctgatcgaag ctatcaacaa
     1861 tggggacttt gaagcctaca caaaaatctg tgacccaggc cttactgctt ttgaacctga
     1921 agctttgggt aatttagtgg aagggatgga ttttcaccga ttctactttg aaaatgcttt
     1981 gtccaaaagc aataaaccaa tccacactat tattctaaac cctcatgtac atctggtagg
     2041 ggatgatgcc gcctgcatag catatattag gctcacacag tacatggatg gcagtggaat
     2101 gccaaagaca atgcagtcag aagagactcg tgtgtggcac cgccgggatg gaaagtggca
     2161 gaatgttcat tttcatcgct cggggtcacc aacagtaccc atcaagccac cctgtattcc
     2221 aaatgggaaa gaaaacttct caggaggcac ctctttgtgg caaaacatct aaggcctgaa
     2281 aaccattcac atatgggtct tctaaatttc aacagtgcca cttctgcatt ctctgttctc
     2341 aaggcacctg gatggtgacc ctgggccgtc ctctcctcct cttcatgcat gtttctgagt
     2401 gcatgaagtt gtgaaggtcc tacatgtaat gcatatgtga tgcatcatct tatcatatat
     2461 tccttcctat acattgttta cacttcaact acggggatgt tccacacaaa cttaaattac
     2521 tgttggcaaa acaatagggg gagattagac aaaaaaaaaa atccacaata ttccaagtac
     2581 aactcttcat caagtttctc tgttaatgcc aagatttaac agacttaaga actattgttc
     2641 tctgaatgac agttgtaaga gaaatgtaaa ttttttagaa ctctttgctg ttaatctgtt
     2701 ttggtttgtt tggttttttt tttttttttt aaggtaaaaa aaaaatacac cttcagtttc
     2761 ctggtgtgat cctggttaaa atggatgatt tttcattgaa agttttgctg attaacaatt
     2821 aaagtgggat gatatgtggg caaaatcact tatgaaagta gaagcaagaa tcagttggtt
     2881 tgctaccaca taaagccatg ctgtttttgg tcaaactgtg taaactggaa aaattcacat
     2941 catttctgag tttaatcact ttaggatata ttcacattgt tttggtgaat ttgctgaatt
     3001 gaattgtttt tctttctcaa atctgtgatc tcttttcttt atcctgtttc tttgttcctt
     3061 tcgtttgctt tcttattttt cttttgttcc attcttttct tacttttttc ccttttcctt
     3121 ttttggggag gctggctagt agtgtgtgag aaaagaatag aagtgaaatt tgcataatga
     3181 atgtaaaagg gaaataaaag tcttttgaag gtagctatac tagcactttt gatcatcttc
     3241 agggcccaca aaaatgttgt caagatttta aaggtttata attctgctta agctctagtt
     3301 tggacttagg tatcctaact atgttggagg tatttgcatt gtttaaagtt aggataaaag
     3361 caagttcctc ctgtgactgc aacgtcttac tgattgggac agttgccagg aggataccaa
     3421 cttgatagca gagggggttt tatgcaaacg cactcacctc cgccttgggg aatgaaaggg
     3481 tcacttctgc atcatcacta gctagttttc tagtgttaga gaggcttaca aatgtttgcc
     3541 attctcataa gtgttttgaa cttgatcttt gtgacttgtg cttttttagc ttctctcttg
     3601 aatcagagta tcattgtctt cctccaagga gttagaattt cccagtttaa aacaaaaagg
     3661 gaaatgtcct aggttttctt tgtgcttctc atttttcctt tgttgattca attcctgtga
     3721 tttttgttct cttccctgaa gtgctttaca gtgcatggaa tctccatcat tgttatttta
     3781 acgatagtaa ttcacagtcc tcagaagcct atttttaaag cagaagcaaa aaagaaaaac
     3841 aaaataacaa aaacaaccct tcctcttttc tctcatctca cctctctgtg ttgattacta
     3901 atcatcttag atattattgc tagtggatgt atggtagatg ggttgaagct tttctgataa
     3961 ttattacaca atttaaaaca acatatatat ttaaaataaa tatatacagt aaatatattg
     4021 agccatgtta acctgccaat gagatctgtg aaaaaataat ggcctcattt ttctcttttt
     4081 aatttctttt acccttttgt gaagcagcta tacgtggcat acatgtattt aaagaaaaaa
     4141 aaatagatgt agagtgtttt ttttacactt ttaacttagc atgtggtgtt gaagtattac
     4201 tgtagatcaa gtttgtcttc cgcactaaga tgtgaggaaa ttgtgatttg ttctctccac
     4261 cacaaatgaa ttacacattt attatcttct atcattttga aacactgcag tttaccatgg
     4321 gacactgtat atatttcttg ccataatggt aaaggactga ttgatatatt taagagttaa
     4381 taaatttgtg atttctgctg acagtgcgtc catctttatt tcttcagaag aggtactgta
     4441 tgtatgcctg catagtgctg gccagtgtca agggcagtgt gtcctactct ggtctcattt
     4501 agtacataac aatttgcact tggtgagaat ggcaagttaa ttgttctctg tgagcaaaac
     4561 aatggtctct tctgggaaaa tgttgctgag aacaatatag ttaacaacta agactcctaa
     4621 aagcttctct aaactgtacc ctccaatcca gccttcacat ggctgctttt tttttttttt
     4681 tttaatacga acctgtcctt gtaacacttt gatgttatca tttctgggat acaggcaagc
     4741 accccagctc ctgctactcc ccagcttgaa cttgagcata catggatgct cagcttcttt
     4801 tgatttgcta aaaacatcac acttgctcac atgcctgttt atgctgttca tgttgtttat
     4861 gtttcttacc tagaataaat agtctcttcc cctacttctt ttcccgactt cttacttttt
     4921 cctaagattc agtgtacagc atcatgctcc acagcaaacc ttcctaggcc ctattctggg
     4981 cttgccttcc ctctcaaaac ctacataata gattgtattt acctctcctg tcaaccacat
     5041 tgttttgaaa atatatttct atttgtgtct cctctactgc agtataatgt ctccatgggc
     5101 aagaactgtg tattcatcat tgcattccta aacccaaacc aaggccagga atggagatat
     5161 cattgataaa tagttgttga attgaggcca agcccttttg ataacagaag cctcaagggg
     5221 tacccagata gtccttgttt taatgatggg ttctctcacc actgtcttga tgctctgagc
     5281 aagttacctc ttccctctga ccctcagttt ccatatttgt aaaatgagaa taaacatacc
     5341 aacttaataa agatattgtg aggattaatg ggtacagagt gactagaatg atatttgata
     5401 gaaattaaat ggtagcagta taactattct gatcactgac attaatattc ctattgttat
     5461 tattctttgc tcacgagggt atacaactct tgttttgctg ttgggctgcc ctctttatgt
     5521 aggtttactg ttaatgctga ggatatactc ggactcaaat gtctcagcag aaggctgaga
     5581 gacaccaaat gaagtggtca tctagctgaa tgtaggaaaa atgaaatgta gtagcaaatc
     5641 agtatattct aaggaaattt tcaaggaata ttaatcttca cccaaatttt gaatttttat
     5701 gtaaaaaatt ataatttaag ggtaaacata gatgacacag ctttcgagtg atttcattga
     5761 ataaaattct actgacttct atgaa
//
