LOCUS       NM_001220               4545 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens calcium/calmodulin dependent protein kinase II beta
            (CAMK2B), transcript variant 1, mRNA.
ACCESSION   NM_001220 XM_936314
VERSION     NM_001220.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4545)
  AUTHORS   Borghi,R., Trivisano,M., Specchio,N., Tartaglia,M. and
            Compagnucci,C.
  TITLE     Understanding the pathogenetic mechanisms underlying altered
            neuronal function associated with CAMK2B mutations
  JOURNAL   Neurosci Biobehav Rev 152, 105299 (2023)
   PUBMED   37391113
  REMARK    GeneRIF: Understanding the pathogenetic mechanisms underlying
            altered neuronal function associated with CAMK2B mutations.
            Review article
REFERENCE   2  (bases 1 to 4545)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4545)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4545)
  AUTHORS   Nicole,O. and Pacary,E.
  TITLE     CaMKIIbeta in Neuronal Development and Plasticity: An Emerging
            Candidate in Brain Diseases
  JOURNAL   Int J Mol Sci 21 (19), 7272 (2020)
   PUBMED   33019657
  REMARK    GeneRIF: CaMKIIbeta in Neuronal Development and Plasticity: An
            Emerging Candidate in Brain Diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4545)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   6  (bases 1 to 4545)
  AUTHORS   Williams,C.L., Phelps,S.H. and Porter,R.A.
  TITLE     Expression of Ca2+/calmodulin-dependent protein kinase types II and
            IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent
            protein kinase inhibitor KN-62
            (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl
            piperazine) in small cell lung carcinoma
  JOURNAL   Biochem Pharmacol 51 (5), 707-715 (1996)
   PUBMED   8615909
REFERENCE   7  (bases 1 to 4545)
  AUTHORS   Penades,J.R., Bernal,D., Revert,F., Johansson,C., Fresquet,V.J.,
            Cervera,J., Wieslander,J., Quinones,S. and Saus,J.
  TITLE     Characterization and expression of multiple alternatively spliced
            transcripts of the Goodpasture antigen gene region. Goodpasture
            antibodies recognize recombinant proteins representing the
            autoantigen and one of its alternative forms
  JOURNAL   Eur J Biochem 229 (3), 754-760 (1995)
   PUBMED   7758473
REFERENCE   8  (bases 1 to 4545)
  AUTHORS   Schworer,C.M., Colbran,R.J., Keefer,J.R. and Soderling,T.R.
  TITLE     Ca2+/calmodulin-dependent protein kinase II. Identification of a
            regulatory autophosphorylation site adjacent to the inhibitory and
            calmodulin-binding domains
  JOURNAL   J Biol Chem 263 (27), 13486-13489 (1988)
   PUBMED   3417668
REFERENCE   9  (bases 1 to 4545)
  AUTHORS   Thiel,G., Czernik,A.J., Gorelick,F., Nairn,A.C. and Greengard,P.
  TITLE     Ca2+/calmodulin-dependent protein kinase II: identification of
            threonine-286 as the autophosphorylation site in the alpha subunit
            associated with the generation of Ca2+-independent activity
  JOURNAL   Proc Natl Acad Sci U S A 85 (17), 6337-6341 (1988)
   PUBMED   2842767
REFERENCE   10 (bases 1 to 4545)
  AUTHORS   Bennett,M.K. and Kennedy,M.B.
  TITLE     Deduced primary structure of the beta subunit of brain type II
            Ca2+/calmodulin-dependent protein kinase determined by molecular
            cloning
  JOURNAL   Proc Natl Acad Sci U S A 84 (7), 1794-1798 (1987)
   PUBMED   3470758
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI550751.1, U23460.1,
            AC006454.4 and AK290148.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001220.4.
            
            Summary: The product of this gene belongs to the serine/threonine
            protein kinase family and to the Ca(2+)/calmodulin-dependent
            protein kinase subfamily. Calcium signaling is crucial for several
            aspects of plasticity at glutamatergic synapses. In mammalian
            cells, the enzyme is composed of four different chains: alpha,
            beta, gamma, and delta. The product of this gene is a beta chain.
            It is possible that distinct isoforms of this chain have different
            cellular localizations and interact differently with calmodulin.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U23460.1, SRR3476690.1104976.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395749.7/ ENSP00000379098.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               BI550751.1         43-251
            210-1398            U23460.1           112-1300
            1399-1512           AC006454.4         23099-23212
            1513-1704           U23460.1           1412-1603
            1705-1770           AC006454.4         26019-26084
            1771-2324           U23460.1           1667-2220
            2325-4431           AC006454.4         33226-35332
            4432-4545           AK290148.1         2175-2288
FEATURES             Location/Qualifiers
     source          1..4545
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..4545
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /note="calcium/calmodulin dependent protein kinase II
                     beta"
                     /db_xref="GeneID:816"
                     /db_xref="HGNC:HGNC:1461"
                     /db_xref="MIM:607707"
     exon            1..238
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..2174
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /EC_number="2.7.11.17"
                     /note="isoform 1 is encoded by transcript variant 1; CaM
                     kinase II beta subunit; CaM-kinase II beta chain; proline
                     rich calmodulin-dependent protein kinase;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit beta; caMK-II subunit beta"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit beta isoform 1"
                     /protein_id="NP_001211.3"
                     /db_xref="CCDS:CCDS5483.1"
                     /db_xref="GeneID:816"
                     /db_xref="HGNC:HGNC:1461"
                     /db_xref="MIM:607707"
                     /translation="MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGL
                     AIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDED
                     QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRS
                     TVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTT
                     MGLVEQAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPVDGIK
                     ESSDSANTTIEDEDAKAPRVPDILSSVRRGSGAPEAEGPLPCPSPAPFSPLPAPSPRI
                     SDILNSVRRGSGTPEAEGPLSAGPPPCLSPALLGPLSSPSPRISDILNSVRRGSGTPE
                     AEGPSPVGPPPCPSPTIPGPLPTPSRKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLT
                     SFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQ
                     YIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQ"
     exon            239..333
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            334..393
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            394..448
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            449..514
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            515..587
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            588..690
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            691..774
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            775..869
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            870..992
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1076
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1119
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1194
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1232
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1304
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1349
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1398
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1512
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1641
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1770
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1846
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1941
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2176
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..4545
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4524..4529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /note="hexamer: AATAAA"
     regulatory      4529..4534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /note="hexamer: AAGAAA"
     polyA_site      4541
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
     polyA_site      4545
                     /gene="CAMK2B"
                     /gene_synonym="CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54"
                     /note="major polyA site"
ORIGIN      
        1 agatctcgcg tgcgctcgcc gcccggcgca gcccagcccg gcccccgcct ggcgccgcga
       61 gccgaggtgt ctcccgcgcc cgcgcccgtg tcgccgccgt gcccgcgagc gggagccgga
      121 gtcgccgccg cccgagcgca gccgagcgca cgccgagccc gtccgccgcc gccatggcca
      181 ccacggtgac ctgcacccgc ttcaccgacg agtaccagct ctacgaggat attggcaagg
      241 gggctttctc tgtggtccga cgctgtgtca agctctgcac cggccatgag tatgcagcca
      301 agatcatcaa caccaagaag ctgtcagcca gagatcacca gaagctggag agagaggctc
      361 ggatctgccg ccttctgaag cattccaaca tcgtgcgtct ccacgacagc atctccgagg
      421 agggcttcca ctacctggtc ttcgatctgg tcactggtgg ggagctcttt gaagacattg
      481 tggcgagaga gtactacagc gaggctgatg ccagtcactg tatccagcag atcctggagg
      541 ccgttctcca ttgtcaccaa atgggggtcg tccacagaga cctcaagccg gagaacctgc
      601 ttctggccag caagtgcaaa ggggctgcag tgaagctggc agacttcggc ctagctatcg
      661 aggtgcaggg ggaccagcag gcatggtttg gtttcgctgg cacaccaggc tacctgtccc
      721 ctgaggtcct tcgcaaagag gcgtatggca agcctgtgga catctgggca tgtggggtga
      781 tcctgtacat cctgctcgtg ggctacccac ccttctggga cgaggaccag cacaagctgt
      841 accagcagat caaggctggt gcctatgact tcccgtcccc tgagtgggac accgtcactc
      901 ctgaagccaa aaacctcatc aaccagatgc tgaccatcaa ccctgccaag cgcatcacag
      961 cccatgaggc cctgaagcac ccgtgggtct gccaacgctc cacggtagca tccatgatgc
     1021 acagacagga gactgtggag tgtctgaaaa agttcaatgc caggagaaag ctcaagggag
     1081 ccatcctcac caccatgctg gccacacgga atttctcagt gggcagacag accaccgctc
     1141 cggccacaat gtccaccgcg gcctccggca ccaccatggg gctggtggaa caagccaaga
     1201 gtttactcaa caagaaagca gatggagtca agccccagac gaatagcacc aaaaacagtg
     1261 cagccgccac cagccccaaa gggacgcttc ctcctgccgc cctggagcct caaaccaccg
     1321 tcatccataa cccagtggac gggattaagg agtcttctga cagtgccaat accaccatag
     1381 aggatgaaga cgctaaagcc cccagggtcc ccgacatcct gagctcagtg aggaggggct
     1441 cgggagcccc agaagccgag gggcccctgc cctgcccatc tccggctccc tttagccccc
     1501 tgccagcccc atcccccagg atctctgaca tcctgaactc tgtgagaagg ggttcaggaa
     1561 ccccagaagc cgagggcccc ctctcagcgg ggcccccgcc ctgcctgtct ccggctctcc
     1621 taggccccct gtcctccccg tcccccagga tctctgacat cctgaactct gtgaggaggg
     1681 gctcagggac cccagaagcc gagggcccct cgccagtggg gcccccgccc tgcccatctc
     1741 cgactatccc tggccccctg cccaccccat cccggaagca ggagatcatt aagaccacgg
     1801 agcagctcat cgaggccgtc aacaacggtg actttgaggc ctacgcgaaa atctgtgacc
     1861 cagggctgac ctcgtttgag cctgaagcac tgggcaacct ggttgaaggg atggacttcc
     1921 acagattcta cttcgagaac ctgctggcca agaacagcaa gccgatccac acgaccatcc
     1981 tgaacccaca cgtgcacgtc attggagagg atgccgcctg catcgcttac atccggctca
     2041 cgcagtacat tgacgggcag ggccggcccc gcaccagcca gtctgaggag acccgcgtgt
     2101 ggcaccgccg cgacggcaag tggcagaacg tgcacttcca ctgctcgggc gcgcctgtgg
     2161 ccccgctgca gtgaagagct gcgccctggt ttcgccggac agagttggtg tttggagccc
     2221 gactgccctc gggcacacgg cctgcctgtc gcatgtttgt gtctgcctcg ttccctcccc
     2281 tggtgcctgt gtctgcagaa aaacaagacc agatgtgatt tgttaaaaaa aaacaaaaaa
     2341 aaaaaaaaaa aaaacaagat gacgacgaca accacaaaaa aaattgacat cagatgaaat
     2401 gaaaaaaaaa aaaaacaaaa aaaactaaag gaaggaaaaa gctgtaaaaa tcactggcat
     2461 tcgtggggcc actccccacc caagctccac gtgtgtccgt ctgtgctcct ggcctctggg
     2521 ggaccagctg ggacatgaac ttgtctgcca ggcccccgtc gcgtgctgaa cggtgttagt
     2581 ttgtaggtaa cgcacacacc ccacacctaa ggtgtctgca tcctcctgcc aacgcatggg
     2641 ctccacgtgg tgtgctcgct ggctgtcgtg actgtcagct gtctcttggg aggggctgtg
     2701 ggggcccgct gggctgcctc ctttcccgct agttgtgcct gagagttgct gttgttcctg
     2761 ctttcccttc ccttcctttc atcccctgaa gggctaggtg tgggttttcc gtgcccggta
     2821 tccccacaca cccagcacgg acaacccttc ggcagagccc aggccggccc ctcaccccct
     2881 ggagtattga aactggagtc ccgtccccaa ggccttcaga gatgccccta cacacccagg
     2941 gctccagctc tggtccttct gggggagtaa agtgcaaaga ggggcacagc ttagttttgg
     3001 gcctctcgcc gagcaagaga cagcactgct ggctacagct ccaacacagc cagctgtggc
     3061 aagaggactc tgcctgggct ggcccccctc ctgtgtgagg tgtctgtccc ttctctgctg
     3121 gccagcagca gatgcactgg cagctcccaa ccctgtttcc gcccctcggc cctcccccag
     3181 cctgttcggc ttctctgcag cccgcaaggg ggagcagact tttgacaaag gactgcgggc
     3241 ctcgctcaag tccctgagcc cccagctgaa gctgggaggg gaggccaggc tttgtgtctg
     3301 ggcatattcg tctgctgatg gggtttgggg aagcctgggg cttggggttt ggtcgggtgg
     3361 tgcagctagt ggcagagcgg gatcagaggt ggtggctgcc cagcttctgg gctgagacaa
     3421 gggtctgtgc aggggtttac tgaagtggga gtgcctttgg aatctgggcc gggagcagaa
     3481 gggagcaaaa gctacagtgg gagccagcct agggcacatg ggaggcgtga gggcagtgct
     3541 gcccgtgcag tgtcaggtgt gccagtgcct tggcgggctg cagtgcgtgt gagggcacct
     3601 tctaggtggg ccagggatgc agctatggag ataaggcggg ctggggacag aaacaggtgg
     3661 gcacagggcc caggacacca gcggatggag ggcagggtct agccctgtgc tcctgagcgt
     3721 cggctgcctg ggttcgaggc ggtgggtccc cggccccttg tgatggtgtg taccatgggg
     3781 gagctcgggg acagggcaag cccgagcatg gtggggctgc agggtgggtc tgaagccagg
     3841 ttgggtgggg gtggtcacaa gccctgactg cagagggtca ggggctcctg ccccagtgcc
     3901 tgcccacttt caattcacat tgttttcaac aaggattttc tttatcttcc cctacaaatc
     3961 aagccaaggg aggggcacag aatggggaac aggacacagg atcctaaact ccaaggggac
     4021 tgtccaccga tgaacactca gagtggacac catcttccgt ccacgctgtg cccaggacag
     4081 ctgtccccat ccatgaacac agggtaaaca tctgccgggc tccgcaccag tggctccctg
     4141 ggccatggga cagcggcagg gctcaccacg gacagcacgt ggcccagcag ccggccaccc
     4201 tggcgtcctg gggcctcctc ccctcctctc cctctcacct tgtcacctcc acggagctgc
     4261 ctgtctggga taatttgggg attttttttc tgggggataa ttcttttgca tgacccctaa
     4321 agagcaagcc acaccggtct gctagctagg tgtccgcggt gtggtggtgg cggccgctgg
     4381 ccagcgctgc aaggggtcgg ctgcccacgg tgctggctgg cctcccctcc tctctctttt
     4441 tgctgagttt cattgtcttt tctttctgag ccttgtaagt gtacaaaaat tattcttatt
     4501 ttgttctgtc tcgggaaact gcaaataaaa gaaaaacagg acaaa
//
