LOCUS       NM_015981               4837 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens calcium/calmodulin dependent protein kinase II alpha
            (CAMK2A), transcript variant 1, mRNA.
ACCESSION   NM_015981
VERSION     NM_015981.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4837)
  AUTHORS   Lin,J., Xia,H., Yu,J., Wang,Y., Wang,H., Xie,D., Cheng,C., Lu,L.,
            Bian,T., Wu,Y. and Liu,Q.
  TITLE     circADAMTS6 via stabilizing CAMK2A is involved in smoking-induced
            emphysema through driving M2 macrophage polarization
  JOURNAL   Environ Int 190, 108832 (2024)
   PUBMED   38936066
  REMARK    GeneRIF: circADAMTS6 via stabilizing CAMK2A is involved in
            smoking-induced emphysema through driving M2 macrophage
            polarization.
REFERENCE   2  (bases 1 to 4837)
  AUTHORS   Zhang,Y., Xia,M., Zhao,T., Zhang,Q., Li,R. and Yang,L.
  TITLE     Camk2a suppresses denervated muscle atrophy by maintaining the Ca2+
            homeostasis in muscle cells
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (11), 25-29 (2023)
   PUBMED   38015546
  REMARK    GeneRIF: Camk2a suppresses denervated muscle atrophy by maintaining
            the Ca2+ homeostasis in muscle cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4837)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 4837)
  AUTHORS   Alphonse,N., Wanford,J.J., Voak,A.A., Gay,J., Venkhaya,S.,
            Burroughs,O., Mathew,S., Lee,T., Evans,S.L., Zhao,W., Frowde,K.,
            Alrehaili,A., Dickenson,R.E., Munk,M., Panina,S., Mahmood,I.F.,
            Llorian,M., Stanifer,M.L., Boulant,S., Berchtold,M.W.,
            Bergeron,J.R.C., Wack,A., Lesser,C.F. and Odendall,C.
  TITLE     A family of conserved bacterial virulence factors dampens
            interferon responses by blocking calcium signaling
  JOURNAL   Cell 185 (13), 2354-2369 (2022)
   PUBMED   35568036
REFERENCE   5  (bases 1 to 4837)
  AUTHORS   Zheng,J., Zhang,Y.W. and Pan,Z.F.
  TITLE     [Dysregulation of MAD2L1/CAMK2A/PTTG1 Gene Cluster Maintains the
            Stemness Characteristics of Uterine Corpus Endometrial Carcinoma]
  JOURNAL   Zhongguo Yi Xue Ke Xue Yuan Xue Bao 43 (5), 685-695 (2021)
   PUBMED   34728029
  REMARK    GeneRIF: [Dysregulation of MAD2L1/CAMK2A/PTTG1 Gene Cluster
            Maintains the Stemness Characteristics of Uterine Corpus
            Endometrial Carcinoma].
REFERENCE   6  (bases 1 to 4837)
  AUTHORS   Bredt,D.S., Ferris,C.D. and Snyder,S.H.
  TITLE     Nitric oxide synthase regulatory sites. Phosphorylation by cyclic
            AMP-dependent protein kinase, protein kinase C, and
            calcium/calmodulin protein kinase; identification of flavin and
            calmodulin binding sites
  JOURNAL   J Biol Chem 267 (16), 10976-10981 (1992)
   PUBMED   1375933
REFERENCE   7  (bases 1 to 4837)
  AUTHORS   Omary,M.B., Baxter,G.T., Chou,C.F., Riopel,C.L., Lin,W.Y. and
            Strulovici,B.
  TITLE     PKC epsilon-related kinase associates with and phosphorylates
            cytokeratin 8 and 18
  JOURNAL   J Cell Biol 117 (3), 583-593 (1992)
   PUBMED   1374067
REFERENCE   8  (bases 1 to 4837)
  AUTHORS   Wegner,M., Cao,Z. and Rosenfeld,M.G.
  TITLE     Calcium-regulated phosphorylation within the leucine zipper of
            C/EBP beta
  JOURNAL   Science 256 (5055), 370-373 (1992)
   PUBMED   1314426
REFERENCE   9  (bases 1 to 4837)
  AUTHORS   Countaway,J.L., Nairn,A.C. and Davis,R.J.
  TITLE     Mechanism of desensitization of the epidermal growth factor
            receptor protein-tyrosine kinase
  JOURNAL   J Biol Chem 267 (2), 1129-1140 (1992)
   PUBMED   1309762
REFERENCE   10 (bases 1 to 4837)
  AUTHORS   Tokui,T., Yamauchi,T., Yano,T., Nishi,Y., Kusagawa,M., Yatani,R.
            and Inagaki,M.
  TITLE     Ca2(+)-calmodulin-dependent protein kinase II phosphorylates
            various types of non-epithelial intermediate filament proteins
  JOURNAL   Biochem Biophys Res Commun 169 (3), 896-904 (1990)
   PUBMED   2114109
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK289776.1, BF951952.1,
            AC011372.7 and BC040457.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 2, 2019 this sequence version replaced NM_015981.3.
            
            Summary: The product of this gene belongs to the serine/threonine
            protein kinases family, and to the Ca(2+)/calmodulin-dependent
            protein kinases subfamily. Calcium signaling is crucial for several
            aspects of plasticity at glutamatergic synapses. This calcium
            calmodulin-dependent protein kinase is composed of four different
            chains: alpha, beta, gamma, and delta. The alpha chain encoded by
            this gene is required for hippocampal long-term potentiation (LTP)
            and spatial learning. In addition to its calcium-calmodulin
            (CaM)-dependent activity, this protein can undergo
            autophosphorylation, resulting in CaM-independent activity. Several
            transcript variants encoding distinct isoforms have been identified
            for this gene. [provided by RefSeq, Jun 2018].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.208418.1,
                                           SRR1660809.257351.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000671881.1/ ENSP00000500386.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1557              AK289776.1         68-1624
            1558-1812           BF951952.1         281-535
            1813-4783           AC011372.7         1177-4147           c
            4784-4837           BC040457.1         4740-4793
FEATURES             Location/Qualifiers
     source          1..4837
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..4837
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /note="calcium/calmodulin dependent protein kinase II
                     alpha"
                     /db_xref="GeneID:815"
                     /db_xref="HGNC:HGNC:1460"
                     /db_xref="MIM:114078"
     exon            1..210
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1618
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /EC_number="2.7.11.17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calcium/calmodulin-dependent protein kinase (CaM kinase)
                     II alpha; CaM-kinase II alpha chain;
                     calcium/calmodulin-dependent protein kinase II alpha-B
                     subunit; CaM kinase II alpha subunit; CaMK-II alpha
                     subunit; calcium/calmodulin-dependent protein kinase type
                     II alpha chain; calcium/calmodulin-dependent protein
                     kinase type II subunit alpha; caMK-II subunit alpha; caM
                     kinase II subunit alpha"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit alpha isoform 1"
                     /protein_id="NP_057065.2"
                     /db_xref="CCDS:CCDS43387.1"
                     /db_xref="GeneID:815"
                     /db_xref="HGNC:HGNC:1460"
                     /db_xref="MIM:114078"
                     /translation="MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKII
                     NTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIV
                     AREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA
                     IEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQ
                     HRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRST
                     VASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKSDGVKKRKSSS
                     SVQLMESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFE
                     PEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLD
                     AGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH"
     exon            211..305
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /inference="alignment:Splign:2.1.0"
     exon            306..365
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /inference="alignment:Splign:2.1.0"
     exon            366..420
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /inference="alignment:Splign:2.1.0"
     exon            421..486
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /inference="alignment:Splign:2.1.0"
     exon            487..559
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /inference="alignment:Splign:2.1.0"
     exon            560..662
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /inference="alignment:Splign:2.1.0"
     exon            663..746
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /inference="alignment:Splign:2.1.0"
     exon            747..841
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /inference="alignment:Splign:2.1.0"
     exon            842..964
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1048
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1091
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1132
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1165
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1214
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1290
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1385
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1614
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..4837
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4812..4817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /note="hexamer: AATAAA"
     polyA_site      4837
                     /gene="CAMK2A"
                     /gene_synonym="CAMKA; CaMKIIalpha; CaMKIINalpha; MRD53;
                     MRT63"
                     /note="major polyA site"
ORIGIN      
        1 agaagccccg ggctcgtcag tcaaaccggt tctctgtttg cactcggcag cacgggcagg
       61 caagtggtcc ctaggttcgg gagcagagca gcagcgcctc agtcctggtc ccccagtccc
      121 aagcctcacc tgcctgccca gcgccaggat ggccaccatc acctgcaccc gcttcacgga
      181 agagtaccag ctcttcgagg aattgggcaa gggagccttc tcggtggtgc gaaggtgtgt
      241 gaaggtgctg gctggccagg agtatgctgc caagatcatc aacacaaaga agctgtcagc
      301 cagagaccat cagaagctgg agcgtgaagc ccgcatctgc cgcctgctga agcaccccaa
      361 catcgtccga ctacatgaca gcatctcaga ggagggacac cactacctga tcttcgacct
      421 ggtcactggt ggggaactgt ttgaagatat cgtggcccgg gagtattaca gtgaggcgga
      481 tgccagtcac tgtatccagc agatcctgga ggctgtgctg cactgccacc agatgggggt
      541 ggtgcaccgg gacctgaagc ctgagaatct gttgctggcc tccaagctca agggtgccgc
      601 agtgaagctg gcagactttg gcctggccat agaggtggag ggggagcagc aggcatggtt
      661 tgggtttgca gggactcctg gatatctctc cccagaagtg ctgcggaagg acccgtacgg
      721 gaagcctgtg gacctgtggg cttgtggggt catcctgtac atcctgctgg ttgggtaccc
      781 cccgttctgg gatgaggacc agcaccgcct gtaccagcag atcaaagccg gcgcctatga
      841 tttcccatcg ccggaatggg acactgtcac cccggaagcc aaggatctga tcaataagat
      901 gctgaccatt aacccatcca aacgcatcac agctgccgaa gcccttaagc acccctggat
      961 ctcgcaccgc tccaccgtgg catcctgcat gcacagacag gagaccgtgg actgcctgaa
     1021 gaagttcaat gccaggagga aactgaaggg agccattctc accacgatgc tggccaccag
     1081 gaacttctcc ggagggaaga gtgggggaaa caagaagagc gatggtgtga agaaaagaaa
     1141 gtccagttcc agcgttcagt taatggaatc ctcagagagc accaacacca ccatcgagga
     1201 tgaagacacc aaagtgcgga aacaggaaat tataaaagtg acagagcagc tgattgaagc
     1261 cataagcaat ggagattttg agtcctacac gaagatgtgc gaccctggca tgacagcctt
     1321 cgaacctgag gccctgggga acctggttga gggcctggac ttccatcgat tctattttga
     1381 aaacctgtgg tcccggaaca gcaagcccgt gcacaccacc atcctgaatc cccacatcca
     1441 cctgatgggc gacgagtcag cctgcatcgc ctacatccgc atcacgcagt acctggacgc
     1501 tggcggcatc ccacgcaccg cccagtcgga ggagacccgt gtctggcacc gccgggatgg
     1561 caaatggcag atcgtccact tccacagatc tggggcgccc tccgtcctgc cccactgagg
     1621 gaccaggctg gggtcgctgc gttgctgtgc cgcagagatc cactctgtcc gtggagtgga
     1681 gctgctggtt ctcccaggtg gattttgctg gaattctccc atgtcatcac cccaccaccg
     1741 tcacttctgt acctgcatca agaaaacctg cttgttcaca aaagtcatcg caacttcaga
     1801 gcgaacggcc acatctcccc acctctcacc cccaccctct cccctgccag gctggggctt
     1861 cctcaggcat gggtgtccac agcactggcc ccctctcccc agcctcagct gctgtccgcc
     1921 tgatctgtct tgggctgtag gctagaatgc ccgggctggt gcccaccagg ggctggggag
     1981 aaggaggggt ggcatgatga ggaaggcagc atccgtccgt ccctctccca gacctctcct
     2041 cttccagtgt ccccggggaa gggcagatga cactcccttc cccctaagcc aaccgcactg
     2101 aaggagtggg gagaagagca tacgccagga gcctcctgcc tcaaagtgct cccctaagtc
     2161 ttcttcctcc tgtgctgacc tcagggtggt ctgacccttc cctcggtgtg ggggatgtgg
     2221 ccctctcagg tgcccctact tgctttctgc ttccttctgg tgaagtccac ctccaacatt
     2281 aacctgccca ccccaccccc gtcatccctg gagaattcca gctttgtcgt atctcagaga
     2341 gggaatctaa ttgtttttgg ggggcaaaag aaagcaacgt ttaggtatca cttctacttg
     2401 gaccgcatgc ctttttatag ccaaatttct gtgtatttcg taaatggatt tcgcgttaat
     2461 ggatatttat gtaataacta gacttctcag attattgtga gaagggtcag gttggaaggg
     2521 gtgtaggaag aggggtgagg ggtagttttt ttctgttcta gttttttttt ttttttttgt
     2581 catctctgag gtggaccttg tcacctgtgg ttattggggc caaggtggac tcagctccgg
     2641 ggagaagggc ctctctgcca tttcggtccc aaggtgagct gacacaggcg ttccttttgg
     2701 gactgtggaa gcatcagatg ccagcactga ctcaggaaca gcaagtcagg gcagagagga
     2761 ggagggaggc tgtcaggatg gaaatacctg gacttttctt tgcttccctc gcaaactggg
     2821 gtcttctcta ccgaacttcc caggatttca tctcaccata tctgtgtgcc gcccccagca
     2881 ccccccaccc acctctgggg ggcccgtgag cgtgtgtctt cattgcctct ctccccttgg
     2941 cgtctgatga ccacagcaaa gcactgggaa tttctactct tcatgcctca tcctgcagcc
     3001 tcgggttcgc attctctctt tcttttcctc tttccctctt tccctgggat tgactctgag
     3061 tggaatacct tggcacatcc actaggatct actgtctgca ctgttttctt tgcatgactt
     3121 tatacgcagt aagtatgttg aaaacaaaca aaaagaagaa aacactcaac aaaaccaatc
     3181 tacatgtttt ggactaaaaa aaaaaataga ggttgtattc tcagtgtccg actcggaatt
     3241 atgttgctgc ctctctgtgc ttttggcctc tgtgtggccg tgttttgcca gcatgagata
     3301 ctgtcccctc tggaggattt taggggagga agagccacgt ccccagggat tggaggaggc
     3361 tccggtaccc tcgaccctcc tgggtgttgg ttggagcaga actggtgagg atgtttgatc
     3421 cgagattttc tgagctctcc ccaatcacca gctgtctgct gggttctttt ctcaagtcct
     3481 gctgcccagg cccaggtgag acaggcaacg ccaggtctgc aggccaggag agatgctgcc
     3541 caggcctcct ggtttccaag ctggtccatc actggcctct gtccttggca gagaccttgc
     3601 tgcccaggcc caggggcagg ctcttggcct gccccaggcc cagagggctt cccagtaagg
     3661 cccagtgatc ccattatccc aggggcaaaa ccacctgtcc ccttttgagc tgccagttcc
     3721 ctacagccat ccccagtcaa gggtgagggt gtggccttca ccaggggctg ctgtaattac
     3781 cgagcaaggt ctgagctctt cttcagcctc agttccctca ttggttaaaa gggttctttg
     3841 ttcccatcca gccgatgaag gagcaaacgt ctggctatgt gaagcctaat ttacctgcag
     3901 gaactggcag ggatagtcac tggctggact cctgtttact tctagacctg gtcaggctcc
     3961 atcccctccc ccacctgccc ctgattcccc tcgtcggtgc ctgtcaactg cttttcagca
     4021 gtggactgca ggggaaagag cagtgatttg gggtgagtag gcttcaattc ccagctctga
     4081 ccagacttgc tgtgtgacct tgggcaagtt cctttccctc tttggagctt ggtttccctg
     4141 ccagaggaaa ctgagctgga ggagcctgag gtcctgcctt tcattggctg acacacctcc
     4201 tgtccactgt gtcactctcc aagtgccaga gaagtggagg cagatcgcta ccccaggctg
     4261 agatggcccc cactgtgaag gccacgcctg tgggtgggca gccacctggt gccaccacag
     4321 ggcaccaggg atgatcctga tgtggcaggc aggggagact cacagaaaaa tctgcccaga
     4381 gcctaccctc accagacaaa ctctgtgctc ctccaaaaca tcctttagat gcaaaataat
     4441 aataataata ataataaata aataaataaa aatccaaacc caagtcaaaa ccttggctcc
     4501 agcatgaaaa cacgtttaca ggaaagtgtt ctcctgggtt tgtgcccacc atggtgcgaa
     4561 tcctgaccca aggcctcctg tctcccttca aagggagacc cttttggggg atgagtttgc
     4621 cagactcccc gtgctggttt ctttgttact atttgtttgg ggttttgttt tagttctttt
     4681 tttttttctt ttctttttta aaaatatgtg gctgtgaact tgaatgaaca ctgctcaaac
     4741 tttctgctat tggggggggc gggtgggatg ggaagaaggg gcgtttgttt tattcttggt
     4801 gttttcagtg caataaatag ctacaaactt ctgtgca
//
