LOCUS       NM_020439               2456 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens calcium/calmodulin dependent protein kinase IG
            (CAMK1G), mRNA.
ACCESSION   NM_020439
VERSION     NM_020439.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2456)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2456)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2456)
  AUTHORS   An,R., Xi,J., Yang,X., Yao,X. and Xu,Y.
  TITLE     No evidence of association between polymorphisms in four genes and
            sporadic amyotrophic lateral sclerosis in Han Chinese
  JOURNAL   Amyotroph Lateral Scler Frontotemporal Degener 16 (3-4), 245-248
            (2015)
   PUBMED   25677198
  REMARK    GeneRIF: No evidence of association between polymorphisms in CAMK1G
            and sporadic amyotrophic lateral sclerosis in Han Chinese
REFERENCE   4  (bases 1 to 2456)
  AUTHORS   Deng,M., Wei,L., Zuo,X., Tian,Y., Xie,F., Hu,P., Zhu,C., Yu,F.,
            Meng,Y., Wang,H., Zhang,F., Ma,H., Ye,R., Cheng,H., Du,J., Dong,W.,
            Zhou,S., Wang,C., Wang,Y., Wang,J., Chen,X., Sun,Z., Zhou,N.,
            Jiang,Y., Liu,X., Li,X., Zhang,N., Liu,N., Guan,Y., Han,Y., Han,Y.,
            Lv,X., Fu,Y., Yu,H., Xi,C., Xie,D., Zhao,Q., Xie,P., Wang,X.,
            Zhang,Z., Shen,L., Cui,Y., Yin,X., Cheng,H., Liang,B., Zheng,X.,
            Lee,T.M., Chen,G., Zhou,F., Veldink,J.H., Robberecht,W.,
            Landers,J.E., Andersen,P.M., Al-Chalabi,A., Shaw,C., Liu,C.,
            Tang,B., Xiao,S., Robertson,J., Zhang,F., van den Berg,L.H.,
            Sun,L., Liu,J., Yang,S., Ju,X., Wang,K. and Zhang,X.
  TITLE     Genome-wide association analyses in Han Chinese identify two new
            susceptibility loci for amyotrophic lateral sclerosis
  JOURNAL   Nat Genet 45 (6), 697-700 (2013)
   PUBMED   23624525
  REMARK    GeneRIF: Two new susceptibility loci for amyotrophic lateral
            sclerosis in the Han Chinese population in chromosome 1, CAMK1G and
            chromosome 22, SUSD2 and CABIN1.
REFERENCE   5  (bases 1 to 2456)
  AUTHORS   Paternoster,L., Evans,D.M., Nohr,E.A., Holst,C., Gaborieau,V.,
            Brennan,P., Gjesing,A.P., Grarup,N., Witte,D.R., Jorgensen,T.,
            Linneberg,A., Lauritzen,T., Sandbaek,A., Hansen,T., Pedersen,O.,
            Elliott,K.S., Kemp,J.P., St Pourcain,B., McMahon,G., Zelenika,D.,
            Hager,J., Lathrop,M., Timpson,N.J., Smith,G.D. and Sorensen,T.I.
  TITLE     Genome-wide population-based association study of extremely
            overweight young adults--the GOYA study
  JOURNAL   PLoS One 6 (9), e24303 (2011)
   PUBMED   21935397
REFERENCE   6  (bases 1 to 2456)
  AUTHORS   Pang,Z.P., Xu,W., Cao,P. and Sudhof,T.C.
  TITLE     Calmodulin suppresses synaptotagmin-2 transcription in cortical
            neurons
  JOURNAL   J Biol Chem 285 (44), 33930-33939 (2010)
   PUBMED   20729199
  REMARK    GeneRIF: Calmodulin suppresses synaptotagmin-2 transcription in
            cortical neurons
REFERENCE   7  (bases 1 to 2456)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   8  (bases 1 to 2456)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2456)
  AUTHORS   Takemoto-Kimura,S., Terai,H., Takamoto,M., Ohmae,S., Kikumura,S.,
            Segi,E., Arakawa,Y., Furuyashiki,T., Narumiya,S. and Bito,H.
  TITLE     Molecular cloning and characterization of CLICK-III/CaMKIgamma, a
            novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein
            kinase (CaMK)
  JOURNAL   J Biol Chem 278 (20), 18597-18605 (2003)
   PUBMED   12637513
  REMARK    GeneRIF: CLICK-III/CaMKIgamma is a novel membrane-anchored neuronal
            Ca2+/calmodulin-dependent protein kinase (CaMK).
REFERENCE   10 (bases 1 to 2456)
  AUTHORS   Schutte,B.C., Bjork,B.C., Coppage,K.B., Malik,M.I., Gregory,S.G.,
            Scott,D.J., Brentzell,L.M., Watanabe,Y., Dixon,M.J. and Murray,J.C.
  TITLE     A preliminary gene map for the Van der Woude syndrome critical
            region derived from 900 kb of genomic sequence at 1q32-q41
  JOURNAL   Genome Res 10 (1), 81-94 (2000)
   PUBMED   10645953
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG715920.1, AL049688.1 and
            BC032787.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020439.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.24178.1,
                                           SRR1660805.92910.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361322.3/ ENSP00000354861.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               BG715920.1         19-310
            293-1809            AL049688.1         222-1738
            1810-2456           BC032787.1         1791-2437
FEATURES             Location/Qualifiers
     source          1..2456
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.2"
     gene            1..2456
                     /gene="CAMK1G"
                     /gene_synonym="CLICK3; CLICKIII; VWS1"
                     /note="calcium/calmodulin dependent protein kinase IG"
                     /db_xref="GeneID:57172"
                     /db_xref="HGNC:HGNC:14585"
                     /db_xref="MIM:614994"
     exon            1..59
                     /gene="CAMK1G"
                     /gene_synonym="CLICK3; CLICKIII; VWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            60..180
                     /gene="CAMK1G"
                     /gene_synonym="CLICK3; CLICKIII; VWS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1519
                     /gene="CAMK1G"
                     /gene_synonym="CLICK3; CLICKIII; VWS1"
                     /EC_number="2.7.11.17"
                     /note="caMKIG; caMKI gamma; caM-KI gamma; caM kinase IG;
                     caM kinase I gamma; caMK-like CREB kinase III"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     1G"
                     /protein_id="NP_065172.1"
                     /db_xref="CCDS:CCDS1486.1"
                     /db_xref="GeneID:57172"
                     /db_xref="HGNC:HGNC:14585"
                     /db_xref="MIM:614994"
                     /translation="MGRKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRL
                     TGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSG
                     GELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKI
                     MITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPP
                     FYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPW
                     IDGNTALHRDIYPSVSLQIQKNFAKSKWRQAFNAAAVVHHMRKLHMNLHSPGVRPEVE
                     NRPPETQASETSRPSSPEITITEAPVLDHSVALPALTQLPCQHGRRPTAPGGRSLNCL
                     VNGSLHISSSLVPMHQGSLAAGPCGCCSSCLNIGSKGKSSYCSEPTLLKKANKKQNFK
                     SEVMVPVKASGSSHCRAGQTGVCLIM"
     exon            181..309
                     /gene="CAMK1G"
                     /gene_synonym="CLICK3; CLICKIII; VWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            310..384
                     /gene="CAMK1G"
                     /gene_synonym="CLICK3; CLICKIII; VWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..523
                     /gene="CAMK1G"
                     /gene_synonym="CLICK3; CLICKIII; VWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            524..647
                     /gene="CAMK1G"
                     /gene_synonym="CLICK3; CLICKIII; VWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..723
                     /gene="CAMK1G"
                     /gene_synonym="CLICK3; CLICKIII; VWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..836
                     /gene="CAMK1G"
                     /gene_synonym="CLICK3; CLICKIII; VWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            837..915
                     /gene="CAMK1G"
                     /gene_synonym="CLICK3; CLICKIII; VWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1003
                     /gene="CAMK1G"
                     /gene_synonym="CLICK3; CLICKIII; VWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1428
                     /gene="CAMK1G"
                     /gene_synonym="CLICK3; CLICKIII; VWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1556
                     /gene="CAMK1G"
                     /gene_synonym="CLICK3; CLICKIII; VWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..2456
                     /gene="CAMK1G"
                     /gene_synonym="CLICK3; CLICKIII; VWS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2432..2437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK1G"
                     /gene_synonym="CLICK3; CLICKIII; VWS1"
                     /note="hexamer: AATAAA"
     polyA_site      2456
                     /gene="CAMK1G"
                     /gene_synonym="CLICK3; CLICKIII; VWS1"
                     /note="major polyA site"
ORIGIN      
        1 ctcacagacc tgtaggagct ggagtgggag ctcaagcagg attcttcccg agtccctggc
       61 atcctcagaa gcttcaactc tggaggcaat gggtcgaaag gaagaagatg actgcagttc
      121 ctggaagaaa cagaccacca acatccggaa aaccttcatt tttatggaag tgctgggatc
      181 aggagctttc tcagaagttt tcctggtgaa gcaaagactg actgggaagc tctttgctct
      241 gaagtgcatc aagaagtcac ctgccttccg ggacagcagc ctggagaatg agattgctgt
      301 gttgaaaaag atcaagcatg aaaacattgt gaccctggag gacatctatg agagcaccac
      361 ccactactac ctggtcatgc agcttgtttc tggtggggag ctctttgacc ggatcctgga
      421 gcggggtgtc tacacagaga aggatgccag tctggtgatc cagcaggtct tgtcggcagt
      481 gaaataccta catgagaatg gcatcgtcca cagagactta aagcccgaaa acctgcttta
      541 ccttacccct gaagagaact ctaagatcat gatcactgac tttggtctgt ccaagatgga
      601 acagaatggc atcatgtcca ctgcctgtgg gaccccaggc tacgtggctc cagaagtgct
      661 ggcccagaaa ccctacagca aggctgtgga ttgctggtcc atcggcgtca tcacctacat
      721 attgctctgt ggataccccc cattctatga agaaacggag tctaagcttt tcgagaagat
      781 caaggagggc tactatgagt ttgagtctcc attctgggat gacatttctg agtcagccaa
      841 ggactttatt tgccacttgc ttgagaagga tccgaacgag cggtacacct gtgagaaggc
      901 cttgagtcat ccctggattg acggaaacac agccctccac cgggacatct acccatcagt
      961 cagcctccag atccagaaga actttgctaa gagcaagtgg aggcaagcct tcaacgcagc
     1021 agctgtggtg caccacatga ggaagctaca catgaacctg cacagcccgg gcgtccgccc
     1081 agaggtggag aacaggccgc ctgaaactca agcctcagaa acctctagac ccagctcccc
     1141 tgagatcacc atcaccgagg cacctgtcct ggaccacagt gtagcactcc ctgccctgac
     1201 ccaattaccc tgccagcatg gccgccggcc cactgcccct ggtggcaggt ccctcaactg
     1261 cctggtcaat ggctccctcc acatcagcag cagcctggtg cccatgcatc aggggtccct
     1321 ggccgccggg ccctgtggct gctgctccag ctgcctgaac attgggagca aaggaaagtc
     1381 ctcctactgc tctgagccca cactcctcaa aaaggccaac aaaaaacaga acttcaagtc
     1441 ggaggtcatg gtaccagtta aagccagtgg cagctcccac tgccgggcag ggcagactgg
     1501 agtctgtctc attatgtgat tcctggagcc tgtgcctatg tcactgcaat tttcaggaga
     1561 catattcaac tcctctgctc ttccaaacct ggtgtctatc cggcagaggg aggaaggcag
     1621 agcaagtgga gcagggctta gcaggagcag tttctggcca gaagcaccag cctgctgcca
     1681 gcggggcagc ccctcatagg aggcccagga gggagcccca aggcgtagaa gccttgttga
     1741 agctgtgagc aggagaagcg gtgcccacca gcttccaggt ctccctgacc tgcctgctct
     1801 atgccccaca ccctacgtgc cgtggctctg tgcagtgtac gtagatagct ctcgcctggg
     1861 tctgtgctgt ttgtcgtgaa aagcttaatg ggctggccag gctgtgtcac cttctccaag
     1921 caaagccata tggagcatct acccagactc ccactctgca cacactcact cccacctctc
     1981 aagcctccaa cctcttggcc agattgggct cattaatgtc gttgcctgcc catctgcatg
     2041 aatgacaggc agctccccat ggtggtctgc ctgtgagctc ttcaagttct aatccttaac
     2101 tccaggatta gctcccaagt gcgctgagac ccagccagca cacttctggc ccttctccct
     2161 gcctcaatct aaaagcagtg ccacaccctc caaagtggaa tagaaagaag ttcatgagta
     2221 agggctgcaa ggaattctta tcctggccac atgtcctccg tgcacacacc caatggagtt
     2281 aaccttggaa gttgactatt ttaatgtctg ccaggagttc taatcctgcc tctgttccct
     2341 tttctctcct tgaaagtcca gcacaccatt cttgtccttc cccagtttcc tcgccctcca
     2401 cccctccagc ttcatgctca gtgttgtgct taataaaatg gacatatttt tctcta
//
