LOCUS       NP_065172                476 aa            linear   PRI 04-APR-2024
DEFINITION  calcium/calmodulin-dependent protein kinase type 1G [Homo sapiens].
ACCESSION   NP_065172
VERSION     NP_065172.1
DBSOURCE    REFSEQ: accession NM_020439.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 476)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (residues 1 to 476)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 476)
  AUTHORS   An,R., Xi,J., Yang,X., Yao,X. and Xu,Y.
  TITLE     No evidence of association between polymorphisms in four genes and
            sporadic amyotrophic lateral sclerosis in Han Chinese
  JOURNAL   Amyotroph Lateral Scler Frontotemporal Degener 16 (3-4), 245-248
            (2015)
   PUBMED   25677198
  REMARK    GeneRIF: No evidence of association between polymorphisms in CAMK1G
            and sporadic amyotrophic lateral sclerosis in Han Chinese
REFERENCE   4  (residues 1 to 476)
  AUTHORS   Deng,M., Wei,L., Zuo,X., Tian,Y., Xie,F., Hu,P., Zhu,C., Yu,F.,
            Meng,Y., Wang,H., Zhang,F., Ma,H., Ye,R., Cheng,H., Du,J., Dong,W.,
            Zhou,S., Wang,C., Wang,Y., Wang,J., Chen,X., Sun,Z., Zhou,N.,
            Jiang,Y., Liu,X., Li,X., Zhang,N., Liu,N., Guan,Y., Han,Y., Han,Y.,
            Lv,X., Fu,Y., Yu,H., Xi,C., Xie,D., Zhao,Q., Xie,P., Wang,X.,
            Zhang,Z., Shen,L., Cui,Y., Yin,X., Cheng,H., Liang,B., Zheng,X.,
            Lee,T.M., Chen,G., Zhou,F., Veldink,J.H., Robberecht,W.,
            Landers,J.E., Andersen,P.M., Al-Chalabi,A., Shaw,C., Liu,C.,
            Tang,B., Xiao,S., Robertson,J., Zhang,F., van den Berg,L.H.,
            Sun,L., Liu,J., Yang,S., Ju,X., Wang,K. and Zhang,X.
  TITLE     Genome-wide association analyses in Han Chinese identify two new
            susceptibility loci for amyotrophic lateral sclerosis
  JOURNAL   Nat Genet 45 (6), 697-700 (2013)
   PUBMED   23624525
  REMARK    GeneRIF: Two new susceptibility loci for amyotrophic lateral
            sclerosis in the Han Chinese population in chromosome 1, CAMK1G and
            chromosome 22, SUSD2 and CABIN1.
REFERENCE   5  (residues 1 to 476)
  AUTHORS   Paternoster,L., Evans,D.M., Nohr,E.A., Holst,C., Gaborieau,V.,
            Brennan,P., Gjesing,A.P., Grarup,N., Witte,D.R., Jorgensen,T.,
            Linneberg,A., Lauritzen,T., Sandbaek,A., Hansen,T., Pedersen,O.,
            Elliott,K.S., Kemp,J.P., St Pourcain,B., McMahon,G., Zelenika,D.,
            Hager,J., Lathrop,M., Timpson,N.J., Smith,G.D. and Sorensen,T.I.
  TITLE     Genome-wide population-based association study of extremely
            overweight young adults--the GOYA study
  JOURNAL   PLoS One 6 (9), e24303 (2011)
   PUBMED   21935397
REFERENCE   6  (residues 1 to 476)
  AUTHORS   Pang,Z.P., Xu,W., Cao,P. and Sudhof,T.C.
  TITLE     Calmodulin suppresses synaptotagmin-2 transcription in cortical
            neurons
  JOURNAL   J Biol Chem 285 (44), 33930-33939 (2010)
   PUBMED   20729199
  REMARK    GeneRIF: Calmodulin suppresses synaptotagmin-2 transcription in
            cortical neurons
REFERENCE   7  (residues 1 to 476)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   8  (residues 1 to 476)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (residues 1 to 476)
  AUTHORS   Takemoto-Kimura,S., Terai,H., Takamoto,M., Ohmae,S., Kikumura,S.,
            Segi,E., Arakawa,Y., Furuyashiki,T., Narumiya,S. and Bito,H.
  TITLE     Molecular cloning and characterization of CLICK-III/CaMKIgamma, a
            novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein
            kinase (CaMK)
  JOURNAL   J Biol Chem 278 (20), 18597-18605 (2003)
   PUBMED   12637513
  REMARK    GeneRIF: CLICK-III/CaMKIgamma is a novel membrane-anchored neuronal
            Ca2+/calmodulin-dependent protein kinase (CaMK).
REFERENCE   10 (residues 1 to 476)
  AUTHORS   Schutte,B.C., Bjork,B.C., Coppage,K.B., Malik,M.I., Gregory,S.G.,
            Scott,D.J., Brentzell,L.M., Watanabe,Y., Dixon,M.J. and Murray,J.C.
  TITLE     A preliminary gene map for the Van der Woude syndrome critical
            region derived from 900 kb of genomic sequence at 1q32-q41
  JOURNAL   Genome Res 10 (1), 81-94 (2000)
   PUBMED   10645953
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG715920.1, AL049688.1 and
            BC032787.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.24178.1,
                                           SRR1660805.92910.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361322.3/ ENSP00000354861.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.2"
     Protein         1..476
                     /product="calcium/calmodulin-dependent protein kinase type
                     1G"
                     /EC_number="2.7.11.17"
                     /note="caMKIG; caMKI gamma; caM-KI gamma; caM kinase IG;
                     caM kinase I gamma; caMK-like CREB kinase III"
                     /calculated_mol_wt=52956
     Region          19..303
                     /region_name="STKc_CaMKI_gamma"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type I gamma;
                     cd14166"
                     /db_xref="CDD:271068"
     Site            order(29..33,37,50,52,81,97..100,104,106,142..143,145,
                     147..148,150,163..164,167,180..184,186)
                     /site_type="active"
                     /db_xref="CDD:271068"
     Site            order(29..32,37,50,52,81,97..100,104,147..148,150,
                     163..164)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271068"
     Site            order(33,104,106,142..143,145,147,167,180..184,186)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271068"
     Site            163..184
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271068"
     Region          277..317
                     /region_name="Autoinhibitory domain.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96NX5.3)"
     Region          297..318
                     /region_name="Calmodulin-binding. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96NX5.3)"
     Region          325..352
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96NX5.3)"
     CDS             1..476
                     /gene="CAMK1G"
                     /gene_synonym="CLICK3; CLICKIII; VWS1"
                     /coded_by="NM_020439.3:89..1519"
                     /db_xref="CCDS:CCDS1486.1"
                     /db_xref="GeneID:57172"
                     /db_xref="HGNC:HGNC:14585"
                     /db_xref="MIM:614994"
ORIGIN      
        1 mgrkeeddcs swkkqttnir ktfifmevlg sgafsevflv kqrltgklfa lkcikkspaf
       61 rdssleneia vlkkikheni vtlediyest thyylvmqlv sggelfdril ergvytekda
      121 slviqqvlsa vkylhengiv hrdlkpenll yltpeenski mitdfglskm eqngimstac
      181 gtpgyvapev laqkpyskav dcwsigvity illcgyppfy eetesklfek ikegyyefes
      241 pfwddisesa kdfichllek dpnerytcek alshpwidgn talhrdiyps vslqiqknfa
      301 kskwrqafna aavvhhmrkl hmnlhspgvr pevenrppet qasetsrpss peititeapv
      361 ldhsvalpal tqlpcqhgrr ptapggrsln clvngslhis sslvpmhqgs laagpcgccs
      421 sclnigskgk ssycseptll kkankkqnfk sevmvpvkas gsshcragqt gvclim
//
