LOCUS       NM_153498               8088 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens calcium/calmodulin dependent protein kinase ID
            (CAMK1D), transcript variant 2, mRNA.
ACCESSION   NM_153498
VERSION     NM_153498.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8088)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 8088)
  AUTHORS   Sui,M.H., Zhang,W.W., Geng,D.M. and Sun,D.J.
  TITLE     CircPRKCI regulates proliferation, migration and cycle of lung
            adenocarcinoma cells by targeting miR-219a-5p-regulated CAMK1D
  JOURNAL   Eur Rev Med Pharmacol Sci 25 (4), 1899-1909 (2021)
   PUBMED   33660800
  REMARK    GeneRIF: CircPRKCI regulates proliferation, migration and cycle of
            lung adenocarcinoma cells by targeting miR-219a-5p-regulated
            CAMK1D.
REFERENCE   3  (bases 1 to 8088)
  AUTHORS   Du,B., Jia,X., Tian,W., Yan,X., Wang,N., Cai,D., Li,X., Zhang,H.,
            Jin,M., Wu,N., Qiu,C. and Zhang,Q.
  TITLE     Associations of SUCNR1, GRK4, CAMK1D gene polymorphisms and the
            susceptibility of type 2 diabetes mellitus and essential
            hypertension in a northern Chinese Han population
  JOURNAL   J Diabetes Complications 35 (1), 107752 (2021)
   PUBMED   33127268
  REMARK    GeneRIF: Associations of SUCNR1, GRK4, CAMK1D gene polymorphisms
            and the susceptibility of type 2 diabetes mellitus and essential
            hypertension in a northern Chinese Han population.
REFERENCE   4  (bases 1 to 8088)
  AUTHORS   Volpin,V., Michels,T., Sorrentino,A., Menevse,A.N., Knoll,G.,
            Ditz,M., Milenkovic,V.M., Chen,C.Y., Rathinasamy,A., Griewank,K.,
            Boutros,M., Haferkamp,S., Berneburg,M., Wetzel,C.H., Seckinger,A.,
            Hose,D., Goldschmidt,H., Ehrenschwender,M., Witzens-Harig,M.,
            Szoor,A., Vereb,G., Khandelwal,N. and Beckhove,P.
  TITLE     CAMK1D Triggers Immune Resistance of Human Tumor Cells Refractory
            to Anti-PD-L1 Treatment
  JOURNAL   Cancer Immunol Res 8 (9), 1163-1179 (2020)
   PUBMED   32665263
  REMARK    GeneRIF: CAMK1D Triggers Immune Resistance of Human Tumor Cells
            Refractory to Anti-PD-L1 Treatment.
REFERENCE   5  (bases 1 to 8088)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   6  (bases 1 to 8088)
  AUTHORS   Sakagami,H., Kamata,A., Nishimura,H., Kasahara,J., Owada,Y.,
            Takeuchi,Y., Watanabe,M., Fukunaga,K. and Kondo,H.
  TITLE     Prominent expression and activity-dependent nuclear translocation
            of Ca2+/calmodulin-dependent protein kinase Idelta in hippocampal
            neurons
  JOURNAL   Eur J Neurosci 22 (11), 2697-2707 (2005)
   PUBMED   16324104
REFERENCE   7  (bases 1 to 8088)
  AUTHORS   Verploegen,S., Ulfman,L., van Deutekom,H.W., van Aalst,C.,
            Honing,H., Lammers,J.W., Koenderman,L. and Coffer,P.J.
  TITLE     Characterization of the role of CaMKI-like kinase (CKLiK) in human
            granulocyte function
  JOURNAL   Blood 106 (3), 1076-1083 (2005)
   PUBMED   15840691
  REMARK    GeneRIF: role of CKLiK in specific granulocyte effector functions
            such as phagocytosis, respiratory burst, migration, and adhesion
REFERENCE   8  (bases 1 to 8088)
  AUTHORS   Ishikawa,Y., Tokumitsu,H., Inuzuka,H., Murata-Hori,M., Hosoya,H.
            and Kobayashi,R.
  TITLE     Identification and characterization of novel components of a
            Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells
  JOURNAL   FEBS Lett 550 (1-3), 57-63 (2003)
   PUBMED   12935886
REFERENCE   9  (bases 1 to 8088)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   10 (bases 1 to 8088)
  AUTHORS   Verploegen,S., Lammers,J.W., Koenderman,L. and Coffer,P.J.
  TITLE     Identification and characterization of CKLiK, a novel granulocyte
            Ca(++)/calmodulin-dependent kinase
  JOURNAL   Blood 96 (9), 3215-3223 (2000)
   PUBMED   11050006
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY168807.1, BC035745.1,
            AK289393.1, AB081726.1, AL512783.22, KF510334.1 and BC073155.1.
            
            On Jun 2, 2019 this sequence version replaced NM_153498.3.
            
            Summary: This gene is a member of the calcium/calmodulin-dependent
            protein kinase 1 family, a subfamily of the serine/threonine
            kinases. The encoded protein is a component of the
            calcium-regulated calmodulin-dependent protein kinase cascade. It
            has been associated with multiple processes including regulation of
            granulocyte function, activation of CREB-dependent gene
            transcription, aldosterone synthesis, differentiation and
            activation of neutrophil cells, and apoptosis of erythroleukemia
            cells. Alternatively spliced transcript variants encoding different
            isoforms of this gene have been described. [provided by RefSeq, Jan
            2015].
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the longer isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB081726.1, BC035745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000619168.5/ ENSP00000478874.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               HY168807.1         6-184
            180-1219            BC035745.1         1-1040
            1220-1220           AK289393.1         1035-1035
            1221-1710           BC035745.1         1042-1531
            1711-1711           AB081726.1         1671-1671
            1712-1789           BC035745.1         1533-1610
            1790-1790           AB081726.1         1750-1750
            1791-1952           BC035745.1         1611-1772
            1953-2275           AB081726.1         1913-2235
            2276-4529           AL512783.22        76617-78870
            4530-4875           KF510334.1         1-346
            4876-7367           AL512783.22        79218-81709
            7368-8088           BC073155.1         913-1633
FEATURES             Location/Qualifiers
     source          1..8088
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p13"
     gene            1..8088
                     /gene="CAMK1D"
                     /gene_synonym="CaM-K1; CaMKID; CKLiK"
                     /note="calcium/calmodulin dependent protein kinase ID"
                     /db_xref="GeneID:57118"
                     /db_xref="HGNC:HGNC:19341"
                     /db_xref="MIM:607957"
     exon            1..364
                     /gene="CAMK1D"
                     /gene_synonym="CaM-K1; CaMKID; CKLiK"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..1430
                     /gene="CAMK1D"
                     /gene_synonym="CaM-K1; CaMKID; CKLiK"
                     /EC_number="2.7.11.17"
                     /note="isoform 2 is encoded by transcript variant 2; CaM
                     kinase ID; CamKI-like protein kinase;
                     calcium/calmodulin-dependent protein kinase type 1D; caMKI
                     delta; caM-KI delta; caM kinase I delta; CAMK1D/ANAPC5
                     fusion"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     1D isoform 2"
                     /protein_id="NP_705718.1"
                     /db_xref="CCDS:CCDS7091.1"
                     /db_xref="GeneID:57118"
                     /db_xref="HGNC:HGNC:19341"
                     /db_xref="MIM:607957"
                     /translation="MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKA
                     TGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVS
                     GGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESK
                     IMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGY
                     PPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARH
                     PWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNAS
                     VSSSLSLASQKDCLAPSTLCSFISSSSGVSGVGAERRPRPTTVTAVHSGSK"
     exon            365..496
                     /gene="CAMK1D"
                     /gene_synonym="CaM-K1; CaMKID; CKLiK"
                     /inference="alignment:Splign:2.1.0"
     exon            497..571
                     /gene="CAMK1D"
                     /gene_synonym="CaM-K1; CaMKID; CKLiK"
                     /inference="alignment:Splign:2.1.0"
     exon            572..710
                     /gene="CAMK1D"
                     /gene_synonym="CaM-K1; CaMKID; CKLiK"
                     /inference="alignment:Splign:2.1.0"
     exon            711..837
                     /gene="CAMK1D"
                     /gene_synonym="CaM-K1; CaMKID; CKLiK"
                     /inference="alignment:Splign:2.1.0"
     exon            838..913
                     /gene="CAMK1D"
                     /gene_synonym="CaM-K1; CaMKID; CKLiK"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1026
                     /gene="CAMK1D"
                     /gene_synonym="CaM-K1; CaMKID; CKLiK"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1105
                     /gene="CAMK1D"
                     /gene_synonym="CaM-K1; CaMKID; CKLiK"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1193
                     /gene="CAMK1D"
                     /gene_synonym="CaM-K1; CaMKID; CKLiK"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1311
                     /gene="CAMK1D"
                     /gene_synonym="CaM-K1; CaMKID; CKLiK"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..8088
                     /gene="CAMK1D"
                     /gene_synonym="CaM-K1; CaMKID; CKLiK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8065..8070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK1D"
                     /gene_synonym="CaM-K1; CaMKID; CKLiK"
                     /note="hexamer: AATAAA"
     polyA_site      8088
                     /gene="CAMK1D"
                     /gene_synonym="CaM-K1; CaMKID; CKLiK"
                     /note="major polyA site"
ORIGIN      
        1 agtagcagaa agtgaggctg gcaggcggcg gcaaaggagc cggcgcgcgg cggcggcagg
       61 aagtctgtgc ccgagaacag cagaaataag agccagggag ggaccgcggc cgcggcggcg
      121 gcggcgagag cgaaagagga aactgcagag gaggaagctg cgccgcagcc cgagccgccc
      181 ggcatccccg ccgcctctgc gcccgcgccg cgcccccggc gccccctccc cagcgcgccc
      241 ccggccgctc ctccgcgccg cgctcgtcgg ccatggcccg ggagaacggc gagagcagct
      301 cctcctggaa aaagcaagct gaagacatca agaagatctt cgagttcaaa gagaccctcg
      361 gaaccggggc cttttccgaa gtggttttag ctgaagagaa ggcaactggc aagctctttg
      421 ctgtgaagtg tatccctaag aaggcgctga agggcaagga aagcagcata gagaatgaga
      481 tagccgtcct gagaaagatt aagcatgaaa atattgttgc cctggaagac atttatgaaa
      541 gcccaaatca cctgtacttg gtcatgcagc tggtgtccgg tggagagctg tttgaccgga
      601 tagtggagaa ggggttttat acagagaagg atgccagcac tctgatccgc caagtcttgg
      661 acgccgtgta ctatctccac agaatgggca tcgtccacag agacctcaag cccgaaaatc
      721 tcttgtacta cagtcaagat gaggagtcca aaataatgat cagtgacttt ggattgtcaa
      781 aaatggaggg caaaggagat gtgatgtcca ctgcctgtgg aactccaggc tatgtcgctc
      841 ctgaagtcct cgcccagaaa ccttacagca aagccgttga ctgctggtcc atcggagtga
      901 ttgcctacat cttgctctgc ggctaccctc ctttttatga tgaaaatgac tccaagctct
      961 ttgagcagat cctcaaggcg gaatatgagt ttgactctcc ctactgggat gacatctccg
     1021 actctgcaaa agacttcatt cggaacctga tggagaagga cccgaataaa agatacacgt
     1081 gtgagcaggc agctcggcac ccatggatcg ctggtgacac agccctcaac aaaaacatcc
     1141 acgagtccgt cagcgcccag atccggaaaa actttgccaa gagcaaatgg agacaagcat
     1201 ttaatgccac ggccgtcgtc agacatatga gaaaactaca cctcggcagc agcctggaca
     1261 gttcaaatgc aagtgtttcg agcagcctca gtttggccag ccaaaaagac tgtctggcac
     1321 cttccacgct ctgtagtttc atttcttctt cgtcgggggt ctcaggagtt ggagccgagc
     1381 ggagacccag gcccaccact gtgacggcag tgcactctgg aagcaagtga ctggccctgg
     1441 aggtggggcc cggggtcggg gctggggaag gggagcccca gggtcgccag agccgcgagc
     1501 cactccagcg agaccccacc ttgcatggtg ccccttcctg cataggactg gaagaccgaa
     1561 gtttttttat ggccatattt tctactgcaa ttctgaagtg ttcatttctc acaaactgta
     1621 ctgactcgag gggcgctgat ttcataggat ctggtgctgt atatacgaat cttgcaaagc
     1681 tctaactgaa cggaccttct tattcctctc ccctaacacc atcgtttcca ctcttctcag
     1741 tgtaggtaac cgtctatggt gtgttttttc attaatgaca aaaaaaaaaa ggtttcaact
     1801 ggattattta aatattggta aatattgtgc attagggttt gtttttcctt ttaagaagta
     1861 tgtcctttgt atctctaagt tacatgacct atatcttttc ctctttaata gtagttttat
     1921 gttaaccttt aagagatttg tttttcctca aaggagaatt taaaggtatt ttttaaaatt
     1981 ctaataagag gatcagccgg gtgcaatgac tcatgcctgt aatcccagca cgttgggagg
     2041 ccaagtcggg cggatcacaa ggtcaggaga tcaaggccat cctggccaac atggtgaaac
     2101 cccacgtcta ctaaaaatac aaaaaattag ccgggcgtgg tggcacacac ctgtagtccc
     2161 ggctactcgg gaggctgagg caggagaatt gcttgaaccc gggagacgga ggttgcagtg
     2221 agctgagatc gtgccactgc actccagcct gggtgacaga gcaagactct gtctcaaaaa
     2281 aaaaaaaaaa aattctaaca agaggatcat gaatctgtct ccaaggctaa gagtgccctt
     2341 cacctctact ccttctgttt ctctcccctt ccccaggagg aggggcccct cagttctgcg
     2401 aggctctctt ctctgcgggg gactttggta gagaatctgc acagagcctt tgctggcaac
     2461 ccatccagca gaacccacac ccaccagaga ccctagaggc ctcttgccat cagcaaccag
     2521 aaataagcct gctcccccga gacgcagggc tcagcttcac aggccagact tgctgtgagt
     2581 gagatgccca cactgcagag atgcaggacc ctcccttgca aaaggaacca gctgccatgt
     2641 tgctgaaagt gggcccacac acaaccctca tttctcacga gagctaacag atgaaagctc
     2701 agctatgcag tgttaaaatt catctctttc tctgtggttt ttaaaaaaat gcatttctaa
     2761 tcttacactt cacgtggcct ccaacacaaa gttctttctc cacattttta ccctcttctc
     2821 acatgaatgt tttccaaggg aaggaaggga gggaagcagc cttgggaaag gatccatttc
     2881 tggtggtaag gagagggggc cctgccaggc taatgggact tcagccacca cagagatgac
     2941 caaagaccac ctccgccagg cccagccagt gcttgcagcc ctcccattgg tcaggggagt
     3001 ctaaaatcaa agatacatgg tggtagggtc accaaacgtc ccatttgccc gagactgaag
     3061 gatttctcag gctgtggaca tttaatgcca aaaccaggaa tatccggggc aaagcaggct
     3121 gtgttgttcg cctttgtgga gccaggcagt gtgtggccca gggaaagctg cgtttcatgg
     3181 aggcttccag gaggctgccc tgtaaagcca ggcaggtggc ttcaagtgcc attcctgcaa
     3241 gtgcccctgc ttcagctctc aggcccatcc aatgcctcga gcccacgggg gtgtcccggc
     3301 aggtctgcgt catcacgacc cagtaacgct gctggctgtg tcctcatgcc ctcttcctct
     3361 ggctggccag tcatgggaag tcctgttggt tgagtcatct ttgtcacttc tacacctttg
     3421 agtatgtaca ggctgaatgt tgagtgatgc ccccccaccc tctcaataaa cacacacaca
     3481 cacacacaca cacacacaca cacacacaat gttattaggc acagcagctc catcctgctc
     3541 cctgagaatg gcagtgcagg cacagagaag agcagttggg aagacaggca gctggtctac
     3601 cctgtccccg cacacttcac aggcactcca ctgcttggca ggaattctgc atggcatctg
     3661 ccacgcatgc tcacagggtg aaaaatcaag ctgtcactct gcaaaatcta aaaaccctgg
     3721 aaaggtctat aagatgacat tagacccagt taagaagcaa gtgtcacctg agttggccat
     3781 gcaatgaatg aatattataa gcagtattgg agaactaggc ggttgcttac taagaagtgt
     3841 cttggaaaca ttcgagttca tacagtgcat gacaaagtaa tagaaggctg caagcgctga
     3901 aaatgcaccc gaatctggta cctaggatga gtacatgaat agtgatgaat agccctttgt
     3961 gctgtgtgct atatacaacc atttgcattc agaaagcagc atttgaagct gagttccatt
     4021 actggtgatt gaagtatttt caggagcaga tacatgtggt gcatgttata tgcacttagt
     4081 ttgaaagtat ccctcaccca aaaagtgcag aacctctgaa aggtgagccg tggtgcaggt
     4141 gcccccctcg ctgttcgggt cagttcttgg ccatgcttgg cctgtcacac gccgggtctc
     4201 aacaacatcg tgcgaggaga cagtgactgg tttcagccca agagtcaact gttgagcatg
     4261 acatcaggaa gcctgtactg tcctgatccc accaggcttg ggttaatttc ctattgcttc
     4321 agagaaagag aggcgctctt gtgcttttga gagagctctc atgttaaaaa gaggttgtct
     4381 ttgcactgcg cttggtatga tttgttttct tataaaacag gaagagaacc tagaatgtgc
     4441 ctttcgtgaa ggtctgacaa atggggtctc agagtcctag gacccgcacc aaggtcagag
     4501 tccacctgta gaggctgagc atttctacat gcacccaggg tgctgggctg aggctaaggg
     4561 tggacgcgta gaccccatca caggcttcct tcctgagccc aagtccccca tttggtcact
     4621 atcccttctc agagcaagtg gattctcttt tcctcacttg gagtattcaa tgttgaagta
     4681 gtggcctgga gtggcctttc cctcagctgc ctgtctgggc tccctggctt cccggatctt
     4741 catctcatac gtgaggcaat aggaggagtt tctattcatt gagacaaaca gtgagcgggc
     4801 accaacaggc cagcagcttg gcccttttca cagaggtggc cttggagtct ggagtctggg
     4861 cagctgtctg cctctctacg gctctgcttc ccagcgggca cacgggtccg gagcctcaga
     4921 atgaagtggt gcagaggcgc agggcacacc taggagaagc tcaatgacca ccaaagccct
     4981 tgaggagaga cggggtttgc tgtgttagag aaatggcaac ccccaggacc atgcacggct
     5041 ctggcagtgc acagtggctg attttcacca gttcctccta cccctgcctc tgtcggagac
     5101 tagaaaacat tctacccctt caggtcttct tttaaaagaa aagagctatg gcaaagcgtg
     5161 ccatacaaag ttaaaaaaag gaagagtggc tttgcgttct tgaccatggc cacaattctg
     5221 gtcacttcta gcatctgacc ttgagaacgg tgtagagtct ctgagccacc gctggccttt
     5281 gagagagtct cactctccag ctagctcttt gtgtagtgtc cagggccccg gcagtcagga
     5341 tagagcgagc aaaagaagat ggacagtgga cagggcgcag tggctcacgc ctgtaatccc
     5401 agcgctttgg gagagcgagg cgggcagatc acaaggtcaa gagatcaaga ccattctggc
     5461 caacatggtg aaaccctgtt tctactaaaa atacaaaaat tagctgggca tggtggtgcg
     5521 tgcctgtaat cccagctact cgggaggctg aggcaggaga atcgcttgaa cccgggaggc
     5581 agaggttgca gtgagccgag atcgtgccac tgcactccag cctgggtgac agagcaagac
     5641 tccgtctcaa aaaagatggc catgctggcc aaggctgggc tcataggaaa tatctgtagt
     5701 aggatgaaag gaatctggcc tagggagccc cggactcggt ttacctaccc cgtactcatc
     5761 ccactcatct gtctacccta gtgtccatca tgccctggat gaatcgtagg tgggagggac
     5821 agaagccgag aacaccaggc acacggggtg gggggaatgg ggggagccca ggtgatcccc
     5881 tttggaaagt ggattgatcc tctcccctgt ggaatgacag cttaacctga ttaacccact
     5941 ggggcttgct attttatgag catttttaaa cagaaaggaa agatgatatc ccagtgcagg
     6001 tagactttat ttttgaaagc atcgtggccc ctcacctctc cctctccccc agaaccttgg
     6061 ccagaattga gtcttcgcgt tggggaggcc acgctggaac cattgctcta gggctgaagg
     6121 tggaagtagg gccactgccg cagcttcagc cagagccctc gctgcttcgc agaatttaac
     6181 aagcacacga ctgggattcc tttggatatg agaaaggaag gcaagtgcgg gcaaagggaa
     6241 gctcctcccg tttttcataa acagaagtaa gatgtcctct ttcccaggtt tgcacaatca
     6301 cttctggcaa attaattgaa ggtccttgaa ttcagccagt gcacgaaacc tttgcatgtt
     6361 cttctgaaac tgtacttctt ccctattctg tctacccaca ctctgcgaac tttgcctttt
     6421 ccttaaacac attccagacc aaacactgtt cagtttgtta aaaaaaaaaa aaaaaaaaaa
     6481 agatgtatat acctgtatgt gatccaccac ccttttgagg ggcacctggt cctcggttgg
     6541 ggctgcaggt gtgcctgaca tttgcaaaag atattccagt ctttcgatgt tcagaattga
     6601 aaatgtggag atagaaaagc tcaaacagac tcctaaaagg agggtttctt tcctgaagac
     6661 tccaagaaaa tgagtgtgca gatgagttag cttgacaacc tcaactctgg ggagcaggca
     6721 ggcggtctga ggaagataag ggcccacgcc ccactcacct ggcacctgtt cggtggtccc
     6781 ggggcatcat ggtctgcagc tctgggcccc cagccccact gtgaagtcag tcctgcatgc
     6841 tggccgaggc ccggccacct cccgatgcct ccagagtcag tgggaaggag tcagcccttc
     6901 ccagacttcc ccgccacctc cagcaggagc agctcagttt gtggctctgg gagctccgct
     6961 tttgcaaacc caaaaaggct gtgcatttgg aagccaaacg ctcagcatgc ggctgccgag
     7021 tctggttttg tggacaaagc aaactgtgga atggcttctc ggtgtctgta taaagggaca
     7081 aacggttgca ttcacccttt gtactataac accgcttctg cattcgccat atccgttttt
     7141 taaccttttt gtctccgggg aacttctcat tcgattatta tgtcttctga tgatttgcca
     7201 tgttatttta aaggtgattt tattttctta tggacaggaa aaaagaaaat gaggaggagt
     7261 tggttttact cttagagata agacttcagc aggggctcag aaaccccaaa ctctagttaa
     7321 attgcttctc ggaggaaaat cttaatctag acagattcag attcccaggc tctcctggaa
     7381 gccctgcact tcagggcaca ggggccctgg gacgtggttg gcagccaggc tgcgagagag
     7441 ctaaaaagga acaagaacat cagctcggat gtttgtctct cagccctgac acctgccact
     7501 ctccttcccg gggcacttgg ccctatcaga gggacatgaa atgctgtccg aatggtggca
     7561 gaaatgcagc gacattgcat gcagcagagt ctttgcttcg aaagatgggg cgccatgttt
     7621 cagagaacat ttatcttagt cccacgttca ggtgagaaga cctcaaaggt accctctgtc
     7681 cagaataaac attggaacaa tctctcaatt ggcttttgtc actacacata atgtaatctc
     7741 ccttctttca gctcccccaa cagtgagcat gcttcccaaa aaattacaac atcaaaacca
     7801 ggaatgtccc cgcatctact attaccaggc ttgcaattgg ttcaattttc ccataaaaac
     7861 atgtttgtcc aaaagaaggg aaactgtgaa tttattccat gcatgtaata aactctgcaa
     7921 gaagtttaac ccacataggt ttgcggcact gcaaaattgt tcatgggtct atgtagcaaa
     7981 tgattctctg ccttgacaat catgtataca tatcaagatt tctatcataa tgataatgag
     8041 attgatgact tcctgttttc ctccaataaa gacaattaat caccttca
//
