LOCUS       NM_003656               1453 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens calcium/calmodulin dependent protein kinase I (CAMK1),
            mRNA.
ACCESSION   NM_003656
VERSION     NM_003656.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1453)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1453)
  AUTHORS   Lei,Y., Yu,T., Li,C., Li,J., Liang,Y., Wang,X., Chen,Y. and Wang,X.
  TITLE     Expression of CAMK1 and its association with clinicopathologic
            characteristics in pancreatic cancer
  JOURNAL   J Cell Mol Med 25 (2), 1198-1206 (2021)
   PUBMED   33342045
  REMARK    GeneRIF: Expression of CAMK1 and its association with
            clinicopathologic characteristics in pancreatic cancer.
REFERENCE   3  (bases 1 to 1453)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1453)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 1453)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1453)
  AUTHORS   Chin,D., Winkler,K.E. and Means,A.R.
  TITLE     Characterization of substrate phosphorylation and use of calmodulin
            mutants to address implications from the enzyme crystal structure
            of calmodulin-dependent protein kinase I
  JOURNAL   J Biol Chem 272 (50), 31235-31240 (1997)
   PUBMED   9395448
REFERENCE   7  (bases 1 to 1453)
  AUTHORS   Yokokura,H., Picciotto,M.R., Nairn,A.C. and Hidaka,H.
  TITLE     The regulatory region of calcium/calmodulin-dependent protein
            kinase I contains closely associated autoinhibitory and
            calmodulin-binding domains
  JOURNAL   J Biol Chem 270 (40), 23851-23859 (1995)
   PUBMED   7559563
REFERENCE   8  (bases 1 to 1453)
  AUTHORS   Haribabu,B., Hook,S.S., Selbert,M.A., Goldstein,E.G., Tomhave,E.D.,
            Edelman,A.M., Snyderman,R. and Means,A.R.
  TITLE     Human calcium-calmodulin dependent protein kinase I: cDNA cloning,
            domain structure and activation by phosphorylation at threonine-177
            by calcium-calmodulin dependent protein kinase I kinase
  JOURNAL   EMBO J 14 (15), 3679-3686 (1995)
   PUBMED   7641687
REFERENCE   9  (bases 1 to 1453)
  AUTHORS   Liu,F., Thompson,M.A., Wagner,S., Greenberg,M.E. and Green,M.R.
  TITLE     Activating transcription factor-1 can mediate Ca(2+)- and
            cAMP-inducible transcriptional activation
  JOURNAL   J Biol Chem 268 (9), 6714-6720 (1993)
   PUBMED   8384217
REFERENCE   10 (bases 1 to 1453)
  AUTHORS   Bredt,D.S., Ferris,C.D. and Snyder,S.H.
  TITLE     Nitric oxide synthase regulatory sites. Phosphorylation by cyclic
            AMP-dependent protein kinase, protein kinase C, and
            calcium/calmodulin protein kinase; identification of flavin and
            calmodulin binding sites
  JOURNAL   J Biol Chem 267 (16), 10976-10981 (1992)
   PUBMED   1375933
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DN990042.1, BC106754.2 and
            AA724193.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003656.4.
            
            Summary: Calcium/calmodulin-dependent protein kinase I is expressed
            in many tissues and is a component of a calmodulin-dependent
            protein kinase cascade.  Calcium/calmodulin directly activates
            calcium/calmodulin-dependent protein kinase I by binding to the
            enzyme and indirectly promotes the phosphorylation and synergistic
            activation of the enzyme by calcium/calmodulin-dependent protein
            kinase I kinase. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1124029.1,
                                           SRR3476690.341547.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256460.8/ ENSP00000256460.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DN990042.1         51-52
            3-1387              BC106754.2         1-1385
            1388-1453           AA724193.1         11-76               c
FEATURES             Location/Qualifiers
     source          1..1453
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..1453
                     /gene="CAMK1"
                     /gene_synonym="CAMKI"
                     /note="calcium/calmodulin dependent protein kinase I"
                     /db_xref="GeneID:8536"
                     /db_xref="HGNC:HGNC:1459"
                     /db_xref="MIM:604998"
     exon            1..116
                     /gene="CAMK1"
                     /gene_synonym="CAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            117..231
                     /gene="CAMK1"
                     /gene_synonym="CAMKI"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1261
                     /gene="CAMK1"
                     /gene_synonym="CAMKI"
                     /EC_number="2.7.11.17"
                     /note="caM-KI; caMKI-alpha; caM kinase I alpha"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     1"
                     /protein_id="NP_003647.1"
                     /db_xref="CCDS:CCDS2582.1"
                     /db_xref="GeneID:8536"
                     /db_xref="HGNC:HGNC:1459"
                     /db_xref="MIM:604998"
                     /translation="MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQK
                     LVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGE
                     LFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMI
                     SDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPF
                     YDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI
                     AGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASH
                     GELLTPVAGGPAAGCCCRDCCVEPGTELSPTLPHQL"
     exon            232..363
                     /gene="CAMK1"
                     /gene_synonym="CAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            364..438
                     /gene="CAMK1"
                     /gene_synonym="CAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            439..577
                     /gene="CAMK1"
                     /gene_synonym="CAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            578..704
                     /gene="CAMK1"
                     /gene_synonym="CAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            705..780
                     /gene="CAMK1"
                     /gene_synonym="CAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            781..893
                     /gene="CAMK1"
                     /gene_synonym="CAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            894..972
                     /gene="CAMK1"
                     /gene_synonym="CAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1060
                     /gene="CAMK1"
                     /gene_synonym="CAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1178
                     /gene="CAMK1"
                     /gene_synonym="CAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1453
                     /gene="CAMK1"
                     /gene_synonym="CAMKI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1433..1438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAMK1"
                     /gene_synonym="CAMKI"
                     /note="hexamer: AATAAA"
     polyA_site      1453
                     /gene="CAMK1"
                     /gene_synonym="CAMKI"
                     /note="major polyA site"
ORIGIN      
        1 agctccagca agagcgcggg cgggtggccc aggcacgcag cggtgaggac cgcggccaca
       61 gctcggcgcc aaccaccgcg ggcctcccag ccagccccgc ggcggggcag ccgcaggagc
      121 cctggctgtg gtcggggggc agtgggccat gctgggggca gtggaaggcc ccaggtggaa
      181 gcaggcggag gacattagag acatctacga cttccgagat gttctgggca cgggggcctt
      241 ctcggaggtg atcctggcag aagataagag gacgcagaag ctggtggcca tcaaatgcat
      301 tgccaaggag gccctggagg gcaaggaagg cagcatggag aatgagattg ctgtcctgca
      361 caagatcaag caccccaaca ttgtagccct ggatgacatc tatgagagtg ggggccacct
      421 ctacctcatc atgcagctgg tgtcgggtgg ggagctcttt gaccgtattg tggaaaaagg
      481 cttctacacg gagcgggacg ccagccgcct catcttccag gtgctggatg ctgtgaaata
      541 cctgcatgac ctgggcattg tacaccggga tctcaagcca gagaatctgc tgtactacag
      601 cctggatgaa gactccaaaa tcatgatctc cgactttggc ctctccaaga tggaggaccc
      661 gggcagtgtg ctctccaccg cctgtggaac tccgggatac gtggcccctg aagtcctggc
      721 ccagaagccc tacagcaagg ctgtggattg ctggtccata ggtgtcatcg cctacatctt
      781 gctctgcggt taccctccct tctatgacga gaatgatgcc aaactctttg aacagatttt
      841 gaaggccgag tacgagtttg actctcctta ctgggacgac atctctgact ctgccaaaga
      901 tttcatccgg cacttgatgg agaaggaccc agagaaaaga ttcacctgtg agcaggcctt
      961 gcagcaccca tggattgcag gagatacagc tctagataag aatatccacc agtcggtgag
     1021 tgagcagatc aagaagaact ttgccaagag caagtggaag caagccttca atgccacggc
     1081 tgtggtgcgg cacatgagga aactgcagct gggcaccagc caggaggggc aggggcagac
     1141 ggcgagccat ggggagctgc tgacaccagt ggctgggggg ccggcagctg gctgttgctg
     1201 tcgagactgc tgcgtggagc cgggcacaga actgtccccc acactgcccc accagctcta
     1261 gggccctgga cctcgggtca tgatcctctg cgtgggaggg cttgggggca gcctgctccc
     1321 cttccctccc tgaaccggga gtttctctgc cctgtcccct cctcacctgc ttccctacca
     1381 ctcctcactg cattttccat acaaatgttt ctattttatt gttccttctt gtaataaagg
     1441 gaagataaaa cca
//
