LOCUS       NM_015722               2260 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens calcyon neuron specific vesicular protein (CALY),
            transcript variant 1, mRNA.
ACCESSION   NM_015722
VERSION     NM_015722.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2260)
  AUTHORS   Muthusamy,N., Chen,Y.J., Yin,D.M., Mei,L. and Bergson,C.
  TITLE     Complementary roles of the neuron-enriched endosomal proteins
            NEEP21 and calcyon in neuronal vesicle trafficking
  JOURNAL   J Neurochem 132 (1), 20-31 (2015)
   PUBMED   25376768
  REMARK    GeneRIF: This review focuses on two closely related,
            neuron-enriched endosomal proteins: NEEP21 and Calcyon which
            perform distinct roles in regulating receptor endocytosis,
            recycling, and degradation--{REVIEW}
            Review article
REFERENCE   2  (bases 1 to 2260)
  AUTHORS   Ha,C.M., Park,D., Han,J.K., Jang,J.I., Park,J.Y., Hwang,E.M.,
            Seok,H. and Chang,S.
  TITLE     Calcyon forms a novel ternary complex with dopamine D1 receptor
            through PSD-95 protein and plays a role in dopamine receptor
            internalization
  JOURNAL   J Biol Chem 287 (38), 31813-31822 (2012)
   PUBMED   22843680
  REMARK    GeneRIF: Calcyon forms a novel ternary complex with dopamine D1
            receptor through PSD-95 protein and plays a role in dopamine
            receptor internalization
REFERENCE   3  (bases 1 to 2260)
  AUTHORS   Li,D., London,S.J., Liu,J., Lee,W., Jiang,X., Van Den Berg,D.,
            Bergen,A.W., Nishita,D., Waleh,N., Swan,G.E., Gallaher,P.,
            Chou,C.P., Shih,J.C., Unger,J.B., Gauderman,W.J., Gilliland,F.,
            Johnson,C.A. and Conti,D.V.
  TITLE     Association of the calcyon neuron-specific vesicular protein gene
            (CALY) with adolescent smoking initiation in China and California
  JOURNAL   Am J Epidemiol 173 (9), 1039-1048 (2011)
   PUBMED   21415033
  REMARK    GeneRIF: Association of the calcyon neuron-specific vesicular
            protein gene (CALY) with adolescent smoking initiation.
REFERENCE   4  (bases 1 to 2260)
  AUTHORS   Ruano,G., Thompson,P.D., Kane,J.P., Pullinger,C.R., Windemuth,A.,
            Seip,R.L., Kocherla,M., Holford,T.R. and Wu,A.H.
  TITLE     Physiogenomic analysis of statin-treated patients: domain-specific
            counter effects within the ACACB gene on low-density lipoprotein
            cholesterol?
  JOURNAL   Pharmacogenomics 11 (7), 959-971 (2010)
   PUBMED   20602615
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2260)
  AUTHORS   Pinheiro,A.P., Bulik,C.M., Thornton,L.M., Sullivan,P.F., Root,T.L.,
            Bloss,C.S., Berrettini,W.H., Schork,N.J., Kaye,W.H., Bergen,A.W.,
            Magistretti,P., Brandt,H., Crawford,S., Crow,S., Fichter,M.M.,
            Goldman,D., Halmi,K.A., Johnson,C., Kaplan,A.S., Keel,P.K.,
            Klump,K.L., La Via,M., Mitchell,J.E., Strober,M., Rotondo,A.,
            Treasure,J. and Woodside,D.B.
  TITLE     Association study of 182 candidate genes in anorexia nervosa
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 153B (5), 1070-1080 (2010)
   PUBMED   20468064
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2260)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2260)
  AUTHORS   Laurin,N., Misener,V.L., Crosbie,J., Ickowicz,A., Pathare,T.,
            Roberts,W., Malone,M., Tannock,R., Schachar,R., Kennedy,J.L. and
            Barr,C.L.
  TITLE     Association of the calcyon gene (DRD1IP) with attention
            deficit/hyperactivity disorder
  JOURNAL   Mol Psychiatry 10 (12), 1117-1125 (2005)
   PUBMED   16172615
  REMARK    GeneRIF: Quantitative trait analyses of most common haplotype,
            designated C1, showed significant relationships with both the
            inattentive and hyperactive/impulsive dimensions of the disorder.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2260)
  AUTHORS   Luo,X., Kranzler,H., Lappalainen,J., Rosenheck,R., Charney,D.,
            Zuo,L., Erdos,J., van Kammen,D.P. and Gelernter,J.
  TITLE     CALCYON gene variation, schizophrenia, and cocaine dependence
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 125B (1), 25-30 (2004)
   PUBMED   14755439
  REMARK    GeneRIF: Genetic variants in the CALCYON gene do not play a major
            role in predisposition to either schizophrenia or cocaine
            dependence i
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2260)
  AUTHORS   Ali,M.K. and Bergson,C.
  TITLE     Elevated intracellular calcium triggers recruitment of the receptor
            cross-talk accessory protein calcyon to the plasma membrane
  JOURNAL   J Biol Chem 278 (51), 51654-51663 (2003)
   PUBMED   14534309
  REMARK    GeneRIF: CaMKII is a key effector in the Ca2+ and
            microtubule-dependent delivery of calcyon to the cell surface.
REFERENCE   10 (bases 1 to 2260)
  AUTHORS   Milligan,G. and White,J.H.
  TITLE     Protein-protein interactions at G-protein-coupled receptors
  JOURNAL   Trends Pharmacol Sci 22 (10), 513-518 (2001)
   PUBMED   11583808
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI914942.1, BC038978.1, BP392207.1 and AL360181.37.
            
            On Nov 22, 2018 this sequence version replaced NM_015722.3.
            
            Summary: The protein encoded by this gene is a type II single
            transmembrane protein. It is required for maximal stimulated
            calcium release after stimulation of purinergic or muscarinic but
            not beta-adrenergic receptors. The encoded protein interacts with
            D1 dopamine receptor and may interact with other DA receptor
            subtypes and/or GPCRs. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL538220.3, AF225903.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146411 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252939.9/ ENSP00000252939.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BI914942.1         76-99
            25-904              BC038978.1         1-880
            905-908             BP392207.1         434-437
            909-2260            AL360181.37        31585-32936         c
FEATURES             Location/Qualifiers
     source          1..2260
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.3"
     gene            1..2260
                     /gene="CALY"
                     /gene_synonym="DRD1IP; NSG3"
                     /note="calcyon neuron specific vesicular protein"
                     /db_xref="GeneID:50632"
                     /db_xref="HGNC:HGNC:17938"
                     /db_xref="MIM:604647"
     exon            1..63
                     /gene="CALY"
                     /gene_synonym="DRD1IP; NSG3"
                     /inference="alignment:Splign:2.1.0"
     exon            64..218
                     /gene="CALY"
                     /gene_synonym="DRD1IP; NSG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..737
                     /gene="CALY"
                     /gene_synonym="DRD1IP; NSG3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calcyon protein; dopamine receptor D1 interacting protein;
                     neuron-specific vesicular protein calcyon; D1 dopamine
                     receptor-interacting protein; calcyon D1 dopamine
                     receptor-interacting protein (CALCYON)"
                     /codon_start=1
                     /product="neuron-specific vesicular protein calcyon
                     isoform 1"
                     /protein_id="NP_056537.1"
                     /db_xref="CCDS:CCDS7678.1"
                     /db_xref="GeneID:50632"
                     /db_xref="HGNC:HGNC:17938"
                     /db_xref="MIM:604647"
                     /translation="MVKLGCSFSGKPGKDPGDQDGAAMDSVPLISPLDISQLQPPLPD
                     QVVIKTQTEYQLSSPDQQNFPDLEGQRLNCSHPEEGRRLPTARMIAFAMALLGCVLIM
                     YKAIWYDQFTCPDGFLLRHKICTPLTLEMYYTEMDPERHRSILAAIGAYPLSRKHGTE
                     TPAAWGDGYRAAKEERKGPTQAGAAAAATEPPGKPSAKAEKEAARKAAGSAAPPPAQ"
     exon            219..329
                     /gene="CALY"
                     /gene_synonym="DRD1IP; NSG3"
                     /inference="alignment:Splign:2.1.0"
     exon            330..443
                     /gene="CALY"
                     /gene_synonym="DRD1IP; NSG3"
                     /inference="alignment:Splign:2.1.0"
     exon            444..765
                     /gene="CALY"
                     /gene_synonym="DRD1IP; NSG3"
                     /inference="alignment:Splign:2.1.0"
     exon            766..2260
                     /gene="CALY"
                     /gene_synonym="DRD1IP; NSG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      886..891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALY"
                     /gene_synonym="DRD1IP; NSG3"
                     /note="hexamer: AGTAAA"
     polyA_site      904
                     /gene="CALY"
                     /gene_synonym="DRD1IP; NSG3"
                     /note="major polyA site"
     regulatory      2237..2242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALY"
                     /gene_synonym="DRD1IP; NSG3"
                     /note="hexamer: ATTAAA"
     polyA_site      2260
                     /gene="CALY"
                     /gene_synonym="DRD1IP; NSG3"
ORIGIN      
        1 atccacatcc gcatcgtcgt cctccccgac cgcgtcctgc agcagctgcc agtggagccg
       61 cctgacaagg actgccatcc accatggtga agctgggctg cagcttctct gggaagccag
      121 gtaaagaccc tggggaccag gatggggctg ccatggacag tgtgcctctg atcagcccct
      181 tggacatcag ccagctccag ccgccactcc ctgaccaggt ggtcatcaag acacagacag
      241 aataccagct gtcctcccca gaccagcaga atttccctga cctggagggc cagaggctga
      301 actgcagcca cccagaggaa gggcgcaggc tgcccaccgc acggatgatc gccttcgcca
      361 tggcgctact gggctgcgtg ctgatcatgt acaaggccat ctggtacgac cagttcacct
      421 gccccgacgg cttcctgctg cggcacaaga tctgcacgcc gctgaccctg gagatgtact
      481 acacggagat ggaccccgag cgccaccgca gcatcctggc ggccatcggg gcctacccgc
      541 tgagccgcaa gcacggcacg gagacgccgg cggcctgggg ggacggctac cgcgcagcca
      601 aggaggagcg caaggggccc acccaggctg gggcggcggc ggcggccacc gaaccccccg
      661 ggaagccgtc ggccaaggcg gagaaggagg cggcgcggaa ggcggccggg agcgcggcgc
      721 ccccgcccgc gcagtgacgt ctccagcccc gcagcccggc ccgggcgtcc tccgccagct
      781 cctgtgacca gcgcgtctcc cgatgctctc cgccgtgttc gtgtccccag gcgccctcgc
      841 tgcagccccg cccccgtggg tctctgactc tgtcgctttt ctctaagtaa agatttcacg
      901 tccaccggag gcttccatct ctcctgcgcg tcctctgccg ggctggcctt tctcccgccc
      961 cccaccccgc cagttgtgag tgaggccggc attgtgctcc ccccagggac ccccgaagga
     1021 cccaggagag accccgtggg gggcagctcc caggaagccg tggtgcgccc aggcggagca
     1081 cgcgcatcct cgcgctgcgt ggtccgggcc ttgtccaagc cccaccggga tgtgccttaa
     1141 tggcggggct ccggcccacc caggggagcc tcgggtccat ccctatccgc tgcccagccc
     1201 cttgtcctgc tggttccccg accccccgcc cccatctacc tggtgctggg cctgggcccc
     1261 gggcgttccc cctctgacag gagtgtctgc ctcccggggg acccctggtt ctgggcggca
     1321 cccatgagca gctcctgcct cctagatgtg tggcccacag gcataaatga ccaagtgaag
     1381 aaaggagtga atgggggcgt ctgagtgggg agtggggcct gatgaggggt gagctctggt
     1441 tcctgggggc tggggtctcc cgtgtccctg gagccagatg aaagatggtg aggctgaaac
     1501 gccaggggag cctggagctg ccatgagtct cccccagcat ccccacccca gccccagcat
     1561 ccccacccca gccccagcat ccccacccca gccccagcca actcccggca ctgaacacta
     1621 cagggaatgg acttccggca gatctcaccc accacctgca ccaccccagc cagcagcagc
     1681 tctgcagccc cgcccacccc agccagcagc agctctgcag ccccgcccac cccagccagc
     1741 agcagctctg cagccccgcc caccccagcc aattgcagca ctgcagcccc gcccacccca
     1801 gccaattgca gcactgcagc cccgcccacc ccagccagca gcggctctgc agccccgccc
     1861 accccagccc ccgaccattg gtggatggaa gccccccacc attggctccc aggcttgctg
     1921 gctaggtgcg ggtctaggca gcttcccagc tcagtgggac tggcctgctt tggaacagcg
     1981 gcagtgccca ggaagcctgt gaactgggcc tgccagggaa gccatggtga gctggaagcc
     2041 agccaggtgg ggtcagggaa ggcagggcca tgcacaccac acccttcact gctgggcttc
     2101 taagggcatt ggccagatga acaagcacac gcagaactga attggccctg atggcctgca
     2161 agggaggggg gcccggggcc tggggcgtca gctgggatat atgggggcag ggagtctctg
     2221 catggccgat gtttgaatta aaatacagct ttcccctgta
//
