LOCUS       NM_138705                670 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens calmodulin like 6 (CALML6), transcript variant 1,
            mRNA.
ACCESSION   NM_138705
VERSION     NM_138705.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 670)
  AUTHORS   Ishikawa,S., Umemura,M., Nakakaji,R., Nagasako,A., Nagao,K.,
            Mizuno,Y., Sugiura,K., Kioi,M., Mitsudo,K. and Ishikawa,Y.
  TITLE     EP4-induced mitochondrial localization and cell migration mediated
            by CALML6 in human oral squamous cell carcinoma
  JOURNAL   Commun Biol 7 (1), 567 (2024)
   PUBMED   38745046
  REMARK    GeneRIF: EP4-induced mitochondrial localization and cell migration
            mediated by CALML6 in human oral squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 670)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 670)
  AUTHORS   Wang,Z., Sheng,C., Yao,C., Chen,H., Wang,D. and Chen,S.
  TITLE     The EF-Hand Protein CALML6 Suppresses Antiviral Innate Immunity by
            Impairing IRF3 Dimerization
  JOURNAL   Cell Rep 26 (5), 1273-1285 (2019)
   PUBMED   30699354
  REMARK    GeneRIF: The EF-hand protein calmodulin-like 6 (CALML6) directly
            bound to the phosphorylated serine-rich (SR) region of IRF3 and
            impaired its dimerization and nuclear translocation.
REFERENCE   4  (bases 1 to 670)
  AUTHORS   Chen,S., Guo,J.H., Saiyin,H., Chen,L., Zhou,G.J., Huang,C.Q. and
            Yu,L.
  TITLE     Cloning and characterization of human CAGLP gene encoding a novel
            EF-hand protein
  JOURNAL   DNA Seq 15 (5-6), 365-368 (2004)
   PUBMED   15621662
  REMARK    GeneRIF: a novel human gene, CAGLP (calglandulin-like protein) was
            predicted, and subsequently isolated from human skeleton muscle
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF490905.2 and AL109917.22.
            
            On Nov 22, 2018 this sequence version replaced NM_138705.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF490905.2, AY566229.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119, SAMEA2158800
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307786.8/ ENSP00000304643.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-668               AF490905.2         434-1101
            669-670             AL109917.22        120471-120472
FEATURES             Location/Qualifiers
     source          1..670
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..670
                     /gene="CALML6"
                     /gene_synonym="CAGLP"
                     /note="calmodulin like 6"
                     /db_xref="GeneID:163688"
                     /db_xref="HGNC:HGNC:24193"
                     /db_xref="MIM:610171"
     exon            1..48
                     /gene="CALML6"
                     /gene_synonym="CAGLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..567
                     /gene="CALML6"
                     /gene_synonym="CAGLP"
                     /note="similar to GenBank Accession Number NT_004350;
                     isoform 1 is encoded by transcript variant 1;
                     calglandulin-like protein; EF-hand protein;
                     calmodulin-like protein 6"
                     /codon_start=1
                     /product="calmodulin-like protein 6 isoform 1"
                     /protein_id="NP_619650.2"
                     /db_xref="CCDS:CCDS30566.1"
                     /db_xref="GeneID:163688"
                     /db_xref="HGNC:HGNC:24193"
                     /db_xref="MIM:610171"
                     /translation="MGLQQEISLQPWCHHPAESCQTTTDMTERLSAEQIKEYKGVFEM
                     FDEEGNGEVKTGELEWLMSLLGINPTKSELASMAKDVDRDNKGFFNCDGFLALMGVYH
                     EKAQNQESELRAAFRVFDKEGKGYIDWNTLKYVLMNAGEPLNEVEAEQMMKEADKDGD
                     RTIDYEEFVAMMTGESFKLIQ"
     exon            49..99
                     /gene="CALML6"
                     /gene_synonym="CAGLP"
                     /inference="alignment:Splign:2.1.0"
     exon            100..274
                     /gene="CALML6"
                     /gene_synonym="CAGLP"
                     /inference="alignment:Splign:2.1.0"
     exon            275..419
                     /gene="CALML6"
                     /gene_synonym="CAGLP"
                     /inference="alignment:Splign:2.1.0"
     exon            420..520
                     /gene="CALML6"
                     /gene_synonym="CAGLP"
                     /inference="alignment:Splign:2.1.0"
     exon            521..670
                     /gene="CALML6"
                     /gene_synonym="CAGLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      652..657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALML6"
                     /gene_synonym="CAGLP"
                     /note="hexamer: AATAAA"
     polyA_site      670
                     /gene="CALML6"
                     /gene_synonym="CAGLP"
                     /note="major polyA site"
ORIGIN      
        1 actgagcacc agctggccag gatgggtctt caacaagaaa tctcactgca gccctggtgt
       61 caccaccctg cagaatcctg tcagacaacc accgacatga cagagcgcct gtcggctgag
      121 cagatcaagg agtacaaggg agtctttgag atgttcgacg aagagggcaa cggggaggtg
      181 aagacggggg agctggagtg gctcatgagc ctgctgggta tcaaccccac caagagtgag
      241 ctggcctcaa tggccaagga tgtggacaga gacaacaaag ggttcttcaa ctgcgatggt
      301 ttcctggcac taatgggagt ttaccatgag aaggcccaga accaggagag cgagctgagg
      361 gcggcattcc gtgtctttga caaagagggc aagggctaca ttgactggaa cacactcaag
      421 tacgtgctaa tgaacgcagg ggagcccctc aacgaggtgg aggcggagca gatgatgaag
      481 gaggccgaca aggatgggga caggaccatc gactatgagg agtttgtggc catgatgacg
      541 ggggagtcct tcaagctgat ccagtaggtg cagctgccgc agccggggga ggcctgcccg
      601 ggaaggctgc tgcccctgcc ccctggcccc cactcccccg gctccgtgta aaataaatgt
      661 tccagcccaa
//
