LOCUS       NM_017422                874 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens calmodulin like 5 (CALML5), mRNA.
ACCESSION   NM_017422
VERSION     NM_017422.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 874)
  AUTHORS   Feng,H., Chen,W. and Zhang,C.
  TITLE     Identification of lactylation gene CALML5 and its correlated
            lncRNAs in cutaneous melanoma by machine learning
  JOURNAL   Medicine (Baltimore) 102 (47), e35999 (2023)
   PUBMED   38013352
  REMARK    GeneRIF: Identification of lactylation gene CALML5 and its
            correlated lncRNAs in cutaneous melanoma by machine learning.
REFERENCE   2  (bases 1 to 874)
  AUTHORS   Kanamori,K., Suina,K., Shukuya,T., Takahashi,F., Hayashi,T.,
            Hara,K., Saito,T., Mitsuishi,Y., Shimamura,S.S., Winardi,W.,
            Tajima,K., Ko,R., Mimori,T., Asao,T., Itoh,M., Kawaji,H.,
            Suehara,Y., Takamochi,K., Suzuki,K. and Takahashi,K.
  TITLE     CALML5 is a novel diagnostic marker for differentiating thymic
            squamous cell carcinoma from type B3 thymoma
  JOURNAL   Thorac Cancer 14 (12), 1089-1097 (2023)
   PUBMED   36924358
  REMARK    GeneRIF: CALML5 is a novel diagnostic marker for differentiating
            thymic squamous cell carcinoma from type B3 thymoma.
REFERENCE   3  (bases 1 to 874)
  AUTHORS   Kitazawa,S., Takaoka,Y., Ueda,Y. and Kitazawa,R.
  TITLE     Identification of calmodulin-like protein 5 as tumor-suppressor
            gene silenced during early stage of carcinogenesis in squamous cell
            carcinoma of uterine cervix
  JOURNAL   Int J Cancer 149 (6), 1358-1368 (2021)
   PUBMED   33997976
  REMARK    GeneRIF: Identification of calmodulin-like protein 5 as
            tumor-suppressor gene silenced during early stage of carcinogenesis
            in squamous cell carcinoma of uterine cervix.
REFERENCE   4  (bases 1 to 874)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 874)
  AUTHORS   Takahara,Y., Miyachi,N., Nawa,M. and Matsuoka,M.
  TITLE     Calmodulin-like skin protein suppresses the increase in
            senescence-associated beta-galactosidase induced by hydrogen
            peroxide or ultraviolet irradiation in keratinocytes
  JOURNAL   Cell Biol Int 43 (7), 835-843 (2019)
   PUBMED   31038250
  REMARK    GeneRIF: The authors results suggest that CLSP may function as a
            senescence-suppressing factor in keratinocytes.
REFERENCE   6  (bases 1 to 874)
  AUTHORS   Babini,E., Bertini,I., Capozzi,F., Chirivino,E. and Luchinat,C.
  TITLE     A structural and dynamic characterization of the EF-hand protein
            CLSP
  JOURNAL   Structure 14 (6), 1029-1038 (2006)
   PUBMED   16765896
  REMARK    GeneRIF: The structure and dynamics of human calmodulin-like skin
            protein (CLSP) have been characterized by NMR spectroscopy.
REFERENCE   7  (bases 1 to 874)
  AUTHORS   Mehul,B., Bernard,D., Brouard,M., Delattre,C. and Schmidt,R.
  TITLE     Influence of calcium on the proteolytic degradation of the
            calmodulin-like skin protein (calmodulin-like protein 5) in
            psoriatic epidermis
  JOURNAL   Exp Dermatol 15 (6), 469-477 (2006)
   PUBMED   16689864
  REMARK    GeneRIF: abnormal elevated levels of CLSP, characteristic of
            psoriatic epidermis, were probably not due to an overexpression of
            the protein, but most likely the result of its non-degradation
REFERENCE   8  (bases 1 to 874)
  AUTHORS   Durussel,I., Mehul,B., Bernard,D., Schmidt,R. and Cox,J.A.
  TITLE     Cation- and peptide-binding properties of human calmodulin-like
            skin protein
  JOURNAL   Biochemistry 41 (17), 5439-5448 (2002)
   PUBMED   11969404
  REMARK    GeneRIF: An investigation of the cation-binding properties of CLSP
            and the ensuing conformational changes finds that, with its high-
            and low-affinity Ca+2+-binding sites and a pronounced effect of
            Mg2+, CLSP is more similar to troponin C than to calmodulin.
REFERENCE   9  (bases 1 to 874)
  AUTHORS   Mehul,B., Bernard,D. and Schmidt,R.
  TITLE     Calmodulin-like skin protein: a new marker of keratinocyte
            differentiation
  JOURNAL   J Invest Dermatol 116 (6), 905-909 (2001)
   PUBMED   11407979
REFERENCE   10 (bases 1 to 874)
  AUTHORS   Mehul,B., Bernard,D., Simonetti,L., Bernard,M.A. and Schmidt,R.
  TITLE     Identification and cloning of a new calmodulin-like protein from
            human epidermis
  JOURNAL   J Biol Chem 275 (17), 12841-12847 (2000)
   PUBMED   10777582
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL732437.12 and AK222744.1.
            
            On May 17, 2019 this sequence version replaced NM_017422.4.
            
            Summary: This gene encodes a novel calcium binding protein
            expressed in the epidermis and related to the calmodulin family of
            calcium binding proteins. Functional studies with recombinant
            protein demonstrate it does bind calcium and undergoes a
            conformational change when it does so. Abundant expression is
            detected only in reconstructed epidermis and is restricted to
            differentiating keratinocytes. In addition, it can associate with
            transglutaminase 3, shown to be a key enzyme in the terminal
            differentiation of keratinocytes. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK222744.1, BC039172.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380332.5/ ENSP00000369689.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               AL732437.12        90153-90394
            243-874             AK222744.1         243-874
FEATURES             Location/Qualifiers
     source          1..874
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.1"
     gene            1..874
                     /gene="CALML5"
                     /gene_synonym="CLSP"
                     /note="calmodulin like 5"
                     /db_xref="GeneID:51806"
                     /db_xref="HGNC:HGNC:18180"
                     /db_xref="MIM:605183"
     exon            1..874
                     /gene="CALML5"
                     /gene_synonym="CLSP"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..573
                     /gene="CALML5"
                     /gene_synonym="CLSP"
                     /note="calmodulin-like skin protein"
                     /codon_start=1
                     /product="calmodulin-like protein 5"
                     /protein_id="NP_059118.2"
                     /db_xref="CCDS:CCDS7068.1"
                     /db_xref="GeneID:51806"
                     /db_xref="HGNC:HGNC:18180"
                     /db_xref="MIM:605183"
                     /translation="MAGELTPEEEAQYKKAFSAVDTDGNGTINAQELGAALKATGKNL
                     SEAQLRKLISEVDSDGDGEISFQEFLTAAKKARAGLEDLQVAFRAFDQDGDGHITVDE
                     LRRAMAGLGQPLPQEELDAMIREADVDQDGRVNYEEFARMLAQE"
     regulatory      853..858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALML5"
                     /gene_synonym="CLSP"
                     /note="hexamer: AATAAA"
     polyA_site      874
                     /gene="CALML5"
                     /gene_synonym="CLSP"
                     /note="major polyA site"
ORIGIN      
        1 agaactgtct gggacagacg ctgcccggat ccctgcggct gcctgcactc tggaccacga
       61 gctctgagag cagcaggttg agggccggtg ggcagcagct cggaggctcc gcgaggtgca
      121 ggagacgcag gcatggccgg tgagctgact cctgaggagg aggcccagta caaaaaggct
      181 ttctccgcgg ttgacacgga tggaaacggc accatcaatg cccaggagct gggcgcggcg
      241 ctgaaggcca cgggcaagaa cctctcggag gcccagctaa ggaaactcat ctccgaggtt
      301 gacagcgacg gcgacggcga aatcagcttc caggagttcc tgacggcggc gaagaaggcc
      361 agggccggcc tggaggacct gcaggtcgcc ttccgcgcct tcgaccagga tggcgacggc
      421 cacatcaccg tggacgagct caggcgggcc atggcggggc tggggcagcc gctgccgcag
      481 gaggagctgg acgccatgat ccgcgaggcc gacgtggacc aggacgggcg ggtgaactac
      541 gaggagttcg cgaggatgct cgcccaggag tgaggctccc cgcctgtgtc cccctggctg
      601 cgctctgagc cttcagggcc accgcccgct gctgcttttg tgctgggact ctccggggaa
      661 acctggtcgg tggatgggaa actgcctccc cctgggagga aggctttgcg ctccggggcc
      721 tggatgcggc gccctcgggc cgcctgcgag cccctctctg cctccagacc ttgggcagaa
      781 ggaggcctcc ttgggcctgg tccccctttg ccctgcagtg gaatgagggc ccctcagccc
      841 cgcattgatc taaataaagg actgccgagt tcca
//
