LOCUS       NM_005185               1811 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens calmodulin like 3 (CALML3), mRNA.
ACCESSION   NM_005185
VERSION     NM_005185.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1811)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1811)
  AUTHORS   Chen,G., Yu,C., Tang,Z., Liu,S., An,F., Zhu,J., Wu,Q., Cao,J.,
            Zhan,Q. and Zhang,S.
  TITLE     Metformin suppresses gastric cancer progression through
            calmodulin-like protein 3 secreted from tumor-associated
            fibroblasts
  JOURNAL   Oncol Rep 41 (1), 405-414 (2019)
   PUBMED   30320344
  REMARK    GeneRIF: Metformin suppresses gastric cancer through stimulating
            Calml3 secretion from TAFs.
REFERENCE   3  (bases 1 to 1811)
  AUTHORS   Jia,Y., Qin,Q., Fang,C.P., Shen,W., Sun,T.T., Huang,Y.L., Li,W.J.
            and Deng,A.M.
  TITLE     UVB induces apoptosis via downregulation of CALML3-dependent JNK1/2
            and ERK1/2 pathways in cataract
  JOURNAL   Int J Mol Med 41 (5), 3041-3050 (2018)
   PUBMED   29436594
  REMARK    GeneRIF: UVB irradiation induced increase in apoptosis, Reactive
            Oxygen Species production and Ca2+ concentration of human lens
            epithelial cells , in part, by downregulating the expression of
            CALML3 and involved oxidative stress, Ca2+, JNK1/2 and ERK1/2
            signaling pathways, suggesting that investigating CALML3 may useful
            for developing cataract treatment.
REFERENCE   4  (bases 1 to 1811)
  AUTHORS   Yang,B., Li,M., Tang,W., Liu,W., Zhang,S., Chen,L. and Xia,J.
  TITLE     Dynamic network biomarker indicates pulmonary metastasis at the
            tipping point of hepatocellular carcinoma
  JOURNAL   Nat Commun 9 (1), 678 (2018)
   PUBMED   29445139
  REMARK    GeneRIF: Loss of CALML3 predicts shorter overall and relapse-free
            survival in postoperative hepatocellular carcinoma (HCC) patients,
            thus providing a prognostic biomarker and therapy target in HCC.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1811)
  AUTHORS   Qin,S., Ingle,J.N., Liu,M., Yu,J., Wickerham,D.L., Kubo,M.,
            Weinshilboum,R.M. and Wang,L.
  TITLE     Calmodulin-like protein 3 is an estrogen receptor alpha coregulator
            for gene expression and drug response in a SNP, estrogen, and
            SERM-dependent fashion
  JOURNAL   Breast Cancer Res 19 (1), 95 (2017)
   PUBMED   28821270
  REMARK    GeneRIF: We identified calmodulin-like protein 3 (CALML3) as a key
            sensor of this SNP and a coregulator of ERalpha, which contributes
            to differential gene transcription regulation in an estrogen and
            SERM-dependent fashion. Furthermore, using CRISPR/Cas9-engineered
            ZR75-1 breast cancer cells with different ZNF423 SNP genotypes,
            striking differences in cellular responses to SERMs and PARP
            inhibitors, alone or in combination
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1811)
  AUTHORS   Koller,M. and Strehler,E.E.
  TITLE     Functional analysis of the promoters of the human CaMIII calmodulin
            gene and of the intronless gene coding for a calmodulin-like
            protein
  JOURNAL   Biochim Biophys Acta 1163 (1), 1-9 (1993)
   PUBMED   8476923
REFERENCE   7  (bases 1 to 1811)
  AUTHORS   Berchtold,M.W., Koller,M., Egli,R., Rhyner,J.A., Hameister,H. and
            Strehler,E.E.
  TITLE     Localization of the intronless gene coding for calmodulin-like
            protein CLP to human chromosome 10p13-ter
  JOURNAL   Hum Genet 90 (5), 496-500 (1993)
   PUBMED   8428750
REFERENCE   8  (bases 1 to 1811)
  AUTHORS   Rhyner,J.A., Koller,M., Durussel-Gerber,I., Cox,J.A. and
            Strehler,E.E.
  TITLE     Characterization of the human calmodulin-like protein expressed in
            Escherichia coli
  JOURNAL   Biochemistry 31 (51), 12826-12832 (1992)
   PUBMED   1334432
REFERENCE   9  (bases 1 to 1811)
  AUTHORS   Yaswen,P., Smoll,A., Peehl,D.M., Trask,D.K., Sager,R. and
            Stampfer,M.R.
  TITLE     Down-regulation of a calmodulin-related gene during transformation
            of human mammary epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7360-7364 (1990)
   PUBMED   2217169
REFERENCE   10 (bases 1 to 1811)
  AUTHORS   Koller,M. and Strehler,E.E.
  TITLE     Characterization of an intronless human calmodulin-like pseudogene
  JOURNAL   FEBS Lett 239 (1), 121-128 (1988)
   PUBMED   3181418
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY060230.1, BC031889.1, CU454493.1, DR421766.1 and AL732437.12.
            
            On May 17, 2019 this sequence version replaced NM_005185.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: M36707.1, M58026.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315238.3/ ENSP00000315299.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                HY060230.1         74-127
            55-771              BC031889.1         35-751
            772-940             CU454493.1         192-360
            941-1308            DR421766.1         40-407
            1309-1811           AL732437.12        62952-63454         c
FEATURES             Location/Qualifiers
     source          1..1811
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.1"
     gene            1..1811
                     /gene="CALML3"
                     /gene_synonym="CLP"
                     /note="calmodulin like 3"
                     /db_xref="GeneID:810"
                     /db_xref="HGNC:HGNC:1452"
                     /db_xref="MIM:114184"
     exon            1..1811
                     /gene="CALML3"
                     /gene_synonym="CLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..575
                     /gene="CALML3"
                     /gene_synonym="CLP"
                     /note="caM-like protein; calmodulin-related protein NB-1"
                     /codon_start=1
                     /product="calmodulin-like protein 3"
                     /protein_id="NP_005176.1"
                     /db_xref="CCDS:CCDS7069.1"
                     /db_xref="GeneID:810"
                     /db_xref="HGNC:HGNC:1452"
                     /db_xref="MIM:114184"
                     /translation="MADQLTEEQVTEFKEAFSLFDKDGDGCITTRELGTVMRSLGQNP
                     TEAELRDMMSEIDRDGNGTVDFPEFLGMMARKMKDTDNEEEIREAFRVFDKDGNGFVS
                     AAELRHVMTRLGEKLSDEEVDEMIRAADTDGDGQVNYEEFVRVLVSK"
     regulatory      1281..1286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALML3"
                     /gene_synonym="CLP"
                     /note="hexamer: AATAAA"
     polyA_site      1303
                     /gene="CALML3"
                     /gene_synonym="CLP"
                     /note="major polyA site"
ORIGIN      
        1 gagacagccc gccggccgcc cggatctcca cctgccaccc cagagctggg acagcagccg
       61 ggctgcggca ctgggaggga gaccccacag tggcctcttc tgccacccac gcccccaccc
      121 ctggcatggc cgaccagctg actgaggagc aggtcacaga attcaaggag gccttctccc
      181 tgtttgacaa ggatggggac ggctgcatca ccacccgcga gctgggcacg gtcatgcggt
      241 ccctgggcca gaaccccacg gaggccgagc tgcgggacat gatgagtgag atcgaccggg
      301 acggcaacgg caccgtggac ttccccgagt tcctgggcat gatggccagg aagatgaagg
      361 acacggacaa cgaggaggag atccgcgagg ccttccgcgt gttcgacaag gacggcaacg
      421 gcttcgtcag cgccgccgag ctgcgacacg tcatgacccg gctgggggag aagctgagtg
      481 acgaggaggt ggacgagatg atccgggccg cggacacgga cggagacgga caggtgaact
      541 acgaggagtt tgtccgtgtg ctggtgtcca agtgaggccg gcgcccacca tgctcctggg
      601 cgcccacgcg gcccacaggg caagaacccg gggcctcccg cctcctcccc catccccctg
      661 cctcccctgg gcactgtggc ttcctcctgc gcctggttga ttcagcccac ctctctgcat
      721 cccgcttccc gcgtctcttc tctgcactcc tgccgacctt cccacctgct cgtctgaatg
      781 acacggaacg ctcccactgc aggcaaaccg tgacgccctc cccactcggg agaagcagag
      841 ctgaccttag gaccgagcac cagggcaggt tgcgctgact ctgcggccct ccaggacgga
      901 caccgggtga ccccttaggg cacccaggca agatccctaa gaggcaccca atgcccaggc
      961 caggggggct gcagccctca gcccccgcca ggattcccgc aggctcctgg actggaagct
     1021 ccctccgcgg tcggattctg gagggtggga ggcatcttgg cctgcagtaa gcggtgctga
     1081 cggggactct ggccacagag gtcaggcctc ctgaaaacag cactgccttc cgcgctgccc
     1141 cagcttgccc cattccttgt ccgccaaccc accgtgattc atcttctgaa gctgggagtg
     1201 aaactgggtc agctgtaacc tgttcctatt catctggaag gagggaggct tggatgagca
     1261 ggggatgaga gctgcaggga aataaatgag atattcgtcc ttatttcatt tccttttttt
     1321 ttttggtttc catggaaatg atccttgtta aattcagggt tgaaacgagg caggaatctc
     1381 catttttgtg ctttttgaaa atgcaatgaa ttcctatacg ggggagcggg aaaggtgcct
     1441 cagagagaga caagtctgga tgagggaaat attgaatatt ctcaatcaaa tggatacgct
     1501 ggcagcaaag agtggttaaa agtccatcag gacttgaaag acctgagtcc attacgttga
     1561 gaagggacct gctgattgct ttgattcccc ctggcaagtg ctccctggtt gtgaagtgcc
     1621 aggcactaga gatggtgagg ggttgggggg cagttgggca cacacagtgt aagagcaatt
     1681 cagagccgtt agtcctgcac tagccctgca agctgctggc aacacctaga gaaggtcgaa
     1741 ggggccctgc cagagatccc ttcaattcta aagggaggta tgttttgcgg gatgggcact
     1801 agacggagct c
//
