LOCUS       NM_001010919            1127 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens calcium homeostasis modulator family member 6
            (CALHM6), transcript variant 1, mRNA.
ACCESSION   NM_001010919 XM_496823
VERSION     NM_001010919.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1127)
  AUTHORS   Malik,U. and Javed,N.
  TITLE     FAM26F: An Enigmatic Protein Having a Complex Role in the Immune
            System
  JOURNAL   Int Rev Immunol 42 (4), 247-257 (2023)
   PUBMED   27645024
  REMARK    GeneRIF: FAM26F: An Enigmatic Protein Having a Complex Role in the
            Immune System.
            Review article
REFERENCE   2  (bases 1 to 1127)
  AUTHORS   Jabeen,K., Malik,U., Mansoor,S., Shahzad,S., Zahid,S. and Javed,A.
  TITLE     Effect of oxidative stress and calcium deregulation on FAM26F
            (CALHM6) expression during hepatitis B virus infection
  JOURNAL   BMC Infect Dis 21 (1), 228 (2021)
   PUBMED   33639860
  REMARK    GeneRIF: Effect of oxidative stress and calcium deregulation on
            FAM26F (CALHM6) expression during hepatitis B virus infection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1127)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1127)
  AUTHORS   Dufek,S., Cheshire,C., Levine,A.P., Trompeter,R.S., Issler,N.,
            Stubbs,M., Mozere,M., Gupta,S., Klootwijk,E., Patel,V., Hothi,D.,
            Waters,A., Webb,H., Tullus,K., Jenkins,L., Godinho,L.,
            Levtchenko,E., Wetzels,J., Knoers,N., Teeninga,N., Nauta,J.,
            Shalaby,M., Eldesoky,S., Kari,J.A., Thalgahagoda,S., Ranawaka,R.,
            Abeyagunawardena,A., Adeyemo,A., Kristiansen,M., Gbadegesin,R.,
            Webb,N.J., Gale,D.P., Stanescu,H.C., Kleta,R. and Bockenhauer,D.
  TITLE     Genetic Identification of Two Novel Loci Associated with
            Steroid-Sensitive Nephrotic Syndrome
  JOURNAL   J Am Soc Nephrol 30 (8), 1375-1384 (2019)
   PUBMED   31263063
  REMARK    GeneRIF: CALHM6 is implicated in regulating the immune response to
            infection and may have a role in typical triggering of
            Steroid-Sensitive Nephrotic Syndrome (SSNS) onset by infections
REFERENCE   5  (bases 1 to 1127)
  AUTHORS   Malik,U., Javed,A., Ali,A. and Asghar,K.
  TITLE     Structural and functional annotation of human FAM26F: A
            multifaceted protein having a critical role in the immune system
  JOURNAL   Gene 597, 66-75 (2017)
   PUBMED   27784631
  REMARK    GeneRIF: FAM26F is a conserved, signal peptide deprived
            transmembrane protein that is secreted through non-classical
            pathway.FAM26F has an immunoglobulin-like fold which emphasizes its
            role in immune responses.
REFERENCE   6  (bases 1 to 1127)
  AUTHORS   Julia,A., Domenech,E., Chaparro,M., Garcia-Sanchez,V., Gomollon,F.,
            Panes,J., Manosa,M., Barreiro-De Acosta,M., Gutierrez,A.,
            Garcia-Planella,E., Aguas,M., Munoz,F., Esteve,M., Mendoza,J.L.,
            Vera,M., Marquez,L., Tortosa,R., Lopez-Lasanta,M., Alonso,A.,
            Gelpi,J.L., Garcia-Montero,A.C., Bertranpetit,J., Absher,D.,
            Myers,R.M., Gisbert,J.P. and Marsal,S.
  TITLE     A genome-wide association study identifies a novel locus at 6q22.1
            associated with ulcerative colitis
  JOURNAL   Hum Mol Genet 23 (25), 6927-6934 (2014)
   PUBMED   25082827
  REMARK    GeneRIF: FAM26Fwas found to be consistently and significantly
            overexpressed in ulcerative colitis patients.
REFERENCE   7  (bases 1 to 1127)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AV734646.2, BM704529.1, DN997293.1 and AF086130.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001010919.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            CDS exon combination :: ERR279836.5680.1, SRR1163657.340109.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2145544, SAMEA2146236 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368605.3/ ENSP00000357594.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AV734646.2         6-23
            19-387              BM704529.1         1-369
            388-756             DN997293.1         309-677
            757-1127            AF086130.1         84-454
FEATURES             Location/Qualifiers
     source          1..1127
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.1"
     gene            1..1127
                     /gene="CALHM6"
                     /gene_synonym="C6orf187; dJ93H18.5; FAM26F; INAM"
                     /note="calcium homeostasis modulator family member 6"
                     /db_xref="GeneID:441168"
                     /db_xref="HGNC:HGNC:33391"
                     /db_xref="MIM:617305"
     exon            1..55
                     /gene="CALHM6"
                     /gene_synonym="C6orf187; dJ93H18.5; FAM26F; INAM"
                     /inference="alignment:Splign:2.1.0"
     exon            56..638
                     /gene="CALHM6"
                     /gene_synonym="C6orf187; dJ93H18.5; FAM26F; INAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1061
                     /gene="CALHM6"
                     /gene_synonym="C6orf187; dJ93H18.5; FAM26F; INAM"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM26F; IFN regulatory factor 3-dependent
                     NK-activating molecule; calcium homeostasis modulator
                     protein 6; family with sequence similarity 26 member F"
                     /codon_start=1
                     /product="calcium homeostasis modulator protein 6 isoform
                     1"
                     /protein_id="NP_001010919.1"
                     /db_xref="CCDS:CCDS34519.1"
                     /db_xref="GeneID:441168"
                     /db_xref="HGNC:HGNC:33391"
                     /db_xref="MIM:617305"
                     /translation="MEKFRAVLDLHVKHHSALGYGLVTLLTAGGERIFSAVAFQCPCS
                     AAWNLPYGLVFLLVPALALFLLGYVLSARTWRLLTGCCSSARASCGSALRGSLVCTQI
                     SAAAALAPLTWVAVALLGGAFYECAATGSAAFAQRLCLGRNRSCAAELPLVPCNQAKA
                     SDVQDLLKDLKAQSQVLGWILIAVVIIILLIFTSVTRCLSPVSFLQLKFWKIYLEQEQ
                     QILKSKATEHATELAKENIKCFFEGSHPKEYNTPSMKEWQQISSLYTFNPKGQYYSML
                     HKYVNRKEKTHSIRSTEGDTVIPVLGFVDSSGINSTPEL"
     exon            639..1127
                     /gene="CALHM6"
                     /gene_synonym="C6orf187; dJ93H18.5; FAM26F; INAM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1114..1119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALHM6"
                     /gene_synonym="C6orf187; dJ93H18.5; FAM26F; INAM"
                     /note="hexamer: AATAAA"
     polyA_site      1127
                     /gene="CALHM6"
                     /gene_synonym="C6orf187; dJ93H18.5; FAM26F; INAM"
                     /note="major polyA site"
ORIGIN      
        1 gctgatttag cttatggaag aggaaccaga aatttgtcct tgaataatgt ttcccgacaa
       61 cgaagaggca gaaggatctg ggcctgtgcg cgacgccccg ggggacgagg ctcatggaga
      121 agtttcgggc ggtgctggac ctgcacgtca agcaccacag cgccttgggc tacggcctgg
      181 tgaccctgct gacggcgggc ggggagcgca tcttctccgc cgtggcattc cagtgcccgt
      241 gcagcgccgc ctggaacctg ccctacggcc tggtcttctt gctggtgccg gcgctcgcgc
      301 tcttcctcct gggctacgtg ctgagcgcac gcacgtggcg cctgctcacc ggatgctgct
      361 ccagcgcccg cgcgagttgc ggatcggcgc tgcgcggctc cctggtgtgc acgcaaatca
      421 gcgcggccgc cgcgctcgcg cccctcacct gggtggccgt ggcgctgctc gggggcgcct
      481 tttacgagtg cgcggccacc gggagcgcgg ccttcgcgca gcgcctgtgc ctcggccgca
      541 accgcagctg cgccgcggag ctgccgctgg tgccgtgcaa ccaggccaag gcgtcggacg
      601 tgcaggacct cctgaaggat ctgaaggctc agtcgcaggt gttgggctgg atcttgatag
      661 cagttgttat catcattctt ctgattttta catctgtcac ccgatgccta tctccagtta
      721 gttttctgca gctgaaattc tggaaaatct atttggaaca ggagcagcag atccttaaaa
      781 gtaaagccac agagcatgca actgaattgg caaaagagaa tattaaatgt ttctttgagg
      841 gctcgcatcc aaaagaatat aacactccaa gcatgaaaga gtggcagcaa atttcatcac
      901 tgtatacttt caatccgaag ggccagtact acagcatgtt gcacaaatat gtcaacagaa
      961 aagagaagac tcacagtatc aggtctactg aaggagatac ggtgattcct gttcttggct
     1021 ttgtagattc atctggtata aacagcactc ctgagttatg accttttgaa tgagtagaaa
     1081 aaaaaattgt tttgaattat tgctttatta aaaaataaac attggta
//
