LOCUS       NM_001366078            3904 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens calcium homeostasis modulator family member 4
            (CALHM4), transcript variant 5, mRNA.
ACCESSION   NM_001366078 XM_005266860
VERSION     NM_001366078.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3904)
  AUTHORS   Drozdzyk,K., Peter,M. and Dutzler,R.
  TITLE     Structural features of heteromeric channels composed of CALHM2 and
            CALHM4 paralogs
  JOURNAL   Elife 13, 96138 (2024)
   PUBMED   38896440
  REMARK    GeneRIF: Structural features of heteromeric channels composed of
            CALHM2 and CALHM4 paralogs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3904)
  AUTHORS   Drozdzyk,K., Sawicka,M., Bahamonde-Santos,M.I., Jonas,Z.,
            Deneka,D., Albrecht,C. and Dutzler,R.
  TITLE     Cryo-EM structures and functional properties of CALHM channels of
            the human placenta
  JOURNAL   Elife 9, e55853 (2020)
   PUBMED   32374262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121953.21.
            
            On Mar 24, 2021 this sequence version replaced NM_001366078.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.2772043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368596.4/ ENSP00000357585.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-601               AL121953.21        49827-50427
            602-3904            AL121953.21        53901-57203
FEATURES             Location/Qualifiers
     source          1..3904
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.1"
     gene            1..3904
                     /gene="CALHM4"
                     /gene_synonym="C6orf78; FAM26D"
                     /note="calcium homeostasis modulator family member 4"
                     /db_xref="GeneID:221301"
                     /db_xref="HGNC:HGNC:21094"
     exon            1..601
                     /gene="CALHM4"
                     /gene_synonym="C6orf78; FAM26D"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..988
                     /gene="CALHM4"
                     /gene_synonym="C6orf78; FAM26D"
                     /note="isoform 5 is encoded by transcript variant 5;
                     protein FAM26D; family with sequence similarity 26 member
                     D; calcium homeostasis modulator protein 4"
                     /codon_start=1
                     /product="calcium homeostasis modulator protein 4 isoform
                     5"
                     /protein_id="NP_001353007.1"
                     /db_xref="CCDS:CCDS93991.1"
                     /db_xref="GeneID:221301"
                     /db_xref="HGNC:HGNC:21094"
                     /translation="MCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQ
                     VGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACL
                     RFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGF
                     PCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQH
                     CYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDIS
                     VPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKP"
     exon            602..3904
                     /gene="CALHM4"
                     /gene_synonym="C6orf78; FAM26D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1333..1338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALHM4"
                     /gene_synonym="C6orf78; FAM26D"
                     /note="hexamer: ATTAAA"
     polyA_site      1352
                     /gene="CALHM4"
                     /gene_synonym="C6orf78; FAM26D"
                     /note="major polyA site"
     regulatory      3880..3885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALHM4"
                     /gene_synonym="C6orf78; FAM26D"
                     /note="hexamer: AATAAA"
     polyA_site      3904
                     /gene="CALHM4"
                     /gene_synonym="C6orf78; FAM26D"
ORIGIN      
        1 atcagaaagg gccacaagct gatttgtgta acagcttccc aagatgtgcc caactctcaa
       61 caatattgtg tcttctctgc agagaaatgg aatatttatc aattctttaa ttgcagcctt
      121 gactattggt gggcaacaac tcttctcctc ttctacattc agctgtcctt gtcaggttgg
      181 aaaaaatttc tattatggtt ctgcttttct tgtcattcct gccttgatcc ttctcgttgc
      241 tggctttgct ctgagaagcc aaatgtggac aattaccggt gaatactgct gcagctgtgc
      301 ccctccatac aggagaatca gccccctaga gtgcaagctg gcttgcctta ggttcttcag
      361 catcactggg agggcagtta ttgctccttt aacttggctg gcggtgaccc tgctgacagg
      421 cacgtattat gaatgtgcag caagtgaatt tgcatctgtg gaccattacc caatgtttga
      481 taatgtcagt gccagcaaac gagaagagat cctggctggg tttccatgtt gcagatcagc
      541 tccttctgac gtgatcctag taagagatga aatagctctt ctgcacagat accagtcaca
      601 gatgctgggt tggattttga tcaccttggc aaccattgct gccttagtct cctgctgtgt
      661 ggcaaagtgc tgctctcccc tcacctctct gcaacattgc tactggacca gccacctcca
      721 gaatgagaga gaactctttg aacaagcagc agagcagcac tctcggctcc tcatgatgca
      781 tcgcataaag aagctatttg gcttcattcc cgggagtgaa gacgtcaaac acatccgcat
      841 tccttcttgt caggactgga aagatatttc agtacccact cttttatgca tgggtgatga
      901 cttgcaaggt cactatagct tccttggaaa tagggtggat gaggataatg aggaagacag
      961 atcaagaggt attgaattaa aaccttgatt acagcacctt tcatgagtca ggttgcttag
     1021 cagatacttg gcttttatgg cttttatgat caggccattt caatgtaatc tcttcatctt
     1081 tttctttctc tctgatattt gtttacgtaa gtccatctca aatattattt ctaaaatcaa
     1141 tctattagat aattgtgcca atctctcatt ttgaaatttt gccaatggtc tggtaatgcc
     1201 tagagtggaa tgtgaagtca catggaaatt tgcatcttag ttctgttact tagtagctgt
     1261 gtgaaaatta atatttctga gtgccatttt gtcatctgca cattgtagct acctcctaga
     1321 gctattatga gaattaaaca tgataataca aagtgtttag cacagtgtct ttcataaaaa
     1381 tagatgctaa tgaatgttac tttctctctt tctcttttgc attccatgtc ttctattcac
     1441 cattttccct gcctctattt tctggtttta tcagtttcta cctttatata atgtccagaa
     1501 cttttcacag cctccccctc tttcttcaga cctaaatatc tgaccttttg ggaagcagga
     1561 cagaaacctc tttctaatcc agtaacatgt gagggagaag cccatgcagg aagctcttga
     1621 gttactgtac tataacctgg ggacaatgat atattattta tcattattag tatcatgtta
     1681 tttgtagcac ctccatacta ggagcatttt tatggccact acatataaag tttcttctag
     1741 aaagcttctc cactgtgctc tactccagag ataccatttg taccttttca ttaccaaatt
     1801 gcacctttgc actcaaaatc catttgtgaa accaaaactg cagtctgtac ttgtatatcc
     1861 attatctgta actacaaaag aggataattc ctgcttggtg ttgctctgcc tggctttact
     1921 aaatgcagcc tacagtatct ggacaatttt ctaatttatc tagattattt ctgtgatata
     1981 tagtgactcg tgcctgattt ttgctacgtt cactgaagca acttgctcat tagcaaaaat
     2041 aagttgtctg agggcattct gtctatttat ttcttcagtc aaaacaatgc ttactggaca
     2101 gtggaccaac tgccaatagt caatccaatt ttcaagattc actttcaagg agaccaagga
     2161 acttgactat actatctaaa atgcaatcaa ttacttggta atctactttt acacaattat
     2221 ggaaggtttt attttctata aagttctggg tccttgaact taataggaag aagcagaaaa
     2281 tgaattttta agaaatcaaa atgttttcag gttttgtttt gtccttcaat aagagactgc
     2341 atattgtagc tctttgctgg gacaggagaa ctgtcctgcc ctcaccatta ctcatctgtc
     2401 atttgacctt ggacaaatca gtccatctct ctggaccctg gatttttttc atctatacaa
     2461 taaaagggat gataatattt tacctcttgg aagaaaataa ctgaactaaa taactgctta
     2521 aggtctcttt tacatcaagt acgattttta tgtttatgtt tatatatata tacaggtcaa
     2581 tatgcataca tctttctgaa atggtagtag acccacgttg cttctcttgg aaggaaaatg
     2641 tccccaactc tgaatctgag ctttctctga aaacatttac tggcattcca cttttaaaag
     2701 aatgttaatg tactgatctt tttcaagtca tcaaggaaag ccattccagt ttgtctacta
     2761 actctacact cagtactgat atgacattac atgaaggatg ttaaaaatac aaatagaagt
     2821 atgttgtgga aggcaactag ggttctagtt ccacactgat acaaatgaac tgtgtaaata
     2881 tggaatgtca catccatttt gttccctaag gtctgctcca gttctaaaat tctgttccta
     2941 tataactgat aattttttat attcttctgt attggaacat actagttaaa tgaacacttt
     3001 caaccatgct cagaattagt ttattagttg tcaggaacta taccacagta aagactcttc
     3061 aataagattt tcggttaaca acaaaatcaa agaatatttg aagttatagc attacatcat
     3121 cagaaagaag attaatagtt gtttataccc taataccagg aaactatttc cactagcttc
     3181 tgaagccctt ctacatcaaa ctcttttagt gtatgatgta aaaattttat attttgagcc
     3241 agttaatcat gatcttcccc tataactttc tggcaaagga ttctaagtat tcgttggctc
     3301 ttctacatgg cttcagaatg atttatagca tctatgtgaa catttaaaag gtagtacaca
     3361 cccctgggat ttcatcttac agtacattat ctatctcaga tcaaataaat ggaattttta
     3421 gtattttggg gggggggggg gctatggtct atagcatttt tttgctccac agctagttaa
     3481 atgaaacttt ttcattaaga acatggtact ccctcccctt tatgcttaat ggatttatgt
     3541 aattataaaa catataatta aagtcaatta tgtgctaata ctactttata ttttgctacc
     3601 aaatgctttt ggctaccaca tcaaaccctg gagcttgaca tatataaacc tgctcctttc
     3661 ttaatttcat tagctcctcc acggtcccat catgacctaa gttgccacct tcccaggaga
     3721 caaatacaaa ccaatgtgta aatgtgtttt actcagcttt ctttatgttt tccaaagctg
     3781 aattgtagaa ccgcatttat actctgtcct tctctgtgtc tcttttctct gttctcagtc
     3841 ttccattcat tttttgtaga aattctaatg catgattgta ataaacaaca gtgagatttt
     3901 gcta
//
