LOCUS       NM_001129742            1652 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens calcium homeostasis modulator 3 (CALHM3), mRNA.
ACCESSION   NM_001129742 XM_001723060 XM_001725622 XM_001725818
VERSION     NM_001129742.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1652)
  AUTHORS   Sundell,G.N., Arnold,R., Ali,M., Naksukpaiboon,P., Orts,J.,
            Guntert,P., Chi,C.N. and Ivarsson,Y.
  TITLE     Proteome-wide analysis of phospho-regulated PDZ domain interactions
  JOURNAL   Mol Syst Biol 14 (8), e8129 (2018)
   PUBMED   30126976
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1652)
  AUTHORS   Ripke,S., O'Dushlaine,C., Chambert,K., Moran,J.L., Kahler,A.K.,
            Akterin,S., Bergen,S.E., Collins,A.L., Crowley,J.J., Fromer,M.,
            Kim,Y., Lee,S.H., Magnusson,P.K., Sanchez,N., Stahl,E.A.,
            Williams,S., Wray,N.R., Xia,K., Bettella,F., Borglum,A.D.,
            Bulik-Sullivan,B.K., Cormican,P., Craddock,N., de Leeuw,C.,
            Durmishi,N., Gill,M., Golimbet,V., Hamshere,M.L., Holmans,P.,
            Hougaard,D.M., Kendler,K.S., Lin,K., Morris,D.W., Mors,O.,
            Mortensen,P.B., Neale,B.M., O'Neill,F.A., Owen,M.J.,
            Milovancevic,M.P., Posthuma,D., Powell,J., Richards,A.L.,
            Riley,B.P., Ruderfer,D., Rujescu,D., Sigurdsson,E., Silagadze,T.,
            Smit,A.B., Stefansson,H., Steinberg,S., Suvisaari,J., Tosato,S.,
            Verhage,M., Walters,J.T., Levinson,D.F., Gejman,P.V., Kendler,K.S.,
            Laurent,C., Mowry,B.J., O'Donovan,M.C., Owen,M.J., Pulver,A.E.,
            Riley,B.P., Schwab,S.G., Wildenauer,D.B., Dudbridge,F., Holmans,P.,
            Shi,J., Albus,M., Alexander,M., Campion,D., Cohen,D., Dikeos,D.,
            Duan,J., Eichhammer,P., Godard,S., Hansen,M., Lerer,F.B.,
            Liang,K.Y., Maier,W., Mallet,J., Nertney,D.A., Nestadt,G.,
            Norton,N., O'Neill,F.A., Papadimitriou,G.N., Ribble,R.,
            Sanders,A.R., Silverman,J.M., Walsh,D., Williams,N.M., Wormley,B.,
            Arranz,M.J., Bakker,S., Bender,S., Bramon,E., Collier,D.,
            Crespo-Facorro,B., Hall,J., Iyegbe,C., Jablensky,A., Kahn,R.S.,
            Kalaydjieva,L., Lawrie,S., Lewis,C.M., Lin,K., Linszen,D.H.,
            Mata,I., McIntosh,A., Murray,R.M., Ophoff,R.A., Powell,J.,
            Rujescu,D., Van Os,J., Walshe,M., Weisbrod,M., Wiersma,D.,
            Donnelly,P., Barroso,I., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A.P., Deloukas,P., Duncanson,A., Jankowski,J.,
            Markus,H.S., Mathew,C.G., Palmer,C.N., Plomin,R., Rautanen,A.,
            Sawcer,S.J., Trembath,R.C., Viswanathan,A.C., Wood,N.W.,
            Spencer,C.C., Band,G., Bellenguez,C., Freeman,C., Hellenthal,G.,
            Giannoulatou,E., Pirinen,M., Pearson,R.D., Strange,A., Su,Z.,
            Vukcevic,D., Donnelly,P., Langford,C., Hunt,S.E., Edkins,S.,
            Gwilliam,R., Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M.,
            Gray,E., Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M.,
            Tashakkori-Ghanbaria,A., Waller,M.J., Weston,P., Widaa,S.,
            Whittaker,P., Barroso,I., Deloukas,P., Mathew,C.G., Blackwell,J.M.,
            Brown,M.A., Corvin,A.P., McCarthy,M.I., Spencer,C.C., Bramon,E.,
            Corvin,A.P., O'Donovan,M.C., Stefansson,K., Scolnick,E.,
            Purcell,S., McCarroll,S.A., Sklar,P., Hultman,C.M. and
            Sullivan,P.F.
  CONSRTM   Multicenter Genetic Studies of Schizophrenia Consortium; Psychosis
            Endophenotypes International Consortium; Wellcome Trust Case
            Control Consortium 2
  TITLE     Genome-wide association analysis identifies 13 new risk loci for
            schizophrenia
  JOURNAL   Nat Genet 45 (10), 1150-1159 (2013)
   PUBMED   23974872
REFERENCE   3  (bases 1 to 1652)
  AUTHORS   Shibata,N., Kuerban,B., Komatsu,M., Ohnuma,T., Baba,H. and Arai,H.
  TITLE     Genetic association between CALHM1, 2, and 3 polymorphisms and
            Alzheimer's disease in a Japanese population
  JOURNAL   J Alzheimers Dis 20 (2), 417-421 (2010)
   PUBMED   20164573
  REMARK    GeneRIF: This study failed to show an association between theeight
            SNPs of the CALHM3 genes and alzheimer disease.
            GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   4  (bases 1 to 1652)
  AUTHORS   Dreses-Werringloer,U., Lambert,J.C., Vingtdeux,V., Zhao,H.,
            Vais,H., Siebert,A., Jain,A., Koppel,J., Rovelet-Lecrux,A.,
            Hannequin,D., Pasquier,F., Galimberti,D., Scarpini,E., Mann,D.,
            Lendon,C., Campion,D., Amouyel,P., Davies,P., Foskett,J.K.,
            Campagne,F. and Marambaud,P.
  TITLE     A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels,
            and Alzheimer's disease risk
  JOURNAL   Cell 133 (7), 1149-1161 (2008)
   PUBMED   18585350
REFERENCE   5  (bases 1 to 1652)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1652)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC043367.1, AL139339.22 and BC039499.1.
            
            On May 17, 2019 this sequence version replaced NM_001129742.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043367.1, SRR1803617.15559.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369783.4/ ENSP00000358798.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               BC043367.1         1-188
            189-189             AL139339.22        56513-56513         c
            190-1038            BC043367.1         190-1038
            1039-1421           BC043367.1         1057-1439
            1422-1422           AL139339.22        50495-50495         c
            1423-1652           BC039499.1         817-1046
FEATURES             Location/Qualifiers
     source          1..1652
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.33"
     gene            1..1652
                     /gene="CALHM3"
                     /gene_synonym="bA225H22.7; FAM26A"
                     /note="calcium homeostasis modulator 3"
                     /db_xref="GeneID:119395"
                     /db_xref="HGNC:HGNC:23458"
                     /db_xref="MIM:618263"
     exon            1..495
                     /gene="CALHM3"
                     /gene_synonym="bA225H22.7; FAM26A"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1243
                     /gene="CALHM3"
                     /gene_synonym="bA225H22.7; FAM26A"
                     /note="family with sequence similarity 26, member A;
                     protein A"
                     /codon_start=1
                     /product="calcium homeostasis modulator protein 3"
                     /protein_id="NP_001123214.1"
                     /db_xref="CCDS:CCDS44476.1"
                     /db_xref="GeneID:119395"
                     /db_xref="HGNC:HGNC:23458"
                     /db_xref="MIM:618263"
                     /translation="MDKFRMLFQHFQSSSESVMNGICLLLAAVTVKLYSSFDFNCPCL
                     VHYNALYGLGLLLTPPLALFLCGLLANRQSVVMVEEWRRPAGHRRKDPGIIRYMCSSV
                     LQRALAAPLVWILLALLDGKCFVCAFSSSVDPEKFLDFANMTPSQVQLFLAKVPCKED
                     ELVRDSPARKAVSRYLRCLSQAIGWSVTLLLIIAAFLARCLRPCFDQTVFLQRRYWSN
                     YVDLEQKLFDETCCEHARDFAHRCVLHFFASMRSELQARGLRRGNAGRRLELPAVPEP
                     PEGLDSGSGKAHLRAISSREQVDRLLSTWYSSKPPLDLAASPGLCGGGLSHRAPTLAL
                     GTRLSQHTDV"
     exon            496..751
                     /gene="CALHM3"
                     /gene_synonym="bA225H22.7; FAM26A"
                     /inference="alignment:Splign:2.1.0"
     exon            752..1652
                     /gene="CALHM3"
                     /gene_synonym="bA225H22.7; FAM26A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1618..1623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALHM3"
                     /gene_synonym="bA225H22.7; FAM26A"
                     /note="hexamer: AATAAT"
     regulatory      1624..1629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALHM3"
                     /gene_synonym="bA225H22.7; FAM26A"
                     /note="hexamer: AATAAT"
     polyA_site      1632
                     /gene="CALHM3"
                     /gene_synonym="bA225H22.7; FAM26A"
                     /note="major polyA site"
     polyA_site      1636
                     /gene="CALHM3"
                     /gene_synonym="bA225H22.7; FAM26A"
                     /note="major polyA site"
     polyA_site      1652
                     /gene="CALHM3"
                     /gene_synonym="bA225H22.7; FAM26A"
                     /note="major polyA site"
ORIGIN      
        1 gcctgtccct gccttaagtg cctactggat cccgggagcc tgggctgggg cctgggcact
       61 gcttcctcct tggcccctca ggcccttgga agcagagaga gaacctcttg cagatcccag
      121 gctcgtcccc agcacagcag acaccaggaa ggtggccaga gcctcactga gccgaaccga
      181 cggccgccca cccacccagg ctggagccat ggataaattc cgcatgctct tccagcactt
      241 ccagtcaagc tcggagtcgg tgatgaatgg catctgcctg ctgctggctg cggtcaccgt
      301 caagctgtac tcctcctttg acttcaactg tccctgcctg gtgcactaca atgcactcta
      361 cggcctgggc ctgctgctga cgcccccgct cgccctgttt ctctgcggcc tcctcgccaa
      421 ccggcagtct gtggtgatgg tcgaggagtg gcgccggccc gcagggcacc ggaggaagga
      481 cccaggcatc atcaggtaca tgtgctcctc tgtgctgcag agggcgctgg ccgcccccct
      541 ggtctggatc ctgctggccc tccttgacgg gaagtgcttc gtgtgtgcct tcagcagctc
      601 tgtggaccct gagaagtttc tggactttgc caacatgacc cccagccagg tacagctctt
      661 cctggccaag gttccctgca aggaggatga gctggtcagg gatagccctg ctcggaaggc
      721 agtgtctcgc tacctgcggt gcctgtcaca ggccatcggc tggagcgtca ccctgctgct
      781 gatcatcgcg gccttcctgg cccgctgcct gaggccctgc ttcgaccaga cagtcttcct
      841 gcagcgcaga tactggagca actacgtgga cctggagcag aagctcttcg acgagacctg
      901 ctgtgagcat gcgcgggact tcgcgcaccg ctgcgtgctg cacttctttg ccagcatgcg
      961 gagtgagctg caggcgcggg ggctgcgccg gggcaatgca ggcaggagac tcgagctccc
     1021 cgcagtgcct gagcccccag aaggcctgga tagtggaagt gggaaggccc acctgcgcgc
     1081 aatctccagc cgggagcagg tggaccgcct cctaagcacg tggtactcca gcaagccgcc
     1141 gctggacctg gctgcatccc ccgggctctg cgggggtggc cttagccacc gcgcccctac
     1201 cttggcactg ggcacgaggc tgtcacaaca caccgacgtg tagggtcctg gccaggcttg
     1261 aagcggcagt gttcgcaggt gaaatgccgc gctgacaaag ttctggagtc tttccaggcc
     1321 gtggggaccc cacggcaggc accctaagtc ttgttagcct cctttttaaa gtagcccaat
     1381 ctctgcctag tttctgggtg tggcctccag cgcgcttcac aaactttaat gtggactcgg
     1441 ttcaccgagg gccttgttaa atacaggttc agacagtgta gccaggaccg agtctgagat
     1501 tctgcatttt aaacaagctc ctggaggctg atgtgctttt ggtcagtgaa ccaaactttg
     1561 agtagcaaga atctaagtaa atctgccatg ggttctgggt tctagatgtc aattctaaat
     1621 aataataatg accttagtct gctgcctcga ta
//
