LOCUS       NM_015916               1914 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens calcium homeostasis modulator family member 2
            (CALHM2), transcript variant 1, mRNA.
ACCESSION   NM_015916
VERSION     NM_015916.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1914)
  AUTHORS   Drozdzyk,K., Peter,M. and Dutzler,R.
  TITLE     Structural features of heteromeric channels composed of CALHM2 and
            CALHM4 paralogs
  JOURNAL   Elife 13, 96138 (2024)
   PUBMED   38896440
  REMARK    GeneRIF: Structural features of heteromeric channels composed of
            CALHM2 and CALHM4 paralogs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1914)
  AUTHORS   Demura,K., Kusakizako,T., Shihoya,W., Hiraizumi,M., Nomura,K.,
            Shimada,H., Yamashita,K., Nishizawa,T., Taruno,A. and Nureki,O.
  TITLE     Cryo-EM structures of calcium homeostasis modulator channels in
            diverse oligomeric assemblies
  JOURNAL   Sci Adv 6 (29), eaba8105 (2020)
   PUBMED   32832629
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1914)
  AUTHORS   Syrjanen,J.L., Michalski,K., Chou,T.H., Grant,T., Rao,S.,
            Simorowski,N., Tucker,S.J., Grigorieff,N. and Furukawa,H.
  TITLE     Structure and assembly of calcium homeostasis modulator proteins
  JOURNAL   Nat Struct Mol Biol 27 (2), 150-159 (2020)
   PUBMED   31988524
  REMARK    GeneRIF: Molecular dynamics simulations suggest that lipids can
            favorably assemble into a bilayer within the larger human CALHM2
            pore, but not within chicken CALHM1, demonstrating the potential
            correlation between pore size, lipid accommodation and channel
            activity.
            Erratum:[Nat Struct Mol Biol. 2020 Mar;27(3):305. doi:
            10.1038/s41594-020-0396-6.. PMID: 32066965]
REFERENCE   4  (bases 1 to 1914)
  AUTHORS   Choi,W., Clemente,N., Sun,W., Du,J. and Lu,W.
  TITLE     The structures and gating mechanism of human calcium homeostasis
            modulator 2
  JOURNAL   Nature 576 (7785), 163-167 (2019)
   PUBMED   31776515
  REMARK    GeneRIF: shows that purified CALHM2 channels form both gap
            junctions and undecameric hemichannels
REFERENCE   5  (bases 1 to 1914)
  AUTHORS   Ripke,S., O'Dushlaine,C., Chambert,K., Moran,J.L., Kahler,A.K.,
            Akterin,S., Bergen,S.E., Collins,A.L., Crowley,J.J., Fromer,M.,
            Kim,Y., Lee,S.H., Magnusson,P.K., Sanchez,N., Stahl,E.A.,
            Williams,S., Wray,N.R., Xia,K., Bettella,F., Borglum,A.D.,
            Bulik-Sullivan,B.K., Cormican,P., Craddock,N., de Leeuw,C.,
            Durmishi,N., Gill,M., Golimbet,V., Hamshere,M.L., Holmans,P.,
            Hougaard,D.M., Kendler,K.S., Lin,K., Morris,D.W., Mors,O.,
            Mortensen,P.B., Neale,B.M., O'Neill,F.A., Owen,M.J.,
            Milovancevic,M.P., Posthuma,D., Powell,J., Richards,A.L.,
            Riley,B.P., Ruderfer,D., Rujescu,D., Sigurdsson,E., Silagadze,T.,
            Smit,A.B., Stefansson,H., Steinberg,S., Suvisaari,J., Tosato,S.,
            Verhage,M., Walters,J.T., Levinson,D.F., Gejman,P.V., Kendler,K.S.,
            Laurent,C., Mowry,B.J., O'Donovan,M.C., Owen,M.J., Pulver,A.E.,
            Riley,B.P., Schwab,S.G., Wildenauer,D.B., Dudbridge,F., Holmans,P.,
            Shi,J., Albus,M., Alexander,M., Campion,D., Cohen,D., Dikeos,D.,
            Duan,J., Eichhammer,P., Godard,S., Hansen,M., Lerer,F.B.,
            Liang,K.Y., Maier,W., Mallet,J., Nertney,D.A., Nestadt,G.,
            Norton,N., O'Neill,F.A., Papadimitriou,G.N., Ribble,R.,
            Sanders,A.R., Silverman,J.M., Walsh,D., Williams,N.M., Wormley,B.,
            Arranz,M.J., Bakker,S., Bender,S., Bramon,E., Collier,D.,
            Crespo-Facorro,B., Hall,J., Iyegbe,C., Jablensky,A., Kahn,R.S.,
            Kalaydjieva,L., Lawrie,S., Lewis,C.M., Lin,K., Linszen,D.H.,
            Mata,I., McIntosh,A., Murray,R.M., Ophoff,R.A., Powell,J.,
            Rujescu,D., Van Os,J., Walshe,M., Weisbrod,M., Wiersma,D.,
            Donnelly,P., Barroso,I., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A.P., Deloukas,P., Duncanson,A., Jankowski,J.,
            Markus,H.S., Mathew,C.G., Palmer,C.N., Plomin,R., Rautanen,A.,
            Sawcer,S.J., Trembath,R.C., Viswanathan,A.C., Wood,N.W.,
            Spencer,C.C., Band,G., Bellenguez,C., Freeman,C., Hellenthal,G.,
            Giannoulatou,E., Pirinen,M., Pearson,R.D., Strange,A., Su,Z.,
            Vukcevic,D., Donnelly,P., Langford,C., Hunt,S.E., Edkins,S.,
            Gwilliam,R., Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M.,
            Gray,E., Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M.,
            Tashakkori-Ghanbaria,A., Waller,M.J., Weston,P., Widaa,S.,
            Whittaker,P., Barroso,I., Deloukas,P., Mathew,C.G., Blackwell,J.M.,
            Brown,M.A., Corvin,A.P., McCarthy,M.I., Spencer,C.C., Bramon,E.,
            Corvin,A.P., O'Donovan,M.C., Stefansson,K., Scolnick,E.,
            Purcell,S., McCarroll,S.A., Sklar,P., Hultman,C.M. and
            Sullivan,P.F.
  CONSRTM   Multicenter Genetic Studies of Schizophrenia Consortium; Psychosis
            Endophenotypes International Consortium; Wellcome Trust Case
            Control Consortium 2
  TITLE     Genome-wide association analysis identifies 13 new risk loci for
            schizophrenia
  JOURNAL   Nat Genet 45 (10), 1150-1159 (2013)
   PUBMED   23974872
REFERENCE   6  (bases 1 to 1914)
  AUTHORS   Shibata,N., Kuerban,B., Komatsu,M., Ohnuma,T., Baba,H. and Arai,H.
  TITLE     Genetic association between CALHM1, 2, and 3 polymorphisms and
            Alzheimer's disease in a Japanese population
  JOURNAL   J Alzheimers Dis 20 (2), 417-421 (2010)
   PUBMED   20164573
  REMARK    GeneRIF: This study failed to show an association between theeight
            SNPs of the CALHM2 genes and alzheimer disease.
            GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   7  (bases 1 to 1914)
  AUTHORS   Dreses-Werringloer,U., Lambert,J.C., Vingtdeux,V., Zhao,H.,
            Vais,H., Siebert,A., Jain,A., Koppel,J., Rovelet-Lecrux,A.,
            Hannequin,D., Pasquier,F., Galimberti,D., Scarpini,E., Mann,D.,
            Lendon,C., Campion,D., Amouyel,P., Davies,P., Foskett,J.K.,
            Campagne,F. and Marambaud,P.
  TITLE     A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels,
            and Alzheimer's disease risk
  JOURNAL   Cell 133 (7), 1149-1161 (2008)
   PUBMED   18585350
REFERENCE   8  (bases 1 to 1914)
  AUTHORS   Wang,L., Gao,X., Gao,P., Deng,W., Yu,P., Ma,J., Guo,J., Wang,X.,
            Cheng,H., Zhang,C., Yu,C., Ma,X., Lv,B., Lu,Y., Shi,T. and Ma,D.
  TITLE     Cell-based screening and validation of human novel genes associated
            with cell viability
  JOURNAL   J Biomol Screen 11 (4), 369-376 (2006)
   PUBMED   16751333
REFERENCE   9  (bases 1 to 1914)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 1914)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB109582.1, BC000039.2 and CA432041.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015916.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the functional protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.67748.1, BC000039.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398, SAMEA2154125
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260743.10/ ENSP00000260743.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                DB109582.1         36-87
            53-1723             BC000039.2         1-1671
            1724-1914           CA432041.1         18-208              c
FEATURES             Location/Qualifiers
     source          1..1914
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.33"
     gene            1..1914
                     /gene="CALHM2"
                     /gene_synonym="FAM26B"
                     /note="calcium homeostasis modulator family member 2"
                     /db_xref="GeneID:51063"
                     /db_xref="HGNC:HGNC:23493"
                     /db_xref="MIM:612235"
     exon            1..215
                     /gene="CALHM2"
                     /gene_synonym="FAM26B"
                     /inference="alignment:Splign:2.1.0"
     exon            216..418
                     /gene="CALHM2"
                     /gene_synonym="FAM26B"
                     /inference="alignment:Splign:2.1.0"
     exon            419..1131
                     /gene="CALHM2"
                     /gene_synonym="FAM26B"
                     /inference="alignment:Splign:2.1.0"
     CDS             577..1548
                     /gene="CALHM2"
                     /gene_synonym="FAM26B"
                     /note="family with sequence similarity 26, member B;
                     calcium homeostasis modulator 2"
                     /codon_start=1
                     /product="calcium homeostasis modulator protein 2"
                     /protein_id="NP_057000.2"
                     /db_xref="CCDS:CCDS7549.1"
                     /db_xref="GeneID:51063"
                     /db_xref="HGNC:HGNC:23493"
                     /db_xref="MIM:612235"
                     /translation="MAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAF
                     HCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLL
                     LSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARF
                     PCKENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEA
                     YWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELIANFPVEGTQPRP
                     QWNAITGVYLYRENQGLPLYSRLHKWAQGLAGNGAAPDNVEMALLPS"
     exon            1132..1914
                     /gene="CALHM2"
                     /gene_synonym="FAM26B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1890..1895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALHM2"
                     /gene_synonym="FAM26B"
                     /note="hexamer: GATAAA"
     polyA_site      1914
                     /gene="CALHM2"
                     /gene_synonym="FAM26B"
                     /note="major polyA site"
ORIGIN      
        1 cactcactgg cgcgcagact ccatcccact gttttcttct ctcttttctg gagttagatt
       61 agtctgaagc cgccaccagc cccaggcccc cgtgcagaag aaaagcggga gggaacggcg
      121 gaggccgccg ctgccctgca ccgccctcct ggaggccact tggagagtcc ggccccgagg
      181 aggccatggc cacaagtgcc cacagctggc cccaggttgc cagcgtcgct acagcccaga
      241 ccaaggcaga ataatctccg gatgagctgg tggcaccgct gagcctttgg tctcaccagg
      301 gcttcctgtt gctggcaggc ggggtggagc ggagctgctg ggaggctgct ggataggaga
      361 ggggtcacgg ctgcggaaga ggaggttctt cgggacaccc gtggatggac acggcaagga
      421 aacaccaggc caaccacagc tggggataaa atagcacaac cacaccctgc cgtccagcgc
      481 ctcccagcct gtgccccttc ctagtaccac cagcaaccat caatcccgtc tcctcctgcc
      541 tcctctcctg caatccaccc cgccacgact atcgccatgg cagccctgat cgcagagaac
      601 ttccgcttcc tgtcactttt cttcaagagc aaggatgtga tgattttcaa cggcctggtg
      661 gcactgggca cggtgggcag ccaggagctg ttctctgtgg tggccttcca ctgcccctgc
      721 tcgccggccc ggaactacct gtacgggctg gcggccatcg gcgtgcccgc cctggtgctc
      781 ttcatcattg gcatcatcct caacaaccac acctggaacc tcgtggccga gtgccagcac
      841 cggaggacca agaactgctc cgccgccccc accttcctcc ttctaagctc catcctggga
      901 cgtgcggctg tggcccctgt cacctggtct gtcatctccc tgctgcgtgg tgaggcttat
      961 gtctgtgctc tcagtgagtt cgtggaccct tcctcactca cggccaggga agagcacttc
     1021 ccatcagccc acgccactga aatcctggcc aggttcccct gcaaggagaa ccctgacaac
     1081 ctgtcagact tccgggagga ggtcagccgc aggctcaggt atgagtccca gctctttgga
     1141 tggctgctca tcggcgtggt ggccatcctg gtgttcctga ccaagtgcct caagcattac
     1201 tgctcaccac tcagctaccg ccaggaggcc tactgggcgc agtaccgcgc caatgaggac
     1261 cagctgttcc agcgcacggc cgaggtgcac tctcgggtgc tcgctgccaa caatgtgcgc
     1321 cgcttctttg gctttgtggc gctcaacaag gatgatgagg aactgattgc caacttccca
     1381 gtggaaggca cgcagccacg gccacagtgg aatgccatca ccggcgtcta cttgtaccgt
     1441 gagaaccagg gcctcccact ctacagccgc ctgcacaagt gggcccaggg tctggcaggc
     1501 aacggcgcgg cccctgacaa cgtggagatg gccctgctcc cctcctaagg aggtgcttcc
     1561 catgctcttt gtaaatggca ctacttggtc ccaaactgaa ccccactgct tgctcacatc
     1621 catatcagaa ggggattttt aaaaaactgt tatcttcttg gccaggggaa aggaccacaa
     1681 ggcaatctgg ggtgtggaca gacccagtag acaatggaag ccccagccag cagggccagg
     1741 tgacagtgaa gctcaccagt gggctccttt atggtactct atgcagttaa catgtatcta
     1801 gctgcatagg gacacccagc gcagcagtgc accactggga agtggcctcc agtgcagcct
     1861 ctggccttat tttatatatt taaatttttg ataaagtttt tcttactaaa agga
//
