LOCUS       NM_033138               5011 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens caldesmon 1 (CALD1), transcript variant 1, mRNA.
ACCESSION   NM_033138
VERSION     NM_033138.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5011)
  AUTHORS   Li,W., Huang,L., Qi,N., Zhang,Q. and Qin,Z.
  TITLE     Upregulation of CALD1 predicted a poor prognosis for
            platinum-treated ovarian cancer and revealed it as a potential
            therapeutic resistance target
  JOURNAL   BMC Genomics 25 (1), 183 (2024)
   PUBMED   38365611
  REMARK    GeneRIF: Upregulation of CALD1 predicted a poor prognosis for
            platinum-treated ovarian cancer and revealed it as a potential
            therapeutic resistance target.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5011)
  AUTHORS   Wu,S., Liu,M., Zhang,M., Ye,X., Gu,H., Jiang,C., Zhu,H., Ye,X.,
            Li,Q., Huang,X. and Cao,M.
  TITLE     The gene expression of CALD1, CDH2, and POSTN in fibroblast are
            related to idiopathic pulmonary fibrosis
  JOURNAL   Front Immunol 15, 1275064 (2024)
   PUBMED   38370408
  REMARK    GeneRIF: The gene expression of CALD1, CDH2, and POSTN in
            fibroblast are related to idiopathic pulmonary fibrosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5011)
  AUTHORS   Chen,R., Zhang,S., Li,H., Yang,M., Lu,Y. and Zhang,X.
  TITLE     METTL14 Promotes Oral Squamous Cell Carcinoma Progression by
            Regulating the mRNA and m6A Levels of CALD1
  JOURNAL   J Environ Pathol Toxicol Oncol 42 (3), 71-81 (2023)
   PUBMED   37017680
  REMARK    GeneRIF: METTL14 Promotes Oral Squamous Cell Carcinoma Progression
            by Regulating the mRNA and m6A Levels of CALD1.
REFERENCE   4  (bases 1 to 5011)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 5011)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   6  (bases 1 to 5011)
  AUTHORS   der Terrossian,E., Deprette,C., Lebbar,I. and Cassoly,R.
  TITLE     Purification and characterization of erythrocyte caldesmon.
            Hypothesis for an actin-linked regulation of a contractile activity
            in the red blood cell membrane
  JOURNAL   Eur J Biochem 219 (1-2), 503-511 (1994)
   PUBMED   8307018
REFERENCE   7  (bases 1 to 5011)
  AUTHORS   Hayashi,K., Yano,H., Hashida,T., Takeuchi,R., Takeda,O., Asada,K.,
            Takahashi,E., Kato,I. and Sobue,K.
  TITLE     Genomic structure of the human caldesmon gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (24), 12122-12126 (1992)
   PUBMED   1465449
REFERENCE   8  (bases 1 to 5011)
  AUTHORS   Adam,L.P., Gapinski,C.J. and Hathaway,D.R.
  TITLE     Phosphorylation sequences in h-caldesmon from phorbol
            ester-stimulated canine aortas
  JOURNAL   FEBS Lett 302 (3), 223-226 (1992)
   PUBMED   1601129
REFERENCE   9  (bases 1 to 5011)
  AUTHORS   Humphrey,M.B., Herrera-Sosa,H., Gonzalez,G., Lee,R. and Bryan,J.
  TITLE     Cloning of cDNAs encoding human caldesmons
  JOURNAL   Gene 112 (2), 197-204 (1992)
   PUBMED   1555769
REFERENCE   10 (bases 1 to 5011)
  AUTHORS   Novy,R.E., Lin,J.L. and Lin,J.J.
  TITLE     Characterization of cDNA clones encoding a human fibroblast
            caldesmon isoform and analysis of caldesmon expression in normal
            and transformed cells
  JOURNAL   J Biol Chem 266 (25), 16917-16924 (1991)
   PUBMED   1885618
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB090561.1, M83216.1,
            AC083870.2, DA546174.1, AU134367.1, CV573441.1, CA447404.1 and
            CN314587.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_033138.3.
            
            Summary: This gene encodes a calmodulin- and actin-binding protein
            that plays an essential role in the regulation of smooth muscle and
            nonmuscle contraction. The conserved domain of this protein
            possesses the binding activities to Ca(2+)-calmodulin, actin,
            tropomyosin, myosin, and phospholipids. This protein is a potent
            inhibitor of the actin-tropomyosin activated myosin MgATPase, and
            serves as a mediating factor for Ca(2+)-dependent inhibition of
            smooth muscle contraction. Alternative splicing of this gene
            results in multiple transcript variants encoding distinct isoforms.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1, also known as aorta h-CaD). It is predominantly expressed in
            smooth muscle tissues.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.225426.1,
                                           SRR1660805.214790.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361675.7/ ENSP00000354826.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DB090561.1         222-237
            17-367              M83216.1           1-351
            368-368             AC083870.2         105501-105501
            369-1434            M83216.1           353-1418
            1435-1435           AC083870.2         110655-110655
            1436-2837           M83216.1           1420-2821
            2838-3398           DA546174.1         18-578
            3399-3820           AU134367.1         194-615
            3821-4382           CV573441.1         51-612
            4383-4923           CA447404.1         15-555              c
            4924-5011           CN314587.1         301-388
FEATURES             Location/Qualifiers
     source          1..5011
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q33"
     gene            1..5011
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /note="caldesmon 1"
                     /db_xref="GeneID:800"
                     /db_xref="HGNC:HGNC:1441"
                     /db_xref="MIM:114213"
     exon            1..116
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /inference="alignment:Splign:2.1.0"
     exon            117..204
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /inference="alignment:Splign:2.1.0"
     exon            205..316
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..2627
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     testis secretory sperm-binding protein Li 227n"
                     /codon_start=1
                     /product="caldesmon isoform 1"
                     /protein_id="NP_149129.2"
                     /db_xref="CCDS:CCDS5835.1"
                     /db_xref="GeneID:800"
                     /db_xref="HGNC:HGNC:1441"
                     /db_xref="MIM:114213"
                     /translation="MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRR
                     ARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR
                     REERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERY
                     EIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTE
                     SQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEE
                     RERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEE
                     EKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQL
                     EEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREK
                     LQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTEN
                     TFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELE
                     ELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE
                     DGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQY
                     TSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKV
                     GVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV"
     exon            317..463
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /inference="alignment:Splign:2.1.0"
     exon            464..1553
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1631
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1777
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..2039
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2180
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2224
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2306
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2444
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2540
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2621
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..5011
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4898..4903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /note="hexamer: AATAAA"
     polyA_site      4923
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /note="major polyA site"
     regulatory      4982..4987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
                     /note="hexamer: AATAAA"
     polyA_site      5011
                     /gene="CALD1"
                     /gene_synonym="CDM; H-CAD; h-CD; HCAD; L-CAD; LCAD; NAG22"
ORIGIN      
        1 agtgtgtatt cggctgcctg cctgcccgcc tgcttgctct ctggctgtgc tcctgcttaa
       61 agaaatcagt ccttcctttc cgacttagtc ctcgggaaga agtttcagac tacaaggtat
      121 cattggaaca tttcaagatc atcaaatcaa attccacagg gattggtgac caaccagaag
      181 gctcagacat ctgattgctg acctgtccag acatcatctg gtctccctga acctgaaatc
      241 acaccatgga tgattttgag cgtcgcagag aacttagaag gcaaaagagg gaggagatgc
      301 gactcgaagc agaaagaatc gcctaccaga ggaatgacga tgatgaagag gaggcagccc
      361 gggaacggcg ccgccgagcc cgacaggaac ggctgcggca gaagcaggag gaagaatcct
      421 tgggacaggt gaccgaccag gtggaggtga atgcccagaa cagtgtgcct gacgaggagg
      481 ccaagacaac caccacaaac actcaagtgg aaggggatga tgaggccgca ttcctggagc
      541 gcctggctcg gcgtgaggaa agacgccaaa aacgccttca ggaggctctg gagcggcaga
      601 aggagttcga cccaacaata acagatgcaa gtctgtcgct cccaagcaga agaatgcaaa
      661 atgacacagc agaaaatgaa actaccgaga aggaagaaaa aagtgaaagt cgccaagaaa
      721 gatacgagat agaggaaaca gaaacagtca ccaagtccta ccagaagaat gattggaggg
      781 atgctgaaga aaacaagaaa gaagacaagg aaaaggagga ggaggaagag gagaagccaa
      841 agcgagggag cattggagaa aatcaggtag aggtgatggt ggaagagaaa acaactgaaa
      901 gccaggagga aacagtggta atgtcattaa aaaatgggca gatcagttca gaagagccta
      961 aacaagagga ggagagggaa caaggttcag atgagatttc ccatcatgaa aagatggaag
     1021 aggaagacaa ggaaagagct gaggcagaga gggcaaggtt ggaagcagaa gaaagagaaa
     1081 gaattaaagc cgagcaagac aaaaagatag cagatgaacg agcaagaatt gaagcagaag
     1141 aaaaagcagc tgcccaagaa agagaaagga gagaggcaga agagagggaa aggatgaggg
     1201 aggaagagaa aagggcagca gaggagaggc agaggataaa ggaggaagag aaaagggcag
     1261 cagaggagag gcagaggata aaggaggaag agaaaagggc agcagaggag aggcagagga
     1321 taaaagagga agagaaaagg gcagcagagg agaggcaaag ggccagggca gaggaggaag
     1381 agaaggctaa ggtagaagag cagaaacgta acaagcagct agaagagaaa aaacatgcca
     1441 tgcaagagac aaagataaaa ggggaaaagg tagaacagaa aatagaaggg aaatgggtaa
     1501 atgaaaagaa agcacaagaa gataaacttc agacagctgt cctaaagaaa cagggagaag
     1561 agaagggaac taaagtgcaa gctaaaagag aaaagctcca agaagacaag cctaccttca
     1621 aaaaagaaga gatcaaagat gaaaagatta aaaaggacaa agaacccaaa gaagaagtta
     1681 agagcttcat ggatcgaaag aagggattta cagaagttaa gtcgcagaat ggagaattca
     1741 tgacccacaa acttaaacat actgagaata ctttcagccg ccctggaggg agggccagcg
     1801 tggacaccaa ggaggctgag ggcgcccccc aggtggaagc cggcaaaagg ctggaggagc
     1861 ttcgtcgtcg tcgcggggag accgagagcg aagagttcga gaagctcaaa cagaagcagc
     1921 aggaggcggc tttggagctg gaggaactca agaaaaagag ggaggagaga aggaaggtcc
     1981 tggaggagga agagcagagg aggaagcagg aggaagccga tcgaaaactc agagaggagg
     2041 aagagaagag gaggctaaag gaagagattg aaaggcgaag agcagaagct gctgagaaac
     2101 gccagaagat gccagaagat ggcttgtcag atgacaagaa accattcaag tgtttcactc
     2161 ctaaaggttc atctctcaag atagaagagc gagcagaatt tttgaataag tctgtgcaga
     2221 aaagcagtgg tgtcaaatcg acccatcaag cagcaatagt ctccaagatt gacagcagac
     2281 tggagcagta taccagtgca attgagggaa caaaaagcgc aaaacctaca aagccggcag
     2341 cctcggatct tcctgttcct gctgaaggtg tacgcaacat caagagtatg tgggagaaag
     2401 ggaatgtgtt ttcatccccc actgcagcag gcacaccaaa taaggaaact gctggcttga
     2461 aggtaggggt ttctagccgc atcaatgaat ggctaactaa aaccccagat ggaaacaagt
     2521 cacctgctcc caaaccttct gacttgagac caggagacgt atccagcaag cggaacctct
     2581 gggaaaagca atctgtggat aaggtcactt cccccactaa ggtttgagac agttccagaa
     2641 agaacccaag ctcaagacgc aggacgagct cagttgtaga gggctaattc gctctgtttt
     2701 gtatttatgt tgatttacta aattgggttc attatctttt atttttcaat atcccagtaa
     2761 acccatgtat attatcacta tatttaataa tcacagtcta gagatgttca tggtaaaagt
     2821 actgcctttg cacaggagcc tgtttctaaa gaaacccatg ctgtgaaata gagacttttc
     2881 tactgatcat cataactctg tatctgagca gtgataccaa ccacatctga agtcaacaga
     2941 agatccaagt ttaaaattgc ctgcggaatg tgtgcagtat ctagaaaaat gaaccgtagt
     3001 ttttgttttt ttaaatacag aagtcatgtt gtttctgcac tttataataa agcatggaag
     3061 aaattatctt agtaggcaat tgtaacactt tttgaaagta acccatttca gatttgaaat
     3121 actgcaataa tggttgtctt taaaaaaaaa aaagaaatgt actgttaagg tattactttt
     3181 tttcatgctg atgattcata tctaaattac attattatgt tagctgacag tggtactgat
     3241 tttttaggtt ggttgttttg tggatttctt tagtagtgat agtagcctga accacatttt
     3301 agataactca attatgtatg tatgtgcata cacatataca aacacactaa tggtagaatg
     3361 cttttttatg tgctagacta ttatatttag tagtatgtca ttgtaactag ccaatatcac
     3421 agcttttgaa aaattaaaaa atcacactat attaatattt tatatttgcc aacagaaaca
     3481 tggcagatag gtatcaatat gttttcaatg cctgatgacc tataagaaga aagtattgaa
     3541 aagaagagag attagaactg ttagaaggag ttgaaatttt ctaaaagaca tagtatttag
     3601 tttataatta aatgcattct tgaagtccag tgtgaatttt attaatgcta tcatctcgac
     3661 caagctcaaa gcctacttat tagaaacaat gaagttcaca ataggtcata aggtctcttc
     3721 cttttctaaa attgaaagac aagaaattta gtgccaatat tgtacagaca gaaattccat
     3781 gtatgagtct caacaaagac tacctttggc taaatgtcta gaagcagaga agtaaagtga
     3841 gcaaaatcca gtgttgagga gtcatgacag tactttgatc tttatatact ctgaagcatt
     3901 tcttcaaact tttctacttt tatttgtcat tgatacctgt agtaagttga caatgtggtg
     3961 aaatttcaaa attatatgta acttctacta gttttacttt ctcccccaag tcttttttaa
     4021 ctcatgattt ttacacacac aatccagaac ttattatata gcctctaagt ctttattctt
     4081 cacagtagat aatgaaagag tcctccagtg tcttggcaaa atgttctagt atagctggat
     4141 acatacagtg gagttctata aactcatacc tcagtggact taaccaaaat tgtgttagtc
     4201 tcaattccta ccacactgag ggagcctccc aaataactat tttcttatct gcagtattcc
     4261 tccagaagag ctaaccaggg cagggctggc atgagaagtg acatctgcgt tacaaagtct
     4321 atcttcctca taagtctgta aagagcaatt gaatcttcta gctttagcaa acctaagcca
     4381 aaggaaggaa agccatgaag aatgcagaag tcaaaccctc atgacaaagt aggcacaagt
     4441 ctacaataag ctaaatcaga atttacaaat acaagtgtcc caggtagcat tgactcccgt
     4501 cattggagtg aaatggatca aagtttgaat taaggcctat ggtaaggtaa cattgctttg
     4561 ttgtactttt gaacaagagc tcctcctgat cactattaca tatttttcta gaaaatctaa
     4621 agttcagaag agaatgtatc actgctgact tttattccaa tatttggatg gagtaagttt
     4681 tagggtagaa ttttgttcag tttggattta atcttttgaa aagtaaattc cttgtttact
     4741 ggtttgacta taattctctg ttatctttac gaggtaaaac tgcaagctga ctagcatgtt
     4801 ctgtgaatct gccattccta aaaattttat aaacacttga tacttttcac tgataatgga
     4861 tcgctccaat aaacatatat tgtgaaaatg catccacaat aaatggaatt ccttcctgca
     4921 aaatgtcttt ttctcactta tttttatgta caatattgat agtgagaggt atgtctatta
     4981 taataaagat tatggcacag taaaacctgt a
//
