LOCUS       NM_001369435            6074 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens calcitonin receptor like receptor (CALCRL), transcript
            variant 4, mRNA.
ACCESSION   NM_001369435 XM_017003151
VERSION     NM_001369435.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6074)
  AUTHORS   Selvarajan,I., Kiema,M., Huang,R.T., Li,J., Zhu,J., Polonen,P.,
            Ord,T., Ounap,K., Godiwala,M., Golebiewski,A.K., Ravindran,A.,
            Maklin,K., Toropainen,A., Stolze,L.K., Arce,M., Magnusson,P.U.,
            White,S., Romanoski,C.E., Heinaniemi,M., Laakkonen,J.P., Fang,Y.
            and Kaikkonen,M.U.
  TITLE     Coronary Artery Disease Risk Variant Dampens the Expression of
            CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer
            in Endothelial Cells In Vitro
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (6), 1330-1345 (2024)
   PUBMED   38602103
  REMARK    GeneRIF: Coronary Artery Disease Risk Variant Dampens the
            Expression of CALCRL by Reducing HSF Binding to Shear Stress
            Responsive Enhancer in Endothelial Cells In Vitro.
REFERENCE   2  (bases 1 to 6074)
  AUTHORS   Tang,S., Li,S., Shi,X., Sheng,L., Mu,Q., Wang,Y., Zhu,H., Xu,K.,
            Zhou,M., Xu,Z., Wu,A. and Ouyang,G.
  TITLE     CALCRL induces resistance to daunorubicin in acute myeloid leukemia
            cells through upregulation of XRCC5/TYK2/JAK1 pathway
  JOURNAL   Anticancer Drugs 35 (2), 163-176 (2024)
   PUBMED   37948318
  REMARK    GeneRIF: CALCRL induces resistance to daunorubicin in acute myeloid
            leukemia cells through upregulation of XRCC5/TYK2/JAK1 pathway.
REFERENCE   3  (bases 1 to 6074)
  AUTHORS   Tang,S., Zhu,H., Sheng,L., Mu,Q., Wang,Y., Xu,K., Zhou,M., Xu,Z.,
            Wu,A. and Ouyang,G.
  TITLE     CALCRL knockdown suppresses cancer stemness and chemoresistance in
            acute myeloid leukemia with FLT3-ITD and DNM3TA-R882 double
            mutations
  JOURNAL   Drug Dev Res 85 (1), e22137 (2024)
   PUBMED   38349260
  REMARK    GeneRIF: CALCRL knockdown suppresses cancer stemness and
            chemoresistance in acute myeloid leukemia with FLT3-ITD and
            DNM3TA-R882 double mutations.
REFERENCE   4  (bases 1 to 6074)
  AUTHORS   Huang,Z., Zhang,H., Xing,C., Zhang,L., Zhu,H., Deng,Z., Yin,L.,
            Dong,E., Wang,C. and Peng,H.
  TITLE     Identification and validation of CALCRL-associated prognostic genes
            in acute myeloid leukemia
  JOURNAL   Gene 809, 146009 (2022)
   PUBMED   34655717
  REMARK    GeneRIF: Identification and validation of CALCRL-associated
            prognostic genes in acute myeloid leukemia.
REFERENCE   5  (bases 1 to 6074)
  AUTHORS   Josephs,T.M., Belousoff,M.J., Liang,Y.L., Piper,S.J., Cao,J.,
            Garama,D.J., Leach,K., Gregory,K.J., Christopoulos,A., Hay,D.L.,
            Danev,R., Wootten,D. and Sexton,P.M.
  TITLE     Structure and dynamics of the CGRP receptor in apo and
            peptide-bound forms
  JOURNAL   Science 372 (6538) (2021)
   PUBMED   33602864
  REMARK    GeneRIF: Structure and dynamics of the CGRP receptor in apo and
            peptide-bound forms.
REFERENCE   6  (bases 1 to 6074)
  AUTHORS   McLatchie,L.M., Fraser,N.J., Main,M.J., Wise,A., Brown,J.,
            Thompson,N., Solari,R., Lee,M.G. and Foord,S.M.
  TITLE     RAMPs regulate the transport and ligand specificity of the
            calcitonin-receptor-like receptor
  JOURNAL   Nature 393 (6683), 333-339 (1998)
   PUBMED   9620797
REFERENCE   7  (bases 1 to 6074)
  AUTHORS   Aiyar,N., Rand,K., Elshourbagy,N.A., Zeng,Z., Adamou,J.E.,
            Bergsma,D.J. and Li,Y.
  TITLE     A cDNA encoding the calcitonin gene-related peptide type 1 receptor
  JOURNAL   J Biol Chem 271 (19), 11325-11329 (1996)
   PUBMED   8626685
REFERENCE   8  (bases 1 to 6074)
  AUTHORS   Fluhmann,B., Muff,R., Hunziker,W., Fischer,J.A. and Born,W.
  TITLE     A human orphan calcitonin receptor-like structure
  JOURNAL   Biochem Biophys Res Commun 206 (1), 341-347 (1995)
   PUBMED   7818539
REFERENCE   9  (bases 1 to 6074)
  AUTHORS   Foord,S.M. and Craig,R.K.
  TITLE     Isolation and characterisation of a human
            calcitonin-gene-related-peptide receptor
  JOURNAL   Eur J Biochem 170 (1-2), 373-379 (1987)
   PUBMED   2826160
REFERENCE   10 (bases 1 to 6074)
  AUTHORS   Skofitsch,G. and Jacobowitz,D.M.
  TITLE     Autoradiographic distribution of 125I calcitonin gene-related
            peptide binding sites in the rat central nervous system
  JOURNAL   Peptides 6 (5), 975-986 (1985)
   PUBMED   3001670
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007319.2, KF456755.1 and AC074020.4.
            
            On Apr 9, 2019 this sequence version replaced XM_017003151.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.4627.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AC007319.2         100518-100731       c
            215-273             AC007319.2         89077-89135         c
            274-341             AC007319.2         83776-83843         c
            342-432             AC007319.2         40145-40235         c
            433-519             KF456755.1         167-253             c
            520-652             AC007319.2         35652-35784         c
            653-763             AC007319.2         33156-33266         c
            764-876             AC007319.2         32946-33058         c
            877-968             AC007319.2         31419-31510         c
            969-1095            AC007319.2         15855-15981         c
            1096-1249           AC007319.2         13077-13230         c
            1250-1310           AC007319.2         11691-11751         c
            1311-1377           AC007319.2         11542-11608         c
            1378-1596           AC007319.2         4593-4811           c
            1597-1638           AC007319.2         4399-4440           c
            1639-6074           AC074020.4         139955-144390       c
FEATURES             Location/Qualifiers
     source          1..6074
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.1"
     gene            1..6074
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /note="calcitonin receptor like receptor"
                     /db_xref="GeneID:10203"
                     /db_xref="HGNC:HGNC:16709"
                     /db_xref="MIM:114190"
     exon            1..214
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /inference="alignment:Splign:2.1.0"
     exon            215..273
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /inference="alignment:Splign:2.1.0"
     exon            274..341
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /inference="alignment:Splign:2.1.0"
     exon            342..432
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /inference="alignment:Splign:2.1.0"
     exon            433..519
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /inference="alignment:Splign:2.1.0"
     CDS             469..1854
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /note="calcitonin gene-related peptide type 1 receptor;
                     CGRP type 1 receptor; calcitonin receptor-like"
                     /codon_start=1
                     /product="calcitonin gene-related peptide type 1 receptor
                     precursor"
                     /protein_id="NP_001356364.1"
                     /db_xref="CCDS:CCDS2293.1"
                     /db_xref="GeneID:10203"
                     /db_xref="HGNC:HGNC:16709"
                     /db_xref="MIM:114190"
                     /translation="MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTA
                     QYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVT
                     KICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISL
                     GIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFI
                     HLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSL
                     YYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKA
                     VRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQ
                     AILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIE
                     NVLLKPENLYN"
     exon            520..652
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /inference="alignment:Splign:2.1.0"
     exon            653..763
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /inference="alignment:Splign:2.1.0"
     exon            764..876
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /inference="alignment:Splign:2.1.0"
     exon            877..968
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1095
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1249
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1310
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1377
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1596
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1638
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..6074
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4723..4728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /note="hexamer: ATTAAA"
     polyA_site      4746
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /note="major polyA site"
     regulatory      4900..4905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /note="hexamer: AATAAA"
     polyA_site      4919
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /note="major polyA site"
     regulatory      6061..6066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
                     /note="hexamer: AATATA"
     polyA_site      6074
                     /gene="CALCRL"
                     /gene_synonym="CGRPR; CRLR; LMPHM8"
ORIGIN      
        1 agaacaacct ctctctctcc agcagagagt gtcacctcct gctttaggac catcaagctc
       61 tgctaactga atctcatcct aattgcagga tcacattgca aagctttcac tctttcccac
      121 cttgcttgtg ggtaaatctc ttctgcggaa tctcagaaag taaagttcca tcctgagaat
      181 atttcacaaa gaatttcctt aagagctgga ctgggtgctt ggtgtaaact tttggatggt
      241 aaagccttat ctgccttttc gactgggaca atgggtccta cgatgataca ccaaccactt
      301 gtgctaccat ctgtcaaaac tttggatggc cctactttca ggtcttgacc cctgaattta
      361 agaaattctt aaagacaatg tcaaatatga tccaagagaa aatgtgattt gagactggag
      421 acaattgtgc attttatgtt atacagcata tttcattttg gcttaatgat ggagaaaaag
      481 tgtaccctgt attttctggt tctcttgcct ttttttatga ttcttgttac agcagaatta
      541 gaagagagtc ctgaggactc aattcagttg ggagttacta gaaataaaat catgacagct
      601 caatatgaat gttaccaaaa gattatgcaa gaccccattc aacaagcaga aggcgtttac
      661 tgcaacagaa cctgggatgg atggctctgc tggaacgatg ttgcagcagg aactgaatca
      721 atgcagctct gccctgatta ctttcaggac tttgatccat cagaaaaagt tacaaagatc
      781 tgtgaccaag atggaaactg gtttagacat ccagcaagca acagaacatg gacaaattat
      841 acccagtgta atgttaacac ccacgagaaa gtgaagactg cactaaattt gttttacctg
      901 accataattg gacacggatt gtctattgca tcactgctta tctcgcttgg catattcttt
      961 tatttcaaga gcctaagttg ccaaaggatt accttacaca aaaatctgtt cttctcattt
     1021 gtttgtaact ctgttgtaac aatcattcac ctcactgcag tggccaacaa ccaggcctta
     1081 gtagccacaa atcctgttag ttgcaaagtg tcccagttca ttcatcttta cctgatgggc
     1141 tgtaattact tttggatgct ctgtgaaggc atttacctac acacactcat tgtggtggcc
     1201 gtgtttgcag agaagcaaca tttaatgtgg tattattttc ttggctgggg atttccactg
     1261 attcctgctt gtatacatgc cattgctaga agcttatatt acaatgacaa ttgctggatc
     1321 agttctgata cccatctcct ctacattatc catggcccaa tttgtgctgc tttactggtg
     1381 aatctttttt tcttgttaaa tattgtacgc gttctcatca ccaagttaaa agttacacac
     1441 caagcggaat ccaatctgta catgaaagct gtgagagcta ctcttatctt ggtgccattg
     1501 cttggcattg aatttgtgct gattccatgg cgacctgaag gaaagattgc agaggaggta
     1561 tatgactaca tcatgcacat ccttatgcac ttccagggtc ttttggtctc taccattttc
     1621 tgcttcttta atggagaggt tcaagcaatt ctgagaagaa actggaatca atacaaaatc
     1681 caatttggaa acagcttttc caactcagaa gctcttcgta gtgcgtctta cacagtgtca
     1741 acaatcagtg atggtccagg ttatagtcat gactgtccta gtgaacactt aaatggaaaa
     1801 agcatccatg atattgaaaa tgttctctta aaaccagaaa atttatataa ttgaaaatag
     1861 aaggatggtt gtctcactgt tttgtgcttc tcctaactca aggacttgga cccatgactc
     1921 tgtagccaga agacttcaat attaaatgac tttttgaatg tcataaagaa gagccttcac
     1981 atgaaattag tagtgtgttg ataagagtgt aacatccagc tctatgtggg aaaaaagaaa
     2041 tcctggtttg taatgtttgt cagtaaatac tcccactatg cctgatgtga cgctactaac
     2101 ctgacatcac caagtgtgga attggagaaa agcacaatca acttttctga gctggtgtaa
     2161 gccagttcca gcacaccatt gcatgaattc acaaacaaat ggctgtaaaa ctaaacatac
     2221 atgttgggca tgattctacc cttattgccc caagagacct agctaaggtc tataaacatg
     2281 aagggaaaat tagcttttag ttttaaaact ctttatccca tcttgattgg ggcagttgac
     2341 tttttttttg cccagagtgc cgtagtcctt tttgtaacta ccctctcaaa tggacaatac
     2401 cagaagtgaa ttatccctgc tggctttctt ttctctatga aaagcaactg agtacaattg
     2461 ttatgatcta ctcatttgct gacacatcag ttatatcttg tggcatatcc attgtggaaa
     2521 ctggatgaac aggatgtata atatgcaatc ctacttctat atcattagga aaacatctta
     2581 gttgatgcta caaaacacct tgtcaacctc ttcctgtctt accaaacagt gggagggaat
     2641 tcctagctgt aaatataaat tttgtccctt ccatttctac tgtataaaca aattagcaat
     2701 cattttatat aaagaaaatc aatgaaggat ttcttatttt cttggaattt tgtaaaaaga
     2761 aattgtgaaa aatgagcttg taaatactcc attattttat tttatagtct caaatcaaat
     2821 acatacaacc tatgtaattt ttaaagcaaa tatataatgc aacaatgtgt gtatgttaat
     2881 atctgatact gtatctgggc tgatttttta aataaaatag agtctggaat gctatatttg
     2941 gtaaatattt taaagacaac cagatgccag catcagaagt ctgtttgaga actaagagaa
     3001 cagaaacatc tatcataaga tatatttatt ttaaaaacac aaggtcacta ttttattgaa
     3061 tatatttgtt ttgataactc ataccttaat aataggtgtg tttgacatat ttcttttttc
     3121 attttgacaa tgaactcaca ttctaatcca gaaattttaa acaactactg tgataaatac
     3181 caatctgcta cttttataga ttttacccca ttaaaatatt actttactga cttttactat
     3241 gtgaagatat atagctttgg aaatgtccca ggctattcaa gaaatataaa aaactagaag
     3301 gatactatat ataccatata caatgcttta atattttaat agagctactg tatataatac
     3361 aaattaggga aatacttgaa tatatcattg agaaaaaatt attgtcagat cttactgaat
     3421 tattgtcaga ctttattaaa taaagataga agaaaacctt gctaatgaat taaagtgaaa
     3481 tttgcatggg attcagtttc tctaatgtta ttttccgctg aaatctctaa agaacaagaa
     3541 tgacttcaat tagtaaaagt caattttggg aaaagtcatg ggtatctgtt ttttaagtgt
     3601 gtcaatctga ttaaaatgga tgaaacaaat tactcatcat aagttgtttc ttaagctgtc
     3661 aatatgtcaa tagatggtga gttcagaact tatttcaaat tgctaagaca aattatctaa
     3721 attcgtaaga attaacatat agaatggtct ggtcagtaca tttataattt atctatgcat
     3781 gaaaaagtat tgttttgttt gaaacatgaa tttcatagca agctgccata gaaaggaacg
     3841 caggctgttc tagaccttca actgcctaaa ttatacaaaa attcatttta ataaactcaa
     3901 ttattagcta tttattattc aaagacccat atttaaatcc tttgctgacc atgttgacat
     3961 atatcagcct tcttctagac aaactgtcaa ctctcaacca tcttgacagt agaagtgaca
     4021 gtaaaaaatg ttgaatgatc agagattata ttaaaataaa catgtaattt tcaagtattt
     4081 ttgttgtgct tttataatat taattctaga tcagatttat tttatagcca gggtttgtct
     4141 gttgtagagt cttgaggcgt agcagtcatt catgattaat cactgttagt tttgtaccca
     4201 tatattttta gaatagtttt aaatgttaga tttctcaaaa gctaaatgct acttaatatc
     4261 tttgtatcat actcataaag caaagtaaat ctgacacttt ttttaaagca aacttctttg
     4321 ctgtcaaaaa aataaatttg gggaaatttc tagcttttaa aatgtagatc tgcattttac
     4381 tgtgattact tgtgaaagtc atattttaat tttctaaatt ctaatttgtc attttatttc
     4441 ctaaagttaa tttccaatgc atttattcat aaaatattca ttctggaatg cagtgtttgt
     4501 ttaaatgtaa tccaatgtat atagaattag tggtggctgt agtgctgtat ttattgctta
     4561 taattttttt taaatgtgaa cttactttta attttctctt ggttttaatc tgctagtaga
     4621 aaccactagt tatctgtaaa aatatattca agatattctg atcaattata acaatttatg
     4681 ttatgcctag agtatatctc tattttttga ttgtatgaaa atattaaagt tatgagttaa
     4741 agtttatttt cactgatatt tactacagtg ccaaataatc taatttataa acataattct
     4801 tacagtaatc aatgggatac ttctcaaaat taacaaatct cttaacaaaa tatatctttt
     4861 gccctcttta aagtcttcag taaaccagta aatgaattca ataaaccaat taagaaaaag
     4921 tcatgatttg tttttcaaac taaaaaaatc caactatact acaatggatg caaactcctt
     4981 cttatgctga aagaagaaaa aggatgtctc aaaataagaa aatgttcaga aattcatctc
     5041 ctttatctac tatatttcat tttgtagttt tgtttaaata ttagaaagaa aaataagtat
     5101 ttaaaggtaa tttttaaaga gggcatattc atggctctca cacaaatata aaatgaaaat
     5161 gtttcaaaga tttcgtttaa ctcattaatt aatgaaggaa caagtaagat gttacaaaaa
     5221 ttcaaaggag aattcaaaat atcacactat atgagaatat taaaaatgtt gaaataaatt
     5281 tataaataag tgcaaaacca ctctatcctt agggcaataa tcagttgcat tccacttaat
     5341 aactaatttt tatttttatg atcaataata atgtacatca ttttctgttt tctggagaaa
     5401 atgcccattt aaaacacttg tgtttttttc ttataatctc tcctccttgt gattatacta
     5461 atctcaaaga aagaatattc ttgattaaaa atattgctag tttaataagg tttggcctat
     5521 tgttgagata ggtacatgag agtgttaatt acaatataga cctcctcaag ttggttttac
     5581 aaatctagaa ccatagtgca ctttttaaca gcttcattga gatatacttg acatatcata
     5641 taatacttca tattcaaagc agtttttagt atattagtag agtatatttt aatacatcca
     5701 tagagacacg ctaccatcac caatttcatt acatttttat gaccttgaga agaaacagtg
     5761 tatcctttag ccatcacttc tctatccctc tatctctact ttcatttcag ctataaacat
     5821 cactaattta cattctgtct caacagattt ccctattcta gactttcata tgattgtaat
     5881 catatagtat gtgacctttt gtgactaaat gatttcactt atgtttttaa aattcattca
     5941 tgttttggca tgtatcaatg tttcctttta ttccattggg tgaacatacc acattttatt
     6001 tattcatttg tctgttgatg gatatgtttg ttttgctttt accttttggt tattataaat
     6061 aatataccta taaa
//
