LOCUS       NM_001742               3572 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens calcitonin receptor (CALCR), transcript variant 2,
            mRNA.
ACCESSION   NM_001742
VERSION     NM_001742.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3572)
  AUTHORS   Yan,H., Xing,Z., Liu,S., Gao,P., Wang,Q. and Guo,G.
  TITLE     CALCR exacerbates renal cell carcinoma progression via stabilizing
            CD44
  JOURNAL   Aging (Albany NY) 16 (13), 10765-10783 (2024)
   PUBMED   38985127
  REMARK    GeneRIF: CALCR exacerbates renal cell carcinoma progression via
            stabilizing CD44.
REFERENCE   2  (bases 1 to 3572)
  AUTHORS   Cao,J., Belousoff,M.J., Danev,R., Christopoulos,A., Wootten,D. and
            Sexton,P.M.
  TITLE     Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with
            CGRP and Gs Protein
  JOURNAL   Biochemistry 63 (9), 1089-1096 (2024)
   PUBMED   38603770
REFERENCE   3  (bases 1 to 3572)
  AUTHORS   Rees,T.A., Labastida-Ramirez,A. and Rubio-Beltran,E.
  TITLE     Calcitonin/PAC1 receptor splice variants: a blind spot in migraine
            research
  JOURNAL   Trends Pharmacol Sci 44 (10), 651-663 (2023)
   PUBMED   37543479
  REMARK    GeneRIF: Calcitonin/PAC1 receptor splice variants: a blind spot in
            migraine research.
            Review article
REFERENCE   4  (bases 1 to 3572)
  AUTHORS   Jowko,E., Dlugolecka,B., Cieslinski,I. and Kotowska,J.
  TITLE     Polymorphisms in Genes Encoding VDR, CALCR and Antioxidant Enzymes
            as Predictors of Bone Tissue Condition in Young, Healthy Men
  JOURNAL   Int J Mol Sci 24 (4), 3373 (2023)
   PUBMED   36834780
  REMARK    GeneRIF: Polymorphisms in Genes Encoding VDR, CALCR and Antioxidant
            Enzymes as Predictors of Bone Tissue Condition in Young, Healthy
            Men.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3572)
  AUTHORS   Ali,F.T., El-Azeem,E.M.A., Hekal,H.F.A., El-Gizawy,M.M.,
            Sayed,M.S., Mandoh,A.Y. and Soliman,A.F.
  TITLE     Association of TRPV5, CASR, and CALCR genetic variants with kidney
            stone disease susceptibility in Egyptians through main effects and
            gene-gene interactions
  JOURNAL   Urolithiasis 50 (6), 701-710 (2022)
   PUBMED   36088585
  REMARK    GeneRIF: Association of TRPV5, CASR, and CALCR genetic variants
            with kidney stone disease susceptibility in Egyptians through main
            effects and gene-gene interactions.
REFERENCE   6  (bases 1 to 3572)
  AUTHORS   Albrandt,K., Brady,E.M., Moore,C.X., Mull,E., Sierzega,M.E. and
            Beaumont,K.
  TITLE     Molecular cloning and functional expression of a third isoform of
            the human calcitonin receptor and partial characterization of the
            calcitonin receptor gene
  JOURNAL   Endocrinology 136 (12), 5377-5384 (1995)
   PUBMED   7588285
REFERENCE   7  (bases 1 to 3572)
  AUTHORS   Nussenzveig,D.R., Mathew,S. and Gershengorn,M.C.
  TITLE     Alternative splicing of a 48-nucleotide exon generates two isoforms
            of the human calcitonin receptor
  JOURNAL   Endocrinology 136 (5), 2047-2051 (1995)
   PUBMED   7720653
REFERENCE   8  (bases 1 to 3572)
  AUTHORS   Egerton,M., Needham,M., Evans,S., Millest,A., Cerillo,G.,
            McPheat,J., Popplewell,M., Johnstone,D. and Hollis,M.
  TITLE     Identification of multiple human calcitonin receptor isoforms:
            heterologous expression and pharmacological characterization
  JOURNAL   J Mol Endocrinol 14 (2), 179-189 (1995)
   PUBMED   7619207
REFERENCE   9  (bases 1 to 3572)
  AUTHORS   Gorn,A.H., Lin,H.Y., Yamin,M., Auron,P.E., Flannery,M.R.,
            Tapp,D.R., Manning,C.A., Lodish,H.F., Krane,S.M. and Goldring,S.R.
  TITLE     Cloning, characterization, and expression of a human calcitonin
            receptor from an ovarian carcinoma cell line
  JOURNAL   J Clin Invest 90 (5), 1726-1735 (1992)
   PUBMED   1331173
REFERENCE   10 (bases 1 to 3572)
  AUTHORS   Blattner,R.J.
  TITLE     Hemolytic anemia associated with Wilson's disease
  JOURNAL   J Pediatr 71 (2), 284-287 (1967)
   PUBMED   4961748
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313996.1, AC005024.2 and
            AC003078.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001742.3.
            
            Summary: This gene encodes a high affinity receptor for the peptide
            hormone calcitonin and belongs to a subfamily of seven
            transmembrane-spanning G protein-coupled receptors. The encoded
            protein is involved in maintaining calcium homeostasis and in
            regulating osteoclast-mediated bone resorption. Polymorphisms in
            this gene have been associated with variations in bone mineral
            density and onset of osteoporosis. Alternate splicing results in
            multiple transcript variants. [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks an alternate in-frame exon in the 5' coding region, compared
            to variant 1. The encoded isoform (2) is shorter than isoform 1.
            Variants 2 and 3 encode the same isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB022177.1, AK313996.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162328 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000426151.7/ ENSP00000389295.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AK313996.1         7-96
            91-145              AC005024.2         1063-1117           c
            146-1702            AK313996.1         153-1709
            1703-3572           AC003078.1         33387-35256         c
FEATURES             Location/Qualifiers
     source          1..3572
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.3"
     gene            1..3572
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
                     /note="calcitonin receptor"
                     /db_xref="GeneID:799"
                     /db_xref="HGNC:HGNC:1440"
                     /db_xref="MIM:114131"
     exon            1..33
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            34..251
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            252..328
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..1702
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="calcitonin receptor isoform 2 precursor"
                     /protein_id="NP_001733.1"
                     /db_xref="CCDS:CCDS5631.1"
                     /db_xref="GeneID:799"
                     /db_xref="HGNC:HGNC:1440"
                     /db_xref="MIM:114131"
                     /translation="MRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYVVG
                     RKKMMDAQYKCYDRMQQLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDF
                     DPSEKVTKYCDEKGVWFKHPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSI
                     FTLVISLGIFVFFRSLGCQRVTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVS
                     CKILHFFHQYMMACNYFWMLCEGIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTI
                     HAITRAVYFNDNCWLSVETHLLYIIHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAE
                     SHMYLKAVKATMILVPLLGIQFVVFPWRPSNKMLGKIYDYVMHSLIHFQGFFVATIYC
                     FCNNEVQTTVKRQWAQFKIQWNQRWGRRPSNRSARAAAAAAEAGDIPIYICHQELRNE
                     PANNQGEESAEIIPLNIIEQESSA"
     exon            329..482
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..593
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..706
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            707..798
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            799..925
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1079
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1140
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1207
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1426
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1468
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..3572
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3494..3499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
                     /note="hexamer: AATACA"
     polyA_site      3519
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
                     /note="major polyA site"
     regulatory      3548..3553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
                     /note="hexamer: AATATA"
     polyA_site      3572
                     /gene="CALCR"
                     /gene_synonym="CRT; CT-R; CTR; CTR1"
ORIGIN      
        1 acagctggga gagcgcagga aggcgccggg aaggaaagcc agcccaccag cgtctgggtg
       61 ggctgcgccg cgcggctggc ggaccttccc gggttggaga agtgcgcacg tccgcacctc
      121 accctgcggc tgacatctcc tgcccaggag atgggcgctg aagcttgagc gcctgagtcc
      181 ctggagccac acctgcgaac accctttgct tctattgagc tgtgcccagc cgcccagtga
      241 cagaattcca ggacaaagag atcttcaaaa atcaaaaatg aggttcacat ttacaagccg
      301 gtgcttggca ctgtttcttc ttctaaatca cccaacccca attcttcctg ccttttcaaa
      361 tcaaacctat ccaacaatag agcccaagcc atttctttac gtcgtaggac gaaagaagat
      421 gatggatgca cagtacaaat gctatgaccg aatgcagcag ttacccgcat accaaggaga
      481 aggtccatat tgcaatcgca cctgggatgg atggctgtgc tgggatgaca caccggctgg
      541 agtattgtcc tatcagttct gcccagatta ttttccggat tttgatccat cagaaaaggt
      601 tacaaaatac tgtgatgaaa aaggtgtttg gtttaaacat cctgaaaaca atcgaacctg
      661 gtccaactat actatgtgca atgctttcac tcctgagaaa ctgaagaatg catatgttct
      721 gtactatttg gctattgtgg gtcattcttt gtcaattttc accctagtga tttccctggg
      781 gattttcgtg tttttcagga gccttggctg ccaaagggta accctgcaca agaacatgtt
      841 tcttacttac attctgaatt ctatgattat catcatccac ctggttgaag tagtacccaa
      901 tggagagctc gtgcgaaggg acccggtgag ctgcaagatt ttgcattttt tccaccagta
      961 catgatggcc tgcaactatt tctggatgct ctgtgaaggg atctatcttc atacactcat
     1021 tgtcgtggct gtgtttactg agaagcaacg cttgcggtgg tattatctct tgggctgggg
     1081 gttcccgctg gtgccaacca ctatccatgc tattaccagg gccgtgtact tcaatgacaa
     1141 ctgctggctg agtgtggaaa cccatttgct ttacataatc catggacctg tcatggcggc
     1201 acttgtggtc aatttcttct ttttgctcaa cattgtccgg gtgcttgtga ccaaaatgag
     1261 ggaaacccat gaggcggaat cccacatgta cctgaaggct gtgaaggcca ccatgatcct
     1321 tgtgcccctg ctgggaatcc agtttgtcgt ctttccctgg agaccttcca acaagatgct
     1381 tgggaagata tatgattacg tgatgcactc tctgattcat ttccagggct tctttgttgc
     1441 gaccatctac tgcttctgca acaatgaggt ccaaaccacc gtgaagcgcc aatgggccca
     1501 attcaaaatt cagtggaacc agcgttgggg gaggcgcccc tccaaccgct ctgctcgcgc
     1561 tgcagccgct gctgcggagg ctggcgacat cccaatttac atctgccatc aggagctgag
     1621 gaatgaacca gccaacaacc aaggcgagga gagtgctgag atcatccctt tgaatatcat
     1681 agagcaagag tcatctgctt gaatgtgaag caaacacagc atcgtgatca ctgagccatc
     1741 atttcctggg agaaagacca tgcatttaaa gtattctcca tcctcccagg aaccgaacat
     1801 atcatttgtg aagaattatt cagtgaattt gtccattgta aatctgaaga aagttattct
     1861 tggtactgtt gctttgggag acagtctagg aatggagtct cccactgcaa cttgtgaact
     1921 ccatcattca tccaggactg agatgcaaat gtcacagtaa tgcaagcaaa gtatcaaaga
     1981 aaaacaatga aattgaccta gttcagatac agggtgctcc ttgtcaatac tgagccattt
     2041 atacctttga aatattaaaa tcactgtcaa tatttttatt tttaactctg gattttgaat
     2101 tagattattt ctgtatttgg ctatggatct gatttttaat ttttttaaat ttcagtcaat
     2161 tctgatgtta ctgagatgtt ttaccatcct tacaatgtaa accacatgaa ctacgtgacc
     2221 tctgcaagac aaagcggctt tctaatagag agattagtaa atatgtgaag aaaaagacct
     2281 gcatttggca ggaagatgta tgctttgaat gcaaaagaaa tttagagtca atttgctgaa
     2341 aacattacat gctcagcttg gttttggaca agcctgtcca ttgggcagga cctagctgtt
     2401 gtaaagaatt ggtcttaatg ttgaatgtat tttggttgct gatgtttata aactgagagg
     2461 tcacaaagaa tctatcacta aaaattttta caaaactgcc aaaaatataa ttcttagtgg
     2521 aagacaatac tccctttaaa gagagtttgc cactccccta aactccagga tttataaagc
     2581 aaattactcc aaggtttata aagcagatta cctcttgccc ttgggtgcta tctagcagta
     2641 aaagataaat ttgttgaata ttggtaatta aaagactcca cataagtcca ttaactgctt
     2701 tccacccagc ttcaaagctt aaaaagagct caggcttttc caggaagatc caggagggct
     2761 aattagaaat caacttgtgg ttgaccgctt gtttcttgtt attaccaaaa caggagggga
     2821 aaaaattaac tgctccaaat ttaaccataa atcaattcat gtttaacgtt tctcattaaa
     2881 atccagtatt atattatcat atctctcttt acttcccagt ataagatttt tgaaaatcct
     2941 gaataaacca gtatcgttac tggcacctga aattaatttg tgaatttgca acagtaatca
     3001 gagttaccat tatttaattt gtatgctaaa tgaggaggta cattgaaacc ctccaaatct
     3061 ccagtctcat ctatgtcata ttttgccact gcctttcaga agtgatttag ttgtggaaag
     3121 ataataaatt gatttgttat ggttacatat ttagcgcacc cagagaaaat taattatatt
     3181 tctacagaga aaatgaattt gggatactaa agtagtttaa gtctccttta ctgaatgtaa
     3241 gggggggatc gaaaagaagg tatttttcca atcacagtgt tatgtagtat tgttctattt
     3301 ttgtttacaa acatggaaaa cagagtattt ctggcagctg tggtacaaat gtgataatat
     3361 attgctaaaa tattttagat gttattatgc taatatagta ggggttgaag aaaacaaaat
     3421 agcttattat agaattgcac atagttctgc ccaaattatg tgaaatgctt atgcttgtgt
     3481 atatgtataa attaatacag agtacgttaa aagcaaaaag atgtatattt gcatattttt
     3541 ctaaagaaat atattattca tcttttcatt ca
//
