LOCUS       NM_020898               5576 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens calcium binding and coiled-coil domain 1 (CALCOCO1),
            transcript variant 1, mRNA.
ACCESSION   NM_020898
VERSION     NM_020898.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5576)
  AUTHORS   Kumar,K., Chidambaram,R., Parashar,S. and Ferro-Novick,S.
  TITLE     RTN3L and CALCOCO1 function in parallel to maintain proteostasis in
            the endoplasmic reticulum
  JOURNAL   Autophagy 20 (9), 2067-2075 (2024)
   PUBMED   38818751
  REMARK    GeneRIF: RTN3L and CALCOCO1 function in parallel to maintain
            proteostasis in the endoplasmic reticulum.
REFERENCE   2  (bases 1 to 5576)
  AUTHORS   Chen,W., Ouyang,X., Chen,L. and Li,L.
  TITLE     Multiple functions of CALCOCO family proteins in selective
            autophagy
  JOURNAL   J Cell Physiol 237 (9), 3505-3516 (2022)
   PUBMED   35853167
  REMARK    Review article
REFERENCE   3  (bases 1 to 5576)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5576)
  AUTHORS   Nthiga,T.M., Kumar Shrestha,B., Sjottem,E., Bruun,J.A., Bowitz
            Larsen,K., Bhujabal,Z., Lamark,T. and Johansen,T.
  TITLE     CALCOCO1 acts with VAMP-associated proteins to mediate ER-phagy
  JOURNAL   EMBO J 39 (15), e103649 (2020)
   PUBMED   32525583
  REMARK    GeneRIF: CALCOCO1 acts with VAMP-associated proteins to mediate
            ER-phagy.
REFERENCE   5  (bases 1 to 5576)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5576)
  AUTHORS   Yang,C.K., Kim,J.H. and Stallcup,M.R.
  TITLE     Role of the N-terminal activation domain of the coiled-coil
            coactivator in mediating transcriptional activation by beta-catenin
  JOURNAL   Mol Endocrinol 20 (12), 3251-3262 (2006)
   PUBMED   16931570
  REMARK    GeneRIF: The N terminus of CoCoA contains another activation domain
            , which is necessary and sufficient for synergistic activation of
            LEF1-mediated transcription by CoCoA and beta-catenin.
REFERENCE   7  (bases 1 to 5576)
  AUTHORS   Kim,J.H., Yang,C.K. and Stallcup,M.R.
  TITLE     Downstream signaling mechanism of the C-terminal activation domain
            of transcriptional coactivator CoCoA
  JOURNAL   Nucleic Acids Res 34 (9), 2736-2750 (2006)
   PUBMED   16717280
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5576)
  AUTHORS   Yang,C.K., Kim,J.H., Li,H. and Stallcup,M.R.
  TITLE     Differential use of functional domains by coiled-coil coactivator
            in its synergistic coactivator function with beta-catenin or GRIP1
  JOURNAL   J Biol Chem 281 (6), 3389-3397 (2006)
   PUBMED   16344550
  REMARK    GeneRIF: CoCoA uses different combinations of functional domains in
            its synergistic coactivator function with beta-catenin or GRIP1
REFERENCE   9  (bases 1 to 5576)
  AUTHORS   Takahashi,K., Inuzuka,M. and Ingi,T.
  TITLE     Cellular signaling mediated by calphoglin-induced activation of IPP
            and PGM
  JOURNAL   Biochem Biophys Res Commun 325 (1), 203-214 (2004)
   PUBMED   15522220
  REMARK    GeneRIF: Results report a novel human protein, calphoglin, which
            activates inorganic pyrophosphatase (IPP) and enhances
            phosphoglucomutase activity through the activated IPP.
REFERENCE   10 (bases 1 to 5576)
  AUTHORS   Lee,S.Y., Obata,Y., Yoshida,M., Stockert,E., Williamson,B.,
            Jungbluth,A.A., Chen,Y.T., Old,L.J. and Scanlan,M.J.
  TITLE     Immunomic analysis of human sarcoma
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2651-2656 (2003)
   PUBMED   12601173
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK315578.1, AL136895.1, BC003177.1 and AC076968.38.
            
            On Nov 23, 2018 this sequence version replaced NM_020898.2.
            
            Transcript Variant: This variant (1) encodes the longer protein
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.174329.1,
                                           SRR1803615.19042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146, SAMEA2467147
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000550804.6/ ENSP00000449960.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AK315578.1         7-23
            18-1176             AL136895.1         1-1159
            1177-2935           BC003177.1         1155-2913
            2936-2975           AL136895.1         2919-2958
            2976-5576           AC076968.38        8352-10952          c
FEATURES             Location/Qualifiers
     source          1..5576
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..5576
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /note="calcium binding and coiled-coil domain 1"
                     /db_xref="GeneID:57658"
                     /db_xref="HGNC:HGNC:29306"
     exon            1..49
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /inference="alignment:Splign:2.1.0"
     exon            50..229
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..2149
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil leucine zipper coactivator 1; calcium-binding
                     and coiled-coil domain-containing protein 1; inorganic
                     pyrophosphatase activator; sarcoma antigen NY-SAR-3;
                     coiled-coil coactivator protein"
                     /codon_start=1
                     /product="calcium-binding and coiled-coil
                     domain-containing protein 1 isoform 1"
                     /protein_id="NP_065949.1"
                     /db_xref="CCDS:CCDS8864.1"
                     /db_xref="GeneID:57658"
                     /db_xref="HGNC:HGNC:29306"
                     /translation="MEESPLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSA
                     SDWIGIFKVEAACVRDYHTFVWSSVPESTTDGSPIHTSVQFQASYLPKPGAQLYQFRY
                     VNRQGQVCGQSPPFQFREPRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQER
                     NDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDI
                     LSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQ
                     ADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQR
                     VAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNG
                     RLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVF
                     KTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLE
                     KVADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMRLPPYGLCERGDPGSSPAG
                     PREASPLVVISQPAPISPHLSGPAEDSSSDSEAEDEKSVLMAAVQSGGEEANLLLPEL
                     GSAFYDMASGFTVGTLSETSTGGPATPTWKECPICKERFPAESDKDALEDHMDGHFFF
                     STQDPFTFE"
     exon            230..332
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /inference="alignment:Splign:2.1.0"
     exon            333..523
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /inference="alignment:Splign:2.1.0"
     exon            524..682
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /inference="alignment:Splign:2.1.0"
     exon            683..831
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /inference="alignment:Splign:2.1.0"
     exon            832..922
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1078
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1333
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1459
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1555
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1664
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1864
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1971
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..5576
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2911..2916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /note="hexamer: AATAAA"
     polyA_site      2935
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /note="major polyA site"
     regulatory      2955..2960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /note="hexamer: AATATA"
     polyA_site      2975
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /note="major polyA site"
     regulatory      5552..5557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
                     /note="hexamer: AATAAA"
     polyA_site      5576
                     /gene="CALCOCO1"
                     /gene_synonym="calphoglin; Cocoa; PP13275"
ORIGIN      
        1 gtttttgttg ttggtgaaag gtgaggggaa cagctgatcc gtctgttggg aggacagata
       61 tctcaaggcc aggatggaag aatcaccact aagccgggca ccatcccgtg gtggagtcaa
      121 ctttctcaat gtagcccgga cctacatccc caacaccaag gtggaatgtc actacaccct
      181 tcccccaggc accatgccca gtgccagtga ctggattggc atcttcaagg tggaggctgc
      241 ctgtgttcgg gattaccaca catttgtgtg gtcttccgtg cctgaaagta caactgatgg
      301 ttcccccatt cacaccagtg tccagttcca agccagctac ctgcccaaac caggagctca
      361 gctctaccag ttccgatatg tgaaccgcca gggccaggtg tgtgggcaga gccccccttt
      421 ccagttccga gagccaaggc ccatggatga actggtgacc ctggaggagg ctgatggggg
      481 ctctgacatc ctgctggttg tccccaaggc aactgtgtta cagaaccagc tcgatgagag
      541 ccagcaagaa cggaatgacc tgatgcagct gaagctacag ctggagggac aggtgacaga
      601 gctgaggagc cgagtgcagg agctcgagag ggctctggca actgccaggc aggagcacac
      661 ggagctgatg gaacagtaca aggggatttc ccggtcccat ggggagatca cagaagagag
      721 ggacatcctg agccggcaac agggagacca tgtggcacgc atcctggagc tagaggatga
      781 catccagacc atcagtgaga aagtgctgac gaaggaagtg gagctggaca ggcttagaga
      841 cacagtgaag gccctgactc gggaacaaga gaagctcctt gggcaactga aagaagtaca
      901 agcagacaag gagcaaagtg aggctgagct ccaagtggca caacaggaga accatcactt
      961 aaatttggac ctgaaggagg cgaagagctg gcaagaggag cagagtgctc aggctcagcg
     1021 actgaaagac aaggtggccc agatgaagga caccctaggc caggcccagc agcgggtggc
     1081 cgagctggag cccttgaagg agcagcttcg aggggcccag gagcttgcag cctcaagcca
     1141 gcagaaagcc acccttcttg gggaggagtt ggccagtgca gcagcagcca gggaccgcac
     1201 catagccgaa ctacaccgca gccgcctgga agtggctgaa gttaacggca ggctggctga
     1261 gctcggtttg cacttgaagg aagaaaaatg ccaatggagc aaggagcggg cagggctgct
     1321 gcagagtgtg gaggcagaga aggacaagat cctgaagctg agtgcagaga tacttcgatt
     1381 ggagaaggca gttcaggagg agaggaccca aaaccaagtg ttcaagactg agctggcccg
     1441 ggagaaggat tctagcctgg tacagttgtc agaaagtaag cgggagctga cagagctgcg
     1501 gtcagccctg cgtgtgctcc agaaggaaaa ggagcagtta caggaggaga aacaggaatt
     1561 gctagagtac atgagaaagc tagaggcccg cctggagaag gtggcagatg agaagtggaa
     1621 tgaggatgcc accacagagg atgaggaggc cgctgtgggg ctgagctgcc cggcagctct
     1681 gacagactca gaggacgagt ccccagaaga catgaggctc ccaccctatg gcctttgtga
     1741 gcgtggagac ccaggctcct ctcctgctgg gcctcgagag gcttctcccc ttgttgtcat
     1801 cagccagccg gctcccattt ctcctcacct ctctgggcca gctgaggaca gtagctctga
     1861 ctcggaggct gaagatgaga agtcagtcct gatggcagct gtgcagagtg ggggtgagga
     1921 ggccaactta ctgcttcctg aactgggcag tgccttctat gacatggcca gtggctttac
     1981 agtgggtacc ctgtcagaaa ccagcactgg gggccctgcc acccccacat ggaaggagtg
     2041 tcctatctgt aaggagcgct ttcctgctga gagtgacaag gatgccctgg aggaccacat
     2101 ggatggacac ttctttttca gcacccagga ccccttcacc tttgagtgat cttactccct
     2161 cgtacatgca caaatacaca ctcatgcaca cacacactca cacacatgca tacacttagg
     2221 tttcatgccc attttctatc acactgggct ccatgatatt ctgttcccta agaactgctt
     2281 ctgtgtgccc tgttttcatc ccaagatttc tcacttcatc ctctcctacc tggctctttt
     2341 gtcccaggga ggggtcctgt tcggaagcag tggctgaatt tatcccctga aagtggtttt
     2401 ggaggaaccg ggatggagga ggccttcccc tgtgggaata gaatcgtcca ctcctagccc
     2461 tggttgcttc tgatacacag ccactgcaca cacacactca cactcacact cccttgtctg
     2521 atgccccaaa gccaattcct ggggcaccct accctctctt atttggagtt tccgttggtt
     2581 tacctgagtt ttctctgggg tctgcacaga ggcagcagca tggacatcat ggcctctcag
     2641 gtcccttttg gttctcagtt tcattggttc ctctttctgt tcccccattg acttctgtgc
     2701 cccaccctag ccttttccat aaccttaggt attcagtttg gaggggtttt ttgtattttt
     2761 gaggattcct gtattctgta tcctctcctc gcatctcctc acatggaaag aaataatgta
     2821 tttgtgcctt ctgtgaggaa tggggggaac aagtggtccc aggtatcccc atttccaagg
     2881 cccccctccc tctccaggtc cccccacagc aataaaagct tccccctgat atccatccct
     2941 ttgtagtttg aacaaatata tttatatgat atgtatgact gttgtcacaa aatgtgttct
     3001 tatcatgagg tgtgactgga acacagggcc cagacctcca gctcttagac cctggtggag
     3061 ggaggaggga aagaggggac gcatccctgc ctcatggcag gggatgctgg gcagttactg
     3121 tcctgtcgtg cctcctggtg tgctggccat gagtgggttg tctcaagtgg gagtctggct
     3181 tggataatgc ggcagttggg gagggagcaa actcatgggt ccctgtcact tctgctcagg
     3241 gtttagtccc agggtgggtg catgccatgg aaaagtggga caagtttccc actgccgaga
     3301 acttcaccct tcatagcagc catcactgta ccttatgcca aaggacaggc tttattcctg
     3361 tcaagagcgt acacctttga gtatctactt agtaaaaaat gccctaagcc tcatacctct
     3421 aaaggcgatt ttatattcct cctgtttctg tttctgtttc tttctctgtt gccatcccct
     3481 catacctgta tgcacactct gcctcaacag tcacaaaaac acattcatcc actctaacca
     3541 gcttcacagg ctagacagac acatacacag catcgtaaag catttgttaa ggacctgcac
     3601 gctcaccaag gctctcagca atggcctgca caagcacatg cctacaaccc cctcgtcctc
     3661 caacccaata gctcccttct cagctgccct cctctccctt cagggcccct gtgtggacca
     3721 cccccaccat tccctttctc cattcacctg aaatgctcct gtccaccccc tttccagccc
     3781 cacctggatg acttcttaca tcgttccttc ttccctcacg tctccgtctc ctagcaaccc
     3841 catcccgttc cctgaatccc ttccaaggaa attagagata atggatctct cctctctcca
     3901 tcccaacccc tctttattga tcctccttta atgaaagtta attataacaa tgatttaatt
     3961 aatagaatcc ctctcttcct ttattgcttc ccgtattaag actattaata aatacgagct
     4021 gggctgacag aggcatccat cacccgcctg ggattccccc catccctcct tttaccttcc
     4081 cccctctccc tctccctctc ttggcctata aacttgccgg ggtagtgggg gttaatcaga
     4141 gaggaattat gagccaacat ccccagcagg aggtgcattt aatgaaatca tgtgtgattt
     4201 attttctggg ggaggttggg gcgagaagaa tctgggaccc acacctcctg gcttccagtg
     4261 agtggctgcc ttgtgcaaaa aaggagaata gtagacaaac aggaacccag gcccctgctc
     4321 ccatgccaca gcccctgcca agccgcacat acacccacag gagccacatg gctagctgca
     4381 caaggccact gatacagaca ctgtcagact aaaagcactt aagaggactg cggtataggt
     4441 tttgttcttt ccaacctcga aaacttcaca tgggtccttc tcacctcctt cctttctctc
     4501 cagccctgtt ctgcttcact gtcccgaatc tgcttcatac tcccctcctc catgaagccc
     4561 cccaaccccc caccaggctc ctcaacatgg atatctagag tttctagctg ctcctttctc
     4621 tgccctttgt gtgtctttct ggcatgcaat ttgcagtttc agactggggg tgccacaaaa
     4681 tgtggggcca tttctcttcc ttactcatgg tttgcctatc ccagtatcca aagcatggtc
     4741 cccgacacag agggggctca aggaagggta attgacggca tgggctgggg gaaacccagg
     4801 ggcagccagc ttccaattct agttctcttt cctactcact gaggggtatt tggcaactca
     4861 gcctttctac ttatttctct tctataatgg atcatccctt tcctccctgc tccccagcat
     4921 ccatgcaaaa gccgatagat ctgaatgggc ttgagactct aatgtgaaag gagatgtcag
     4981 ccaagtagca gcaaatagga actcgcgtca gtatttggtg gtgaaagaac gaatccaaac
     5041 acaccactcc cccacttatc gaacctcaat ggccacctgt tacctacagg aatgagaaat
     5101 gtagattgct tagtgtgcca gtcagggtct tcaccatctg tcccaacttg cccttccatt
     5161 tcccatctac cctaaggaac cctgtactcc agtataacag aaccattcca caaaaacata
     5221 cactactttc ctcctagctc aaaggatacc acctacatgg agccttactt gactgccctc
     5281 agttatcctt tgacatacca cgtagagcac tttataaaaa gatgctacat gtgtttacaa
     5341 ctttttattc tccctaaact gtaagcaact tgaaggcaga ttctatgctt atacatcact
     5401 gtgttcctaa aatctagtat agagactgga acataggacc agtcctccag aaataatctt
     5461 taagttattt taatgaaatg ttttatacat acaaaataat atatgtaatg aataataaag
     5521 tgaacatcat tgagctcacc aactagcttc aaataaatat taccaatacc attaaa
//
