LOCUS       NM_000728               1044 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens calcitonin related polypeptide beta (CALCB), mRNA.
ACCESSION   NM_000728 XM_350824
VERSION     NM_000728.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1044)
  AUTHORS   Dai,C., Zhang,B., Liao,Y., Liu,Q., Wu,F., Lv,X., Zeng,K. and Zhu,X.
  TITLE     CALCB rs3829222 T/T Genotype and Low Expression of CALCB Are
            High-Risk Factors for Adenoid Cystic Carcinoma of Salivary Gland
  JOURNAL   Dis Markers 2021, 5546858 (2021)
   PUBMED   34234876
  REMARK    GeneRIF: CALCB rs3829222 T/T Genotype and Low Expression of CALCB
            Are High-Risk Factors for Adenoid Cystic Carcinoma of Salivary
            Gland.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1044)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1044)
  AUTHORS   Maruyama,R., Shimizu,M., Ishijima,T., Nakai,Y., Inoue,J. and
            Sato,R.
  TITLE     Searching for novel ATF4 target genes in human hepatoma cells by
            microarray analysis
  JOURNAL   Biosci Biotechnol Biochem 80 (6), 1149-1154 (2016)
   PUBMED   26967115
  REMARK    GeneRIF: The results suggest that C12orf39, CSTA, and CALCB are
            novel ATF4 target genes, and that C12orf39 promoter activity is
            activated by ATF4 through amino acid response element.
REFERENCE   4  (bases 1 to 1044)
  AUTHORS   Dong,Y., Betancourt,A., Chauhan,M., Balakrishnan,M., Lugo,F.,
            Anderson,M.L., Espinoza,J., Fox,K., Belfort,M. and Yallampalli,C.
  TITLE     Pregnancy Increases Relaxation in Human Omental Arteries to the
            CGRP Family of Peptides
  JOURNAL   Biol Reprod 93 (6), 134 (2015)
   PUBMED   26510864
REFERENCE   5  (bases 1 to 1044)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   6  (bases 1 to 1044)
  AUTHORS   Kitamura,K., Kangawa,K., Kawamoto,M., Ichiki,Y., Matsuo,H. and
            Eto,T.
  TITLE     Isolation and characterization of peptides which act on rat
            platelets, from a pheochromocytoma
  JOURNAL   Biochem Biophys Res Commun 185 (1), 134-141 (1992)
   PUBMED   1318039
REFERENCE   7  (bases 1 to 1044)
  AUTHORS   Wimalawansa,S.J., Morris,H.R., Etienne,A., Blench,I., Panico,M. and
            MacIntyre,I.
  TITLE     Isolation, purification and characterization of beta-hCGRP from
            human spinal cord
  JOURNAL   Biochem Biophys Res Commun 167 (3), 993-1000 (1990)
   PUBMED   2322288
REFERENCE   8  (bases 1 to 1044)
  AUTHORS   Petermann,J.B., Born,W., Chang,J.Y. and Fischer,J.A.
  TITLE     Identification in the human central nervous system, pituitary, and
            thyroid of a novel calcitonin gene-related peptide, and partial
            amino acid sequence in the spinal cord
  JOURNAL   J Biol Chem 262 (2), 542-545 (1987)
   PUBMED   3492492
REFERENCE   9  (bases 1 to 1044)
  AUTHORS   Steenbergh,P.H., Hoppener,J.W., Zandberg,J., Visser,A., Lips,C.J.
            and Jansz,H.S.
  TITLE     Structure and expression of the human calcitonin/CGRP genes
  JOURNAL   FEBS Lett 209 (1), 97-103 (1986)
   PUBMED   3492393
REFERENCE   10 (bases 1 to 1044)
  AUTHORS   Steenbergh,P.H., Hoppener,J.W., Zandberg,J., Lips,C.J. and
            Jansz,H.S.
  TITLE     A second human calcitonin/CGRP gene
  JOURNAL   FEBS Lett 183 (2), 403-407 (1985)
   PUBMED   2985435
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090744.5, BI668461.1, AI937230.1 and X02404.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000728.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092468.1, BI668461.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2145313
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324229.11/ ENSP00000346017.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC090744.5         189383-189389       c
            8-560               BI668461.1         10-562
            561-998             AI937230.1         43-480              c
            999-1038            X02404.1           757-796
            1039-1044           AC090744.5         184345-184350       c
FEATURES             Location/Qualifiers
     source          1..1044
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.2"
     gene            1..1044
                     /gene="CALCB"
                     /gene_synonym="CALC2; CGRP-II; CGRP2"
                     /note="calcitonin related polypeptide beta"
                     /db_xref="GeneID:797"
                     /db_xref="HGNC:HGNC:1438"
                     /db_xref="MIM:114160"
     exon            1..71
                     /gene="CALCB"
                     /gene_synonym="CALC2; CGRP-II; CGRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            72..166
                     /gene="CALCB"
                     /gene_synonym="CALC2; CGRP-II; CGRP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..464
                     /gene="CALCB"
                     /gene_synonym="CALC2; CGRP-II; CGRP2"
                     /note="calcitonin 2; calcitonin gene-related peptide 2;
                     beta-type CGRP; calcitonin gene-related peptide II;
                     beta-CGRP"
                     /codon_start=1
                     /product="calcitonin gene-related peptide 2 precursor"
                     /protein_id="NP_000719.1"
                     /db_xref="CCDS:CCDS7820.1"
                     /db_xref="GeneID:797"
                     /db_xref="HGNC:HGNC:1438"
                     /db_xref="MIM:114160"
                     /translation="MGFRKFSPFLALSILVLYQAGSLQAAPFRSALESSPDPATLSKE
                     DARLLLAALVQDYVQMKASELKQEQETQGSSSAAQKRACNTATCVTHRLAGLLSRSGG
                     MVKSNFVPTNVGSKAFGRRRRDLQA"
     exon            167..304
                     /gene="CALCB"
                     /gene_synonym="CALC2; CGRP-II; CGRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            305..489
                     /gene="CALCB"
                     /gene_synonym="CALC2; CGRP-II; CGRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            490..1044
                     /gene="CALCB"
                     /gene_synonym="CALC2; CGRP-II; CGRP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1020..1025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALCB"
                     /gene_synonym="CALC2; CGRP-II; CGRP2"
                     /note="hexamer: AATAAA"
     polyA_site      1044
                     /gene="CALCB"
                     /gene_synonym="CALC2; CGRP-II; CGRP2"
                     /note="major polyA site"
ORIGIN      
        1 gcccacagca ggtgtggtgt tcatcccggg tcgaccggcc gctcgcgctg ccctgaaact
       61 ctagtcgcca gagaggcggc atgggtttcc ggaagttctc ccccttcctg gctctcagta
      121 tcttggtcct gtaccaggcg ggcagcctcc aggcggcgcc attcaggtct gccctggaga
      181 gcagcccaga cccggccaca ctcagtaaag aggacgcgcg cctcctgctg gctgcactgg
      241 tgcaggacta tgtgcagatg aaggccagtg agctgaagca ggagcaggag acacagggct
      301 ccagctccgc tgcccagaag agagcctgca acactgccac ctgtgtgact catcggctgg
      361 caggcttgct gagcagatca gggggcatgg tgaagagcaa cttcgtgccc accaatgtgg
      421 gttccaaagc ctttggcagg cgccgcaggg accttcaagc ctgagcagat gaatgactcc
      481 aggaagaagg ttatcatgaa actgaactca ccatttctat taatttctgt tggtaagaac
      541 ttggtgagaa tgccccgtgg aagatacaca tgtttgcatc ctaagatact gaaaaaaggg
      601 cacctttgtc acttgaaagg aatgaaactg aatgcaaaat aagctaattc catatttgct
      661 gtgcatcatt tttatattta attctatgtc cagtaaaagt gatggcatct ctcattgact
      721 tatctggtag caaactggtt ctttcggagc catcctgttg atcatgcagc tccaccaaac
      781 cttaggggga cgtgaaatca ctgcctgttg tggtctccga ggacacatgg taatggtgat
      841 gctgtgcctt gttatctaag aacatgattg tataatttgt ttaagaaaat gtcaatattg
      901 tgccatttgt gaacttcatc aagattaaaa gcatattttg ggtacatttg tttcaaaacc
      961 ttggtgatgc attacaactt gttttcttat gtaataataa tgatgatgat gatgataata
     1021 ataaatattt ttgagtgctt acta
//
