LOCUS       NM_001741                840 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens calcitonin related polypeptide alpha (CALCA),
            transcript variant 1, mRNA.
ACCESSION   NM_001741
VERSION     NM_001741.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 840)
  AUTHORS   Pepin,R., Ringuet,J., Beaudet,M.J., Bellenfant,S., Galbraith,T.,
            Veillette,H., Pouliot,R. and Berthod,F.
  TITLE     Sensory neurons increase keratinocyte proliferation through CGRP
            release in a tissue engineered in vitro model of innervation in
            psoriasis
  JOURNAL   Acta Biomater 182, 1-13 (2024)
   PUBMED   38750917
  REMARK    GeneRIF: Sensory neurons increase keratinocyte proliferation
            through CGRP release in a tissue engineered in vitro model of
            innervation in psoriasis.
REFERENCE   2  (bases 1 to 840)
  AUTHORS   Cao,J., Belousoff,M.J., Danev,R., Christopoulos,A., Wootten,D. and
            Sexton,P.M.
  TITLE     Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with
            CGRP and Gs Protein
  JOURNAL   Biochemistry 63 (9), 1089-1096 (2024)
   PUBMED   38603770
REFERENCE   3  (bases 1 to 840)
  AUTHORS   Li,C., Yu,Y., Li,N., Yin,Y.N., Zhang,L., Xie,K. and Huang,D.
  TITLE     Calcitonin gene-related peptide: a possible biomarker in migraine
            patients with patent foramen ovale
  JOURNAL   BMC Neurol 24 (1), 126 (2024)
   PUBMED   38627623
  REMARK    GeneRIF: Calcitonin gene-related peptide: a possible biomarker in
            migraine patients with patent foramen ovale.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 840)
  AUTHORS   El Karim,I.A., Linden,G.J., Orr,D.F. and Lundy,F.T.
  TITLE     Antimicrobial activity of neuropeptides against a range of
            micro-organisms from skin, oral, respiratory and gastrointestinal
            tract sites
  JOURNAL   J Neuroimmunol 200 (1-2), 11-16 (2008)
   PUBMED   18603306
  REMARK    GeneRIF: CGRP displays antimicrobial activity against S. mutans, L.
            acidophilus, E. faecalis, E. coli, P. aeruginosa, and C. albicans.
REFERENCE   5  (bases 1 to 840)
  AUTHORS   Kitamura,K., Kangawa,K., Kawamoto,M., Ichiki,Y., Matsuo,H. and
            Eto,T.
  TITLE     Isolation and characterization of peptides which act on rat
            platelets, from a pheochromocytoma
  JOURNAL   Biochem Biophys Res Commun 185 (1), 134-141 (1992)
   PUBMED   1318039
REFERENCE   6  (bases 1 to 840)
  AUTHORS   Sung,C.P., Arleth,A.J., Aiyar,N., Bhatnagar,P.K., Lysko,P.G. and
            Feuerstein,G.
  TITLE     CGRP stimulates the adhesion of leukocytes to vascular endothelial
            cells
  JOURNAL   Peptides 13 (3), 429-434 (1992)
   PUBMED   1326102
REFERENCE   7  (bases 1 to 840)
  AUTHORS   Minvielle,S., Giscard-Dartevelle,S., Cohen,R., Taboulet,J.,
            Labye,F., Jullienne,A., Rivaille,P., Milhaud,G., Moukhtar,M.S. and
            Lasmoles,F.
  TITLE     A novel calcitonin carboxyl-terminal peptide produced in medullary
            thyroid carcinoma by alternative RNA processing of the
            calcitonin/calcitonin gene-related peptide gene
  JOURNAL   J Biol Chem 266 (36), 24627-24631 (1991)
   PUBMED   1761559
REFERENCE   8  (bases 1 to 840)
  AUTHORS   Mallette,L.E.
  TITLE     Regulation of blood calcium in humans
  JOURNAL   Endocrinol Metab Clin North Am 18 (3), 601-610 (1989)
   PUBMED   2673764
  REMARK    Review article
REFERENCE   9  (bases 1 to 840)
  AUTHORS   Marshall,I., Al-Kazwini,S.J., Holman,J.J. and Craig,R.K.
  TITLE     Human alpha-calcitonin gene-related peptide (CGRP) is a potent
            vasodilator in human mesenteric vasculature
  JOURNAL   Br J Clin Pharmacol 26 (6), 691-695 (1988)
   PUBMED   3266556
REFERENCE   10 (bases 1 to 840)
  AUTHORS   Hillyard,C.J., Myers,C., Abeyasekera,G., Stevvensvenson,J.C.,
            Craig,R.K. and MacIntyre,I.
  TITLE     Katacalcin: a new plasma calcium-lowering hormone
  JOURNAL   Lancet 1 (8329), 846-848 (1983)
   PUBMED   6132180
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090835.7, BC069704.1 and
            BF942024.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001741.2.
            
            Summary: This gene encodes the peptide hormones calcitonin,
            calcitonin gene-related peptide and katacalcin by tissue-specific
            alternative RNA splicing of the gene transcripts and cleavage of
            inactive precursor proteins. Calcitonin is involved in calcium
            regulation and acts to regulate phosphorus metabolism. Calcitonin
            gene-related peptide functions as a vasodilator and as an
            antimicrobial peptide while katacalcin is a calcium-lowering
            peptide. Multiple transcript variants encoding different isoforms
            have been found for this gene.[provided by RefSeq, Aug 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138508.36673.1, X00356.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331587.9/ ENSP00000331746.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC090835.7         47511-47575
            66-799              BC069704.1         1-734
            800-840             BF942024.1         281-321
FEATURES             Location/Qualifiers
     source          1..840
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.2"
     gene            1..840
                     /gene="CALCA"
                     /gene_synonym="CALC1; CGRP; CGRP-alpha; CGRP-I; CGRP1; CT;
                     KC; PCT"
                     /note="calcitonin related polypeptide alpha"
                     /db_xref="GeneID:796"
                     /db_xref="HGNC:HGNC:1437"
                     /db_xref="MIM:114130"
     exon            1..107
                     /gene="CALCA"
                     /gene_synonym="CALC1; CGRP; CGRP-alpha; CGRP-I; CGRP1; CT;
                     KC; PCT"
                     /inference="alignment:Splign:2.1.0"
     exon            108..202
                     /gene="CALCA"
                     /gene_synonym="CALC1; CGRP; CGRP-alpha; CGRP-I; CGRP1; CT;
                     KC; PCT"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..542
                     /gene="CALCA"
                     /gene_synonym="CALC1; CGRP; CGRP-alpha; CGRP-I; CGRP1; CT;
                     KC; PCT"
                     /note="isoform CT preproprotein is encoded by transcript
                     variant 1; calcitonin 1; calcitonin/calcitonin-related
                     polypeptide, alpha; katacalcin; calcitonin gene-related
                     peptide 1; alpha-type CGRP; calcitonin gene-related
                     peptide I"
                     /codon_start=1
                     /product="calcitonin isoform CT preproprotein"
                     /protein_id="NP_001732.1"
                     /db_xref="CCDS:CCDS7819.1"
                     /db_xref="GeneID:796"
                     /db_xref="HGNC:HGNC:1437"
                     /db_xref="MIM:114130"
                     /translation="MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSE
                     DEARLLLAALVQDYVQMKASELEQEQEREGSSLDSPRSKRCGNLSTCMLGTYTQDFNK
                     FHTFPQTAIGVGAPGKKRDMSSDLERDHRPHVSMPQNAN"
     exon            203..343
                     /gene="CALCA"
                     /gene_synonym="CALC1; CGRP; CGRP-alpha; CGRP-I; CGRP1; CT;
                     KC; PCT"
                     /inference="alignment:Splign:2.1.0"
     exon            344..840
                     /gene="CALCA"
                     /gene_synonym="CALC1; CGRP; CGRP-alpha; CGRP-I; CGRP1; CT;
                     KC; PCT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      819..824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CALCA"
                     /gene_synonym="CALC1; CGRP; CGRP-alpha; CGRP-I; CGRP1; CT;
                     KC; PCT"
                     /note="hexamer: AATAAA"
     polyA_site      840
                     /gene="CALCA"
                     /gene_synonym="CALC1; CGRP; CGRP-alpha; CGRP-I; CGRP1; CT;
                     KC; PCT"
                     /note="major polyA site"
ORIGIN      
        1 atcagagaca ctgcccagcc caagtgtcgc cgccgcttcc acagggctct ggctggacgc
       61 cgccgccgcc gctgccaccg cctctgatcc aagccacctc ccgccagaga ggtgtcatgg
      121 gcttccaaaa gttctccccc ttcctggctc tcagcatctt ggtcctgttg caggcaggca
      181 gcctccatgc agcaccattc aggtctgccc tggagagcag cccagcagac ccggccacgc
      241 tcagtgagga cgaagcgcgc ctcctgctgg ctgcactggt gcaggactat gtgcagatga
      301 aggccagtga gctggagcag gagcaagaga gagagggctc cagcctggac agccccagat
      361 ctaagcggtg cggtaatctg agtacttgca tgctgggcac atacacgcag gacttcaaca
      421 agtttcacac gttcccccaa actgcaattg gggttggagc acctggaaag aaaagggata
      481 tgtccagcga cttggagaga gaccatcgcc ctcatgttag catgccccag aatgccaact
      541 aaactcctcc ctttccttcc taatttccct tcttgcatcc ttcctataac ttgatgcatg
      601 tggtttggtt cctctctggt ggctctttgg gctggtattg gtggctttcc ttgtggcaga
      661 ggatgtctca aacttcagat gggaggaaag agagcaggac tcacaggttg gaagagaatc
      721 acctgggaaa ataccagaaa atgagggccg ctttgagtcc cccagagatg tcatcagagc
      781 tcctctgtcc tgcttctgaa tgtgctgatc atttgaggaa taaaattatt tttccccaaa
//
