LOCUS       NM_001170692            3283 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cancer antigen 1 (CAGE1), transcript variant 1, mRNA.
ACCESSION   NM_001170692
VERSION     NM_001170692.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3283)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3283)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   3  (bases 1 to 3283)
  AUTHORS   Kim,Y., Park,D., Kim,H., Choi,M., Lee,H., Lee,Y.S., Choe,J.,
            Kim,Y.M. and Jeoung,D.
  TITLE     miR-200b and cancer/testis antigen CAGE form a feedback loop to
            regulate the invasion and tumorigenic and angiogenic responses of a
            cancer cell line to microtubule-targeting drugs
  JOURNAL   J Biol Chem 288 (51), 36502-36518 (2013)
   PUBMED   24174534
  REMARK    GeneRIF: CAGE and miR-200b form a feedback regulatory loop.
REFERENCE   4  (bases 1 to 3283)
  AUTHORS   Kunze,E. and Schlott,T.
  TITLE     High frequency of promoter methylation of the 14-3-3 sigma and
            CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene,
            in primary adenocarcinomas and signet ring cell carcinomas of the
            urinary bladder
  JOURNAL   Int J Mol Med 20 (4), 557-563 (2007)
   PUBMED   17786288
  REMARK    GeneRIF: The present data suggest that promoter methylation of the
            14-3-3 sigma and CAGE-1 genes plays a crucial role during the
            phenotypical morphogenesis of vesical adenocarcinomas including
            signet ring cell carcinomas by an epigenetic mechanism.
REFERENCE   5  (bases 1 to 3283)
  AUTHORS   Parmigiani,R.B., Bettoni,F., Vibranovski,M.D., Lopes,M.H.,
            Martins,W.K., Cunha,I.W., Soares,F.A., Simpson,A.J., de Souza,S.J.
            and Camargo,A.A.
  TITLE     Characterization of a cancer/testis (CT) antigen gene family
            capable of eliciting humoral response in cancer patients
  JOURNAL   Proc Natl Acad Sci U S A 103 (48), 18066-18071 (2006)
   PUBMED   17114284
  REMARK    GeneRIF: CTSP-1 should be considered a promising candidate for
            cancer immunotherapy
REFERENCE   6  (bases 1 to 3283)
  AUTHORS   Kunze,E., Wendt,M. and Schlott,T.
  TITLE     Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes
            is related to the various phenotypes of urinary bladder carcinomas
            and associated with progression of transitional cell carcinomas
  JOURNAL   Int J Mol Med 18 (4), 547-557 (2006)
   PUBMED   16964403
  REMARK    GeneRIF: The different patterns of aberrant methylation of the
            CAGE-1 gene in the various histopathological cancer types of the
            urinary bladder point to a role in tumor cell differentiation.
REFERENCE   7  (bases 1 to 3283)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 3283)
  AUTHORS   Park,S., Lim,Y., Lee,D., Cho,B., Bang,Y.J., Sung,S., Kim,H.Y.,
            Kim,D.K., Lee,Y.S., Song,Y. and Jeoung,D.I.
  TITLE     Identification and characterization of a novel cancer/testis
            antigen gene CAGE-1
  JOURNAL   Biochim Biophys Acta 1625 (2), 173-182 (2003)
   PUBMED   12531476
  REMARK    GeneRIF: identification and characterization of CAGE-1 gene;
            displays testis-specific expression among normal tissues, and wide
            expression among various cancer tissues and cancer cell lines
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139095.15.
            
            On Nov 23, 2018 this sequence version replaced NM_001170692.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments, including macaque AB070119.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000502583.6/ ENSP00000425493.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-541               AL139095.15        149867-150407       c
            542-759             AL139095.15        147644-147861       c
            760-847             AL139095.15        146450-146537       c
            848-1251            AL139095.15        139282-139685       c
            1252-2310           AL139095.15        133738-134796       c
            2311-2457           AL139095.15        130584-130730       c
            2458-2568           AL139095.15        129353-129463       c
            2569-2649           AL139095.15        126469-126549       c
            2650-2757           AL139095.15        126133-126240       c
            2758-2862           AL139095.15        116690-116794       c
            2863-2933           AL139095.15        115706-115776       c
            2934-3002           AL139095.15        94687-94755         c
            3003-3042           AL139095.15        90514-90553         c
            3043-3283           AL139095.15        87324-87564         c
FEATURES             Location/Qualifiers
     source          1..3283
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p24.3"
     gene            1..3283
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /note="cancer antigen 1"
                     /db_xref="GeneID:285782"
                     /db_xref="HGNC:HGNC:21622"
                     /db_xref="MIM:608304"
     exon            1..541
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /inference="alignment:Splign:2.1.0"
     exon            542..759
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             565..3084
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cancer/testis antigen 95; cancer/testis antigen 3;
                     cancer-associated gene 1 protein; cancer/testis antigen
                     gene 1"
                     /codon_start=1
                     /product="cancer-associated gene 1 protein isoform 1"
                     /protein_id="NP_001164163.1"
                     /db_xref="CCDS:CCDS54965.1"
                     /db_xref="GeneID:285782"
                     /db_xref="HGNC:HGNC:21622"
                     /db_xref="MIM:608304"
                     /translation="MNKDYQKFWSSPSDPVHFEVDTSHEKVESMSESDTMNVSNLSQG
                     VMLSHSPICMETTGTTCDLPQNEIKNFERENEYESTLCEDAYGTLDNLLNDNNIENYS
                     TNALIQPVDTISISSLRQFETVCKFHWVEAFDDEMTEKPEFQSQVYNYAKDNNIKQDS
                     FKEENPMETSVSANTDQLGNEYFRQPPPRSPPLIHCSGEMLKFTEKSLAKSIAKESAL
                     NPSQPPSFLCKTAVPSKEIQNYGEIPEMSVSYEKEVTAEGVERPEIVSTWSSAGISWR
                     SEACRENCEMPDWEQSAESLQPVQEDMALNEVLQKLKHTNRKQEVRIQELQCSNLYLE
                     KRVKELQMKITKQQVFIDVINKLKENVEELIEDKYKIILEKNDTKKTLQNLEEVLANT
                     QKHLQESRNDKEMLQLQFKKIKANYVCLQERYMTEMQQKNKSVSQYLEMDKTLSKKEE
                     EVERLQQLKKELEKATASALDLLKREKEAQEQEFLSLQEEFQKLEKENLEERQKLKSR
                     LEKLLTQVRNLQFMSENERTKNIKLQQQINEVKNENAKLKQQVARSEEQNYVPKFETA
                     QLKDQLEEVLKSDITKDTKTTHSNLLPDCSPCEERLNPADIKRASQLASKMHSLLALM
                     VGLLTCQDIINSDAEHFKESEKVSDIMLQKLKSLHLKKKTLDKELLKHKDRITTFREL
                     IAKEKAFQDHAIKVIDCDSDEAKSIRDVPTLLGAKLDKYHSLNEELDFLITKLGHLLE
                     SKENHCNRLIEENDKYQRHLGNLIKKVTSYEEIIECADQRLAISHSQIAHLEERNKHL
                     EDLIRKPREKARKPRSKSLENHPKSMTMMPALFKENRNDLD"
     exon            760..847
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1251
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..2310
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2457
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2568
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2649
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2757
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..2862
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..2933
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3002
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3042
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3283
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3181..3186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /note="hexamer: ATTAAA"
     regulatory      3192..3197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /note="hexamer: TATAAA"
     polyA_site      3204
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /note="major polyA site"
     polyA_site      3219
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
     regulatory      3262..3267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /note="hexamer: AATATA"
     polyA_site      3283
                     /gene="CAGE1"
                     /gene_synonym="bA69L16.7; CT3; CT95; CTAG3"
                     /note="major polyA site"
ORIGIN      
        1 ggagctctct ggatggcgcg ctgtataggg ctgtggatgt tctgtgctct caggaaggcg
       61 tgttgagtag ccggcacggc gaggcccgtg ctggccgttt cttcccggag ttttcgtttc
      121 tgtaccccac tttgtgttta ctgcggcagg aggcgccagc tagcccacag gctgttcggc
      181 ctagggggtc gtaccttcct aacttcacca ctctctggga agacaccgca cccacagtag
      241 ggtcgctcgg gcctcgcggg ctgcacctgt ctctgcggag ttcccccggc gcgggcggac
      301 gtcacacagg ggcgttccag cactccggga gcccgattgc gagtttgtga gagtccttgg
      361 tggaggaggt tggaaagcgt tctccctccc acaaaacccg gtgcagaggg agggagagcc
      421 aggtccgtag cgtgggtcca agaaactatg gatcctggaa gtgagcacac ttttgtgtct
      481 taaaaagttt ggtgtctcgt tttgaggtga aaaatgaatg agataagtgc tttttaaaaa
      541 gaagtcttct attgttcaac agttatgaac aaggactatc aaaaattttg gtcatcacct
      601 tcagatcctg tacattttga agtggatact tctcatgaaa aagtagaaag catgtcagaa
      661 tcggatacca tgaatgtcag caatctttct caaggtgtaa tgctttcaca ttctccaatc
      721 tgtatggaaa ccaccggcac cacttgtgac ttgcctcaga acgaaataaa gaattttgaa
      781 agggaaaatg agtatgaatc cacactttgt gaagatgctt atggcacact agacaatttg
      841 ttaaatgata acaacattga aaattactca acgaatgcac taattcagcc agttgacacc
      901 atcagcatat cttccttgag acaatttgaa accgtttgca aatttcactg ggtagaagca
      961 tttgatgatg aaatgacaga gaagccagaa tttcaaagtc aagtgtataa ttatgcaaaa
     1021 gacaacaata taaagcaaga ctcatttaag gaagaaaatc caatggaaac tagtgtttct
     1081 gcaaatacag accaacttgg taacgagtat tttagacagc ctcctcctag aagcccgcct
     1141 ctaatccact gcagtggaga gatgctgaaa tttacagaaa agtcactggc taaaagtatt
     1201 gccaaggaat ctgccctcaa ccctagccaa cctccaagct tcttatgtaa gactgcagtt
     1261 ccttcaaaag aaatacagaa ttatggggag attcctgaga tgtcagtcag ttatgaaaag
     1321 gaagtcacag cagagggtgt ggagaggcca gaaattgtct caacttggtc ttcggcaggc
     1381 atttcctgga ggagtgaagc atgtcgggag aactgtgaga tgcctgactg ggagcaaagt
     1441 gctgaaagct tacaacctgt tcaagaggac atggctttaa atgaagtctt gcagaaatta
     1501 aaacatacta acagaaagca ggaagtgcga atccaagaac tccagtgtag taacctgtat
     1561 ttagagaaga gggttaaaga actacagatg aagattacca aacagcaagt gttcattgat
     1621 gtcatcaata agctaaagga gaatgttgaa gaattaattg aagacaaata caaaataatc
     1681 ctagagaaga atgatactaa aaagacattg cagaatttgg aagaggtttt agctaacacg
     1741 caaaaacatc ttcaggaatc caggaatgac aaggaaatgt tacagcttca atttaagaag
     1801 atcaaggcta attatgtgtg tttacaggaa aggtacatga ctgaaatgca acaaaaaaat
     1861 aaatctgtaa gtcagtattt agagatggac aaaaccttaa gcaagaaaga agaagaggta
     1921 gagagactac aacaactcaa aaaagaactg gaaaaggcca cagcttctgc tttggacttg
     1981 ttgaaacggg aaaaagaggc ccaagaacaa gagttcttgt ctttacagga ggaattccag
     2041 aaacttgaaa aggaaaacct ggaagaaaga cagaaactga aatctagact tgagaaattg
     2101 ctcactcaag ttagaaattt gcaatttatg tctgaaaatg aaagaacgaa gaatataaaa
     2161 cttcagcagc aaatcaacga agtaaaaaat gagaatgcaa aacttaaaca gcaggttgca
     2221 aggagtgaag agcaaaatta tgtccctaaa tttgagacag ctcagttaaa ggatcaatta
     2281 gaggaagtct tgaagtcaga tattaccaag gatacaaaaa cgacacattc taatctgctc
     2341 ccggattgct caccttgtga agagaggctg aatcctgcag atataaaaag agcttctcag
     2401 ctggcctcca aaatgcacag tcttctggct ctgatggtgg gacttctcac atgccaggac
     2461 atcatcaatt ctgatgctga acatttcaaa gagagtgaga aggttagtga tataatgctg
     2521 caaaaactga agagcctcca tcttaaaaag aaaactttag ataaagagct actgaaacat
     2581 aaagatagaa tcacaacctt tagagagtta attgctaagg aaaaagcatt tcaagatcat
     2641 gctattaagg tcatagactg tgattcagat gaagccaaga gtatcagaga tgtacctacc
     2701 cttctgggag ccaaactgga taagtaccac agtctaaatg aggagcttga tttcttgatc
     2761 acaaaactgg gacatctcct agagtcaaaa gaaaaccact gcaacagact cattgaagaa
     2821 aatgacaagt atcaaagaca tttaggcaac ttaataaaga aggttacatc atatgaagaa
     2881 atcattgaat gtgctgacca aaggcttgca atatcccact cccagattgc acatttggaa
     2941 gagagaaata aacatttaga ggatttaatt agaaagccca gagaaaaagc cagaaaacca
     3001 agatcaaaaa gcttagaaaa tcatccgaag tccatgacca tgatgccagc tctttttaaa
     3061 gaaaatagaa atgatttaga ttaaacaagc ctgaagatta aacagtaatc atttttgtca
     3121 accactccag gaagagtcat tactacatat gctagccaaa tcaatccatg cagatgatat
     3181 attaaaatct gtataaaggg taaagtctta cattccaaag atgtgattac ttttcttcta
     3241 atttcttcct gtgaataatc aaatatattc tatttaacat aaa
//
