LOCUS       NM_001363399            5841 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens calcium dependent secretion activator 2 (CADPS2),
            transcript variant 14, mRNA.
ACCESSION   NM_001363399 XM_017012797
VERSION     NM_001363399.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5841)
  AUTHORS   Andersen,J.S., Vijayakumaran,A., Godbehere,C., Lorentzen,E.,
            Mennella,V. and Schou,K.B.
  TITLE     Uncovering structural themes across cilia microtubule inner
            proteins with implications for human cilia function
  JOURNAL   Nat Commun 15 (1), 2687 (2024)
   PUBMED   38538594
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5841)
  AUTHORS   Yoo,H., Yang,S.H., Kim,J.Y., Yang,E., Park,H.S., Lee,S.J.,
            Rhyu,I.J., Turecki,G., Lee,H.W. and Kim,H.
  TITLE     Down-regulation of habenular calcium-dependent secretion activator
            2 induces despair-like behavior
  JOURNAL   Sci Rep 11 (1), 3700 (2021)
   PUBMED   33580180
  REMARK    GeneRIF: Down-regulation of habenular calcium-dependent secretion
            activator 2 induces despair-like behavior.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5841)
  AUTHORS   Zhang,K., Fan,Z., Wang,Y., Faraone,S.V., Yang,L. and Chang,S.
  TITLE     Genetic analysis for cognitive flexibility in the trail-making test
            in attention deficit hyperactivity disorder patients from single
            nucleotide polymorphism, gene to pathway level
  JOURNAL   World J Biol Psychiatry 20 (6), 476-485 (2019)
   PUBMED   28971736
  REMARK    GeneRIF: The top SNP rs2049161 involved gene DLGAP1 and the top
            gene CADPS2 in the gene-based analysis resulted in much literature
            evidence of associations with psychiatric disorders. Gene
            expression and network analysis showed their contribution to
            cognition function.
REFERENCE   4  (bases 1 to 5841)
  AUTHORS   Obergasteiger,J., Uberbacher,C., Pramstaller,P.P., Hicks,A.A.,
            Corti,C. and Volta,M.
  TITLE     CADPS2 gene expression is oppositely regulated by LRRK2 and
            alpha-synuclein
  JOURNAL   Biochem Biophys Res Commun 490 (3), 876-881 (2017)
   PUBMED   28647363
  REMARK    GeneRIF: These results indicate that LRRK2 and alpha-synuclein
            participate in the dysregulation of CADPS2 by altering
            transcription and support the hypothesis that synaptic
            dysfunctions, through different mechanisms, might contribute to the
            neuronal defects of diseases such as Parkinson's disease.
REFERENCE   5  (bases 1 to 5841)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   6  (bases 1 to 5841)
  AUTHORS   Brunk,I., Blex,C., Speidel,D., Brose,N. and Ahnert-Hilger,G.
  TITLE     Ca2+-dependent activator proteins of secretion promote vesicular
            monoamine uptake
  JOURNAL   J Biol Chem 284 (2), 1050-1056 (2009)
   PUBMED   19008227
  REMARK    GeneRIF: CAPS proteins are involved in optimizing vesicular
            monoamine uptake and storage mediated by VMAT1 and VMAT2
REFERENCE   7  (bases 1 to 5841)
  AUTHORS   Sadakata,T., Washida,M., Iwayama,Y., Shoji,S., Sato,Y., Ohkura,T.,
            Katoh-Semba,R., Nakajima,M., Sekine,Y., Tanaka,M., Nakamura,K.,
            Iwata,Y., Tsuchiya,K.J., Mori,N., Detera-Wadleigh,S.D.,
            Ichikawa,H., Itohara,S., Yoshikawa,T. and Furuichi,T.
  TITLE     Autistic-like phenotypes in Cadps2-knockout mice and aberrant
            CADPS2 splicing in autistic patients
  JOURNAL   J Clin Invest 117 (4), 931-943 (2007)
   PUBMED   17380209
  REMARK    GeneRIF: Genetic disturbance in CADPS2-mediated neurotrophin
            release contributes to autism susceptibility.
            GeneRIF: CADPS2-KO mice show autistic-like phenotypes. Moreover,
            the results show that some autistic patients have an aberrant
            splicing variant of CADPS2 mRNA, suggesting that a disturbance in
            CADPS2-mediated neurotrophin release contributes to autism.
            GeneRIF: Results from Cadps2-deficient mice and human data suggest
            that a disturbance in CADPS2-mediated neurotrophin release
            contributes to autistic-like cellular and behavioral phenotypes.
REFERENCE   8  (bases 1 to 5841)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   9  (bases 1 to 5841)
  AUTHORS   Speidel,D., Varoqueaux,F., Enk,C., Nojiri,M., Grishanin,R.N.,
            Martin,T.F., Hofmann,K., Brose,N. and Reim,K.
  TITLE     A family of Ca2+-dependent activator proteins for secretion:
            comparative analysis of structure, expression, localization, and
            function
  JOURNAL   J Biol Chem 278 (52), 52802-52809 (2003)
   PUBMED   14530279
  REMARK    GeneRIF: identification, cloning, and comparative characterization
            of a second mammalian CAPS isoform, CAPS2; concluded that at the
            functional level, CAPS2 is largely redundant with CAPS1
REFERENCE   10 (bases 1 to 5841)
  AUTHORS   Cisternas,F.A., Vincent,J.B., Scherer,S.W. and Ray,P.N.
  TITLE     Cloning and characterization of human CADPS and CADPS2, new members
            of the Ca2+-dependent activator for secretion protein family
  JOURNAL   Genomics 81 (3), 279-291 (2003)
   PUBMED   12659812
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004838.2, AC006463.4,
            AC091438.4, AC006009.2, AC004594.2 and AC015983.7.
            
            On Aug 13, 2020 this sequence version replaced NM_001363399.1.
            
            Summary: This gene encodes a member of the calcium-dependent
            activator of secretion (CAPS) protein family, which are calcium
            binding proteins that regulate the exocytosis of synaptic and
            dense-core vesicles in neurons and neuroendocrine cells. Mutations
            in this gene may contribute to autism susceptibility. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Nov 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-462               AC004838.2         120142-120603
            463-514             AC004838.2         121157-121208
            515-628             AC006463.4         119220-119333       c
            629-961             AC006463.4         45502-45834         c
            962-1042            AC006463.4         11513-11593         c
            1043-1279           AC006463.4         3746-3982           c
            1280-1398           AC091438.4         28833-28951         c
            1399-1510           AC006009.2         88573-88684         c
            1511-1650           AC006009.2         61944-62083         c
            1651-1717           AC006009.2         20643-20709         c
            1718-1826           AC004594.2         150380-150488       c
            1827-2027           AC004594.2         149149-149349       c
            2028-2036           AC004594.2         139920-139928       c
            2037-2173           AC004594.2         133449-133585       c
            2174-2361           AC004594.2         130443-130630       c
            2362-2463           AC004594.2         110442-110543       c
            2464-2527           AC004594.2         100580-100643       c
            2528-2651           AC004594.2         97409-97532         c
            2652-2672           AC004594.2         95428-95448         c
            2673-2776           AC004594.2         75129-75232         c
            2777-2785           AC004594.2         73136-73144         c
            2786-2942           AC004594.2         66608-66764         c
            2943-3084           AC004594.2         52509-52650         c
            3085-3204           AC004594.2         52264-52383         c
            3205-3360           AC004594.2         47651-47806         c
            3361-3508           AC004594.2         46094-46241         c
            3509-3583           AC004594.2         38436-38510         c
            3584-3667           AC004594.2         19998-20081         c
            3668-3700           AC004594.2         19856-19888         c
            3701-3808           AC004594.2         4642-4749           c
            3809-3913           AC015983.7         161821-161925       c
            3914-5841           AC015983.7         154755-156682       c
FEATURES             Location/Qualifiers
     source          1..5841
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.32"
     gene            1..5841
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="calcium dependent secretion activator 2"
                     /db_xref="GeneID:93664"
                     /db_xref="HGNC:HGNC:16018"
                     /db_xref="MIM:609978"
     exon            1..462
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            463..514
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            515..628
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            629..961
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             659..4087
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="isoform n is encoded by transcript variant 14;
                     Ca2+-dependent activator protein for secretion 2; Ca2+
                     dependent secretion activator 2; CAPS-2; calcium-dependent
                     activator protein for secretion 2; Ca++-dependent
                     secretion activator 2"
                     /codon_start=1
                     /product="calcium-dependent secretion activator 2 isoform
                     n"
                     /protein_id="NP_001350328.1"
                     /db_xref="GeneID:93664"
                     /db_xref="HGNC:HGNC:16018"
                     /db_xref="MIM:609978"
                     /translation="MVQSGGCSANDFREVFKKNIEKRVRSLPEIDGLSKETVLSSWIA
                     KYDAIYRGEEDLCKQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQL
                     DNADEQAAQIRRELDGRLQLADKMAKERKFPKFIAKDMENMYIEELRSSVNLLMANLE
                     SLPVSKGGPEFKLQKLKRSQNSAFLDIGDENEIQLSKSDVVLSFTLEIVIMEVQGLKS
                     VAPNRIVYCTMEVEGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLA
                     LEDKELGRVILYPTSNSSKSAELHRMVVPKNSQDSDLKIKLAVRMDKPAHMKHSGYLY
                     ALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQELMQLEGYTVDYTDPHPGLQ
                     GGCMFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTL
                     HADAQLSGKDADRFQKHGMDEFISANPCKLDHAFLFRILQRQTLDHRLNDSYSCLGWF
                     SPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYSFAFCASHVHG
                     NRPDGIGTVSVEEKERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERV
                     LMKDIATPIPAEEVKKVVRKCLEKAALINYTRLTEYAKIEGPAEKETETMNQASPARK
                     LEEILHLAELCIEVLQQNEEHHAEGREAFAWWPDLLAEHAEKFWALFTVDMDTALEAQ
                     PQDSWDSFPLFQLLNNFLRNDTLLCNGKFHKHLQEIFVPLVVRYVDLMESSIAQSIHR
                     GFEQETWQPVKNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYESTNGSATSE
                     DLFWKLDALQMFVFDLHWPEQEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQKAS
                     KTTDLRIPASVCTMFNVLVDAKKQSTKLCALDGGQEQQYHSKIDDLIDNSVKEIISLL
                     VSKFVSVLEGVLSKLSRYDEGTFFSSILSFTVKAAAKYVDVPKPGMDLADTYIMFVRQ
                     NQDILREKVNEEMYIEKLFDQWYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKKTY
                     RDFRLQGVLEGTLNSKTYDTVHRRLTVEEATASVSEGGGLQGITMKDSDEEEEG"
     exon            962..1042
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1279
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1398
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1510
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1650
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1717
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1826
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2027
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2036
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2173
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2361
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2463
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2527
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2651
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2672
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2776
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2785
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2942
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3084
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3204
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3360
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3508
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3509..3583
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3584..3667
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3668..3700
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3701..3808
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3809..3913
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3914..5841
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4833..4838
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AATAAA"
     polyA_site      4855
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="major polyA site"
     regulatory      4894..4899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AGTAAA"
     polyA_site      4928
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
     regulatory      5003..5008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AGTAAA"
     polyA_site      5023
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
     regulatory      5803..5808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AATAAA"
     polyA_site      5841
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
ORIGIN      
        1 agttttcctt tcgttctgcg gccgctgcag ccagccccgc ggctccctca gacccgcggg
       61 cgcagccgcc gggggtgagg cgcttgggga ccgcgggccg agcggcgggg atccccgagc
      121 accatgctgg acccgtcttc cagcgaagag gagtcggacg aggggctgga agaggaaagc
      181 cgcgatgtgc tggtggcagc cggcagctcg cagcgagctc ctccagcccc gactcgggaa
      241 gggcggcggg acgcgccggg gcgcgcgggc ggcggcggcg cggccagatc tgtgagcccg
      301 agcccctctg tgctcagcga ggggcgagac gagccccagc ggcagctgga cgatgagcag
      361 gagcggagga tccgcctgca gctctacgtc ttcgtcgtga ggtgcatcgc gtaccccttc
      421 aacgccaagc agcccaccga catggcccgg aggcagcaga aggacatcaa atccaaacac
      481 cgagaaggca tgcagctttg taaagtgttt gtggcttaac aaacaacagt tgcagttact
      541 gaaagaacgg ttccaggcct tcctcaatgg ggaaacccaa attgtagctg acgaagcatt
      601 ttgcaacgca gttcggagtt attatgaggt ttttctaaag agtgaccgag tggccagaat
      661 ggtacagagt ggagggtgtt ctgctaatga cttcagagaa gtatttaaga aaaacataga
      721 aaaacgtgtg cggagtttgc cagaaataga tggcttgagc aaagagacag tgttgagctc
      781 atggatagcc aaatatgatg ccatttacag aggtgaagag gacttgtgca aacagccaaa
      841 tagaatggcc ctaagtgcag tgtctgaact tattctgagc aaggaacaac tctatgaaat
      901 gtttcagcag attctgggta ttaaaaaact ggaacaccag ctcctttata atgcatgtca
      961 gctggataac gcagatgaac aagcagccca gatcagaagg gaacttgatg gccggctgca
     1021 attggcagat aaaatggcaa aggaaagaaa attccccaaa tttatagcaa aagatatgga
     1081 gaatatgtat atagaagagt tgcggtcttc agtgaatttg ctaatggcca atttggaaag
     1141 tcttccagtt tcgaaaggtg gtccggaatt taaattacaa aaattaaaac gttcacagaa
     1201 ctctgcattt ttggacatag gagatgagaa tgagattcag ctgtcaaagt ccgacgtggt
     1261 actgtcattc accttagaga ttgtcataat ggaagtgcaa ggcctgaagt cagttgctcc
     1321 caatcgaatt gtttactgta caatggaagt ggaaggagaa aaacttcaga cagaccaggc
     1381 cgaagcctca aggccacaat gggggactca aggagatttc accaccaccc atcctcggcc
     1441 tgtggtcaaa gtgaaactct tcacagaaag cactggagtt ctggccctgg aagataaaga
     1501 actgggaagg gtgatattat acccaacttc taatagctcc aaatcagctg aattacaccg
     1561 aatggtagtt ccaaaaaata gccaggattc tgacttaaaa atcaaactgg cagtgcgaat
     1621 ggataaacca gcacatatga agcatagtgg atatctgtat gcccttggac agaaggtttg
     1681 gaaaagatgg aaaaaacgtt actttgttct agttcaggtt agccaatata cctttgctat
     1741 gtgcagttat agagaaaaga agtctgaacc acaagaatta atgcagcttg aaggctatac
     1801 tgtggattat accgatcccc acccaggcct tcagggtggt tgtatgttct ttaatgctgt
     1861 taaagaagga gatactgtaa tctttgccag tgatgatgaa caggacagaa tattatgggt
     1921 tcaagccatg tatagggcca caggtcaatc atataaacca gttcctgcaa ttcaaaccca
     1981 gaaactgaat cctaaaggag gaactctcca tgcagatgct cagctttctg gtaaagatgc
     2041 agatcgtttt cagaaacatg gtatggatga gtttatttct gcaaacccct gcaagcttga
     2101 tcatgccttc ctttttagaa tactccagag gcagactttg gatcacagac tgaatgattc
     2161 ctattcttgc ttgggatggt ttagccctgg ccaagtcttt gtgttagatg agtactgtgc
     2221 ccgttatggt gtgagaggct gtcacagaca tctctgctac cttgcagaac tgatggaaca
     2281 ttcagaaaat ggtgctgtca ttgaccctac cctgctccat tacagctttg cattctgtgc
     2341 ctctcatgtg cacggcaaca ggcctgatgg aattgggact gtttcagtgg aagaaaaaga
     2401 aagatttgag gagataaaag agagactctc ttccctttta gaaaatcaga taagccattt
     2461 cagatactgt tttccctttg gacgacctga aggtgctcta aaagctacac tttcattact
     2521 tgaaagggtt ttaatgaaag atattgccac tcccatacca gcagaagagg tgaagaaagt
     2581 ggtcagaaaa tgtctcgaga aagctgcctt gatcaattac actagactca cagaatatgc
     2641 caaaatagaa ggcccagcag aaaaggaaac agagaccatg aaccaggcat ctcctgctag
     2701 aaagctggaa gagattcttc atctggcaga gctctgcata gaagtcttac agcagaatga
     2761 agagcatcat gcagagggaa gagaggcatt tgcctggtgg cctgatttat tggctgaaca
     2821 tgcagagaaa ttttgggctt tatttacagt ggatatggac actgcactag aggctcaacc
     2881 gcaagactcc tgggatagtt ttcctctttt ccaactgctt aataatttcc tccgaaatga
     2941 cacacttttg tgtaatggaa aatttcacaa acacttgcaa gaaatctttg tacccttggt
     3001 tgtccgctat gtggatctca tggagtcttc catcgcccag tcaattcaca gaggttttga
     3061 gcaggagaca tggcagcctg tcaagaatat cgccaacagt cttcccaatg tagctcttcc
     3121 aaaagttcca agtctgcctc ttaatcttcc acagattcct aacatttcta ctgcttcgtg
     3181 gatgccttct ttatatgagt ccaccaatgg ctcagcaaca tcagaagacc ttttttggaa
     3241 gcttgatgca ctgcaaatgt ttgtctttga tctgcactgg ccagaacagg aatttgccca
     3301 ccacttagag caaagactta aactaatggc cagtgatatg ctagaggcct gtgtcaaaag
     3361 aacaagaact gcatttgaac tcaagctaca aaaggcaagc aaaacaactg acttgcgcat
     3421 tccagcttcc gtttgcacta tgtttaatgt attagtcgat gccaaaaagc aaagcaccaa
     3481 actctgtgcc ctggatggag gacaagagca acagtaccat tcaaaaatag atgatctgat
     3541 cgacaacagt gtaaaagaaa tcatttcact gttagtttca aagtttgttt cagtgttgga
     3601 aggcgtgttg tctaagctgt caaggtatga tgaaggcact ttcttttcat ccattctgtc
     3661 attcactgtg aaagcagctg caaaatatgt tgatgttcca aaaccaggaa tggatctggc
     3721 agacacctat attatgtttg ttcggcaaaa ccaagatatt cttcgagaaa aggtcaatga
     3781 ggaaatgtat atagaaaagt tatttgatca atggtacagc agttccatga aagtcatttg
     3841 cgtgtggttg actgatagat tagacctcca actccatatt taccagctga agacgctcat
     3901 caagattgtg aagaaaacct acagggactt tcgattgcag ggtgtgttgg aaggaacact
     3961 gaacagtaag acttatgata ctgtgcacag acgtttaaca gtagaggagg ccacagcctc
     4021 tgtttcagaa ggaggaggac ttcagggcat tactatgaaa gacagtgacg aagaagaaga
     4081 aggctgatat cacacagctt tgcagaagga aggaagacct tgatcgacat tgttttttat
     4141 ttttttaacc ttgtccttgt aattacattc attgtttgtt ttggccaaat aaaaatgctt
     4201 gtatttcttt aaaaagtaag cctgaatgta gagtaaaagg ggaaatgcca agattttggg
     4261 gtttttttgt ttcctttttt tgtttgtttg tttgtttgtt tttttggaga agagcatcct
     4321 cttttgtgta gtttgaccta aaaatgaacc ttggctctgc ttgtgatcag aacatgaact
     4381 ttttttttta aagaagattt gagcattttt ctgtaatcac atcaaaatga tgttttctgt
     4441 gtaaagcgag atacatattt ctcataatgc agcattgtga gaagtcagtt cggaccactg
     4501 caccaacact gtcgtatcct tgttaaaatg gtgtgtacct tacaaattat aatttatgtg
     4561 ccaggttcgt tttgtactta atttgctatt attgtgatgt gtataaaatc tttaatcttg
     4621 gttcttagta ctttgaattg gtctacaggt atattcctgg gatgaaagga ttgccaaacc
     4681 caaatataga ctagattatc caatgggttt gtgtctttgt tccattctca acatttcttc
     4741 tttcaactat aagtaatccc caggtgtggg gtagcaagtg tgcttccgtc aagataccat
     4801 attctcctgc tccagtataa cagcttgcag gcaataaaaa tctatttgct cataactact
     4861 tctgtattta ttagacttat atagagcaaa tgcagtaaaa gaggtttgca gtgtttcaaa
     4921 catcccaact atctgactct gtgtttttgt ttcttgagtt ttttgtttgt tttgtttgta
     4981 atattttgtt tttaatcaaa tgagtaaaag atagtaacac tgactgttct ttgtacctaa
     5041 taggcacata cattgttaaa agaattacta tgacagcata tttccatagc agaggaaata
     5101 tatatttcat atattattag ttaatattag taatcaatgt taactaataa ttagtaatgt
     5161 tagtaatatt aactagtaat tcacattatt agtggttctc tcaaaatatt ttcttgctag
     5221 ggtttgagag ataattgtat tatgttgcgt aagttctcta tgaattattt ttgtgatatt
     5281 tcccaaaaca tattggcaga ttgtgctact gcatttatta ataagtaatt tttaaatgaa
     5341 ggcagttaat gcagaataag tggaggtatc cctgcattta tgaaaacgtt tattctgaaa
     5401 ctttagaaat gaaacaactt ggacctccag attcgttctc ccatggtgta ataagtggtc
     5461 gttaggtacc tagactagcc ttaaaaatct atttaatcta cagttactat ttagcattgt
     5521 tttggctcat tttctgggcc ctagggctaa gataacaaac aaggaaattt cttccttctt
     5581 ccgggattaa agactaactc taccaactca ctatctttga aaggcagttt gggaatgttc
     5641 tccctccttt tcttctctat tcacacacca aatactattt tctccaaacc ctcaaatgtc
     5701 cagtcatgct atcccaaact ctccaatggc accatcccca agcttgctgt tccacgacac
     5761 attgctctgt acttagtaat tacccaccct tcttttcctt tcaataaaat gtccatttcc
     5821 ttgatacaga tcatctccaa a
//
