LOCUS       NM_001363397            5639 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens calcium dependent secretion activator 2 (CADPS2),
            transcript variant 12, mRNA.
ACCESSION   NM_001363397 XM_011516697
VERSION     NM_001363397.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5639)
  AUTHORS   Andersen,J.S., Vijayakumaran,A., Godbehere,C., Lorentzen,E.,
            Mennella,V. and Schou,K.B.
  TITLE     Uncovering structural themes across cilia microtubule inner
            proteins with implications for human cilia function
  JOURNAL   Nat Commun 15 (1), 2687 (2024)
   PUBMED   38538594
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5639)
  AUTHORS   Yoo,H., Yang,S.H., Kim,J.Y., Yang,E., Park,H.S., Lee,S.J.,
            Rhyu,I.J., Turecki,G., Lee,H.W. and Kim,H.
  TITLE     Down-regulation of habenular calcium-dependent secretion activator
            2 induces despair-like behavior
  JOURNAL   Sci Rep 11 (1), 3700 (2021)
   PUBMED   33580180
  REMARK    GeneRIF: Down-regulation of habenular calcium-dependent secretion
            activator 2 induces despair-like behavior.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5639)
  AUTHORS   Zhang,K., Fan,Z., Wang,Y., Faraone,S.V., Yang,L. and Chang,S.
  TITLE     Genetic analysis for cognitive flexibility in the trail-making test
            in attention deficit hyperactivity disorder patients from single
            nucleotide polymorphism, gene to pathway level
  JOURNAL   World J Biol Psychiatry 20 (6), 476-485 (2019)
   PUBMED   28971736
  REMARK    GeneRIF: The top SNP rs2049161 involved gene DLGAP1 and the top
            gene CADPS2 in the gene-based analysis resulted in much literature
            evidence of associations with psychiatric disorders. Gene
            expression and network analysis showed their contribution to
            cognition function.
REFERENCE   4  (bases 1 to 5639)
  AUTHORS   Obergasteiger,J., Uberbacher,C., Pramstaller,P.P., Hicks,A.A.,
            Corti,C. and Volta,M.
  TITLE     CADPS2 gene expression is oppositely regulated by LRRK2 and
            alpha-synuclein
  JOURNAL   Biochem Biophys Res Commun 490 (3), 876-881 (2017)
   PUBMED   28647363
  REMARK    GeneRIF: These results indicate that LRRK2 and alpha-synuclein
            participate in the dysregulation of CADPS2 by altering
            transcription and support the hypothesis that synaptic
            dysfunctions, through different mechanisms, might contribute to the
            neuronal defects of diseases such as Parkinson's disease.
REFERENCE   5  (bases 1 to 5639)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   6  (bases 1 to 5639)
  AUTHORS   Brunk,I., Blex,C., Speidel,D., Brose,N. and Ahnert-Hilger,G.
  TITLE     Ca2+-dependent activator proteins of secretion promote vesicular
            monoamine uptake
  JOURNAL   J Biol Chem 284 (2), 1050-1056 (2009)
   PUBMED   19008227
  REMARK    GeneRIF: CAPS proteins are involved in optimizing vesicular
            monoamine uptake and storage mediated by VMAT1 and VMAT2
REFERENCE   7  (bases 1 to 5639)
  AUTHORS   Sadakata,T., Washida,M., Iwayama,Y., Shoji,S., Sato,Y., Ohkura,T.,
            Katoh-Semba,R., Nakajima,M., Sekine,Y., Tanaka,M., Nakamura,K.,
            Iwata,Y., Tsuchiya,K.J., Mori,N., Detera-Wadleigh,S.D.,
            Ichikawa,H., Itohara,S., Yoshikawa,T. and Furuichi,T.
  TITLE     Autistic-like phenotypes in Cadps2-knockout mice and aberrant
            CADPS2 splicing in autistic patients
  JOURNAL   J Clin Invest 117 (4), 931-943 (2007)
   PUBMED   17380209
  REMARK    GeneRIF: Genetic disturbance in CADPS2-mediated neurotrophin
            release contributes to autism susceptibility.
            GeneRIF: CADPS2-KO mice show autistic-like phenotypes. Moreover,
            the results show that some autistic patients have an aberrant
            splicing variant of CADPS2 mRNA, suggesting that a disturbance in
            CADPS2-mediated neurotrophin release contributes to autism.
            GeneRIF: Results from Cadps2-deficient mice and human data suggest
            that a disturbance in CADPS2-mediated neurotrophin release
            contributes to autistic-like cellular and behavioral phenotypes.
REFERENCE   8  (bases 1 to 5639)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   9  (bases 1 to 5639)
  AUTHORS   Speidel,D., Varoqueaux,F., Enk,C., Nojiri,M., Grishanin,R.N.,
            Martin,T.F., Hofmann,K., Brose,N. and Reim,K.
  TITLE     A family of Ca2+-dependent activator proteins for secretion:
            comparative analysis of structure, expression, localization, and
            function
  JOURNAL   J Biol Chem 278 (52), 52802-52809 (2003)
   PUBMED   14530279
  REMARK    GeneRIF: identification, cloning, and comparative characterization
            of a second mammalian CAPS isoform, CAPS2; concluded that at the
            functional level, CAPS2 is largely redundant with CAPS1
REFERENCE   10 (bases 1 to 5639)
  AUTHORS   Cisternas,F.A., Vincent,J.B., Scherer,S.W. and Ray,P.N.
  TITLE     Cloning and characterization of human CADPS and CADPS2, new members
            of the Ca2+-dependent activator for secretion protein family
  JOURNAL   Genomics 81 (3), 279-291 (2003)
   PUBMED   12659812
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA248542.1, KJ534803.1,
            AC006463.4, AC004594.2, KJ534802.1, AB046811.1, AC015983.7 and
            BX110721.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001363397.1.
            
            Summary: This gene encodes a member of the calcium-dependent
            activator of secretion (CAPS) protein family, which are calcium
            binding proteins that regulate the exocytosis of synaptic and
            dense-core vesicles in neurons and neuroendocrine cells. Mutations
            in this gene may contribute to autism susceptibility. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Nov 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KJ534802.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               DA248542.1         296-418
            124-878             KJ534803.1         1-755
            879-879             AC006463.4         45532-45532         c
            880-2579            KJ534803.1         757-2456
            2580-2580           AC004594.2         97428-97428         c
            2581-3882           KJ534802.1         2458-3759
            3883-4095           AB046811.1         3057-3269
            4096-5416           AC015983.7         154978-156298       c
            5417-5626           BX110721.1         5-214
            5627-5639           AC015983.7         154755-154767       c
FEATURES             Location/Qualifiers
     source          1..5639
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.32"
     gene            1..5639
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="calcium dependent secretion activator 2"
                     /db_xref="GeneID:93664"
                     /db_xref="HGNC:HGNC:16018"
                     /db_xref="MIM:609978"
     exon            1..462
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..3885
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="isoform l is encoded by transcript variant 12;
                     Ca2+-dependent activator protein for secretion 2; Ca2+
                     dependent secretion activator 2; CAPS-2; calcium-dependent
                     activator protein for secretion 2; Ca++-dependent
                     secretion activator 2"
                     /codon_start=1
                     /product="calcium-dependent secretion activator 2 isoform
                     l"
                     /protein_id="NP_001350326.1"
                     /db_xref="GeneID:93664"
                     /db_xref="HGNC:HGNC:16018"
                     /db_xref="MIM:609978"
                     /translation="MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDA
                     PGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAK
                     QPTDMARRQQKLNKQQLQLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVA
                     RMVQSGGCSANDFREVFKKNIEKRVRSLPEIDGLSKETVLSSWIAKYDAIYRGEEDLC
                     KQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLDNADEQAAQIRRE
                     LDGRLQLADKMAKERKFPKFIAKDMENMYIEELRSSVNLLMANLESLPVSKGGPEFKL
                     QKLKRSQNSAFLDIGDENEIQLSKSDVVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEV
                     EGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELGRVILYP
                     TSNSSKSAELHRMVVPKNSQDSDLKIKLAVRMDKPAHMKHSGYLYALGQKVWKRWKKR
                     YFVLVQVSQYTFAMCSYREKKSEPQELMQLEGYTVDYTDPHPGLQGGCMFFNAVKEGD
                     TVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLSGKDADR
                     FQKHGMDEFISANPCKLDHAFLFRILQRQTLDHRLNDSYSCLGWFSPGQVFVLDEYCA
                     RYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYSFAFCASHVHGNRPDGIGTVSVEE
                     KERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEE
                     VKKVVRKCLEKAALINYTRLTEYAKIEETMNQASPARKLEEILHLAELCIEVLQQNEE
                     HHAEAFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQDSWDSFPLFQLLNNFLRNDTL
                     LCNGKFHKHLQEIFVPLVVRYVDLMESSIAQSIHRGFEQETWQPVNNGSATSEDLFWK
                     LDALQMFVFDLHWPEQEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQKASKTTDL
                     RIPASVCTMFNVLVDAKKQSTKLCALDGGQEQQYHSKIDDLIDNSVKEIISLLVSKFV
                     SVLEGVLSKLSRYDEGTFFSSILSFTVKAAAKYVDVPKPGMDLADTYIMFVRQNQDIL
                     REKVNEEMYIEKLFDQWYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKKTYRDFRL
                     QGVLEGTLNSKTYDTVHRRLTVEEATASVSEGGGLQGITMKDSDEEEEG"
     exon            463..576
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..909
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..990
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1227
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1346
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1458
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1598
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1665
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1774
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1975
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..1984
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2121
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2309
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2411
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2475
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2599
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2703
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2860
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..3002
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3158
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3306
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3307..3381
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3465
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3466..3498
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3499..3606
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3607..3711
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3712..5639
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4631..4636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AATAAA"
     polyA_site      4653
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="major polyA site"
     regulatory      4692..4697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AGTAAA"
     polyA_site      4726
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
     regulatory      4801..4806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AGTAAA"
     polyA_site      4821
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
     regulatory      5601..5606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AATAAA"
     polyA_site      5639
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
ORIGIN      
        1 agttttcctt tcgttctgcg gccgctgcag ccagccccgc ggctccctca gacccgcggg
       61 cgcagccgcc gggggtgagg cgcttgggga ccgcgggccg agcggcgggg atccccgagc
      121 accatgctgg acccgtcttc cagcgaagag gagtcggacg aggggctgga agaggaaagc
      181 cgcgatgtgc tggtggcagc cggcagctcg cagcgagctc ctccagcccc gactcgggaa
      241 gggcggcggg acgcgccggg gcgcgcgggc ggcggcggcg cggccagatc tgtgagcccg
      301 agcccctctg tgctcagcga ggggcgagac gagccccagc ggcagctgga cgatgagcag
      361 gagcggagga tccgcctgca gctctacgtc ttcgtcgtga ggtgcatcgc gtaccccttc
      421 aacgccaagc agcccaccga catggcccgg aggcagcaga agcttaacaa acaacagttg
      481 cagttactga aagaacggtt ccaggccttc ctcaatgggg aaacccaaat tgtagctgac
      541 gaagcatttt gcaacgcagt tcggagttat tatgaggttt ttctaaagag tgaccgagtg
      601 gccagaatgg tacagagtgg agggtgttct gctaatgact tcagagaagt atttaagaaa
      661 aacatagaaa aacgtgtgcg gagtttgcca gaaatagatg gcttgagcaa agagacagtg
      721 ttgagctcat ggatagccaa atatgatgcc atttacagag gtgaagagga cttgtgcaaa
      781 cagccaaata gaatggccct aagtgcagtg tctgaactta ttctgagcaa ggaacaactc
      841 tatgaaatgt ttcagcagat tctgggtatt aaaaaactgg aacaccagct cctttataat
      901 gcatgtcagc tggataacgc agatgaacaa gcagcccaga tcagaaggga acttgatggc
      961 cggctgcaat tggcagataa aatggcaaag gaaagaaaat tccccaaatt tatagcaaaa
     1021 gatatggaga atatgtatat agaagagttg cggtcttcag tgaatttgct aatggccaat
     1081 ttggaaagtc ttccagtttc gaaaggtggt ccggaattta aattacaaaa attaaaacgt
     1141 tcacagaact ctgcattttt ggacatagga gatgagaatg agattcagct gtcaaagtcc
     1201 gacgtggtac tgtcattcac cttagagatt gtcataatgg aagtgcaagg cctgaagtca
     1261 gttgctccca atcgaattgt ttactgtaca atggaagtgg aaggagaaaa acttcagaca
     1321 gaccaggccg aagcctcaag gccacaatgg gggactcaag gagatttcac caccacccat
     1381 cctcggcctg tggtcaaagt gaaactcttc acagaaagca ctggagttct ggccctggaa
     1441 gataaagaac tgggaagggt gatattatac ccaacttcta atagctccaa atcagctgaa
     1501 ttacaccgaa tggtagttcc aaaaaatagc caggattctg acttaaaaat caaactggca
     1561 gtgcgaatgg ataaaccagc acatatgaag catagtggat atctgtatgc ccttggacag
     1621 aaggtttgga aaagatggaa aaaacgttac tttgttctag ttcaggttag ccaatatacc
     1681 tttgctatgt gcagttatag agaaaagaag tctgaaccac aagaattaat gcagcttgaa
     1741 ggctatactg tggattatac cgatccccac ccaggccttc agggtggttg tatgttcttt
     1801 aatgctgtta aagaaggaga tactgtaatc tttgccagtg atgatgaaca ggacagaata
     1861 ttatgggttc aagccatgta tagggccaca ggtcaatcat ataaaccagt tcctgcaatt
     1921 caaacccaga aactgaatcc taaaggagga actctccatg cagatgctca gctttctggt
     1981 aaagatgcag atcgttttca gaaacatggt atggatgagt ttatttctgc aaacccctgc
     2041 aagcttgatc atgccttcct ttttagaata ctccagaggc agactttgga tcacagactg
     2101 aatgattcct attcttgctt gggatggttt agccctggcc aagtctttgt gttagatgag
     2161 tactgtgccc gttatggtgt gagaggctgt cacagacatc tctgctacct tgcagaactg
     2221 atggaacatt cagaaaatgg tgctgtcatt gaccctaccc tgctccatta cagctttgca
     2281 ttctgtgcct ctcatgtgca cggcaacagg cctgatggaa ttgggactgt ttcagtggaa
     2341 gaaaaagaaa gatttgagga gataaaagag agactctctt cccttttaga aaatcagata
     2401 agccatttca gatactgttt tccctttgga cgacctgaag gtgctctaaa agctacactt
     2461 tcattacttg aaagggtttt aatgaaagat attgccactc ccataccagc agaagaggtg
     2521 aagaaagtgg tcagaaaatg tctcgagaaa gctgccttga tcaattacac tagactcaca
     2581 gaatatgcca aaatagaaga gaccatgaac caggcatctc ctgctagaaa gctggaagag
     2641 attcttcatc tggcagagct ctgcatagaa gtcttacagc agaatgaaga gcatcatgca
     2701 gaggcatttg cctggtggcc tgatttattg gctgaacatg cagagaaatt ttgggcttta
     2761 tttacagtgg atatggacac tgcactagag gctcaaccgc aagactcctg ggatagtttt
     2821 cctcttttcc aactgcttaa taatttcctc cgaaatgaca cacttttgtg taatggaaaa
     2881 tttcacaaac acttgcaaga aatctttgta cccttggttg tccgctatgt ggatctcatg
     2941 gagtcttcca tcgcccagtc aattcacaga ggttttgagc aggagacatg gcagcctgtc
     3001 aacaatggct cagcaacatc agaagacctt ttttggaagc ttgatgcact gcaaatgttt
     3061 gtctttgatc tgcactggcc agaacaggaa tttgcccacc acttagagca aagacttaaa
     3121 ctaatggcca gtgatatgct agaggcctgt gtcaaaagaa caagaactgc atttgaactc
     3181 aagctacaaa aggcaagcaa aacaactgac ttgcgcattc cagcttccgt ttgcactatg
     3241 tttaatgtat tagtcgatgc caaaaagcaa agcaccaaac tctgtgccct ggatggagga
     3301 caagagcaac agtaccattc aaaaatagat gatctgatcg acaacagtgt aaaagaaatc
     3361 atttcactgt tagtttcaaa gtttgtttca gtgttggaag gcgtgttgtc taagctgtca
     3421 aggtatgatg aaggcacttt cttttcatcc attctgtcat tcactgtgaa agcagctgca
     3481 aaatatgttg atgttccaaa accaggaatg gatctggcag acacctatat tatgtttgtt
     3541 cggcaaaacc aagatattct tcgagaaaag gtcaatgagg aaatgtatat agaaaagtta
     3601 tttgatcaat ggtacagcag ttccatgaaa gtcatttgcg tgtggttgac tgatagatta
     3661 gacctccaac tccatattta ccagctgaag acgctcatca agattgtgaa gaaaacctac
     3721 agggactttc gattgcaggg tgtgttggaa ggaacactga acagtaagac ttatgatact
     3781 gtgcacagac gtttaacagt agaggaggcc acagcctctg tttcagaagg aggaggactt
     3841 cagggcatta ctatgaaaga cagtgacgaa gaagaagaag gctgatatca cacagctttg
     3901 cagaaggaag gaagaccttg atcgacattg ttttttattt ttttaacctt gtccttgtaa
     3961 ttacattcat tgtttgtttt ggccaaataa aaatgcttgt atttctttaa aaagtaagcc
     4021 tgaatgtaga gtaaaagggg aaatgccaag attttggggt ttttttgttt cctttttttg
     4081 tttgtttgtt tgtttgtttt tttggagaag agcatcctct tttgtgtagt ttgacctaaa
     4141 aatgaacctt ggctctgctt gtgatcagaa catgaacttt tttttttaaa gaagatttga
     4201 gcatttttct gtaatcacat caaaatgatg ttttctgtgt aaagcgagat acatatttct
     4261 cataatgcag cattgtgaga agtcagttcg gaccactgca ccaacactgt cgtatccttg
     4321 ttaaaatggt gtgtacctta caaattataa tttatgtgcc aggttcgttt tgtacttaat
     4381 ttgctattat tgtgatgtgt ataaaatctt taatcttggt tcttagtact ttgaattggt
     4441 ctacaggtat attcctggga tgaaaggatt gccaaaccca aatatagact agattatcca
     4501 atgggtttgt gtctttgttc cattctcaac atttcttctt tcaactataa gtaatcccca
     4561 ggtgtggggt agcaagtgtg cttccgtcaa gataccatat tctcctgctc cagtataaca
     4621 gcttgcaggc aataaaaatc tatttgctca taactacttc tgtatttatt agacttatat
     4681 agagcaaatg cagtaaaaga ggtttgcagt gtttcaaaca tcccaactat ctgactctgt
     4741 gtttttgttt cttgagtttt ttgtttgttt tgtttgtaat attttgtttt taatcaaatg
     4801 agtaaaagat agtaacactg actgttcttt gtacctaata ggcacataca ttgttaaaag
     4861 aattactatg acagcatatt tccatagcag aggaaatata tatttcatat attattagtt
     4921 aatattagta atcaatgtta actaataatt agtaatgtta gtaatattaa ctagtaattc
     4981 acattattag tggttctctc aaaatatttt cttgctaggg tttgagagat aattgtatta
     5041 tgttgcgtaa gttctctatg aattattttt gtgatatttc ccaaaacata ttggcagatt
     5101 gtgctactgc atttattaat aagtaatttt taaatgaagg cagttaatgc agaataagtg
     5161 gaggtatccc tgcatttatg aaaacgttta ttctgaaact ttagaaatga aacaacttgg
     5221 acctccagat tcgttctccc atggtgtaat aagtggtcgt taggtaccta gactagcctt
     5281 aaaaatctat ttaatctaca gttactattt agcattgttt tggctcattt tctgggccct
     5341 agggctaaga taacaaacaa ggaaatttct tccttcttcc gggattaaag actaactcta
     5401 ccaactcact atctttgaaa ggcagtttgg gaatgttctc cctccttttc ttctctattc
     5461 acacaccaaa tactattttc tccaaaccct caaatgtcca gtcatgctat cccaaactct
     5521 ccaatggcac catccccaag cttgctgttc cacgacacat tgctctgtac ttagtaatta
     5581 cccacccttc ttttcctttc aataaaatgt ccatttcctt gatacagatc atctccaaa
//
