LOCUS       NM_001363396            5648 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens calcium dependent secretion activator 2 (CADPS2),
            transcript variant 11, mRNA.
ACCESSION   NM_001363396 XM_011516696
VERSION     NM_001363396.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5648)
  AUTHORS   Andersen,J.S., Vijayakumaran,A., Godbehere,C., Lorentzen,E.,
            Mennella,V. and Schou,K.B.
  TITLE     Uncovering structural themes across cilia microtubule inner
            proteins with implications for human cilia function
  JOURNAL   Nat Commun 15 (1), 2687 (2024)
   PUBMED   38538594
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5648)
  AUTHORS   Yoo,H., Yang,S.H., Kim,J.Y., Yang,E., Park,H.S., Lee,S.J.,
            Rhyu,I.J., Turecki,G., Lee,H.W. and Kim,H.
  TITLE     Down-regulation of habenular calcium-dependent secretion activator
            2 induces despair-like behavior
  JOURNAL   Sci Rep 11 (1), 3700 (2021)
   PUBMED   33580180
  REMARK    GeneRIF: Down-regulation of habenular calcium-dependent secretion
            activator 2 induces despair-like behavior.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5648)
  AUTHORS   Zhang,K., Fan,Z., Wang,Y., Faraone,S.V., Yang,L. and Chang,S.
  TITLE     Genetic analysis for cognitive flexibility in the trail-making test
            in attention deficit hyperactivity disorder patients from single
            nucleotide polymorphism, gene to pathway level
  JOURNAL   World J Biol Psychiatry 20 (6), 476-485 (2019)
   PUBMED   28971736
  REMARK    GeneRIF: The top SNP rs2049161 involved gene DLGAP1 and the top
            gene CADPS2 in the gene-based analysis resulted in much literature
            evidence of associations with psychiatric disorders. Gene
            expression and network analysis showed their contribution to
            cognition function.
REFERENCE   4  (bases 1 to 5648)
  AUTHORS   Obergasteiger,J., Uberbacher,C., Pramstaller,P.P., Hicks,A.A.,
            Corti,C. and Volta,M.
  TITLE     CADPS2 gene expression is oppositely regulated by LRRK2 and
            alpha-synuclein
  JOURNAL   Biochem Biophys Res Commun 490 (3), 876-881 (2017)
   PUBMED   28647363
  REMARK    GeneRIF: These results indicate that LRRK2 and alpha-synuclein
            participate in the dysregulation of CADPS2 by altering
            transcription and support the hypothesis that synaptic
            dysfunctions, through different mechanisms, might contribute to the
            neuronal defects of diseases such as Parkinson's disease.
REFERENCE   5  (bases 1 to 5648)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   6  (bases 1 to 5648)
  AUTHORS   Brunk,I., Blex,C., Speidel,D., Brose,N. and Ahnert-Hilger,G.
  TITLE     Ca2+-dependent activator proteins of secretion promote vesicular
            monoamine uptake
  JOURNAL   J Biol Chem 284 (2), 1050-1056 (2009)
   PUBMED   19008227
  REMARK    GeneRIF: CAPS proteins are involved in optimizing vesicular
            monoamine uptake and storage mediated by VMAT1 and VMAT2
REFERENCE   7  (bases 1 to 5648)
  AUTHORS   Sadakata,T., Washida,M., Iwayama,Y., Shoji,S., Sato,Y., Ohkura,T.,
            Katoh-Semba,R., Nakajima,M., Sekine,Y., Tanaka,M., Nakamura,K.,
            Iwata,Y., Tsuchiya,K.J., Mori,N., Detera-Wadleigh,S.D.,
            Ichikawa,H., Itohara,S., Yoshikawa,T. and Furuichi,T.
  TITLE     Autistic-like phenotypes in Cadps2-knockout mice and aberrant
            CADPS2 splicing in autistic patients
  JOURNAL   J Clin Invest 117 (4), 931-943 (2007)
   PUBMED   17380209
  REMARK    GeneRIF: Genetic disturbance in CADPS2-mediated neurotrophin
            release contributes to autism susceptibility.
            GeneRIF: CADPS2-KO mice show autistic-like phenotypes. Moreover,
            the results show that some autistic patients have an aberrant
            splicing variant of CADPS2 mRNA, suggesting that a disturbance in
            CADPS2-mediated neurotrophin release contributes to autism.
            GeneRIF: Results from Cadps2-deficient mice and human data suggest
            that a disturbance in CADPS2-mediated neurotrophin release
            contributes to autistic-like cellular and behavioral phenotypes.
REFERENCE   8  (bases 1 to 5648)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   9  (bases 1 to 5648)
  AUTHORS   Speidel,D., Varoqueaux,F., Enk,C., Nojiri,M., Grishanin,R.N.,
            Martin,T.F., Hofmann,K., Brose,N. and Reim,K.
  TITLE     A family of Ca2+-dependent activator proteins for secretion:
            comparative analysis of structure, expression, localization, and
            function
  JOURNAL   J Biol Chem 278 (52), 52802-52809 (2003)
   PUBMED   14530279
  REMARK    GeneRIF: identification, cloning, and comparative characterization
            of a second mammalian CAPS isoform, CAPS2; concluded that at the
            functional level, CAPS2 is largely redundant with CAPS1
REFERENCE   10 (bases 1 to 5648)
  AUTHORS   Cisternas,F.A., Vincent,J.B., Scherer,S.W. and Ray,P.N.
  TITLE     Cloning and characterization of human CADPS and CADPS2, new members
            of the Ca2+-dependent activator for secretion protein family
  JOURNAL   Genomics 81 (3), 279-291 (2003)
   PUBMED   12659812
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA248542.1, KJ534803.1,
            AC006463.4, KJ534798.1, AK054853.1, AC015983.7 and BX110721.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001363396.1.
            
            Summary: This gene encodes a member of the calcium-dependent
            activator of secretion (CAPS) protein family, which are calcium
            binding proteins that regulate the exocytosis of synaptic and
            dense-core vesicles in neurons and neuroendocrine cells. Mutations
            in this gene may contribute to autism susceptibility. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Nov 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KJ534798.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               DA248542.1         296-418
            124-878             KJ534803.1         1-755
            879-879             AC006463.4         45532-45532         c
            880-3891            KJ534798.1         757-3768
            3892-4104           AK054853.1         1470-1682
            4105-5425           AC015983.7         154978-156298       c
            5426-5635           BX110721.1         5-214
            5636-5648           AC015983.7         154755-154767       c
FEATURES             Location/Qualifiers
     source          1..5648
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.32"
     gene            1..5648
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="calcium dependent secretion activator 2"
                     /db_xref="GeneID:93664"
                     /db_xref="HGNC:HGNC:16018"
                     /db_xref="MIM:609978"
     exon            1..462
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..3894
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="isoform k is encoded by transcript variant 11;
                     Ca2+-dependent activator protein for secretion 2; Ca2+
                     dependent secretion activator 2; CAPS-2; calcium-dependent
                     activator protein for secretion 2; Ca++-dependent
                     secretion activator 2"
                     /codon_start=1
                     /product="calcium-dependent secretion activator 2 isoform
                     k"
                     /protein_id="NP_001350325.1"
                     /db_xref="GeneID:93664"
                     /db_xref="HGNC:HGNC:16018"
                     /db_xref="MIM:609978"
                     /translation="MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDA
                     PGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAK
                     QPTDMARRQQKLNKQQLQLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVA
                     RMVQSGGCSANDFREVFKKNIEKRVRSLPEIDGLSKETVLSSWIAKYDAIYRGEEDLC
                     KQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLDNADEQAAQIRRE
                     LDGRLQLADKMAKERKFPKFIAKDMENMYIEELRSSVNLLMANLESLPVSKGGPEFKL
                     QKLKRSQNSAFLDIGDENEIQLSKSDVVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEV
                     EGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELGRVILYP
                     TSNSSKSAELHRMVVPKNSQDSDLKIKLAVRMDKPAHMKHSGYLYALGQKVWKRWKKR
                     YFVLVQVSQYTFAMCSYREKKSEPQELMQLEGYTVDYTDPHPGLQGGCMFFNAVKEGD
                     TVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLSGKDADR
                     FQKHGMDEFISANPCKLDHAFLFRILQRQTLDHRLNDSYSCLGWFSPGQVFVLDEYCA
                     RYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYSFAFCASHVHGNRPDGIGTVSVEE
                     KERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEE
                     VKKVVRKCLEKAALINYTRLTEYAKIEETMNQASPARKLEEILHLAELCIEVLQQNEE
                     HHAEGREAFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQDSWDSFPLFQLLNNFLRN
                     DTLLCNGKFHKHLQEIFVPLVVRYVDLMESSIAQSIHRGFEQETWQPVNNGSATSEDL
                     FWKLDALQMFVFDLHWPEQEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQKASKT
                     TDLRIPASVCTMFNVLVDAKKQSTKLCALDGGQEQQYHSKIDDLIDNSVKEIISLLVS
                     KFVSVLEGVLSKLSRYDEGTFFSSILSFTVKAAAKYVDVPKPGMDLADTYIMFVRQNQ
                     DILREKVNEEMYIEKLFDQWYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKKTYRD
                     FRLQGVLEGTLNSKTYDTVHRRLTVEEATASVSEGGGLQGITMKDSDEEEEG"
     exon            463..576
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..909
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..990
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1227
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1346
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1458
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1598
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1665
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1774
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1975
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..1984
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2121
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2309
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2411
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2475
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2599
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2703
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2712
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2869
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..3011
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3167
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3168..3315
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..3390
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3391..3474
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3507
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3508..3615
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3616..3720
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3721..5648
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4640..4645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AATAAA"
     polyA_site      4662
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="major polyA site"
     regulatory      4701..4706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AGTAAA"
     polyA_site      4735
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
     regulatory      4810..4815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AGTAAA"
     polyA_site      4830
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
     regulatory      5610..5615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AATAAA"
     polyA_site      5648
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
ORIGIN      
        1 agttttcctt tcgttctgcg gccgctgcag ccagccccgc ggctccctca gacccgcggg
       61 cgcagccgcc gggggtgagg cgcttgggga ccgcgggccg agcggcgggg atccccgagc
      121 accatgctgg acccgtcttc cagcgaagag gagtcggacg aggggctgga agaggaaagc
      181 cgcgatgtgc tggtggcagc cggcagctcg cagcgagctc ctccagcccc gactcgggaa
      241 gggcggcggg acgcgccggg gcgcgcgggc ggcggcggcg cggccagatc tgtgagcccg
      301 agcccctctg tgctcagcga ggggcgagac gagccccagc ggcagctgga cgatgagcag
      361 gagcggagga tccgcctgca gctctacgtc ttcgtcgtga ggtgcatcgc gtaccccttc
      421 aacgccaagc agcccaccga catggcccgg aggcagcaga agcttaacaa acaacagttg
      481 cagttactga aagaacggtt ccaggccttc ctcaatgggg aaacccaaat tgtagctgac
      541 gaagcatttt gcaacgcagt tcggagttat tatgaggttt ttctaaagag tgaccgagtg
      601 gccagaatgg tacagagtgg agggtgttct gctaatgact tcagagaagt atttaagaaa
      661 aacatagaaa aacgtgtgcg gagtttgcca gaaatagatg gcttgagcaa agagacagtg
      721 ttgagctcat ggatagccaa atatgatgcc atttacagag gtgaagagga cttgtgcaaa
      781 cagccaaata gaatggccct aagtgcagtg tctgaactta ttctgagcaa ggaacaactc
      841 tatgaaatgt ttcagcagat tctgggtatt aaaaaactgg aacaccagct cctttataat
      901 gcatgtcagc tggataacgc agatgaacaa gcagcccaga tcagaaggga acttgatggc
      961 cggctgcaat tggcagataa aatggcaaag gaaagaaaat tccccaaatt tatagcaaaa
     1021 gatatggaga atatgtatat agaagagttg cggtcttcag tgaatttgct aatggccaat
     1081 ttggaaagtc ttccagtttc gaaaggtggt ccggaattta aattacaaaa attaaaacgt
     1141 tcacagaact ctgcattttt ggacatagga gatgagaatg agattcagct gtcaaagtcc
     1201 gacgtggtac tgtcattcac cttagagatt gtcataatgg aagtgcaagg cctgaagtca
     1261 gttgctccca atcgaattgt ttactgtaca atggaagtgg aaggagaaaa acttcagaca
     1321 gaccaggccg aagcctcaag gccacaatgg gggactcaag gagatttcac caccacccat
     1381 cctcggcctg tggtcaaagt gaaactcttc acagaaagca ctggagttct ggccctggaa
     1441 gataaagaac tgggaagggt gatattatac ccaacttcta atagctccaa atcagctgaa
     1501 ttacaccgaa tggtagttcc aaaaaatagc caggattctg acttaaaaat caaactggca
     1561 gtgcgaatgg ataaaccagc acatatgaag catagtggat atctgtatgc ccttggacag
     1621 aaggtttgga aaagatggaa aaaacgttac tttgttctag ttcaggttag ccaatatacc
     1681 tttgctatgt gcagttatag agaaaagaag tctgaaccac aagaattaat gcagcttgaa
     1741 ggctatactg tggattatac cgatccccac ccaggccttc agggtggttg tatgttcttt
     1801 aatgctgtta aagaaggaga tactgtaatc tttgccagtg atgatgaaca ggacagaata
     1861 ttatgggttc aagccatgta tagggccaca ggtcaatcat ataaaccagt tcctgcaatt
     1921 caaacccaga aactgaatcc taaaggagga actctccatg cagatgctca gctttctggt
     1981 aaagatgcag atcgttttca gaaacatggt atggatgagt ttatttctgc aaacccctgc
     2041 aagcttgatc atgccttcct ttttagaata ctccagaggc agactttgga tcacagactg
     2101 aatgattcct attcttgctt gggatggttt agccctggcc aagtctttgt gttagatgag
     2161 tactgtgccc gttatggtgt gagaggctgt cacagacatc tctgctacct tgcagaactg
     2221 atggaacatt cagaaaatgg tgctgtcatt gaccctaccc tgctccatta cagctttgca
     2281 ttctgtgcct ctcatgtgca cggcaacagg cctgatggaa ttgggactgt ttcagtggaa
     2341 gaaaaagaaa gatttgagga gataaaagag agactctctt cccttttaga aaatcagata
     2401 agccatttca gatactgttt tccctttgga cgacctgaag gtgctctaaa agctacactt
     2461 tcattacttg aaagggtttt aatgaaagat attgccactc ccataccagc agaagaggtg
     2521 aagaaagtgg tcagaaaatg tctcgagaaa gctgccttga tcaattacac tagactcaca
     2581 gaatatgcca aaatagaaga gaccatgaac caggcatctc ctgctagaaa gctggaagag
     2641 attcttcatc tggcagagct ctgcatagaa gtcttacagc agaatgaaga gcatcatgca
     2701 gagggaagag aggcatttgc ctggtggcct gatttattgg ctgaacatgc agagaaattt
     2761 tgggctttat ttacagtgga tatggacact gcactagagg ctcaaccgca agactcctgg
     2821 gatagttttc ctcttttcca actgcttaat aatttcctcc gaaatgacac acttttgtgt
     2881 aatggaaaat ttcacaaaca cttgcaagaa atctttgtac ccttggttgt ccgctatgtg
     2941 gatctcatgg agtcttccat cgcccagtca attcacagag gttttgagca ggagacatgg
     3001 cagcctgtca acaatggctc agcaacatca gaagaccttt tttggaagct tgatgcactg
     3061 caaatgtttg tctttgatct gcactggcca gaacaggaat ttgcccacca cttagagcaa
     3121 agacttaaac taatggccag tgatatgcta gaggcctgtg tcaaaagaac aagaactgca
     3181 tttgaactca agctacaaaa ggcaagcaaa acaactgact tgcgcattcc agcttccgtt
     3241 tgcactatgt ttaatgtatt agtcgatgcc aaaaagcaaa gcaccaaact ctgtgccctg
     3301 gatggaggac aagagcaaca gtaccattca aaaatagatg atctgatcga caacagtgta
     3361 aaagaaatca tttcactgtt agtttcaaag tttgtttcag tgttggaagg cgtgttgtct
     3421 aagctgtcaa ggtatgatga aggcactttc ttttcatcca ttctgtcatt cactgtgaaa
     3481 gcagctgcaa aatatgttga tgttccaaaa ccaggaatgg atctggcaga cacctatatt
     3541 atgtttgttc ggcaaaacca agatattctt cgagaaaagg tcaatgagga aatgtatata
     3601 gaaaagttat ttgatcaatg gtacagcagt tccatgaaag tcatttgcgt gtggttgact
     3661 gatagattag acctccaact ccatatttac cagctgaaga cgctcatcaa gattgtgaag
     3721 aaaacctaca gggactttcg attgcagggt gtgttggaag gaacactgaa cagtaagact
     3781 tatgatactg tgcacagacg tttaacagta gaggaggcca cagcctctgt ttcagaagga
     3841 ggaggacttc agggcattac tatgaaagac agtgacgaag aagaagaagg ctgatatcac
     3901 acagctttgc agaaggaagg aagaccttga tcgacattgt tttttatttt tttaaccttg
     3961 tccttgtaat tacattcatt gtttgttttg gccaaataaa aatgcttgta tttctttaaa
     4021 aagtaagcct gaatgtagag taaaagggga aatgccaaga ttttggggtt tttttgtttc
     4081 ctttttttgt ttgtttgttt gtttgttttt ttggagaaga gcatcctctt ttgtgtagtt
     4141 tgacctaaaa atgaaccttg gctctgcttg tgatcagaac atgaactttt ttttttaaag
     4201 aagatttgag catttttctg taatcacatc aaaatgatgt tttctgtgta aagcgagata
     4261 catatttctc ataatgcagc attgtgagaa gtcagttcgg accactgcac caacactgtc
     4321 gtatccttgt taaaatggtg tgtaccttac aaattataat ttatgtgcca ggttcgtttt
     4381 gtacttaatt tgctattatt gtgatgtgta taaaatcttt aatcttggtt cttagtactt
     4441 tgaattggtc tacaggtata ttcctgggat gaaaggattg ccaaacccaa atatagacta
     4501 gattatccaa tgggtttgtg tctttgttcc attctcaaca tttcttcttt caactataag
     4561 taatccccag gtgtggggta gcaagtgtgc ttccgtcaag ataccatatt ctcctgctcc
     4621 agtataacag cttgcaggca ataaaaatct atttgctcat aactacttct gtatttatta
     4681 gacttatata gagcaaatgc agtaaaagag gtttgcagtg tttcaaacat cccaactatc
     4741 tgactctgtg tttttgtttc ttgagttttt tgtttgtttt gtttgtaata ttttgttttt
     4801 aatcaaatga gtaaaagata gtaacactga ctgttctttg tacctaatag gcacatacat
     4861 tgttaaaaga attactatga cagcatattt ccatagcaga ggaaatatat atttcatata
     4921 ttattagtta atattagtaa tcaatgttaa ctaataatta gtaatgttag taatattaac
     4981 tagtaattca cattattagt ggttctctca aaatattttc ttgctagggt ttgagagata
     5041 attgtattat gttgcgtaag ttctctatga attatttttg tgatatttcc caaaacatat
     5101 tggcagattg tgctactgca tttattaata agtaattttt aaatgaaggc agttaatgca
     5161 gaataagtgg aggtatccct gcatttatga aaacgtttat tctgaaactt tagaaatgaa
     5221 acaacttgga cctccagatt cgttctccca tggtgtaata agtggtcgtt aggtacctag
     5281 actagcctta aaaatctatt taatctacag ttactattta gcattgtttt ggctcatttt
     5341 ctgggcccta gggctaagat aacaaacaag gaaatttctt ccttcttccg ggattaaaga
     5401 ctaactctac caactcacta tctttgaaag gcagtttggg aatgttctcc ctccttttct
     5461 tctctattca cacaccaaat actattttct ccaaaccctc aaatgtccag tcatgctatc
     5521 ccaaactctc caatggcacc atccccaagc ttgctgttcc acgacacatt gctctgtact
     5581 tagtaattac ccacccttct tttcctttca ataaaatgtc catttccttg atacagatca
     5641 tctccaaa
//
