LOCUS       NM_001363394            5660 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens calcium dependent secretion activator 2 (CADPS2),
            transcript variant 9, mRNA.
ACCESSION   NM_001363394 XM_005250705
VERSION     NM_001363394.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5660)
  AUTHORS   Andersen,J.S., Vijayakumaran,A., Godbehere,C., Lorentzen,E.,
            Mennella,V. and Schou,K.B.
  TITLE     Uncovering structural themes across cilia microtubule inner
            proteins with implications for human cilia function
  JOURNAL   Nat Commun 15 (1), 2687 (2024)
   PUBMED   38538594
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5660)
  AUTHORS   Yoo,H., Yang,S.H., Kim,J.Y., Yang,E., Park,H.S., Lee,S.J.,
            Rhyu,I.J., Turecki,G., Lee,H.W. and Kim,H.
  TITLE     Down-regulation of habenular calcium-dependent secretion activator
            2 induces despair-like behavior
  JOURNAL   Sci Rep 11 (1), 3700 (2021)
   PUBMED   33580180
  REMARK    GeneRIF: Down-regulation of habenular calcium-dependent secretion
            activator 2 induces despair-like behavior.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5660)
  AUTHORS   Zhang,K., Fan,Z., Wang,Y., Faraone,S.V., Yang,L. and Chang,S.
  TITLE     Genetic analysis for cognitive flexibility in the trail-making test
            in attention deficit hyperactivity disorder patients from single
            nucleotide polymorphism, gene to pathway level
  JOURNAL   World J Biol Psychiatry 20 (6), 476-485 (2019)
   PUBMED   28971736
  REMARK    GeneRIF: The top SNP rs2049161 involved gene DLGAP1 and the top
            gene CADPS2 in the gene-based analysis resulted in much literature
            evidence of associations with psychiatric disorders. Gene
            expression and network analysis showed their contribution to
            cognition function.
REFERENCE   4  (bases 1 to 5660)
  AUTHORS   Obergasteiger,J., Uberbacher,C., Pramstaller,P.P., Hicks,A.A.,
            Corti,C. and Volta,M.
  TITLE     CADPS2 gene expression is oppositely regulated by LRRK2 and
            alpha-synuclein
  JOURNAL   Biochem Biophys Res Commun 490 (3), 876-881 (2017)
   PUBMED   28647363
  REMARK    GeneRIF: These results indicate that LRRK2 and alpha-synuclein
            participate in the dysregulation of CADPS2 by altering
            transcription and support the hypothesis that synaptic
            dysfunctions, through different mechanisms, might contribute to the
            neuronal defects of diseases such as Parkinson's disease.
REFERENCE   5  (bases 1 to 5660)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   6  (bases 1 to 5660)
  AUTHORS   Brunk,I., Blex,C., Speidel,D., Brose,N. and Ahnert-Hilger,G.
  TITLE     Ca2+-dependent activator proteins of secretion promote vesicular
            monoamine uptake
  JOURNAL   J Biol Chem 284 (2), 1050-1056 (2009)
   PUBMED   19008227
  REMARK    GeneRIF: CAPS proteins are involved in optimizing vesicular
            monoamine uptake and storage mediated by VMAT1 and VMAT2
REFERENCE   7  (bases 1 to 5660)
  AUTHORS   Sadakata,T., Washida,M., Iwayama,Y., Shoji,S., Sato,Y., Ohkura,T.,
            Katoh-Semba,R., Nakajima,M., Sekine,Y., Tanaka,M., Nakamura,K.,
            Iwata,Y., Tsuchiya,K.J., Mori,N., Detera-Wadleigh,S.D.,
            Ichikawa,H., Itohara,S., Yoshikawa,T. and Furuichi,T.
  TITLE     Autistic-like phenotypes in Cadps2-knockout mice and aberrant
            CADPS2 splicing in autistic patients
  JOURNAL   J Clin Invest 117 (4), 931-943 (2007)
   PUBMED   17380209
  REMARK    GeneRIF: Genetic disturbance in CADPS2-mediated neurotrophin
            release contributes to autism susceptibility.
            GeneRIF: CADPS2-KO mice show autistic-like phenotypes. Moreover,
            the results show that some autistic patients have an aberrant
            splicing variant of CADPS2 mRNA, suggesting that a disturbance in
            CADPS2-mediated neurotrophin release contributes to autism.
            GeneRIF: Results from Cadps2-deficient mice and human data suggest
            that a disturbance in CADPS2-mediated neurotrophin release
            contributes to autistic-like cellular and behavioral phenotypes.
REFERENCE   8  (bases 1 to 5660)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   9  (bases 1 to 5660)
  AUTHORS   Speidel,D., Varoqueaux,F., Enk,C., Nojiri,M., Grishanin,R.N.,
            Martin,T.F., Hofmann,K., Brose,N. and Reim,K.
  TITLE     A family of Ca2+-dependent activator proteins for secretion:
            comparative analysis of structure, expression, localization, and
            function
  JOURNAL   J Biol Chem 278 (52), 52802-52809 (2003)
   PUBMED   14530279
  REMARK    GeneRIF: identification, cloning, and comparative characterization
            of a second mammalian CAPS isoform, CAPS2; concluded that at the
            functional level, CAPS2 is largely redundant with CAPS1
REFERENCE   10 (bases 1 to 5660)
  AUTHORS   Cisternas,F.A., Vincent,J.B., Scherer,S.W. and Ray,P.N.
  TITLE     Cloning and characterization of human CADPS and CADPS2, new members
            of the Ca2+-dependent activator for secretion protein family
  JOURNAL   Genomics 81 (3), 279-291 (2003)
   PUBMED   12659812
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA248542.1, KJ534803.1,
            AC006463.4, AC004594.2, AB046811.1, AC015983.7 and BX110721.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001363394.1.
            
            Summary: This gene encodes a member of the calcium-dependent
            activator of secretion (CAPS) protein family, which are calcium
            binding proteins that regulate the exocytosis of synaptic and
            dense-core vesicles in neurons and neuroendocrine cells. Mutations
            in this gene may contribute to autism susceptibility. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Nov 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KJ534803.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               DA248542.1         296-418
            124-878             KJ534803.1         1-755
            879-879             AC006463.4         45532-45532         c
            880-2579            KJ534803.1         757-2456
            2580-2580           AC004594.2         97428-97428         c
            2581-3903           KJ534803.1         2458-3780
            3904-4116           AB046811.1         3057-3269
            4117-5437           AC015983.7         154978-156298       c
            5438-5647           BX110721.1         5-214
            5648-5660           AC015983.7         154755-154767       c
FEATURES             Location/Qualifiers
     source          1..5660
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.32"
     gene            1..5660
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="calcium dependent secretion activator 2"
                     /db_xref="GeneID:93664"
                     /db_xref="HGNC:HGNC:16018"
                     /db_xref="MIM:609978"
     exon            1..462
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..3906
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="isoform i is encoded by transcript variant 9;
                     Ca2+-dependent activator protein for secretion 2; Ca2+
                     dependent secretion activator 2; CAPS-2; calcium-dependent
                     activator protein for secretion 2; Ca++-dependent
                     secretion activator 2"
                     /codon_start=1
                     /product="calcium-dependent secretion activator 2 isoform
                     i"
                     /protein_id="NP_001350323.1"
                     /db_xref="GeneID:93664"
                     /db_xref="HGNC:HGNC:16018"
                     /db_xref="MIM:609978"
                     /translation="MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDA
                     PGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAK
                     QPTDMARRQQKLNKQQLQLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVA
                     RMVQSGGCSANDFREVFKKNIEKRVRSLPEIDGLSKETVLSSWIAKYDAIYRGEEDLC
                     KQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLDNADEQAAQIRRE
                     LDGRLQLADKMAKERKFPKFIAKDMENMYIEELRSSVNLLMANLESLPVSKGGPEFKL
                     QKLKRSQNSAFLDIGDENEIQLSKSDVVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEV
                     EGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELGRVILYP
                     TSNSSKSAELHRMVVPKNSQDSDLKIKLAVRMDKPAHMKHSGYLYALGQKVWKRWKKR
                     YFVLVQVSQYTFAMCSYREKKSEPQELMQLEGYTVDYTDPHPGLQGGCMFFNAVKEGD
                     TVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLSGKDADR
                     FQKHGMDEFISANPCKLDHAFLFRILQRQTLDHRLNDSYSCLGWFSPGQVFVLDEYCA
                     RYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYSFAFCASHVHGNRPDGIGTVSVEE
                     KERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEE
                     VKKVVRKCLEKAALINYTRLTEYAKIEGPAEKETETMNQASPARKLEEILHLAELCIE
                     VLQQNEEHHAEAFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQDSWDSFPLFQLLNN
                     FLRNDTLLCNGKFHKHLQEIFVPLVVRYVDLMESSIAQSIHRGFEQETWQPVNNGSAT
                     SEDLFWKLDALQMFVFDLHWPEQEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQK
                     ASKTTDLRIPASVCTMFNVLVDAKKQSTKLCALDGGQEQQYHSKIDDLIDNSVKEIIS
                     LLVSKFVSVLEGVLSKLSRYDEGTFFSSILSFTVKAAAKYVDVPKPGMDLADTYIMFV
                     RQNQDILREKVNEEMYIEKLFDQWYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKK
                     TYRDFRLQGVLEGTLNSKTYDTVHRRLTVEEATASVSEGGGLQGITMKDSDEEEEG"
     exon            463..576
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..909
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..990
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1227
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1346
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1458
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1598
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1665
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1774
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1975
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..1984
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2121
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2309
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2411
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2475
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2599
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2620
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2724
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2881
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..3023
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..3179
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..3327
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3328..3402
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..3486
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3487..3519
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3520..3627
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3628..3732
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3733..5660
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4652..4657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AATAAA"
     polyA_site      4674
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="major polyA site"
     regulatory      4713..4718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AGTAAA"
     polyA_site      4747
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
     regulatory      4822..4827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AGTAAA"
     polyA_site      4842
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
     regulatory      5622..5627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AATAAA"
     polyA_site      5660
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
ORIGIN      
        1 agttttcctt tcgttctgcg gccgctgcag ccagccccgc ggctccctca gacccgcggg
       61 cgcagccgcc gggggtgagg cgcttgggga ccgcgggccg agcggcgggg atccccgagc
      121 accatgctgg acccgtcttc cagcgaagag gagtcggacg aggggctgga agaggaaagc
      181 cgcgatgtgc tggtggcagc cggcagctcg cagcgagctc ctccagcccc gactcgggaa
      241 gggcggcggg acgcgccggg gcgcgcgggc ggcggcggcg cggccagatc tgtgagcccg
      301 agcccctctg tgctcagcga ggggcgagac gagccccagc ggcagctgga cgatgagcag
      361 gagcggagga tccgcctgca gctctacgtc ttcgtcgtga ggtgcatcgc gtaccccttc
      421 aacgccaagc agcccaccga catggcccgg aggcagcaga agcttaacaa acaacagttg
      481 cagttactga aagaacggtt ccaggccttc ctcaatgggg aaacccaaat tgtagctgac
      541 gaagcatttt gcaacgcagt tcggagttat tatgaggttt ttctaaagag tgaccgagtg
      601 gccagaatgg tacagagtgg agggtgttct gctaatgact tcagagaagt atttaagaaa
      661 aacatagaaa aacgtgtgcg gagtttgcca gaaatagatg gcttgagcaa agagacagtg
      721 ttgagctcat ggatagccaa atatgatgcc atttacagag gtgaagagga cttgtgcaaa
      781 cagccaaata gaatggccct aagtgcagtg tctgaactta ttctgagcaa ggaacaactc
      841 tatgaaatgt ttcagcagat tctgggtatt aaaaaactgg aacaccagct cctttataat
      901 gcatgtcagc tggataacgc agatgaacaa gcagcccaga tcagaaggga acttgatggc
      961 cggctgcaat tggcagataa aatggcaaag gaaagaaaat tccccaaatt tatagcaaaa
     1021 gatatggaga atatgtatat agaagagttg cggtcttcag tgaatttgct aatggccaat
     1081 ttggaaagtc ttccagtttc gaaaggtggt ccggaattta aattacaaaa attaaaacgt
     1141 tcacagaact ctgcattttt ggacatagga gatgagaatg agattcagct gtcaaagtcc
     1201 gacgtggtac tgtcattcac cttagagatt gtcataatgg aagtgcaagg cctgaagtca
     1261 gttgctccca atcgaattgt ttactgtaca atggaagtgg aaggagaaaa acttcagaca
     1321 gaccaggccg aagcctcaag gccacaatgg gggactcaag gagatttcac caccacccat
     1381 cctcggcctg tggtcaaagt gaaactcttc acagaaagca ctggagttct ggccctggaa
     1441 gataaagaac tgggaagggt gatattatac ccaacttcta atagctccaa atcagctgaa
     1501 ttacaccgaa tggtagttcc aaaaaatagc caggattctg acttaaaaat caaactggca
     1561 gtgcgaatgg ataaaccagc acatatgaag catagtggat atctgtatgc ccttggacag
     1621 aaggtttgga aaagatggaa aaaacgttac tttgttctag ttcaggttag ccaatatacc
     1681 tttgctatgt gcagttatag agaaaagaag tctgaaccac aagaattaat gcagcttgaa
     1741 ggctatactg tggattatac cgatccccac ccaggccttc agggtggttg tatgttcttt
     1801 aatgctgtta aagaaggaga tactgtaatc tttgccagtg atgatgaaca ggacagaata
     1861 ttatgggttc aagccatgta tagggccaca ggtcaatcat ataaaccagt tcctgcaatt
     1921 caaacccaga aactgaatcc taaaggagga actctccatg cagatgctca gctttctggt
     1981 aaagatgcag atcgttttca gaaacatggt atggatgagt ttatttctgc aaacccctgc
     2041 aagcttgatc atgccttcct ttttagaata ctccagaggc agactttgga tcacagactg
     2101 aatgattcct attcttgctt gggatggttt agccctggcc aagtctttgt gttagatgag
     2161 tactgtgccc gttatggtgt gagaggctgt cacagacatc tctgctacct tgcagaactg
     2221 atggaacatt cagaaaatgg tgctgtcatt gaccctaccc tgctccatta cagctttgca
     2281 ttctgtgcct ctcatgtgca cggcaacagg cctgatggaa ttgggactgt ttcagtggaa
     2341 gaaaaagaaa gatttgagga gataaaagag agactctctt cccttttaga aaatcagata
     2401 agccatttca gatactgttt tccctttgga cgacctgaag gtgctctaaa agctacactt
     2461 tcattacttg aaagggtttt aatgaaagat attgccactc ccataccagc agaagaggtg
     2521 aagaaagtgg tcagaaaatg tctcgagaaa gctgccttga tcaattacac tagactcaca
     2581 gaatatgcca aaatagaagg cccagcagaa aaggaaacag agaccatgaa ccaggcatct
     2641 cctgctagaa agctggaaga gattcttcat ctggcagagc tctgcataga agtcttacag
     2701 cagaatgaag agcatcatgc agaggcattt gcctggtggc ctgatttatt ggctgaacat
     2761 gcagagaaat tttgggcttt atttacagtg gatatggaca ctgcactaga ggctcaaccg
     2821 caagactcct gggatagttt tcctcttttc caactgctta ataatttcct ccgaaatgac
     2881 acacttttgt gtaatggaaa atttcacaaa cacttgcaag aaatctttgt acccttggtt
     2941 gtccgctatg tggatctcat ggagtcttcc atcgcccagt caattcacag aggttttgag
     3001 caggagacat ggcagcctgt caacaatggc tcagcaacat cagaagacct tttttggaag
     3061 cttgatgcac tgcaaatgtt tgtctttgat ctgcactggc cagaacagga atttgcccac
     3121 cacttagagc aaagacttaa actaatggcc agtgatatgc tagaggcctg tgtcaaaaga
     3181 acaagaactg catttgaact caagctacaa aaggcaagca aaacaactga cttgcgcatt
     3241 ccagcttccg tttgcactat gtttaatgta ttagtcgatg ccaaaaagca aagcaccaaa
     3301 ctctgtgccc tggatggagg acaagagcaa cagtaccatt caaaaataga tgatctgatc
     3361 gacaacagtg taaaagaaat catttcactg ttagtttcaa agtttgtttc agtgttggaa
     3421 ggcgtgttgt ctaagctgtc aaggtatgat gaaggcactt tcttttcatc cattctgtca
     3481 ttcactgtga aagcagctgc aaaatatgtt gatgttccaa aaccaggaat ggatctggca
     3541 gacacctata ttatgtttgt tcggcaaaac caagatattc ttcgagaaaa ggtcaatgag
     3601 gaaatgtata tagaaaagtt atttgatcaa tggtacagca gttccatgaa agtcatttgc
     3661 gtgtggttga ctgatagatt agacctccaa ctccatattt accagctgaa gacgctcatc
     3721 aagattgtga agaaaaccta cagggacttt cgattgcagg gtgtgttgga aggaacactg
     3781 aacagtaaga cttatgatac tgtgcacaga cgtttaacag tagaggaggc cacagcctct
     3841 gtttcagaag gaggaggact tcagggcatt actatgaaag acagtgacga agaagaagaa
     3901 ggctgatatc acacagcttt gcagaaggaa ggaagacctt gatcgacatt gttttttatt
     3961 tttttaacct tgtccttgta attacattca ttgtttgttt tggccaaata aaaatgcttg
     4021 tatttcttta aaaagtaagc ctgaatgtag agtaaaaggg gaaatgccaa gattttgggg
     4081 tttttttgtt tccttttttt gtttgtttgt ttgtttgttt ttttggagaa gagcatcctc
     4141 ttttgtgtag tttgacctaa aaatgaacct tggctctgct tgtgatcaga acatgaactt
     4201 ttttttttaa agaagatttg agcatttttc tgtaatcaca tcaaaatgat gttttctgtg
     4261 taaagcgaga tacatatttc tcataatgca gcattgtgag aagtcagttc ggaccactgc
     4321 accaacactg tcgtatcctt gttaaaatgg tgtgtacctt acaaattata atttatgtgc
     4381 caggttcgtt ttgtacttaa tttgctatta ttgtgatgtg tataaaatct ttaatcttgg
     4441 ttcttagtac tttgaattgg tctacaggta tattcctggg atgaaaggat tgccaaaccc
     4501 aaatatagac tagattatcc aatgggtttg tgtctttgtt ccattctcaa catttcttct
     4561 ttcaactata agtaatcccc aggtgtgggg tagcaagtgt gcttccgtca agataccata
     4621 ttctcctgct ccagtataac agcttgcagg caataaaaat ctatttgctc ataactactt
     4681 ctgtatttat tagacttata tagagcaaat gcagtaaaag aggtttgcag tgtttcaaac
     4741 atcccaacta tctgactctg tgtttttgtt tcttgagttt tttgtttgtt ttgtttgtaa
     4801 tattttgttt ttaatcaaat gagtaaaaga tagtaacact gactgttctt tgtacctaat
     4861 aggcacatac attgttaaaa gaattactat gacagcatat ttccatagca gaggaaatat
     4921 atatttcata tattattagt taatattagt aatcaatgtt aactaataat tagtaatgtt
     4981 agtaatatta actagtaatt cacattatta gtggttctct caaaatattt tcttgctagg
     5041 gtttgagaga taattgtatt atgttgcgta agttctctat gaattatttt tgtgatattt
     5101 cccaaaacat attggcagat tgtgctactg catttattaa taagtaattt ttaaatgaag
     5161 gcagttaatg cagaataagt ggaggtatcc ctgcatttat gaaaacgttt attctgaaac
     5221 tttagaaatg aaacaacttg gacctccaga ttcgttctcc catggtgtaa taagtggtcg
     5281 ttaggtacct agactagcct taaaaatcta tttaatctac agttactatt tagcattgtt
     5341 ttggctcatt ttctgggccc tagggctaag ataacaaaca aggaaatttc ttccttcttc
     5401 cgggattaaa gactaactct accaactcac tatctttgaa aggcagtttg ggaatgttct
     5461 ccctcctttt cttctctatt cacacaccaa atactatttt ctccaaaccc tcaaatgtcc
     5521 agtcatgcta tcccaaactc tccaatggca ccatccccaa gcttgctgtt ccacgacaca
     5581 ttgctctgta cttagtaatt acccaccctt cttttccttt caataaaatg tccatttcct
     5641 tgatacagat catctccaaa
//
