LOCUS       NM_001009571            5645 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens calcium dependent secretion activator 2 (CADPS2),
            transcript variant 2, mRNA.
ACCESSION   NM_001009571
VERSION     NM_001009571.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5645)
  AUTHORS   Andersen,J.S., Vijayakumaran,A., Godbehere,C., Lorentzen,E.,
            Mennella,V. and Schou,K.B.
  TITLE     Uncovering structural themes across cilia microtubule inner
            proteins with implications for human cilia function
  JOURNAL   Nat Commun 15 (1), 2687 (2024)
   PUBMED   38538594
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5645)
  AUTHORS   Yoo,H., Yang,S.H., Kim,J.Y., Yang,E., Park,H.S., Lee,S.J.,
            Rhyu,I.J., Turecki,G., Lee,H.W. and Kim,H.
  TITLE     Down-regulation of habenular calcium-dependent secretion activator
            2 induces despair-like behavior
  JOURNAL   Sci Rep 11 (1), 3700 (2021)
   PUBMED   33580180
  REMARK    GeneRIF: Down-regulation of habenular calcium-dependent secretion
            activator 2 induces despair-like behavior.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5645)
  AUTHORS   Zhang,K., Fan,Z., Wang,Y., Faraone,S.V., Yang,L. and Chang,S.
  TITLE     Genetic analysis for cognitive flexibility in the trail-making test
            in attention deficit hyperactivity disorder patients from single
            nucleotide polymorphism, gene to pathway level
  JOURNAL   World J Biol Psychiatry 20 (6), 476-485 (2019)
   PUBMED   28971736
  REMARK    GeneRIF: The top SNP rs2049161 involved gene DLGAP1 and the top
            gene CADPS2 in the gene-based analysis resulted in much literature
            evidence of associations with psychiatric disorders. Gene
            expression and network analysis showed their contribution to
            cognition function.
REFERENCE   4  (bases 1 to 5645)
  AUTHORS   Obergasteiger,J., Uberbacher,C., Pramstaller,P.P., Hicks,A.A.,
            Corti,C. and Volta,M.
  TITLE     CADPS2 gene expression is oppositely regulated by LRRK2 and
            alpha-synuclein
  JOURNAL   Biochem Biophys Res Commun 490 (3), 876-881 (2017)
   PUBMED   28647363
  REMARK    GeneRIF: These results indicate that LRRK2 and alpha-synuclein
            participate in the dysregulation of CADPS2 by altering
            transcription and support the hypothesis that synaptic
            dysfunctions, through different mechanisms, might contribute to the
            neuronal defects of diseases such as Parkinson's disease.
REFERENCE   5  (bases 1 to 5645)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   6  (bases 1 to 5645)
  AUTHORS   Brunk,I., Blex,C., Speidel,D., Brose,N. and Ahnert-Hilger,G.
  TITLE     Ca2+-dependent activator proteins of secretion promote vesicular
            monoamine uptake
  JOURNAL   J Biol Chem 284 (2), 1050-1056 (2009)
   PUBMED   19008227
  REMARK    GeneRIF: CAPS proteins are involved in optimizing vesicular
            monoamine uptake and storage mediated by VMAT1 and VMAT2
REFERENCE   7  (bases 1 to 5645)
  AUTHORS   Sadakata,T., Washida,M., Iwayama,Y., Shoji,S., Sato,Y., Ohkura,T.,
            Katoh-Semba,R., Nakajima,M., Sekine,Y., Tanaka,M., Nakamura,K.,
            Iwata,Y., Tsuchiya,K.J., Mori,N., Detera-Wadleigh,S.D.,
            Ichikawa,H., Itohara,S., Yoshikawa,T. and Furuichi,T.
  TITLE     Autistic-like phenotypes in Cadps2-knockout mice and aberrant
            CADPS2 splicing in autistic patients
  JOURNAL   J Clin Invest 117 (4), 931-943 (2007)
   PUBMED   17380209
  REMARK    GeneRIF: Genetic disturbance in CADPS2-mediated neurotrophin
            release contributes to autism susceptibility.
            GeneRIF: CADPS2-KO mice show autistic-like phenotypes. Moreover,
            the results show that some autistic patients have an aberrant
            splicing variant of CADPS2 mRNA, suggesting that a disturbance in
            CADPS2-mediated neurotrophin release contributes to autism.
            GeneRIF: Results from Cadps2-deficient mice and human data suggest
            that a disturbance in CADPS2-mediated neurotrophin release
            contributes to autistic-like cellular and behavioral phenotypes.
REFERENCE   8  (bases 1 to 5645)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   9  (bases 1 to 5645)
  AUTHORS   Speidel,D., Varoqueaux,F., Enk,C., Nojiri,M., Grishanin,R.N.,
            Martin,T.F., Hofmann,K., Brose,N. and Reim,K.
  TITLE     A family of Ca2+-dependent activator proteins for secretion:
            comparative analysis of structure, expression, localization, and
            function
  JOURNAL   J Biol Chem 278 (52), 52802-52809 (2003)
   PUBMED   14530279
  REMARK    GeneRIF: identification, cloning, and comparative characterization
            of a second mammalian CAPS isoform, CAPS2; concluded that at the
            functional level, CAPS2 is largely redundant with CAPS1
REFERENCE   10 (bases 1 to 5645)
  AUTHORS   Cisternas,F.A., Vincent,J.B., Scherer,S.W. and Ray,P.N.
  TITLE     Cloning and characterization of human CADPS and CADPS2, new members
            of the Ca2+-dependent activator for secretion protein family
  JOURNAL   Genomics 81 (3), 279-291 (2003)
   PUBMED   12659812
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA248542.1, AF401638.1,
            AB046811.1, AC015983.7 and BX110721.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001009571.3.
            
            Summary: This gene encodes a member of the calcium-dependent
            activator of secretion (CAPS) protein family, which are calcium
            binding proteins that regulate the exocytosis of synaptic and
            dense-core vesicles in neurons and neuroendocrine cells. Mutations
            in this gene may contribute to autism susceptibility. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Nov 2009].
            
            Transcript Variant: This variant (2) lacks three alternate in-frame
            exons and includes an alternate in-frame exon, compared to variant
            3. The resulting isoform (b) differs in four regions and is shorter
            compared to isoform c.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF401638.1, BC136601.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-267               DA248542.1         296-562
            268-1586            AF401638.1         236-1554
            1587-4101           AB046811.1         755-3269
            4102-5422           AC015983.7         154978-156298       c
            5423-5632           BX110721.1         5-214
            5633-5645           AC015983.7         154755-154767       c
FEATURES             Location/Qualifiers
     source          1..5645
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.32"
     gene            1..5645
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="calcium dependent secretion activator 2"
                     /db_xref="GeneID:93664"
                     /db_xref="HGNC:HGNC:16018"
                     /db_xref="MIM:609978"
     exon            1..462
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..3891
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="isoform b is encoded by transcript variant 2;
                     Ca2+-dependent activator protein for secretion 2; Ca2+
                     dependent secretion activator 2; CAPS-2; calcium-dependent
                     activator protein for secretion 2; Ca++-dependent
                     secretion activator 2"
                     /codon_start=1
                     /product="calcium-dependent secretion activator 2 isoform
                     b"
                     /protein_id="NP_001009571.2"
                     /db_xref="CCDS:CCDS47691.1"
                     /db_xref="GeneID:93664"
                     /db_xref="HGNC:HGNC:16018"
                     /db_xref="MIM:609978"
                     /translation="MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDA
                     PGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAK
                     QPTDMARRQQKLNKQQLQLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVA
                     RMVQSGGCSANDFREVFKKNIEKRVRSLPEIDGLSKETVLSSWIAKYDAIYRGEEDLC
                     KQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLDNADEQAAQIRRE
                     LDGRLQLADKMAKERKFPKFIAKDMENMYIEELRSSVNLLMANLESLPVSKGGPEFKL
                     QKLKRSQNSAFLDIGDENEIQLSKSDVVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEV
                     EGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELGRVILYP
                     TSNSSKSAELHRMVVPKNSQDSDLKIKLAVRMDKPAHMKHSGYLYALGQKVWKRWKKR
                     YFVLVQVSQYTFAMCSYREKKSEPQELMQLEGYTVDYTDPHPGLQGGCMFFNAVKEGD
                     TVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLYADRFQK
                     HGMDEFISANPCKLDHAFLFRILQRQTLDHRLNDSYSCLGWFSPGQVFVLDEYCARYG
                     VRGCHRHLCYLAELMEHSENGAVIDPTLLHYSFAFCASHVHGNRPDGIGTVSVEEKER
                     FEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEEVKK
                     VVRKCLEKAALINYTRLTEYAKIEETMNQASPARKLEEILHLAELCIEVLQQNEEHHA
                     EAFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQDSWDSFPLFQLLNNFLRNDTLLCN
                     GKFHKHLQEIFVPLVVRYVDLMESSIAQSIHRGFEQETWQPVNNGSATSEDLFWKLDA
                     LQMFVFDLHWPEQEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQKASKTTDLRIP
                     ASVCTMFNVLVDAKKQSTKLCALDGGQEFGSQWQQYHSKIDDLIDNSVKEIISLLVSK
                     FVSVLEGVLSKLSRYDEGTFFSSILSFTVKAAAKYVDVPKPGMDLADTYIMFVRQNQD
                     ILREKVNEEMYIEKLFDQWYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKKTYRDF
                     RLQGVLEGTLNSKTYDTVHRRLTVEEATASVSEGGGLQGITMKDSDEEEEG"
     exon            463..576
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..909
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..990
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1227
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1346
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1458
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1598
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1665
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1774
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1975
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2112
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2300
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2402
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2466
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2590
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2694
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2851
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..2993
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3149
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3297
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3298..3312
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3313..3387
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3388..3471
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3472..3504
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..3612
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3613..3717
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3718..5645
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4637..4642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AATAAA"
     polyA_site      4659
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="major polyA site"
     regulatory      4698..4703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AGTAAA"
     polyA_site      4732
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
     regulatory      4807..4812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AGTAAA"
     polyA_site      4827
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
     regulatory      5607..5612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
                     /note="hexamer: AATAAA"
     polyA_site      5645
                     /gene="CADPS2"
                     /gene_synonym="CAPS2"
ORIGIN      
        1 agttttcctt tcgttctgcg gccgctgcag ccagccccgc ggctccctca gacccgcggg
       61 cgcagccgcc gggggtgagg cgcttgggga ccgcgggccg agcggcgggg atccccgagc
      121 accatgctgg acccgtcttc cagcgaagag gagtcggacg aggggctgga agaggaaagc
      181 cgcgatgtgc tggtggcagc cggcagctcg cagcgagctc ctccagcccc gactcgggaa
      241 gggcggcggg acgcgccggg gcgcgcgggc ggcggcggcg cggccagatc tgtgagcccg
      301 agcccctctg tgctcagcga ggggcgagac gagccccagc ggcagctgga cgatgagcag
      361 gagcggagga tccgcctgca gctctacgtc ttcgtcgtga ggtgcatcgc gtaccccttc
      421 aacgccaagc agcccaccga catggcccgg aggcagcaga agcttaacaa acaacagttg
      481 cagttactga aagaacggtt ccaggccttc ctcaatgggg aaacccaaat tgtagctgac
      541 gaagcatttt gcaacgcagt tcggagttat tatgaggttt ttctaaagag tgaccgagtg
      601 gccagaatgg tacagagtgg agggtgttct gctaatgact tcagagaagt atttaagaaa
      661 aacatagaaa aacgtgtgcg gagtttgcca gaaatagatg gcttgagcaa agagacagtg
      721 ttgagctcat ggatagccaa atatgatgcc atttacagag gtgaagagga cttgtgcaaa
      781 cagccaaata gaatggccct aagtgcagtg tctgaactta ttctgagcaa ggaacaactc
      841 tatgaaatgt ttcagcagat tctgggtatt aaaaaactgg aacaccagct cctttataat
      901 gcatgtcagc tggataacgc agatgaacaa gcagcccaga tcagaaggga acttgatggc
      961 cggctgcaat tggcagataa aatggcaaag gaaagaaaat tccccaaatt tatagcaaaa
     1021 gatatggaga atatgtatat agaagagttg cggtcttcag tgaatttgct aatggccaat
     1081 ttggaaagtc ttccagtttc gaaaggtggt ccggaattta aattacaaaa attaaaacgt
     1141 tcacagaact ctgcattttt ggacatagga gatgagaatg agattcagct gtcaaagtcc
     1201 gacgtggtac tgtcattcac cttagagatt gtcataatgg aagtgcaagg cctgaagtca
     1261 gttgctccca atcgaattgt ttactgtaca atggaagtgg aaggagaaaa acttcagaca
     1321 gaccaggccg aagcctcaag gccacaatgg gggactcaag gagatttcac caccacccat
     1381 cctcggcctg tggtcaaagt gaaactcttc acagaaagca ctggagttct ggccctggaa
     1441 gataaagaac tgggaagggt gatattatac ccaacttcta atagctccaa atcagctgaa
     1501 ttacaccgaa tggtagttcc aaaaaatagc caggattctg acttaaaaat caaactggca
     1561 gtgcgaatgg ataaaccagc acatatgaag catagtggat atctgtatgc ccttggacag
     1621 aaggtttgga aaagatggaa aaaacgttac tttgttctag ttcaggttag ccaatatacc
     1681 tttgctatgt gcagttatag agaaaagaag tctgaaccac aagaattaat gcagcttgaa
     1741 ggctatactg tggattatac cgatccccac ccaggccttc agggtggttg tatgttcttt
     1801 aatgctgtta aagaaggaga tactgtaatc tttgccagtg atgatgaaca ggacagaata
     1861 ttatgggttc aagccatgta tagggccaca ggtcaatcat ataaaccagt tcctgcaatt
     1921 caaacccaga aactgaatcc taaaggagga actctccatg cagatgctca gctttatgca
     1981 gatcgttttc agaaacatgg tatggatgag tttatttctg caaacccctg caagcttgat
     2041 catgccttcc tttttagaat actccagagg cagactttgg atcacagact gaatgattcc
     2101 tattcttgct tgggatggtt tagccctggc caagtctttg tgttagatga gtactgtgcc
     2161 cgttatggtg tgagaggctg tcacagacat ctctgctacc ttgcagaact gatggaacat
     2221 tcagaaaatg gtgctgtcat tgaccctacc ctgctccatt acagctttgc attctgtgcc
     2281 tctcatgtgc acggcaacag gcctgatgga attgggactg tttcagtgga agaaaaagaa
     2341 agatttgagg agataaaaga gagactctct tcccttttag aaaatcagat aagccatttc
     2401 agatactgtt ttccctttgg acgacctgaa ggtgctctaa aagctacact ttcattactt
     2461 gaaagggttt taatgaaaga tattgccact cccataccag cagaagaggt gaagaaagtg
     2521 gtcagaaaat gtctcgagaa agctgccttg atcaattaca ctagactcac agaatatgcc
     2581 aaaatagaag agaccatgaa ccaggcatct cctgctagaa agctggaaga gattcttcat
     2641 ctggcagagc tctgcataga agtcttacag cagaatgaag agcatcatgc agaggcattt
     2701 gcctggtggc ctgatttatt ggctgaacat gcagagaaat tttgggcttt atttacagtg
     2761 gatatggaca ctgcactaga ggctcaaccg caagactcct gggatagttt tcctcttttc
     2821 caactgctta ataatttcct ccgaaatgac acacttttgt gtaatggaaa atttcacaaa
     2881 cacttgcaag aaatctttgt acccttggtt gtccgctatg tggatctcat ggagtcttcc
     2941 atcgcccagt caattcacag aggttttgag caggagacat ggcagcctgt caacaatggc
     3001 tcagcaacat cagaagacct tttttggaag cttgatgcac tgcaaatgtt tgtctttgat
     3061 ctgcactggc cagaacagga atttgcccac cacttagagc aaagacttaa actaatggcc
     3121 agtgatatgc tagaggcctg tgtcaaaaga acaagaactg catttgaact caagctacaa
     3181 aaggcaagca aaacaactga cttgcgcatt ccagcttccg tttgcactat gtttaatgta
     3241 ttagtcgatg ccaaaaagca aagcaccaaa ctctgtgccc tggatggagg acaagagttt
     3301 ggtagtcaat ggcaacagta ccattcaaaa atagatgatc tgatcgacaa cagtgtaaaa
     3361 gaaatcattt cactgttagt ttcaaagttt gtttcagtgt tggaaggcgt gttgtctaag
     3421 ctgtcaaggt atgatgaagg cactttcttt tcatccattc tgtcattcac tgtgaaagca
     3481 gctgcaaaat atgttgatgt tccaaaacca ggaatggatc tggcagacac ctatattatg
     3541 tttgttcggc aaaaccaaga tattcttcga gaaaaggtca atgaggaaat gtatatagaa
     3601 aagttatttg atcaatggta cagcagttcc atgaaagtca tttgcgtgtg gttgactgat
     3661 agattagacc tccaactcca tatttaccag ctgaagacgc tcatcaagat tgtgaagaaa
     3721 acctacaggg actttcgatt gcagggtgtg ttggaaggaa cactgaacag taagacttat
     3781 gatactgtgc acagacgttt aacagtagag gaggccacag cctctgtttc agaaggagga
     3841 ggacttcagg gcattactat gaaagacagt gacgaagaag aagaaggctg atatcacaca
     3901 gctttgcaga aggaaggaag accttgatcg acattgtttt ttattttttt aaccttgtcc
     3961 ttgtaattac attcattgtt tgttttggcc aaataaaaat gcttgtattt ctttaaaaag
     4021 taagcctgaa tgtagagtaa aaggggaaat gccaagattt tggggttttt ttgtttcctt
     4081 tttttgtttg tttgtttgtt tgtttttttg gagaagagca tcctcttttg tgtagtttga
     4141 cctaaaaatg aaccttggct ctgcttgtga tcagaacatg aacttttttt tttaaagaag
     4201 atttgagcat ttttctgtaa tcacatcaaa atgatgtttt ctgtgtaaag cgagatacat
     4261 atttctcata atgcagcatt gtgagaagtc agttcggacc actgcaccaa cactgtcgta
     4321 tccttgttaa aatggtgtgt accttacaaa ttataattta tgtgccaggt tcgttttgta
     4381 cttaatttgc tattattgtg atgtgtataa aatctttaat cttggttctt agtactttga
     4441 attggtctac aggtatattc ctgggatgaa aggattgcca aacccaaata tagactagat
     4501 tatccaatgg gtttgtgtct ttgttccatt ctcaacattt cttctttcaa ctataagtaa
     4561 tccccaggtg tggggtagca agtgtgcttc cgtcaagata ccatattctc ctgctccagt
     4621 ataacagctt gcaggcaata aaaatctatt tgctcataac tacttctgta tttattagac
     4681 ttatatagag caaatgcagt aaaagaggtt tgcagtgttt caaacatccc aactatctga
     4741 ctctgtgttt ttgtttcttg agttttttgt ttgttttgtt tgtaatattt tgtttttaat
     4801 caaatgagta aaagatagta acactgactg ttctttgtac ctaataggca catacattgt
     4861 taaaagaatt actatgacag catatttcca tagcagagga aatatatatt tcatatatta
     4921 ttagttaata ttagtaatca atgttaacta ataattagta atgttagtaa tattaactag
     4981 taattcacat tattagtggt tctctcaaaa tattttcttg ctagggtttg agagataatt
     5041 gtattatgtt gcgtaagttc tctatgaatt atttttgtga tatttcccaa aacatattgg
     5101 cagattgtgc tactgcattt attaataagt aatttttaaa tgaaggcagt taatgcagaa
     5161 taagtggagg tatccctgca tttatgaaaa cgtttattct gaaactttag aaatgaaaca
     5221 acttggacct ccagattcgt tctcccatgg tgtaataagt ggtcgttagg tacctagact
     5281 agccttaaaa atctatttaa tctacagtta ctatttagca ttgttttggc tcattttctg
     5341 ggccctaggg ctaagataac aaacaaggaa atttcttcct tcttccggga ttaaagacta
     5401 actctaccaa ctcactatct ttgaaaggca gtttgggaat gttctccctc cttttcttct
     5461 ctattcacac accaaatact attttctcca aaccctcaaa tgtccagtca tgctatccca
     5521 aactctccaa tggcaccatc cccaagcttg ctgttccacg acacattgct ctgtacttag
     5581 taattaccca cccttctttt cctttcaata aaatgtccat ttccttgata cagatcatct
     5641 ccaaa
//
