LOCUS       NP_003707               1353 aa            linear   PRI 03-OCT-2024
DEFINITION  calcium-dependent secretion activator 1 isoform 1 [Homo sapiens].
ACCESSION   NP_003707
VERSION     NP_003707.2
DBSOURCE    REFSEQ: accession NM_003716.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1353)
  AUTHORS   Sitbon,J., Nestvogel,D., Kappeler,C., Nicolas,A., Maciuba,S.,
            Henrion,A., Troudet,R., Courtois,E., Grannec,G., Latapie,V.,
            Barau,C., Le Corvoisier,P., Pietrancosta,N., Henry,C., Leboyer,M.,
            Etain,B., Nosten-Bertrand,M., Martin,T.F.J., Rhee,J. and Jamain,S.
  TITLE     CADPS functional mutations in patients with bipolar disorder
            increase the sensitivity to stress
  JOURNAL   Mol Psychiatry 27 (2), 1145-1157 (2022)
   PUBMED   35169262
  REMARK    GeneRIF: CADPS functional mutations in patients with bipolar
            disorder increase the sensitivity to stress.
REFERENCE   2  (residues 1 to 1353)
  AUTHORS   Weng,S., Janssen,H.L.A., Zhang,N., Tang,W., Bai,E., Yang,B. and
            Dong,L.
  TITLE     CAPS1 Suppresses Tumorigenesis in Cholangiocarcinoma
  JOURNAL   Dig Dis Sci 65 (4), 1053-1063 (2020)
   PUBMED   31562609
  REMARK    GeneRIF: CAPS1 Suppresses Tumorigenesis in Cholangiocarcinoma.
REFERENCE   3  (residues 1 to 1353)
  AUTHORS   Wu,B., Sun,D., Ma,L., Deng,Y., Zhang,S., Dong,L. and Chen,S.
  TITLE     Exosomes isolated from CAPS1-overexpressing colorectal cancer cells
            promote cell migration
  JOURNAL   Oncol Rep 42 (6), 2528-2536 (2019)
   PUBMED   31638236
  REMARK    GeneRIF: Study revealed that CAPS1 promoted normal colonic
            epithelial FHC cells migration by altering the protein expression
            profile of exosomes derived from colorectal cancer cells cells.
            GW4869, an exosome inhibitor, inhibited CAPS1-induced cell
            migration.
REFERENCE   4  (residues 1 to 1353)
  AUTHORS   Zhao,G.X., Xu,Y.Y., Weng,S.Q., Zhang,S., Chen,Y., Shen,X.Z.,
            Dong,L. and Chen,S.
  TITLE     CAPS1 promotes colorectal cancer metastasis via Snail mediated
            epithelial mesenchymal transformation
  JOURNAL   Oncogene 38 (23), 4574-4589 (2019)
   PUBMED   30742066
  REMARK    GeneRIF: CAPS1 promotes colorectal cancer metastasis through
            PI3K/Akt/GSK3beta/Snail signal pathway-mediated epithelial
            mesenchymal transformation process
REFERENCE   5  (residues 1 to 1353)
  AUTHORS   Yu,B., Zheng,Y., Alexander,D., Manolio,T.A., Alonso,A.,
            Nettleton,J.A. and Boerwinkle,E.
  TITLE     Genome-wide association study of a heart failure related
            metabolomic profile among African Americans in the Atherosclerosis
            Risk in Communities (ARIC) study
  JOURNAL   Genet Epidemiol 37 (8), 840-845 (2013)
   PUBMED   23934736
REFERENCE   6  (residues 1 to 1353)
  AUTHORS   Berwin,B., Floor,E. and Martin,T.F.
  TITLE     CAPS (mammalian UNC-31) protein localizes to membranes involved in
            dense-core vesicle exocytosis
  JOURNAL   Neuron 21 (1), 137-145 (1998)
   PUBMED   9697858
REFERENCE   7  (residues 1 to 1353)
  AUTHORS   Loyet,K.M., Kowalchyk,J.A., Chaudhary,A., Chen,J., Prestwich,G.D.
            and Martin,T.F.
  TITLE     Specific binding of phosphatidylinositol 4,5-bisphosphate to
            calcium-dependent activator protein for secretion (CAPS), a
            potential phosphoinositide effector protein for regulated
            exocytosis
  JOURNAL   J Biol Chem 273 (14), 8337-8343 (1998)
   PUBMED   9525942
REFERENCE   8  (residues 1 to 1353)
  AUTHORS   Ann,K., Kowalchyk,J.A., Loyet,K.M. and Martin,T.F.
  TITLE     Novel Ca2+-binding protein (CAPS) related to UNC-31 required for
            Ca2+-activated exocytosis
  JOURNAL   J Biol Chem 272 (32), 19637-19640 (1997)
   PUBMED   9289490
REFERENCE   9  (residues 1 to 1353)
  AUTHORS   Nishizaki,T., Walent,J.H., Kowalchyk,J.A. and Martin,T.F.
  TITLE     A key role for a 145-kDa cytosolic protein in the stimulation of
            Ca(2+)-dependent secretion by protein kinase C
  JOURNAL   J Biol Chem 267 (33), 23972-23981 (1992)
   PUBMED   1429734
REFERENCE   10 (residues 1 to 1353)
  AUTHORS   Walent,J.H., Porter,B.W. and Martin,T.F.
  TITLE     A novel 145 kd brain cytosolic protein reconstitutes
            Ca(2+)-regulated secretion in permeable neuroendocrine cells
  JOURNAL   Cell 70 (5), 765-775 (1992)
   PUBMED   1516133
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012519.9, AC092039.2 and
            AC104161.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 4, 2003 this sequence version replaced NP_003707.1.
            
            Summary: This gene encodes a novel neural/endocrine-specific
            cytosolic and peripheral membrane protein required for the
            Ca2+-regulated exocytosis of secretory vesicles. The protein acts
            at a stage in exocytosis that follows ATP-dependent priming, which
            involves the essential synthesis of phosphatidylinositol
            4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been
            observed at this locus and three variants, encoding distinct
            isoforms, are described. [provided by RefSeq, Aug 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB032947.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383710.9/ ENSP00000373215.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1353
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.2"
     Protein         1..1353
                     /product="calcium-dependent secretion activator 1 isoform
                     1"
                     /note="Ca2+-dependent activator protein for secretion;
                     Ca2+-regulated cytoskeletal protein; calcium-dependent
                     secretion activator 1; CAPS-1; calcium-dependent activator
                     protein for secretion 1; Ca++-dependent secretion
                     activator; Ca2+ dependent secretion activator"
                     /calculated_mol_wt=152656
     Region          1..109
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ULU8.3)"
     Site            34
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q80TJ1; propagated from
                     UniProtKB/Swiss-Prot (Q9ULU8.3)"
     Site            91
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q62717; propagated from
                     UniProtKB/Swiss-Prot (Q9ULU8.3)"
     Site            98
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q62717; propagated from
                     UniProtKB/Swiss-Prot (Q9ULU8.3)"
     Site            261
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q62717; propagated from
                     UniProtKB/Swiss-Prot (Q9ULU8.3)"
     Region          515..634
                     /region_name="PH_CADPS"
                     /note="Ca2+-dependent activator protein (also called CAPS)
                     Pleckstrin homology (PH) domain; cd01234"
                     /db_xref="CDD:269940"
     Region          790..1129
                     /region_name="Interaction with DRD2.
                     /evidence=ECO:0000269|PubMed:15857609"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ULU8.3)"
     Region          836..1300
                     /region_name="MUN"
                     /note="MUN domain; pfam06292"
                     /db_xref="CDD:461870"
     Region          1177..1353
                     /region_name="Mediates targeting and association with
                     DCVs. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ULU8.3)"
     Region          1329..1353
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ULU8.3)"
     CDS             1..1353
                     /gene="CADPS"
                     /gene_synonym="CADPS1; CAPS; CAPS1; UNC-31"
                     /coded_by="NM_003716.4:388..4449"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS46858.1"
                     /db_xref="GeneID:8618"
                     /db_xref="HGNC:HGNC:1426"
                     /db_xref="MIM:604667"
ORIGIN      
        1 mldpssseee sdeiveeesg kevlgsapsg arlspsrtse gsagsaglgg ggagagagvg
       61 agggggsgas sgggagglqp ssragggrps spspsvvsek ekeelerlqk eeeerkkrlq
      121 lyvfvmrcia ypfnakqptd marrqqkisk qqlqtvkdrf qaflngetqi madeafmnav
      181 qsyyevflks drvarmvqsg gcsandsrev fkkhiekrvr slpeidglsk etvlsswmak
      241 fdaiyrgeed prkqqarmta saaselilsk eqlyemfqni lgikkfehql lynacqldnp
      301 deqaaqirre ldgrlqmadq iarerkfpkf vskemenmyi eelkssvnll manlesmpvs
      361 kggefklqkl krshnasiid mgeesenqls ksdvvlsfsl evvimevqgl kslapnrivy
      421 ctmeveggek lqtdqaeask ptwgtqgdfs tthalpavkv klftestgvl aledkelgrv
      481 ilhptpnspk qsewhkmtvs kncpdqdlki klavrmdkpq nmkhsgylwa igknvwkrwk
      541 krffvlvqvs qytfamcsyr ekkaepqell qldgytvdyt dpqpgleggr affnavkegd
      601 tvifasddeq drilwvqamy ratgqshkpv pptqvqklna kggnvpqlda pisqfyadra
      661 qkhgmdefis snpcnfdhas lfemvqrltl dhrlndsysc lgwfspgqvf vldeycarng
      721 vrgchrhlcy lrdlleraen gamidptllh ysfafcashv hgnrpdgigt vtveekerfe
      781 eikerlrvll enqithfryc fpfgrpegal katlsllerv lmkdivtpvp qeevktvirk
      841 cleqaalvny srlseyakie enqkdaenvg rlitpakkle dtirlaelvi evlqqneehh
      901 aephvdkgea fawwsdlmve haetflslfa vdmdaalevq ppdtwdsfpl fqllndflrt
      961 dynlcngkfh khlqdlfapl vvryvdlmes siaqsihrgf ereswepvks ltsnlpnvnl
     1021 pnvnlpkvpn lpvniplgip qmptfsapsw maaiydadng sgtsedlfwk ldalqtfird
     1081 lhwpeeefgk hleqrlklma sdmiescvkr triafevklq ktsrstdfrv pqsictmfnv
     1141 mvdakaqstk lcsmemgqeh qyhskideli eetvkemitl lvakfvtile gvlaklsryd
     1201 egtlfssfls ftvkaaskyv dvpkpgmdva dayvtfvrhs qdvlrdkvne emyierlfdq
     1261 wynssmnvic twltdrmdlq lhiyqlktli rmvkktyrdf rlqgvldstl nsktyetirn
     1321 rltveeatas vseggglqgi smkdsdeede edd
//
