LOCUS       NM_145296               2189 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cell adhesion molecule 4 (CADM4), mRNA.
ACCESSION   NM_145296
VERSION     NM_145296.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2189)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2189)
  AUTHORS   Luo,F., Zhao,Y. and Liu,J.
  TITLE     Cell adhesion molecule 4 suppresses cell growth and metastasis by
            inhibiting the Akt signaling pathway in non-small cell lung cancer
  JOURNAL   Int J Biochem Cell Biol 123, 105750 (2020)
   PUBMED   32325280
  REMARK    GeneRIF: Cell adhesion molecule 4 suppresses cell growth and
            metastasis by inhibiting the Akt signaling pathway in non-small
            cell lung cancer.
REFERENCE   3  (bases 1 to 2189)
  AUTHORS   Rifatbegovic,F., Frech,C., Abbasi,M.R., Taschner-Mandl,S.,
            Weiss,T., Schmidt,W.M., Schmidt,I., Ladenstein,R., Ambros,I.M. and
            Ambros,P.F.
  TITLE     Neuroblastoma cells undergo transcriptomic alterations upon
            dissemination into the bone marrow and subsequent tumor progression
  JOURNAL   Int J Cancer 142 (2), 297-307 (2018)
   PUBMED   28921546
  REMARK    GeneRIF: Low CADM4 expression is associated with bone marrow
            metastasis in neuroblastoma.
REFERENCE   4  (bases 1 to 2189)
  AUTHORS   Yamana,S., Tokiyama,A., Fujita,H., Terao,Y., Horibe,S., Sasaki,N.,
            Satomi-Kobayashi,S., Hirata,K.I. and Rikitake,Y.
  TITLE     Necl-4 enhances the PLCgamma-c-Raf-MEK-ERK pathway without
            affecting internalization of VEGFR2
  JOURNAL   Biochem Biophys Res Commun 490 (2), 169-175 (2017)
   PUBMED   28601637
  REMARK    GeneRIF: The results suggest that Necl-4 enhances VEGF-induced
            activation of PLCgamma-c-Raf-MEK-ERK pathway without affecting the
            phosphorylation and internalization of VEGFR2.
REFERENCE   5  (bases 1 to 2189)
  AUTHORS   Sayar,I., Gokce,A., Demirtas,L., Eken,H., Cimen,F.K. and Cimen,O.
  TITLE     Necl 4 and RNase 5 Are Important Biomarkers for Gastric and Colon
            Adenocarcinomas
  JOURNAL   Med Sci Monit 23, 2654-2659 (2017)
   PUBMED   28561015
  REMARK    GeneRIF: There was a significant association between RNase 5 and
            histological differentiation in colon adenocarcinomas, but no
            association between RNase 5 and Necl 4 in gastric or colon
            adenocarcinomas
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2189)
  AUTHORS   Nagata,M., Sakurai-Yageta,M., Yamada,D., Goto,A., Ito,A.,
            Fukuhara,H., Kume,H., Morikawa,T., Fukayama,M., Homma,Y. and
            Murakami,Y.
  TITLE     Aberrations of a cell adhesion molecule CADM4 in renal clear cell
            carcinoma
  JOURNAL   Int J Cancer 130 (6), 1329-1337 (2012)
   PUBMED   21544807
  REMARK    GeneRIF: CADM4, as well as 4.1B is expressed specifically in human
            proximal tubules.
REFERENCE   7  (bases 1 to 2189)
  AUTHORS   Karasik,D., Hsu,Y.H., Zhou,Y., Cupples,L.A., Kiel,D.P. and
            Demissie,S.
  TITLE     Genome-wide pleiotropy of osteoporosis-related phenotypes: the
            Framingham Study
  JOURNAL   J Bone Miner Res 25 (7), 1555-1563 (2010)
   PUBMED   20200953
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 2189)
  AUTHORS   Raveh,S., Gavert,N., Spiegel,I. and Ben-Ze'ev,A.
  TITLE     The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the
            growth and tumorigenic ability of colon cancer cells
  JOURNAL   J Cell Biochem 108 (1), 326-336 (2009)
   PUBMED   19565570
  REMARK    GeneRIF: Nec- 4 suppress the growth and tumorigenic ability of
            colon cancer cells.
REFERENCE   9  (bases 1 to 2189)
  AUTHORS   Williams,Y.N., Masuda,M., Sakurai-Yageta,M., Maruyama,T.,
            Shibuya,M. and Murakami,Y.
  TITLE     Cell adhesion and prostate tumor-suppressor activity of
            TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to
            TSLC1/IGSF4
  JOURNAL   Oncogene 25 (10), 1446-1453 (2006)
   PUBMED   16261159
  REMARK    GeneRIF: TSLL2 is expressed at the cell-cell attachment sites in
            the renal tubules, the transitional epithelia of the bladder, and
            the glandular epithelia of the prostate, and is a tumor-suppressor
            candidate in prostate cancer.
REFERENCE   10 (bases 1 to 2189)
  AUTHORS   Fukuhara,H., Kuramochi,M., Nobukuni,T., Fukami,T., Saino,M.,
            Maruyama,T., Nomura,S., Sekiya,T. and Murakami,Y.
  TITLE     Isolation of the TSLL1 and TSLL2 genes, members of the tumor
            suppressor TSLC1 gene family encoding transmembrane proteins
  JOURNAL   Oncogene 20 (38), 5401-5407 (2001)
   PUBMED   11536053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005525.2 and AF363368.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145296.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068457.1, AF363368.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222374.3/ ENSP00000222374.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC005525.2         28458-28468         c
            12-2187             AF363368.1         1-2176
            2188-2189           AC005525.2         10986-10987         c
FEATURES             Location/Qualifiers
     source          1..2189
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..2189
                     /gene="CADM4"
                     /gene_synonym="IGSF4C; Necl-4; NECL4; synCAM4; TSLL2"
                     /note="cell adhesion molecule 4"
                     /db_xref="GeneID:199731"
                     /db_xref="HGNC:HGNC:30825"
                     /db_xref="MIM:609744"
     exon            1..124
                     /gene="CADM4"
                     /gene_synonym="IGSF4C; Necl-4; NECL4; synCAM4; TSLL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1227
                     /gene="CADM4"
                     /gene_synonym="IGSF4C; Necl-4; NECL4; synCAM4; TSLL2"
                     /note="nectin-like 4; TSLC1-like 2; TSLC1-like protein 2;
                     nectin-like protein 4; immunoglobulin superfamily member
                     4C"
                     /codon_start=1
                     /product="cell adhesion molecule 4 precursor"
                     /protein_id="NP_660339.1"
                     /db_xref="CCDS:CCDS12627.1"
                     /db_xref="GeneID:199731"
                     /db_xref="HGNC:HGNC:30825"
                     /db_xref="MIM:609744"
                     /translation="MGRARRFQWPLLLLWAAAAGPGAGQEVQTENVTVAEGGVAEITC
                     RLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGY
                     FCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYR
                     DRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVL
                     DVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETL
                     TLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVPYAIVGGILALLV
                     FLIICVLVGMVWCSVRQKGSYLTHEASGLDEQGEAREAFLNGSDGHKRKEEFFI"
     exon            125..271
                     /gene="CADM4"
                     /gene_synonym="IGSF4C; Necl-4; NECL4; synCAM4; TSLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            272..424
                     /gene="CADM4"
                     /gene_synonym="IGSF4C; Necl-4; NECL4; synCAM4; TSLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            425..559
                     /gene="CADM4"
                     /gene_synonym="IGSF4C; Necl-4; NECL4; synCAM4; TSLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            560..724
                     /gene="CADM4"
                     /gene_synonym="IGSF4C; Necl-4; NECL4; synCAM4; TSLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            725..815
                     /gene="CADM4"
                     /gene_synonym="IGSF4C; Necl-4; NECL4; synCAM4; TSLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            816..988
                     /gene="CADM4"
                     /gene_synonym="IGSF4C; Necl-4; NECL4; synCAM4; TSLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1117
                     /gene="CADM4"
                     /gene_synonym="IGSF4C; Necl-4; NECL4; synCAM4; TSLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..2189
                     /gene="CADM4"
                     /gene_synonym="IGSF4C; Necl-4; NECL4; synCAM4; TSLL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2169..2174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADM4"
                     /gene_synonym="IGSF4C; Necl-4; NECL4; synCAM4; TSLL2"
                     /note="hexamer: ATTAAA"
     polyA_site      2189
                     /gene="CADM4"
                     /gene_synonym="IGSF4C; Necl-4; NECL4; synCAM4; TSLL2"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcgggcg gtgcaggtgc cgggccggga gcgagcggcg gcggcggcgg cggcggcacc
       61 atgggccggg cccggcgctt ccagtggccg ctgctgctgc tgtgggcggc cgcggcgggg
      121 ccaggggcag gacaggaagt acagacagag aacgtgacag tggctgaggg tggggtggct
      181 gagatcacct gccgtctgca ccagtatgat gggtccatag ttgtcatcca gaacccagcc
      241 cggcagaccc tcttcttcaa tggcacccgt gccttgaagg atgagcgttt ccagcttgag
      301 gagttctccc cacgccgggt gcggatccgg ctctcagatg cccgcctgga ggacgagggg
      361 ggctatttct gccagctcta cacagaagac acccaccacc agattgccac gctcacggta
      421 ctagtggccc cagagaatcc tgtggtggag gtccgggagc aggcggtaga gggcggcgag
      481 gtggagctca gctgcctcgt tccgcggtcc cgtccggctg ccaccctgcg ctggtaccgg
      541 gaccgcaagg agctgaaagg agtgagcagc agccaggaaa atggcaaggt ctggagcgtg
      601 gcaagcacag tacggtttcg tgtggaccgt aaggacgacg gtggtatcat catctgtgag
      661 gcgcagaacc aggcgctgcc ctccggacac agcaagcaga cgcagtacgt gctggatgtg
      721 cagtactccc ccacggcccg gattcatgcc tcccaagctg tggtgaggga gggagacacg
      781 ctggtgttga cgtgtgctgt cacggggaac cccaggccaa accagatccg ctggaaccgc
      841 gggaatgagt ctttgccgga gagggcggag gccgtgggag agacgctcac gctgccgggt
      901 ctggtatccg cggataacgg cacctacact tgcgaggcgt ccaataagca cggccatgcg
      961 agggcgctct acgtacttgt ggtctacgac cctggtgcgg tggtagaggc tcagacgtcg
     1021 gttccctatg ccattgtggg cggcatcctg gcgctgctgg tgtttctgat catatgtgtg
     1081 ctagtgggca tggtctggtg ctcggtacgg cagaagggtt cctatctgac ccacgaagcc
     1141 agtggcttgg atgaacaggg agaagcaaga gaagccttcc tcaatggcag cgacggacac
     1201 aagaggaaag aggaattctt catctgaccc tatccccacc ccaggcctag gcctgggcct
     1261 gggctggggt cccccccact gccagctgca aggaaccagc aaagacattt accagagtct
     1321 gggatggtgg gcttctcccc ccaccactaa cacctcagac gcttgggcag ggatgggggt
     1381 gttggatgcc tggatctctg taagggccag aagtgagggc ccagaggtct gggtccccca
     1441 gggggcaggg gccaaaggtc cagacccccc aagtccagtg agggcagtag ggattgggtt
     1501 gggggaagat aactggggga aggccagggc ccctaggcta caaaaccagg tcttgtgggg
     1561 agggggtcag tttctgggaa gggtgggggg ggcagggaag gggaacacag atttctttgg
     1621 gggtcctaga ccccatgcca gccattgtaa gagttccaca gagctctggg cacttctttg
     1681 caaagccatg tttgcacggt ggggggatgg gtggggggag ggcgtggaaa tagggattct
     1741 gtgtctttgt gtcataactt tgatgggggc agtgagggag acagccccaa cccttttctc
     1801 caatccccct tccccaggtt cctgggctcc ccttctctct accttctccc ccaacgtctg
     1861 tcccatccat atttgtctct ctgtccaccc actcctgggg gggccttccc catctctcct
     1921 ccaggccccc cggggagggg gaaaggagtt tggggaggat tcgtggtctt catggtttta
     1981 tatataatat attaaaaaat caaaagtctg tatgaaaata tcagattgca cccccctctc
     2041 cccattcctg gcttttgccc cctttttctt gttaaaaaac aaaaaacaaa aaacaaaaaa
     2101 ccacacacac attttgtacg gggtggggag gggaatgggg agggggtttg gcaatctcac
     2161 taaccaccat taaactgagg agagaacaa
//
