LOCUS       NM_001127173            3739 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cell adhesion molecule 3 (CADM3), transcript variant
            2, mRNA.
ACCESSION   NM_001127173
VERSION     NM_001127173.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3739)
  AUTHORS   Ren,H., Wang,Z., Zhang,L., Zhu,G., Li,F. and Chen,B.
  TITLE     Clinical significance of low expression of CADM3 in breast cancer
            and preliminary exploration of related mechanisms
  JOURNAL   BMC Cancer 24 (1), 367 (2024)
   PUBMED   38515057
  REMARK    GeneRIF: Clinical significance of low expression of CADM3 in breast
            cancer and preliminary exploration of related mechanisms.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3739)
  AUTHORS   Rebelo,A.P., Cortese,A., Abraham,A., Eshed-Eisenbach,Y., Shner,G.,
            Vainshtein,A., Buglo,E., Camarena,V., Gaidosh,G., Shiekhattar,R.,
            Abreu,L., Courel,S., Burns,D.K., Bai,Y., Bacon,C., Feely,S.M.E.,
            Castro,D., Peles,E., Reilly,M.M., Shy,M.E. and Zuchner,S.
  TITLE     A CADM3 variant causes Charcot-Marie-Tooth disease with marked
            upper limb involvement
  JOURNAL   Brain 144 (4), 1197-1213 (2021)
   PUBMED   33889941
  REMARK    GeneRIF: A CADM3 variant causes Charcot-Marie-Tooth disease with
            marked upper limb involvement.
            Erratum:[Brain. 2021 Aug 17;144(7):e64. doi:
            10.1093/brain/awab181.. PMID: 34037698]
REFERENCE   3  (bases 1 to 3739)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3739)
  AUTHORS   Miao,X., Wang,Z., Chen,B., Chen,Y., Wang,X., Jiang,L., Jiang,S.,
            Hao,K. and Zhang,W.
  TITLE     miR-140-5p suppresses retinoblastoma cell proliferation, migration,
            and invasion by targeting CEMIP and CADM3
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 64 (6), 42-47 (2018)
   PUBMED   29808799
  REMARK    GeneRIF: CADM3 expression was increased in retinoblastoma tissues
            and cells. miR-140-5p inhibited CADM3 expression possibly by
            targeting the 3'-UTR.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3739)
  AUTHORS   Dong,X., Xu,F., Gong,Y., Gao,J., Lin,P., Chen,T., Peng,Y.,
            Qiang,B., Yuan,J., Peng,X. and Rao,Z.
  TITLE     Crystal structure of the V domain of human Nectin-like
            molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific
            immunoglobulin-like cell-cell adhesion molecule
  JOURNAL   J Biol Chem 281 (15), 10610-10617 (2006)
   PUBMED   16467305
  REMARK    GeneRIF: crystallographic analysis of human Nectin-like
            molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific
            immunoglobulin-like cell-cell adhesion molecule
REFERENCE   6  (bases 1 to 3739)
  AUTHORS   Kakunaga,S., Ikeda,W., Itoh,S., Deguchi-Tawarada,M., Ohtsuka,T.,
            Mizoguchi,A. and Takai,Y.
  TITLE     Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific
            immunoglobulin-like cell-cell adhesion molecule localizing at
            non-junctional contact sites of presynaptic nerve terminals, axons
            and glia cell processes
  JOURNAL   J Cell Sci 118 (Pt 6), 1267-1277 (2005)
   PUBMED   15741237
  REMARK    GeneRIF: Necl-1 is a neural-tissue-specific Ca2+-independent
            immunoglobulin-like cell-cell adhesion molecule which potentially
            has membrane-associated guanylate kinase subfamily member-binding
            activity and localizes at the non-junctional cell-cell contact
            sites
REFERENCE   7  (bases 1 to 3739)
  AUTHORS   Fukami,T., Satoh,H., Williams,Y.N., Masuda,M., Fukuhara,H.,
            Maruyama,T., Yageta,M., Kuramochi,M., Takamoto,S. and Murakami,Y.
  TITLE     Isolation of the mouse Tsll1 and Tsll2 genes, orthologues of the
            human TSLC1-like genes 1 and 2 (TSLL1 and TSLL2)
  JOURNAL   Gene 323, 11-18 (2003)
   PUBMED   14659875
REFERENCE   8  (bases 1 to 3739)
  AUTHORS   Shingai,T., Ikeda,W., Kakunaga,S., Morimoto,K., Takekuni,K.,
            Itoh,S., Satoh,K., Takeuchi,M., Imai,T., Monden,M. and Takai,Y.
  TITLE     Implications of nectin-like
            molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion
            and transmembrane protein localization in epithelial cells
  JOURNAL   J Biol Chem 278 (37), 35421-35427 (2003)
   PUBMED   12826663
REFERENCE   9  (bases 1 to 3739)
  AUTHORS   Reymond,N., Fabre,S., Lecocq,E., Adelaide,J., Dubreuil,P. and
            Lopez,M.
  TITLE     Nectin4/PRR4, a new afadin-associated member of the nectin family
            that trans-interacts with nectin1/PRR1 through V domain interaction
  JOURNAL   J Biol Chem 276 (46), 43205-43215 (2001)
   PUBMED   11544254
REFERENCE   10 (bases 1 to 3739)
  AUTHORS   Fukuhara,H., Kuramochi,M., Nobukuni,T., Fukami,T., Saino,M.,
            Maruyama,T., Nomura,S., Sekiya,T. and Murakami,Y.
  TITLE     Isolation of the TSLL1 and TSLL2 genes, members of the tumor
            suppressor TSLC1 gene family encoding transmembrane proteins
  JOURNAL   Oncogene 20 (38), 5401-5407 (2001)
   PUBMED   11536053
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA221489.1, AF363367.1 and
            HY346099.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001127173.2.
            
            Summary: The protein encoded by this gene is a calcium-independent
            cell-cell adhesion protein that can form homodimers or heterodimers
            with other nectin proteins. The encoded protein has both homophilic
            and heterophilic cell-cell adhesion activity. This gene is reported
            to be a tumor suppressor gene. [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF363367.1, SRR3476690.355046.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368125.9/ ENSP00000357107.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA221489.1         53-63
            12-3568             AF363367.1         1-3557
            3569-3739           HY346099.1         32-202              c
FEATURES             Location/Qualifiers
     source          1..3739
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.2"
     gene            1..3739
                     /gene="CADM3"
                     /gene_synonym="BIgR; CMT2FF; IGSF4B; Necl-1; NECL1;
                     synCAM3; TSLL1"
                     /note="cell adhesion molecule 3"
                     /db_xref="GeneID:57863"
                     /db_xref="HGNC:HGNC:17601"
                     /db_xref="MIM:609743"
     exon            1..239
                     /gene="CADM3"
                     /gene_synonym="BIgR; CMT2FF; IGSF4B; Necl-1; NECL1;
                     synCAM3; TSLL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1348
                     /gene="CADM3"
                     /gene_synonym="BIgR; CMT2FF; IGSF4B; Necl-1; NECL1;
                     synCAM3; TSLL1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; brain immunoglobulin receptor; TSLC1-like 1;
                     synaptic cell adhesion molecule 3; immunoglobulin
                     superfamily member 4B"
                     /codon_start=1
                     /product="cell adhesion molecule 3 isoform 2 precursor"
                     /protein_id="NP_001120645.1"
                     /db_xref="CCDS:CCDS44251.1"
                     /db_xref="GeneID:57863"
                     /db_xref="HGNC:HGNC:17601"
                     /db_xref="MIM:609743"
                     /translation="MGAPAASLLLLLLLFACCWAPGGANLSQDDSQPWTSDETVVAGG
                     TVVLKCQVKDHEDSSLQWSNPAQQTLYFGEKRALRDNRIQLVTSTPHELSISISNVAL
                     ADEGEYTCSIFTMPVRTAKSLVTVLGIPQKPIITGYKSSLREKDTATLNCQSSGSKPA
                     ARLTWRKGDQELHGEPTRIQEDPNGKTFTVSSSVTFQVTREDDGASIVCSVNHESLKG
                     ADRSTSQRIEVLYTPTAMIRPDPPHPREGQKLLLHCEGRGNPVPQQYLWEKEGSVPPL
                     KMTQESALIFPFLNKSDSGTYGCTATSNMGSYKAYYTLNVNDPSPVPSSSSTYHAIIG
                     GIVAFIVFLLLIMLIFLGHYLIRHKGTYLTHEAKGSDDAPDADTAIINAEGGQSGGDD
                     KKEYFI"
     exon            240..380
                     /gene="CADM3"
                     /gene_synonym="BIgR; CMT2FF; IGSF4B; Necl-1; NECL1;
                     synCAM3; TSLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..533
                     /gene="CADM3"
                     /gene_synonym="BIgR; CMT2FF; IGSF4B; Necl-1; NECL1;
                     synCAM3; TSLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            534..671
                     /gene="CADM3"
                     /gene_synonym="BIgR; CMT2FF; IGSF4B; Necl-1; NECL1;
                     synCAM3; TSLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            672..842
                     /gene="CADM3"
                     /gene_synonym="BIgR; CMT2FF; IGSF4B; Necl-1; NECL1;
                     synCAM3; TSLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..933
                     /gene="CADM3"
                     /gene_synonym="BIgR; CMT2FF; IGSF4B; Necl-1; NECL1;
                     synCAM3; TSLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1103
                     /gene="CADM3"
                     /gene_synonym="BIgR; CMT2FF; IGSF4B; Necl-1; NECL1;
                     synCAM3; TSLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1229
                     /gene="CADM3"
                     /gene_synonym="BIgR; CMT2FF; IGSF4B; Necl-1; NECL1;
                     synCAM3; TSLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..3739
                     /gene="CADM3"
                     /gene_synonym="BIgR; CMT2FF; IGSF4B; Necl-1; NECL1;
                     synCAM3; TSLL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3546..3551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADM3"
                     /gene_synonym="BIgR; CMT2FF; IGSF4B; Necl-1; NECL1;
                     synCAM3; TSLL1"
                     /note="hexamer: AATATA"
     polyA_site      3569
                     /gene="CADM3"
                     /gene_synonym="BIgR; CMT2FF; IGSF4B; Necl-1; NECL1;
                     synCAM3; TSLL1"
                     /note="major polyA site"
     regulatory      3721..3726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADM3"
                     /gene_synonym="BIgR; CMT2FF; IGSF4B; Necl-1; NECL1;
                     synCAM3; TSLL1"
                     /note="hexamer: AATATA"
     polyA_site      3739
                     /gene="CADM3"
                     /gene_synonym="BIgR; CMT2FF; IGSF4B; Necl-1; NECL1;
                     synCAM3; TSLL1"
ORIGIN      
        1 ggctccctcc cggtccccac ctcggccccg ggctccgaag cggctcgggg gcgccctttc
       61 ggtcaacatc gtagtccacc ccctccccat ccccagcccc cggggattca ggctcgccag
      121 cgcccagcca gggagccggc cgggaagcgc gatgggggcc ccagccgcct cgctcctgct
      181 cctgctcctg ctgttcgcct gctgctgggc gcccggcggg gccaacctct cccaggacga
      241 cagccagccc tggacatctg atgaaacagt ggtggctggt ggcaccgtgg tgctcaagtg
      301 ccaagtgaaa gatcacgagg actcatccct gcaatggtct aaccctgctc agcagactct
      361 ctactttggg gagaagagag cccttcgaga taatcgaatt cagctggtta cctctacgcc
      421 ccacgagctc agcatcagca tcagcaatgt ggccctggca gacgagggcg agtacacctg
      481 ctcaatcttc actatgcctg tgcgaactgc caagtccctc gtcactgtgc taggaattcc
      541 acagaagccc atcatcactg gttataaatc ttcattacgg gaaaaagaca cagccaccct
      601 aaactgtcag tcttctggga gcaagcctgc agcccggctc acctggagaa agggtgacca
      661 agaactccac ggagaaccaa cccgcataca ggaagatccc aatggtaaaa ccttcactgt
      721 cagcagctcg gtgacattcc aggttacccg ggaggatgat ggggcgagca tcgtgtgctc
      781 tgtgaaccat gaatctctaa agggagctga cagatccacc tctcaacgca ttgaagtttt
      841 atacacacca actgcgatga ttaggccaga ccctccccat cctcgtgagg gccagaagct
      901 gttgctacac tgtgagggtc gcggcaatcc agtcccccag cagtacctat gggagaagga
      961 gggcagtgtg ccacccctga agatgaccca ggagagtgcc ctgatcttcc ctttcctcaa
     1021 caagagtgac agtggcacct acggctgcac agccaccagc aacatgggca gctacaaggc
     1081 ctactacacc ctcaatgtta atgaccccag tccggtgccc tcctcctcca gcacctacca
     1141 cgccatcatc ggtgggatcg tggctttcat tgtcttcctg ctgctcatca tgctcatctt
     1201 ccttggccac tacttgatcc ggcacaaagg aacctacctg acacatgagg caaaaggctc
     1261 cgacgatgct ccagacgcgg acacggccat catcaatgca gaaggcgggc agtcaggagg
     1321 ggacgacaag aaggaatatt tcatctagag gcgcctgccc acttcctgcg ccccccaggg
     1381 gccctgtggg gactgctggg gccgtcacca acccggactt gtacagagca accgcagggc
     1441 cgcccctccc gcttgctccc cagcccaccc acccccctgt acagaatgtc tgctttgggt
     1501 gcggttttgt actcggtttg gaatggggag ggaggagggc ggggggaggg gagggttgcc
     1561 ctcagccctt tccgtggctt ctctgcattt gggttattat tatttttgta acaatcccaa
     1621 atcaaatctg tctccaggct ggagaggcag gagccctggg gtgagaaaag caaaaaacaa
     1681 acaaaaaaca aaaccctgga gtgttaggag gagagtgaag gtagaggggt gaggaagggt
     1741 aaggggcagg gctggtttca gctgggggct ctcaccagcc ctcctttcag cctctacaac
     1801 agagcagctt cccagacttc tccaggaacc cagaaacggg atggttgtcg gcaaaggttg
     1861 ggagtggctt ttcctctggt agccacacac ctgagcacta cggacaggga ggcaggtgcc
     1921 accttgacac ctctcttcca tagcaatggg aaagtgatga gtgcgggagt cctgaggaga
     1981 tgtggcctgc agacaacatg cagccatgca gggacccagg actgtaacct ggggaggacg
     2041 cgggtccctg caaggaagag tagatttgga gaggaaggat ggaggtggac tctcacccca
     2101 ttccccccgg aaatgaacaa agccgggccc tttccatagg aactgccctt ggagatagca
     2161 gagtgtggct gcccctcctt gctccagcag cagtgggaga ggcactgctc tggggcctga
     2221 actgcctctg cttccccccc tgaggggccc ctcactctta cccaagactc tggattgttg
     2281 cacggcaacc actcctccca tggcattgct cagcaactac ttctcccttc ccggccaccc
     2341 tgtgccccct tcctggtccc aacgccagcc cttcatcctt cctccctcag cagccaggca
     2401 gacataacaa caaaactact aaaaggagct tcactgcagt gagctgtttc ctgcccaaac
     2461 taagggaata atgtgaactg tgtgcatgtg tgtggtgtgt atgcatgtgt gcatgtgtgt
     2521 gtgtgtgtgt gcatgtgtgt gagtgagtga gaggcagagc gaggaactga ggaggagggc
     2581 taagagccag gggtcctggg caagtggaca gggctgtggg acatgttggg gaggctttgg
     2641 gaatggggta ttcctagtca gggttcacac ctcacctggg atgttgttcc atgctggtat
     2701 ttcctctgcc acccccaatg cccatcggtc ttggagaaag gagtccccgg gtgtgtgttt
     2761 gcccagctgt ccattctatc tctcccttaa acacagagca ttcagccctt ccctggattt
     2821 ccctcctctg agccatggag tcagtgccac agcctttgct atgcacctct caggcctctc
     2881 cttggcgttg accctggaaa gacctaccac cacctatttt ttcccatagt ctgtacccag
     2941 tgagttgaag gctgggtccc cacccttcct tttgatttcc tgtcttcctt ctcgtggccc
     3001 cagctggttg ctgtggagat gaggttcctg gtcctccctg tcctggctgg actgccccgc
     3061 ctcagatcca ggatgccctt ggcatcgctc ccaccctccc ccagcttttc ctccctggtc
     3121 tgacaatggg catgcaaaaa ggggcagctg caatctagca ggcctgccca cccccttcag
     3181 ttcaggtaat acagttgtga atcttccagc cgctggttag ggccttgggc accacaggca
     3241 gcccctcacc taagccgggg cctactcctc ttacaacagc aagagagccc tggggcccca
     3301 ggcctgttga gcttcttgtc tcccagcacc cgcttttggg aaaatgactt ttcctcttca
     3361 agctgaacca ctctgtccat attacacaga agccatattt gtacgggggg gtgggaggga
     3421 gaggggctgt tgtgctgtgt gtgtctgtcc aggggtgggg gggtggggga agggagcagg
     3481 gaggggaccg tgtatcttta taatctttct aactctcctg tgctaatctc agaggggtca
     3541 ccctcaatat atctggatta tccgtgtcat tcagctgcct cctttctggt cctcttgctg
     3601 ctgctgggat gtgtgtatgt gagggtcttc ttcccatacc ccttgcacct ggtgcctggt
     3661 gcctcaaaag gtggtgtgtc ccttgccagg ccactctcaa gaatatctat gtacagcaac
     3721 aatataactc tacaaggga
//
