LOCUS       NM_001167675            9480 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens cell adhesion molecule 2 (CADM2), transcript variant
            2, mRNA.
ACCESSION   NM_001167675
VERSION     NM_001167675.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9480)
  AUTHORS   Wang,Z., Zhang,Q., Zhang,C., Yan,J., Yang,T. and Jiang,A.
  TITLE     CADM2 participates in endometriosis development by influencing the
            epithelial-mesenchymal transition
  JOURNAL   Reprod Sci 31 (10), 3049-3057 (2024)
   PUBMED   38767769
  REMARK    GeneRIF: CADM2 participates in endometriosis development by
            influencing the epithelial-mesenchymal transition.
            Erratum:[Reprod Sci. 2024 Jul;31(7):2135. doi:
            10.1007/s43032-024-01609-5.. PMID: 38819523]
REFERENCE   2  (bases 1 to 9480)
  AUTHORS   Wang,Y., Li,Z., He,J., Chen,W., Li,Y., Chen,X., Liang,J., Yu,Q. and
            Zhou,J.
  TITLE     hsa_circ_0002980 prevents proliferation, migration, invasion, and
            epithelial-mesenchymal transition of liver cancer cells through
            microRNA-1303/cell adhesion molecule 2 axis
  JOURNAL   Aging (Albany NY) 15 (24), 14915-14929 (2023)
   PUBMED   38126999
  REMARK    GeneRIF: hsa_circ_0002980 prevents proliferation, migration,
            invasion, and epithelial-mesenchymal transition of liver cancer
            cells through microRNA-1303/cell adhesion molecule 2 axis.
REFERENCE   3  (bases 1 to 9480)
  AUTHORS   Liu,X. and Li,Y.
  TITLE     Genetic correlation for alcohol consumption between Europeans and
            East Asians
  JOURNAL   BMC Genomics 24 (1), 652 (2023)
   PUBMED   37904118
  REMARK    GeneRIF: Genetic correlation for alcohol consumption between
            Europeans and East Asians.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9480)
  AUTHORS   Hu,J., Xie,C., Xu,S., Pu,Q., Liu,H., Yang,L., Wang,W., Mao,L.,
            Li,Z. and Chen,W.
  TITLE     Liver fibrosis-derived exosomal miR-106a-5p facilitates the
            malignancy by targeting SAMD12 and CADM2 in hepatocellular
            carcinoma
  JOURNAL   PLoS One 18 (5), e0286017 (2023)
   PUBMED   37228062
  REMARK    GeneRIF: Liver fibrosis-derived exosomal miR-106a-5p facilitates
            the malignancy by targeting SAMD12 and CADM2 in hepatocellular
            carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9480)
  AUTHORS   Sanchez-Roige,S., Jennings,M.V., Thorpe,H.H.A., Mallari,J.E., van
            der Werf,L.C., Bianchi,S.B., Huang,Y., Lee,C., Mallard,T.T.,
            Barnes,S.A., Wu,J.Y., Barkley-Levenson,A.M., Boussaty,E.C.,
            Snethlage,C.E., Schafer,D., Babic,Z., Winters,B.D., Watters,K.E.,
            Biederer,T., Mackillop,J., Stephens,D.N., Elson,S.L.,
            Fontanillas,P., Khokhar,J.Y., Young,J.W. and Palmer,A.A.
  CONSRTM   23andMe Research Team
  TITLE     CADM2 is implicated in impulsive personality and numerous other
            traits by genome- and phenome-wide association studies in humans
            and mice
  JOURNAL   Transl Psychiatry 13 (1), 167 (2023)
   PUBMED   37173343
  REMARK    GeneRIF: CADM2 is implicated in impulsive personality and numerous
            other traits by genome- and phenome-wide association studies in
            humans and mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9480)
  AUTHORS   Chang,G., Xu,S., Dhir,R., Chandran,U., O'Keefe,D.S., Greenberg,N.M.
            and Gingrich,J.R.
  TITLE     Hypoexpression and epigenetic regulation of candidate tumor
            suppressor gene CADM-2 in human prostate cancer
  JOURNAL   Clin Cancer Res 16 (22), 5390-5401 (2010)
   PUBMED   21062931
  REMARK    GeneRIF: Its expression is regulated in part by promoter
            methylation and implicates CADM-2 as a previously unrecognized
            tumor suppressor gene in a proportion of human prostate cancers.
REFERENCE   7  (bases 1 to 9480)
  AUTHORS   Speliotes,E.K., Willer,C.J., Berndt,S.I., Monda,K.L.,
            Thorleifsson,G., Jackson,A.U., Lango Allen,H., Lindgren,C.M.,
            Luan,J., Magi,R., Randall,J.C., Vedantam,S., Winkler,T.W., Qi,L.,
            Workalemahu,T., Heid,I.M., Steinthorsdottir,V., Stringham,H.M.,
            Weedon,M.N., Wheeler,E., Wood,A.R., Ferreira,T., Weyant,R.J.,
            Segre,A.V., Estrada,K., Liang,L., Nemesh,J., Park,J.H.,
            Gustafsson,S., Kilpelainen,T.O., Yang,J., Bouatia-Naji,N., Esko,T.,
            Feitosa,M.F., Kutalik,Z., Mangino,M., Raychaudhuri,S., Scherag,A.,
            Smith,A.V., Welch,R., Zhao,J.H., Aben,K.K., Absher,D.M., Amin,N.,
            Dixon,A.L., Fisher,E., Glazer,N.L., Goddard,M.E., Heard-Costa,N.L.,
            Hoesel,V., Hottenga,J.J., Johansson,A., Johnson,T., Ketkar,S.,
            Lamina,C., Li,S., Moffatt,M.F., Myers,R.H., Narisu,N., Perry,J.R.,
            Peters,M.J., Preuss,M., Ripatti,S., Rivadeneira,F., Sandholt,C.,
            Scott,L.J., Timpson,N.J., Tyrer,J.P., van Wingerden,S.,
            Watanabe,R.M., White,C.C., Wiklund,F., Barlassina,C., Chasman,D.I.,
            Cooper,M.N., Jansson,J.O., Lawrence,R.W., Pellikka,N.,
            Prokopenko,I., Shi,J., Thiering,E., Alavere,H., Alibrandi,M.T.,
            Almgren,P., Arnold,A.M., Aspelund,T., Atwood,L.D., Balkau,B.,
            Balmforth,A.J., Bennett,A.J., Ben-Shlomo,Y., Bergman,R.N.,
            Bergmann,S., Biebermann,H., Blakemore,A.I., Boes,T.,
            Bonnycastle,L.L., Bornstein,S.R., Brown,M.J., Buchanan,T.A.,
            Busonero,F., Campbell,H., Cappuccio,F.P., Cavalcanti-Proenca,C.,
            Chen,Y.D., Chen,C.M., Chines,P.S., Clarke,R., Coin,L., Connell,J.,
            Day,I.N., den Heijer,M., Duan,J., Ebrahim,S., Elliott,P.,
            Elosua,R., Eiriksdottir,G., Erdos,M.R., Eriksson,J.G.,
            Facheris,M.F., Felix,S.B., Fischer-Posovszky,P., Folsom,A.R.,
            Friedrich,N., Freimer,N.B., Fu,M., Gaget,S., Gejman,P.V.,
            Geus,E.J., Gieger,C., Gjesing,A.P., Goel,A., Goyette,P.,
            Grallert,H., Grassler,J., Greenawalt,D.M., Groves,C.J.,
            Gudnason,V., Guiducci,C., Hartikainen,A.L., Hassanali,N.,
            Hall,A.S., Havulinna,A.S., Hayward,C., Heath,A.C., Hengstenberg,C.,
            Hicks,A.A., Hinney,A., Hofman,A., Homuth,G., Hui,J., Igl,W.,
            Iribarren,C., Isomaa,B., Jacobs,K.B., Jarick,I., Jewell,E.,
            John,U., Jorgensen,T., Jousilahti,P., Jula,A., Kaakinen,M.,
            Kajantie,E., Kaplan,L.M., Kathiresan,S., Kettunen,J., Kinnunen,L.,
            Knowles,J.W., Kolcic,I., Konig,I.R., Koskinen,S., Kovacs,P.,
            Kuusisto,J., Kraft,P., Kvaloy,K., Laitinen,J., Lantieri,O.,
            Lanzani,C., Launer,L.J., Lecoeur,C., Lehtimaki,T., Lettre,G.,
            Liu,J., Lokki,M.L., Lorentzon,M., Luben,R.N., Ludwig,B.,
            Manunta,P., Marek,D., Marre,M., Martin,N.G., McArdle,W.L.,
            McCarthy,A., McKnight,B., Meitinger,T., Melander,O., Meyre,D.,
            Midthjell,K., Montgomery,G.W., Morken,M.A., Morris,A.P., Mulic,R.,
            Ngwa,J.S., Nelis,M., Neville,M.J., Nyholt,D.R., O'Donnell,C.J.,
            O'Rahilly,S., Ong,K.K., Oostra,B., Pare,G., Parker,A.N., Perola,M.,
            Pichler,I., Pietilainen,K.H., Platou,C.G., Polasek,O., Pouta,A.,
            Rafelt,S., Raitakari,O., Rayner,N.W., Ridderstrale,M., Rief,W.,
            Ruokonen,A., Robertson,N.R., Rzehak,P., Salomaa,V., Sanders,A.R.,
            Sandhu,M.S., Sanna,S., Saramies,J., Savolainen,M.J., Scherag,S.,
            Schipf,S., Schreiber,S., Schunkert,H., Silander,K., Sinisalo,J.,
            Siscovick,D.S., Smit,J.H., Soranzo,N., Sovio,U., Stephens,J.,
            Surakka,I., Swift,A.J., Tammesoo,M.L., Tardif,J.C.,
            Teder-Laving,M., Teslovich,T.M., Thompson,J.R., Thomson,B.,
            Tonjes,A., Tuomi,T., van Meurs,J.B., van Ommen,G.J., Vatin,V.,
            Viikari,J., Visvikis-Siest,S., Vitart,V., Vogel,C.I., Voight,B.F.,
            Waite,L.L., Wallaschofski,H., Walters,G.B., Widen,E., Wiegand,S.,
            Wild,S.H., Willemsen,G., Witte,D.R., Witteman,J.C., Xu,J.,
            Zhang,Q., Zgaga,L., Ziegler,A., Zitting,P., Beilby,J.P.,
            Farooqi,I.S., Hebebrand,J., Huikuri,H.V., James,A.L., Kahonen,M.,
            Levinson,D.F., Macciardi,F., Nieminen,M.S., Ohlsson,C.,
            Palmer,L.J., Ridker,P.M., Stumvoll,M., Beckmann,J.S., Boeing,H.,
            Boerwinkle,E., Boomsma,D.I., Caulfield,M.J., Chanock,S.J.,
            Collins,F.S., Cupples,L.A., Smith,G.D., Erdmann,J., Froguel,P.,
            Gronberg,H., Gyllensten,U., Hall,P., Hansen,T., Harris,T.B.,
            Hattersley,A.T., Hayes,R.B., Heinrich,J., Hu,F.B., Hveem,K.,
            Illig,T., Jarvelin,M.R., Kaprio,J., Karpe,F., Khaw,K.T.,
            Kiemeney,L.A., Krude,H., Laakso,M., Lawlor,D.A., Metspalu,A.,
            Munroe,P.B., Ouwehand,W.H., Pedersen,O., Penninx,B.W., Peters,A.,
            Pramstaller,P.P., Quertermous,T., Reinehr,T., Rissanen,A.,
            Rudan,I., Samani,N.J., Schwarz,P.E., Shuldiner,A.R., Spector,T.D.,
            Tuomilehto,J., Uda,M., Uitterlinden,A., Valle,T.T., Wabitsch,M.,
            Waeber,G., Wareham,N.J., Watkins,H., Wilson,J.F., Wright,A.F.,
            Zillikens,M.C., Chatterjee,N., McCarroll,S.A., Purcell,S.,
            Schadt,E.E., Visscher,P.M., Assimes,T.L., Borecki,I.B.,
            Deloukas,P., Fox,C.S., Groop,L.C., Haritunians,T., Hunter,D.J.,
            Kaplan,R.C., Mohlke,K.L., O'Connell,J.R., Peltonen,L.,
            Schlessinger,D., Strachan,D.P., van Duijn,C.M., Wichmann,H.E.,
            Frayling,T.M., Thorsteinsdottir,U., Abecasis,G.R., Barroso,I.,
            Boehnke,M., Stefansson,K., North,K.E., McCarthy,M.I.,
            Hirschhorn,J.N., Ingelsson,E. and Loos,R.J.
  CONSRTM   MAGIC; Procardis Consortium
  TITLE     Association analyses of 249,796 individuals reveal 18 new loci
            associated with body mass index
  JOURNAL   Nat Genet 42 (11), 937-948 (2010)
   PUBMED   20935630
REFERENCE   8  (bases 1 to 9480)
  AUTHORS   Festen,E.A., Stokkers,P.C., van Diemen,C.C., van Bodegraven,A.A.,
            Boezen,H.M., Crusius,B.J., Hommes,D.W., van der Woude,C.J.,
            Balschun,T., Verspaget,H.W., Schreiber,S., de Jong,D.J., Franke,A.,
            Dijkstra,G., Wijmenga,C. and Weersma,R.K.
  TITLE     Genetic analysis in a Dutch study sample identifies more ulcerative
            colitis susceptibility loci and shows their additive role in
            disease risk
  JOURNAL   Am J Gastroenterol 105 (2), 395-402 (2010)
   PUBMED   19861958
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Am J Gastroenterol. 2010 Feb;105(2):479. van der Woude,
            Janneke C [corrected to van der Woude, C Janneke]]
REFERENCE   9  (bases 1 to 9480)
  AUTHORS   Pellissier,F., Gerber,A., Bauer,C., Ballivet,M. and Ossipow,V.
  TITLE     The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated
            axons, binds to oligodendrocytes and promotes cell adhesion
  JOURNAL   BMC Neurosci 8, 90 (2007)
   PUBMED   17967169
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 9480)
  AUTHORS   Biederer,T.
  TITLE     Bioinformatic characterization of the SynCAM family of
            immunoglobulin-like domain-containing adhesion molecules
  JOURNAL   Genomics 87 (1), 139-150 (2006)
   PUBMED   16311015
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC105999.1 and AC107024.5.
            
            On Jun 2, 2019 this sequence version replaced NM_001167675.1.
            
            Summary: This gene encodes a member of the synaptic cell adhesion
            molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig)
            superfamily. The encoded protein has three Ig-like domains and a
            cytosolic protein 4.1 binding site near the C-terminus. Proteins
            belonging to the protein 4.1 family crosslink spectrin and interact
            with other cytoskeletal proteins. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Feb 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.173649.1,
                                           SRR1660807.243174.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383699.8/ ENSP00000373200.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2435              BC105999.1         8-2442
            2436-9480           AC107024.5         62342-69386         c
FEATURES             Location/Qualifiers
     source          1..9480
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p12.1"
     gene            1..9480
                     /gene="CADM2"
                     /gene_synonym="IGSF4D; Necl-3; NECL3; SynCAM 2; SynCAM-2;
                     synCAM2"
                     /note="cell adhesion molecule 2"
                     /db_xref="GeneID:253559"
                     /db_xref="HGNC:HGNC:29849"
                     /db_xref="MIM:609938"
     exon            1..680
                     /gene="CADM2"
                     /gene_synonym="IGSF4D; Necl-3; NECL3; SynCAM 2; SynCAM-2;
                     synCAM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             620..1834
                     /gene="CADM2"
                     /gene_synonym="IGSF4D; Necl-3; NECL3; SynCAM 2; SynCAM-2;
                     synCAM2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; nectin-like protein 3; nectin-like 3;
                     immunoglobulin superfamily member 4D; synaptic cell
                     adhesion molecule 2"
                     /codon_start=1
                     /product="cell adhesion molecule 2 isoform 2 precursor"
                     /protein_id="NP_001161147.1"
                     /db_xref="CCDS:CCDS54613.1"
                     /db_xref="GeneID:253559"
                     /db_xref="HGNC:HGNC:29849"
                     /db_xref="MIM:609938"
                     /translation="MIWKRSAVLRFYSVCGLLLQAAASKNKVKGSQGQFPLTQNVTVV
                     EGGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISVSD
                     VSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGS
                     KPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHES
                     LNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPLILTCESKGKPLPEPVLWTKDGGE
                     LPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVHDPNALAGQNGP
                     DHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGS
                     QVNAEEKKEYFI"
     exon            681..707
                     /gene="CADM2"
                     /gene_synonym="IGSF4D; Necl-3; NECL3; SynCAM 2; SynCAM-2;
                     synCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..857
                     /gene="CADM2"
                     /gene_synonym="IGSF4D; Necl-3; NECL3; SynCAM 2; SynCAM-2;
                     synCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1010
                     /gene="CADM2"
                     /gene_synonym="IGSF4D; Necl-3; NECL3; SynCAM 2; SynCAM-2;
                     synCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1148
                     /gene="CADM2"
                     /gene_synonym="IGSF4D; Necl-3; NECL3; SynCAM 2; SynCAM-2;
                     synCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1319
                     /gene="CADM2"
                     /gene_synonym="IGSF4D; Necl-3; NECL3; SynCAM 2; SynCAM-2;
                     synCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1410
                     /gene="CADM2"
                     /gene_synonym="IGSF4D; Necl-3; NECL3; SynCAM 2; SynCAM-2;
                     synCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1589
                     /gene="CADM2"
                     /gene_synonym="IGSF4D; Necl-3; NECL3; SynCAM 2; SynCAM-2;
                     synCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1715
                     /gene="CADM2"
                     /gene_synonym="IGSF4D; Necl-3; NECL3; SynCAM 2; SynCAM-2;
                     synCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..9480
                     /gene="CADM2"
                     /gene_synonym="IGSF4D; Necl-3; NECL3; SynCAM 2; SynCAM-2;
                     synCAM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3819..3824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADM2"
                     /gene_synonym="IGSF4D; Necl-3; NECL3; SynCAM 2; SynCAM-2;
                     synCAM2"
                     /note="hexamer: AATAAA"
     polyA_site      3852
                     /gene="CADM2"
                     /gene_synonym="IGSF4D; Necl-3; NECL3; SynCAM 2; SynCAM-2;
                     synCAM2"
                     /note="major polyA site"
     regulatory      8675..8680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADM2"
                     /gene_synonym="IGSF4D; Necl-3; NECL3; SynCAM 2; SynCAM-2;
                     synCAM2"
                     /note="hexamer: AATAAA"
     polyA_site      8710
                     /gene="CADM2"
                     /gene_synonym="IGSF4D; Necl-3; NECL3; SynCAM 2; SynCAM-2;
                     synCAM2"
     regulatory      9452..9457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADM2"
                     /gene_synonym="IGSF4D; Necl-3; NECL3; SynCAM 2; SynCAM-2;
                     synCAM2"
                     /note="hexamer: ATTAAA"
     polyA_site      9480
                     /gene="CADM2"
                     /gene_synonym="IGSF4D; Necl-3; NECL3; SynCAM 2; SynCAM-2;
                     synCAM2"
                     /note="major polyA site"
ORIGIN      
        1 gtagagctgc cgccgtcgcc gctgccgctg ccgccacagc cgccgctgca gccggagcat
       61 ccgggagccg ccactgccgc cgccgctgcc gctgctaccg ccactagcgc tgcttccact
      121 gcttctacct cccctcccag gaccccgaga caccccgggc gcgagcggca gtgctgcttg
      181 cttgctcctc ctctccccca gcccttcccc tccgtgacct acccactcct tgcagccctc
      241 gcccgcacct tctccaacac cccggcatcc ctgcaccacc tgctcgggca gccccggcgg
      301 gctctgggac ttgctgtgcg cgccgagagg aaggcaagct ccaaacccct gcctggaaga
      361 cgggctgtcg cggctgcacc accagcagga ggaggaggag aagaaactat ttcgcgatac
      421 cccattctgc gggtgctttg ccgctgccgc ttctgctgcc gccgatccga gtccgcgggt
      481 tcgaacaccg cagcggtggg gacggtgggt ccggcgggcg ccgggaggag gacaccagcg
      541 gagccctgca ctctcgtgcc ccgctcacca gcatctactt gccccctcgt tccttcccca
      601 gccctttaga gaagggacca tgatttggaa acgcagcgcc gttctccgct tctacagtgt
      661 ctgcgggctc ctgctacaag cggctgcttc aaagaataaa gttaaaggca gccaagggca
      721 gtttccacta acacagaatg taaccgttgt tgaaggtgga actgcaattt tgacctgcag
      781 ggttgatcaa aatgataaca cctccctcca gtggtcaaat ccagctcaac agactctgta
      841 ctttgacgac aagaaagctt taagggacaa taggatcgag ctggttcgcg cttcctggca
      901 tgaattgagt attagtgtca gtgatgtgtc tctctctgat gaaggacagt acacctgttc
      961 tttatttaca atgcctgtca aaacttccaa ggcatatctc accgttctgg gtgttcctga
     1021 aaagcctcag attagtggat tctcatcacc agttatggag ggtgacttga tgcagctgac
     1081 ttgcaaaaca tctggtagta aacctgcagc tgatataaga tggttcaaaa atgacaaaga
     1141 gattaaagat gtaaaatatt taaaagaaga ggatgcaaat cgcaagacat tcactgtcag
     1201 cagcacactg gacttccgag tggaccggag tgatgatgga gtggcggtca tctgcagagt
     1261 agatcacgaa tccctcaatg ccacccctca ggtagccatg caggtgctag aaatacacta
     1321 tacaccatca gttaagatta taccatcgac tccttttcca caagaaggac agcctttaat
     1381 tttgacttgt gaatccaaag gaaaaccact gccagaacct gttttgtgga caaaggatgg
     1441 cggagaatta ccagatcctg accgaatggt tgtgagtggt agggagctaa acattctttt
     1501 cctgaacaaa acggataatg gtacatatcg atgtgaagcc acaaacacca ttggccaaag
     1561 cagtgcggaa tatgttctca ttgtgcatga tcctaatgct ttggctggcc agaatggccc
     1621 tgaccatgct ctcataggag gaatagtggc tgtagttgta tttgtcacgc tgtgttctat
     1681 ctttctgctt ggtcgatatc tggcaaggca taaaggaacg tatttaacaa atgaagctaa
     1741 aggagctgaa gatgcaccag atgctgatac agccattatc aatgctgaag gcagccaagt
     1801 caatgctgaa gagaaaaaag agtatttcat ttaagatgca ggccaagatt ctgagtttta
     1861 ctaccaggct gaatgctgga gaaaactggc tatcatcttt cagaagtcat ttctaccatc
     1921 gtctgctacc cttattaact cccatactgt actgctatca gtagccagtg tataccaaca
     1981 atcagctgtt gaaagcatca ttctttaatt actgtaccat ccataatgca ggacatttct
     2041 tactgcctaa atttcacacc attgctcttt taacatacag tgcttgaata tacagcctta
     2101 acaatgttaa tcatctcctt ggatcattat attgagtggt ttttatacat taaaaaatgt
     2161 atgcagagtt tttttccccc attttttccc ctttaagtca tagaccttat cagtttgcca
     2221 ttggacagct ttcacaagta acaggattag ggaaggacat aatgtattta agaataagtg
     2281 aaggttagag gtttacaatt aatgttttct acatgtctgt cttcaaagac aacatgcttt
     2341 ggaaacatat gtcctagaaa acataaaatt aaaaaaaaac actatagtgt agtttttgga
     2401 atgttggaga ttatactggt aaagctgtat cgatttgcta ttgaaatata gtatttgata
     2461 caggagccat gtgtacgaat tgcaatcatg acatggtatt ttctataatt atagagatct
     2521 tactattagg atattgtagc ttcatttacc aataaattat tccaaatgat ttactgcttt
     2581 tggaatcaca aatatttaat tcatttctct aatttgattc tataatttat ttgcttcata
     2641 aagattcacc tgcctaaaca atattgaagt atccataggg cacaattttc agacatttta
     2701 gtatctgtat atagtgcata taataaatcc aattaaacat tatttgatac atatttaact
     2761 tttttggctg tatgtaattc agtcataagt aagcattttc taacgtccat tatatccctt
     2821 taggtattac ttaaaccaat attataagta gataacatgt attagtattt ttgtctgtat
     2881 gtcctagcac tgttcaacaa caaatttttc tagttcttgt taatttttat ttgttataca
     2941 atggaagcac aatgttataa ggaaaggtaa ttttaagcta acaaccagtg cacagcctca
     3001 ggttttaaat tacaaccaca gttgaataat aacctaaaaa taaattttag tttgctaaaa
     3061 atttacaaat tttcattttg cagttccaga gctgcttacc tatgttggtt tgccaaaaag
     3121 aagtgtttaa gatatgtttt ctgtataaat gaactaattc tttatattaa attcctgtct
     3181 atgcattttg tgaggtacaa actgatgaaa cagtgagtga tagagaattt ctgccatgct
     3241 tttaactcca aagtgaaagt ctctttctct ggattatttt aaaattttgg cgtgtttaac
     3301 cattaagaaa tgctgtattc ttaaatatga aacagttaat ctaaagtctt attatttctt
     3361 ctagtaaaat aaaatattgt tagattagtt ctcattaaat ttattatatg ctaaagaata
     3421 aaactccagt tagatttaaa aaaatcccat ttacaagcat tgcaccttta agaagaaaac
     3481 aaatatgaca gtatggtagc tatacttgtg atgtctgacg catgatggcc tatggtttta
     3541 aaaatagtat tgtggaatat atttttgggt aataagaatg gttgagtgca acatcatgta
     3601 ttaatatcaa atgaaagaca agggtgctgt atctttgatt atttatcaaa aaagtataaa
     3661 tcttttaagg aaaatgttag aattttaaag tttttttttg attgttgaag catttatctt
     3721 gttgatttct tacaaaagaa aaaggacgat gtcagtcaag cagcactttt tcagaatata
     3781 cagaacataa ataatatgat gtggttgagt gttaacataa taaatcatat acagtatgac
     3841 attttaagga aataagtctg cattgatgtg attgcatgct tgtttttaca gttcactcca
     3901 taccatctgt ggaaaaatgc aataatatgt taatatagta tggtagtttg agagaatcag
     3961 gtaggtgcta ctagacacat tgaaactaga ataggtttat aaactgttca tatctttcaa
     4021 tgcataatct ttagaaagac tccacaaagc aaaattcatc ctgttagtac aaaatggaaa
     4081 ggttcttatt acagaagtaa gttgtacaaa ctgcatcatc aattactatg taaagcctaa
     4141 tttcaggatg cacttacaaa attgctactc ttcatcgatg ccgtatttac atccctcttc
     4201 atttcatcta tattctactt ggctccaaca actaaattgt tgcctaaata actcaatcat
     4261 tatttatagc actgtaaaat tagaaatcca aaattggttg catttcatga tttttgactc
     4321 ttttaaccct tcagagtaat ataaaatctc attagaactc ttataaaacc agttagctaa
     4381 aacaactaga ttattatact agttataaat gctggtatat tataatttgt gggatctaat
     4441 taaatgtttg cctattaaat atagtttgat ttaaatgaga caccatgttc tgaactggag
     4501 aaaacaatat caatgaagtc atattttcat acctttaaaa attatttaat tttcaaccaa
     4561 acaaaaaata aattgtaaaa attatgctca tttctattcc aacaagtcag aaaataatga
     4621 cataatattt ctaaatgaga atgatgtcaa tttcattgtc tggaacatgc acacttgtgt
     4681 gcacatagag tcaatttctg tctcttctaa gtgagcacag taggtaggga actcaatgga
     4741 agcagtgtgc acacacacac acccttagta gaatatggag cattattctt taccaaaagt
     4801 agctattctc tgccagtgta ctgtttacag tgtaaattga ttgtcctccg tcaaaatcaa
     4861 gtctaagcgg cattttactt ttcttttctt ttttattttc catttttggg tgttctagat
     4921 aggattatta tcaaaagtag gaggaaaaag aaatgtttgt gagtgcaaga ttaaagacag
     4981 agcgcatgag cagagtactg atggtgtgcg tgtttgtgtg tgtgtatatg tgtgtgtata
     5041 agagagaaag agaaatcgaa aagagagaga aatttcaact tgttttcttt taccagagaa
     5101 tccaagaagc agtttaagga acctgatatt ggagtttaat ctagaaactg gatgatctca
     5161 tattgattca tgatgcttaa tctttcattg aaactccaca attaaaataa caaatagaga
     5221 aagaaaacta actttcctaa atatggcaaa gaaactaaca cctcatttat ttttatttct
     5281 ttgtaaaaat ataaatatct caatcaaaag tacaggctca tttgtaatta tgtactcatg
     5341 attgtaacag cattgagatt tcatataggc acatgtatag cagctgtttg acagtgatgg
     5401 ctcttccatg taacatagca gttatcgtgt aatttagtgc cacttattgc aaagtgttac
     5461 caaggggaac atttcaaatg ccttttgttt ttctttggac atcaaggtaa tttagtggac
     5521 aacaaatatt aaattttaca ttatgctttt taattgtgga gaaaatgcaa aacctcatgt
     5581 cttaccacaa ctttcccatg gtattgctaa ttacttagag tctctaaaat tgcccaatat
     5641 tatttccctt tgcaaatggt aatttctgat aaaacaatac aaaacaaaaa aaaagcagta
     5701 atcacagcca aataaatgaa acacctaatg agaattactg ttgagtaatg ctttttatta
     5761 agtggcacaa agtacacact aaaaactatg caaaatatag gtaactacag tgtacgtaca
     5821 tgtaagtatc ttgtacttgc tgtgtatgga tgttggaaac ccatgtaatt ataatatgca
     5881 ttttgaatat tgggaaagag gaaatcttag tgtagataat agaatttgtt ttgaaatata
     5941 cactggcaat attgaaatat actcagtgca atatctgcag ttctattgct ggatacttaa
     6001 tgcaaaggga ttttaaagaa ttcttcagca agatccaaga ggttgctaat cttcacctct
     6061 cacatactaa agcattcatt aaaaatacaa ctaattcaag gacaagttaa gtttttctta
     6121 ttaatgtgac acagtaacat ttttatttgg attagttttt ggtgttattg cagagaaaga
     6181 aataacctga gttttaaatt tcgattcata tctcattgaa ttgggaattc ttcaattttg
     6241 tttgaaatgt gtgcatgttt tcatagattg tagcaagtac aaatgtattc aatgaaagaa
     6301 catagggtag ttttaatagt taaagtcact atatcttaat gggaatttta aaatatcttt
     6361 tctttttcta ttcatttttt ccctttctct ctctattcta cccccaaaca agccctttgc
     6421 actcataccc ttccaaaggc aatggattga aagtagcaag ataataaaga gagttaaagg
     6481 ggacaacata taacaatggg ttctaaaatc atcagcattt ttatgtattg agattattaa
     6541 tattgaatgc aatagttatt ggatatagct ggtaagttct ctgccatgca tacttacaat
     6601 aatccttcta cctctcactt ttaacatggg ctatgatact tcaatataaa tagaggaaat
     6661 aattatttac cagatatccc aggaagcatt cttatggaac tattataaca gtgcactccc
     6721 caccccctgg gaaatctcaa aagccaagtt cttcagtgta ttctatggtg tatgaatctg
     6781 catttgtttt tccttttcta tcattagctt ttcctaaagg caaaatatta taactttata
     6841 agaatagtcc ttctcctgcc tatttaatat ttcaatgtta atataattgt attggttttt
     6901 aaaaataatt aaaatggcaa cactttgcga tccaatctga tatttaattt ttaaaatgta
     6961 acaatttctt ataaattcat gctgtgtttt aagtaaaaat catgtatatg aattatttta
     7021 ccaagtagta ttatctgcac gagacaaatt taagtatttt aaaaatcatc cttattaata
     7081 aataatcctc atataatgca cagtattgcc acaaatgccc acttcatttt gtctgcatag
     7141 acatattaag aatttttcaa tgatgtaatt taattatcct aaaagaaatg acagattctt
     7201 ctgtaggaaa aaataaaaac atgaatatct caaattataa tggttaatct ctaaaatatg
     7261 cttaaagtaa gatgtttcta tgttatgtgg ttatgttatc aataatattt ggttgatctt
     7321 cacatatttt atatgcatat atatatcaag aagttatata tatataactc aagaaactca
     7381 agttatatat atatgtcaag aaatgtatga ttattttgga gagaatgggc ccaaatgtga
     7441 aaaagatata aaaaaaacaa aaaaaacaaa aaaaaaacac tattttcccc tacgaaatat
     7501 actgtatatt tcaaaagaag aaaagttaaa agatatttga agattgcagg ggcaaaacaa
     7561 aaacctacca gggctcagca cttaagcact tttcccacat ccagggtcaa agcagcagta
     7621 actacatgga cttttaagtg cggtatgaaa tgcaacatta cgcttacaaa cagtactgtc
     7681 aaacctcaaa tgctttcttt cttcagatgc tttttcgtgt acatgatact agtagacact
     7741 tttctcttta tatttactga tagtgaaaat catacgcaat aaaatattga tgtttgaagg
     7801 cagtggtcac caattggtta aaaaactatg aaatgtaaac tgaattgtta tatctctatc
     7861 ctttttgctt ttctctgtgt ttttaatgta tggaataaat ctcataaata gaaagaaaaa
     7921 taatctagaa atttttcaaa gctagtactc tttctcctta taaatgtaca caattttaat
     7981 ctttttacaa atttatttaa ctgtacctac tgtacttatt gtagattcaa tgacgcagtt
     8041 aagtcatcac ccaaggattt atgaatttga gattactgac ctgttttctt catattgcat
     8101 tcacatcaat atttgtgaat ttgttgttca gcttttcatt caaacaaaaa atattccctc
     8161 aagaaagctc catttttatc ataaacattt caacataacc aacattagaa caagtctgcc
     8221 atgttaaaaa taatttaaag acttatctct gaaaacggta tccagaaacg caggtgttcc
     8281 cagtaatgta gcttcaaaaa taaaatgtgc tatttatatg acatgaaatt cataactttt
     8341 ggaagggtat atttatgaca gcataaaaaa taaattctgt gctataaaga agatccaaca
     8401 aattaaccat ataagcacag aaaatagaga aacacagtta ttgaatctac tcttgtcatt
     8461 aacattttca aaaaacaaaa tgcatattgt aatatttggt acatgacact tgcatgttga
     8521 tatgcctata tacttacaaa gtattcaatg tgtacttagc ggcgcttaaa atatgtcatg
     8581 tacaactctt ataaacattt ttacagggtt cccatttgca cttcatcttt cagtaaagtc
     8641 ttgtcagaaa aaaattgtct gataaatatg gaaaaataaa atttgaattt tagttatctg
     8701 ttggacatta ctgaattgtc tattcattta gtacattttc ttaaccttga aaacagacat
     8761 tgaaagatgg aactttcttt tttccagtga caggtcatta aatcgatggt acaaaacata
     8821 cttctttatg ccaaacacat tattttgaat accttttttt caacttcata cattatccat
     8881 ccattttagt tttcctcgat gatgcccatt ttctttgtaa atttctaagt ggaagtttta
     8941 aaaattaagc atcagtaaaa taaatgttat cttatttgta caacatttaa tcgttattcc
     9001 ttggaatata tgaaccttgt aaagtgatga ctaagggtca aaaaaaatgt tgctgactta
     9061 gggaaatttg cttgagaatg ccaaaatttt aaaactctgt aaaggtaatt ttacattcac
     9121 ttatgtgtgt ttactaatgt tgagtaggaa cagaagcaaa aatacctaaa cctatttttt
     9181 ttaaccttca cactctaacc agtattatat atttcagcta cctaagataa tgcaattaat
     9241 catatatcca acctaagctt ctgccaataa ggatttcaga taagctttta aatttatgga
     9301 ggattttctt tgtgtctttg gaagttcact taccataaag tattttatag tctactttaa
     9361 ataacagatt ttgttacaca gggtaagcca aaggctgtac aagatttagt gtcattgggt
     9421 ctcatatttg tgttagacca tgaaatattc cattaaaatt tatctgtaaa tacaaggcaa
//
