LOCUS       NM_001301043            8675 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens cell adhesion molecule 1 (CADM1), transcript variant
            3, mRNA.
ACCESSION   NM_001301043 XM_005271491
VERSION     NM_001301043.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8675)
  AUTHORS   Xie,B., Zhao,L., Zhang,Z., Zhou,C., Tian,Y., Kang,Y., Chen,J.,
            Wei,H. and Li,L.
  TITLE     CADM1 impairs the effect of miR-1246 on promoting cell cycle
            progression in chemo-resistant leukemia cells
  JOURNAL   BMC Cancer 23 (1), 955 (2023)
   PUBMED   37814227
  REMARK    GeneRIF: CADM1 impairs the effect of miR-1246 on promoting cell
            cycle progression in chemo-resistant leukemia cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8675)
  AUTHORS   Neinaa,Y.M.E., El-Maadawy,I.H., Atteia,I.A. and Mohamed,D.A.E.
  TITLE     Cell adhesion molecule 1 expression in mycosis fungoides versus
            parapsoriasis versus inflammatory dermatosis: an
            immunohistochemical comparative study
  JOURNAL   Arch Dermatol Res 315 (8), 2403-2411 (2023)
   PUBMED   36943432
  REMARK    GeneRIF: Cell adhesion molecule 1 expression in mycosis fungoides
            versus parapsoriasis versus inflammatory dermatosis: an
            immunohistochemical comparative study.
REFERENCE   3  (bases 1 to 8675)
  AUTHORS   Wu,X., Azizan,E.A.B., Goodchild,E., Garg,S., Hagiyama,M.,
            Cabrera,C.P., Fernandes-Rosa,F.L., Boulkroun,S., Kuan,J.L.,
            Tiang,Z., David,A., Murakami,M., Mein,C.A., Wozniak,E., Zhao,W.,
            Marker,A., Buss,F., Saleeb,R.S., Salsbury,J., Tezuka,Y., Satoh,F.,
            Oki,K., Udager,A.M., Cohen,D.L., Wachtel,H., King,P.J., Drake,W.M.,
            Gurnell,M., Ceral,J., Ryska,A., Mustangin,M., Wong,Y.P., Tan,G.C.,
            Solar,M., Reincke,M., Rainey,W.E., Foo,R.S., Takaoka,Y.,
            Murray,S.A., Zennaro,M.C., Beuschlein,F., Ito,A. and Brown,M.J.
  TITLE     Somatic mutations of CADM1 in aldosterone-producing adenomas and
            gap junction-dependent regulation of aldosterone production
  JOURNAL   Nat Genet 55 (6), 1009-1021 (2023)
   PUBMED   37291193
  REMARK    GeneRIF: Somatic mutations of CADM1 in aldosterone-producing
            adenomas and gap junction-dependent regulation of aldosterone
            production.
REFERENCE   4  (bases 1 to 8675)
  AUTHORS   Takemoto,R., Hirai,Y., Watanabe,S., Harada,H., Suzuki,T.,
            Hashiguchi,T., Yanagi,Y. and Shirogane,Y.
  TITLE     Interaction of the Hemagglutinin Stalk Region with Cell Adhesion
            Molecule (CADM) 1 and CADM2 Mediates the Spread between Neurons and
            Neuropathogenicity of Measles Virus with a Hyperfusogenic Fusion
            Protein
  JOURNAL   J Virol 97 (5), e0034023 (2023)
   PUBMED   37166307
  REMARK    GeneRIF: Interaction of the Hemagglutinin Stalk Region with Cell
            Adhesion Molecule (CADM) 1 and CADM2 Mediates the Spread between
            Neurons and Neuropathogenicity of Measles Virus with a
            Hyperfusogenic Fusion Protein.
REFERENCE   5  (bases 1 to 8675)
  AUTHORS   He,H., Cong,S., Wang,Y., Ji,Q., Liu,W. and Qu,N.
  TITLE     Analysis of the key ligand receptor CADM1_CADM1 in the regulation
            of thyroid cancer based on scRNA-seq and bulk RNA-seq data
  JOURNAL   Front Endocrinol (Lausanne) 13, 969914 (2022)
   PUBMED   36523593
  REMARK    GeneRIF: Analysis of the key ligand receptor CADM1_CADM1 in the
            regulation of thyroid cancer based on scRNA-seq and bulk RNA-seq
            data.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8675)
  AUTHORS   Masuda,M., Yageta,M., Fukuhara,H., Kuramochi,M., Maruyama,T.,
            Nomoto,A. and Murakami,Y.
  TITLE     The tumor suppressor protein TSLC1 is involved in cell-cell
            adhesion
  JOURNAL   J Biol Chem 277 (34), 31014-31019 (2002)
   PUBMED   12050160
  REMARK    GeneRIF: TSLC1 mediates intracellular adhesion through homophilic
            interactions in a Ca(2+)/Mg(2+)-independent manner
REFERENCE   7  (bases 1 to 8675)
  AUTHORS   Allinen,M., Peri,L., Kujala,S., Lahti-Domenici,J., Outila,K.,
            Karppinen,S.M., Launonen,V. and Winqvist,R.
  TITLE     Analysis of 11q21-24 loss of heterozygosity candidate target genes
            in breast cancer: indications of TSLC1 promoter hypermethylation
  JOURNAL   Genes Chromosomes Cancer 34 (4), 384-389 (2002)
   PUBMED   12112527
  REMARK    GeneRIF: The TSLC1 promoter region has many methylated cytosines in
            the CpG islands in chromosome 11q LOH in breast cancer.
REFERENCE   8  (bases 1 to 8675)
  AUTHORS   Fukuhara,H., Kuramochi,M., Fukami,T., Kasahara,K., Furuhata,M.,
            Nobukuni,T., Maruyama,T., Isogai,K., Sekiya,T., Shuin,T.,
            Kitamura,T., Reeves,R.H. and Murakami,Y.
  TITLE     Promoter methylation of TSLC1 and tumor suppression by its gene
            product in human prostate cancer
  JOURNAL   Jpn J Cancer Res 93 (6), 605-609 (2002)
   PUBMED   12079507
  REMARK    GeneRIF: alteration of TSLC1 is involved in prostate cancer
REFERENCE   9  (bases 1 to 8675)
  AUTHORS   Kuramochi,M., Fukuhara,H., Nobukuni,T., Kanbe,T., Maruyama,T.,
            Ghosh,H.P., Pletcher,M., Isomura,M., Onizuka,M., Kitamura,T.,
            Sekiya,T., Reeves,R.H. and Murakami,Y.
  TITLE     TSLC1 is a tumor-suppressor gene in human non-small-cell lung
            cancer
  JOURNAL   Nat Genet 27 (4), 427-430 (2001)
   PUBMED   11279526
REFERENCE   10 (bases 1 to 8675)
  AUTHORS   Gomyo,H., Arai,Y., Tanigami,A., Murakami,Y., Hattori,M., Hosoda,F.,
            Arai,K., Aikawa,Y., Tsuda,H., Hirohashi,S., Asakawa,S., Shimizu,N.,
            Soeda,E., Sakaki,Y. and Ohki,M.
  TITLE     A 2-Mb sequence-ready contig map and a novel immunoglobulin
            superfamily gene IGSF4 in the LOH region of chromosome 11q23.2
  JOURNAL   Genomics 62 (2), 139-146 (1999)
   PUBMED   10610705
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC047021.1, HE586498.1, AP003179.2 and CA447277.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001301043.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (A).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853561.5859.1,
                                           SRR1660809.178651.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331581.11/ ENSP00000329797.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BC047021.1         109-126
            19-1444             HE586498.1         1-1426
            1445-3649           AP003179.2         60419-62623         c
            3650-4286           CA447277.1         18-654              c
            4287-8675           AP003179.2         55393-59781         c
FEATURES             Location/Qualifiers
     source          1..8675
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..8675
                     /gene="CADM1"
                     /gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
                     sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
                     /note="cell adhesion molecule 1"
                     /db_xref="GeneID:23705"
                     /db_xref="HGNC:HGNC:5951"
                     /db_xref="MIM:605686"
     exon            1..145
                     /gene="CADM1"
                     /gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
                     sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1437
                     /gene="CADM1"
                     /gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
                     sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
                     /note="isoform A precursor is encoded by transcript
                     variant 3; tumor suppressor in lung cancer 1; nectin-like
                     protein 2; nectin-like 2; TSLC1/Nectin-like 2/IGSF4;
                     TSLC-1; synaptic cell adhesion molecule; immunoglobulin
                     superfamily member 4; spermatogenic immunoglobulin
                     superfamily"
                     /codon_start=1
                     /product="cell adhesion molecule 1 isoform A precursor"
                     /protein_id="NP_001287972.1"
                     /db_xref="CCDS:CCDS73399.1"
                     /db_xref="GeneID:23705"
                     /db_xref="HGNC:HGNC:5951"
                     /db_xref="MIM:605686"
                     /translation="MASVVLPSGSQCAAAAAAAAPPGLRLRLLLLLFSAAALIPTGDG
                     QNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNF
                     SSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGE
                     EIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPV
                     ICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPV
                     MVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPP
                     TTIPPPTTTTTTTTTTTTTILTIITDTTATTEPAVHGLTQLPNSAEELDSEDLSDSRA
                     GEEGSIRAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADAD
                     TAIINAEGGQNNSEEKKEYFI"
     exon            146..292
                     /gene="CADM1"
                     /gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
                     sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            293..445
                     /gene="CADM1"
                     /gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
                     sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..583
                     /gene="CADM1"
                     /gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
                     sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..742
                     /gene="CADM1"
                     /gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
                     sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..842
                     /gene="CADM1"
                     /gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
                     sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1015
                     /gene="CADM1"
                     /gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
                     sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1099
                     /gene="CADM1"
                     /gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
                     sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1132
                     /gene="CADM1"
                     /gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
                     sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1186
                     /gene="CADM1"
                     /gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
                     sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1318
                     /gene="CADM1"
                     /gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
                     sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..8675
                     /gene="CADM1"
                     /gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
                     sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1485..1490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADM1"
                     /gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
                     sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
                     /note="hexamer: GATAAA"
     polyA_site      1508
                     /gene="CADM1"
                     /gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
                     sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
                     /note="major polyA site"
     polyA_site      1614
                     /gene="CADM1"
                     /gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
                     sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
     regulatory      4258..4263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CADM1"
                     /gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
                     sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
                     /note="hexamer: AATAAA"
     polyA_site      4278
                     /gene="CADM1"
                     /gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
                     sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
                     /note="major polyA site"
ORIGIN      
        1 agtctgaggc aggtgcccga catggcgagt gtagtgctgc cgagcggatc ccagtgtgcg
       61 gcggcagcgg cggcggcggc gcctcccggg ctccggctcc ggcttctgct gttgctcttc
      121 tccgccgcgg cactgatccc cacaggtgat gggcagaatc tgtttacgaa agacgtgaca
      181 gtgatcgagg gagaggttgc gaccatcagt tgccaagtca ataagagtga cgactctgtg
      241 attcagctac tgaatcccaa caggcagacc atttatttca gggacttcag gcctttgaag
      301 gacagcaggt ttcagttgct gaatttttct agcagtgaac tcaaagtatc attgacaaac
      361 gtctcaattt ctgatgaagg aagatacttt tgccagctct ataccgatcc cccacaggaa
      421 agttacacca ccatcacagt cctggtccca ccacgtaatc tgatgatcga tatccagaaa
      481 gacactgcgg tggaaggtga ggagattgaa gtcaactgca ctgctatggc cagcaagcca
      541 gccacgacta tcaggtggtt caaagggaac acagagctaa aaggcaaatc ggaggtggaa
      601 gagtggtcag acatgtacac tgtgaccagt cagctgatgc tgaaggtgca caaggaggac
      661 gatggggtcc cagtgatctg ccaggtggag caccctgcgg tcactggaaa cctgcagacc
      721 cagcggtatc tagaagtaca gtataagcct caagtgcaca ttcagatgac ttatcctcta
      781 caaggcttaa cccgggaagg ggacgcgctt gagttaacat gtgaagccat cgggaagccc
      841 cagcctgtga tggtaacttg ggtgagagtc gatgatgaaa tgcctcaaca cgccgtactg
      901 tctgggccca acctgttcat caataaccta aacaaaacag ataatggtac ataccgctgt
      961 gaagcttcaa acatagtggg gaaagctcac tcggattata tgctgtatgt atacgatccc
     1021 cccacaacta tccctcctcc cacaacaacc accaccacca ccaccaccac caccaccacc
     1081 atccttacca tcatcacaga cacaacggcg acgacagaac cagcagttca cggccttact
     1141 cagttgccca attccgcaga agaactggac agtgaggacc tctcagattc ccgagcaggt
     1201 gaagaaggct cgatcagggc agtggatcat gccgtgatcg gtggcgtcgt ggcggtggtg
     1261 gtgttcgcca tgctgtgctt gctcatcatt ctggggcgct attttgccag acataaaggt
     1321 acatacttca ctcatgaagc caaaggagcc gatgacgcag cagacgcaga cacagctata
     1381 atcaatgcag aaggaggaca gaacaactcc gaagaaaaga aagagtactt catctagatc
     1441 agcctttttg tttcaatgag gtgtccaact ggccctattt agatgataaa gagacagtga
     1501 tattggaact tgcgagaaat tcgtgtgttt ttttatgaat gggtggaaag gtgtgagact
     1561 gggaaggctt gggatttgct gtgtaaaaaa aaaaaaaatg ttctttggaa agtacactct
     1621 gctgtttgac acctcttttt tcgtttgttt gtttgtttaa tttttatttc ttcctaccaa
     1681 gtcaaacttg gatacttgga tttagtttca gtagattgca gaaaattctg tgccttgttt
     1741 tttgtttgtt tgttgcgttc ctttcttttc cccctttgtg cacatttatt tcctccctct
     1801 accccaattt cggatttttt ccaaaatctc ccattttgga atttgcctgc tgggattcct
     1861 tagactcttt tccttccctt ttctgttcta gttttttact tttgtttatt tttatggtaa
     1921 ctgctttctg ttccaaattc agtttcataa aaggagaacc agcacagctt agatttcata
     1981 gttcagaatt tagtgtatcc ataatgcatt cttctctgtt gtcgtaaaga tttgggtgaa
     2041 caaacaatga aaactctttg ctgctgccca tgtttcaaat acttagagca gtgaagacta
     2101 gaaaattaga ctgtgattca gaaaatgttc tgtttgctgt ggaactacat tactgtacag
     2161 ggttatctgc aagtgaggtg tgtcacaatg agattgaatt tcactgtctt taattctgta
     2221 tctgtagacg gctcagtata gataccctac gctgtccaga aaggtttggg gcagaaagga
     2281 ctcctccttt ttccatgccc taaacagacc tgacaggtga ggtctgttcc ttttatataa
     2341 gtggacaaat tttgagttgc cacaggaggg gaagtaggga ggggggaaat acagttctgc
     2401 tctggttgtt tctgttccaa atgattccat ccacctttcc caatcggcct tacttctcac
     2461 taatttgtag gaaaaagcaa gttcgtctgt tgtgcgaatg actgaatggg acagagttga
     2521 tttttttttt tttttccttt gtgcttagtt aggaaggcag taggatgtgg cctgcatgta
     2581 ctgtatatta cagatatttg tcatgctggg atttccaact cgaatctgtg tgaaactttc
     2641 attccttcag atttggcttg acaaaggcag gaggtacaaa agaagggctg gtattgttct
     2701 cacactggtc tgctgtcgct ctcagttctc gataggtcag agcagaggtg gaaaaacagc
     2761 atgtacggat tttcagttac ttaatcaaaa ctcaaatgtg agtgttttta tctttttacc
     2821 tttcatacac tagccttggc ctctttcctc agccttaaga accatctgcc aaaaattact
     2881 gatcctcgca tgatggcagc catagtgcat agctactaaa atcagtgacc ttgaacatat
     2941 cttagatggg gagcctcggg aaaaggtaga ggagtcacgt taccatttac atgttttaaa
     3001 gaaagaagtg tggggatttt cactgaaacg tctaggaaat ctagaagtag tcctgaagga
     3061 cagaaactaa actcttacca tatgtttggt aagactccag actccagcta acagtcccta
     3121 tggaaagatg gcatcaaaaa agatagatct atatatatat ataaatatat attctattac
     3181 attttcagtg agtaattttg gattttgcaa ggtgcatttt tactattgtt acattatgtg
     3241 gaaaacttat gctgatttat ttaaggggga aaaagtgtca actctttgtt atttgaaaac
     3301 atgtttattt ttcttgtctt tattttaacc tttgatagaa ccattgcaat atgggggcct
     3361 tttgggaacg gactggtatg taaaagaaaa tccattatcg agcagcattt tatttacccc
     3421 tcccctatcc ctaggcactt aaccaagaca aaaagccaca atgaacatcc ctttttcaat
     3481 gaattttata atctgcagct ctattccgag cccttagcac ccattccgac catagtataa
     3541 tcatatcaaa gggtgagaat catttagcat gttgttgaaa ggtttttttt cagttgttct
     3601 ttttagaaaa aaagaaaaac aaaaacaaaa acaaaaaaaa aaaatcacac cattgctcac
     3661 agaattggca tctcattttt gggacctccc atctttctgt tttgaaaagt gtacagtagt
     3721 gcagtgttcc tgatgtaact ttatggctta caatgttgac atgtctcagg ttcatgtgtt
     3781 gcgattggtg ttttccgtct caggtagatt gcaaagtgta ggccccacac attggaaaaa
     3841 ataataataa aacaaagcaa aaacaggaaa ttatggattt tagttgtata ttggtttatg
     3901 tattttttct taagtataca gtgcactgtt tgaaatgtat tgttgagtat tactttgtac
     3961 aggttgatca ctttttttag agtgaagaaa gaacaaactt gttttttgtg ttttttaaag
     4021 gaatataaaa taatgaagga tgtataattg atgccaaata agcttgttct ttagtcacac
     4081 cgacgtctta tttttccctt taggccagtt ctgtttttaa ggtgtacatg gacaatgtta
     4141 cagtgtaaga aactccatat ccatatgttc ccattcgcat tttgtattgg ttcatgtata
     4201 ccatttttac aaaaaaaaaa agaaaaaaaa gaagtactat aaaatatctg tcttcttaat
     4261 aaaaaaaaat taatgttaca aagtgatcct ttaatctctt tatggacttc ttatggacgc
     4321 ctccgagtga gagaagagat gggcctctgg tcccagcttc ctccttagga ccatgtacgg
     4381 ggccaggaac gctggcagta gatgctagga catgctgccg gctgggttgc tgggggccgc
     4441 gctctctctc cttctccgct catccttcct gtccttgttc tcttccccac tctcagtgga
     4501 caggtgagcc aagtgctgtg ccgtggctga gtctgggctc ccacgtggac tcagcgattt
     4561 gtgcaggtgt gcgagctgtc gtggcgggcc cgccggaaca ggccgctccc gtagatgtgt
     4621 cttccgcact catcccctct ctcaccgccc ccccaccctc accaacttcc ctgtgttggc
     4681 tgctccacct gtctcttact ttgggagttt gtgtcttaac aattcattct gccttcttcc
     4741 ttgaaagttc tctctccttt cataaaaaga agacgtgagc tgtggaggac tggcttggct
     4801 gcctgcagaa gattgttctc acttgctgtt taggttgctg agacttccag gcctgggtag
     4861 acagcaggat ttgctctgtt gtcatcgtcc ttgccttgca ggctgaagtg agcaatgact
     4921 acacttcatg gtggccgatc ttataaatgt gcagataacg tctggccagg cccaaagtgc
     4981 ccttttccca ccatcccctc agctgtggtt gatgagttcc ccttttctcc cttggccacg
     5041 tcatggggaa agttccatag gaaaagcaaa ggtaagctcc agaaagactg aaggctgtgc
     5101 atctcccctt gagccacttc catcctggcc tggtctctta cctgtctctg ttaaaaaaaa
     5161 aaaaaaaaaa aaaaaaaaaa aaaaatcaga tatgcagtta ttgagcacct gctgtatgtc
     5221 cagcatggtg agggatgcag agaagtataa ggcggtctct ggaggccaag tagagcatca
     5281 gttacatcac ctgaaaactt gaagtgaccc tgagccatgg gtgccccact gaacacagag
     5341 aagcccagag agtgctatga gaattttctg gagaagggta atcagtgaag gctggtgagt
     5401 ccctagacag cttcacaaag agctgggacc ccagctggat cttaaaggat ggtttcgtgg
     5461 agaaggaatg tgagtcaaaa gtacagaggg caacaagccc agccagcctg ctgatttgta
     5521 tggggagaag aaagcaattc cgtgtgcagg gtgggatggg tcttgtggct gtactgaaaa
     5581 gtccgggcag aggactcgat acttcagtga cctctcccag cctctgccag agggcaagga
     5641 gcagtaggga gtactcattc attgcatctc tataaaaaga cccagagaga tagaataagg
     5701 atcaaaagca cacactagag agaggctgcc tgcattcaga tccctgtccc accatgtagc
     5761 agtgaaacct cgggtgagta gcccagccta cctggcttca gtctcttgct ctgcaaggtg
     5821 gacatcacca tagcctcgaa ggttgttagg aaagatcagt gagatatgca gtcagcgctc
     5881 agccaaaaag gtgccagaca cacactactt gttcattaca tgtcagtcac aggatagagg
     5941 caaatggtga ctaaaacgat agaaggttac ccagggctac gaagaagcgg tcactactca
     6001 gagggagctc tgagggctcc tctgcatata gacacatcat gcccttgcaa accacgactt
     6061 agaaggttta atgacccttt tctcttcacc attcattagc agacttattc caagccacgt
     6121 ggcatgcagt atgtttagtc tccccacccc tctccctctt gtctgcagca tgaggctcca
     6181 gctttagctg taccctacag aaaaaagtcc cagaagttcc ttgagctgag gcagacagga
     6241 ggtggtgact gctgtacatt tgccttttga gctccacagg gtatgcaaat gagaaggtgc
     6301 tagaagccgt ccccgctcaa aggatcttga taagttgccc actccttcat ttgagaagag
     6361 tgcgtacgag agtgaaaatg gccctcgttt cccccagaga gttttcacaa atgttttggc
     6421 ctggcattct ccaaatacat caactggaac cctgaggtga tatgcgggtg ttaattggtg
     6481 caatctttca ctgtcctctg tctacctgaa atgtaattct tttaccgctg tggacttgct
     6541 ccatggagaa atgctccttt gattctgtca tcaagaacct caaagaaacc atgtggccac
     6601 tgtgttacag gtagaaagac cctgcttaag tgaaggtatt tttgttttat tataaaatca
     6661 tgcccaagat taatacacct ttttgccagg atcccaaata cgcagccctt tgtcatgaag
     6721 aactggcagc cacattcctt cagggtgaaa tttgtattca cagccataca tgtatagttt
     6781 ttgaagcgct ggccccccgt acaggagaag aaagaaggga ctcttggctc atccatgacc
     6841 ttgtaggtca ataccatatt aaagttcctg tcaggcacgc agtagtcacc cagcaagtat
     6901 cagctgatta aagggagaag agtcgagcac ctggctgact gagccttacg ttacacttaa
     6961 tctgaatggg ccaccgatgc tgtatttcaa accttgatgt ttgcatgtcc atccttacta
     7021 caggtggctt tcaggttggc cgtgaaggga caagccagcc agtcctgagt ttagagcgat
     7081 tggccctatc attctcaagg acccactgga atagtatcag ggaatatcat tttgggtaat
     7141 ggccaagcaa agccttagta ttgctatcat atattgtgag gggccttcag aatgcaatat
     7201 ggcctctttt aaaaatgcaa actatagtcc ttgccttatc tgtgtttatc tcaaaatgtt
     7261 gaaatgtgcc tctaatagga actgcaggat tcagtccccc cccaccaccc cccacccaac
     7321 actcacatca ttacacatga gcatccctga actgagacct gaaagcaaga atcttctctg
     7381 ttttcaggtg ttccaaacct cagcttccag cctcttcagt acacaggaaa ctttgtttca
     7441 tttttatgtt tttatttatt tttttcattc ccaaaaaaca taaaatgtct actgcccctg
     7501 gtggtcagtg ctgggaaata caactcgagc cttgcctatt gaaatgcaga atgtattcca
     7561 acaaggaacc tgacattgtc tactgctttt tctctcacac acatgcacac ctacctgcgc
     7621 ctcccatttt actccctcct aatccttcga agtgttgatc tggggaaggt gagaaccact
     7681 actgaggggc aaatcaaccg gttctctggg cccgggactt cagctgccct ccagacgtgc
     7741 acaggctcac agtcatattt cagacgtgac cgcctcaaat cttccttaag tgctatcttc
     7801 tcaggttaat taatcaccag gcttaaactt gctgttacca gcaggaagtc catcctgaag
     7861 tcagcaatgt tacgattgca tcttctaata ctgtttatcc tgcattagtg tttacttagg
     7921 gggaaaattg atccgtaatt gatatttcag tcttccagag ctggtgttgg aagagcctaa
     7981 tgcaggcctt taatagcaag caaatattta aatcccttaa tggttgctga atattgaaat
     8041 gtgtgacttt attactcttt ttggtttgtt ttctctgtag ttgtgtattt catcgtttaa
     8101 acctgcaatg gatgctggca agtgcaagtc tagctaatcc acaaaagctg tttgcccaga
     8161 cacagcagac ctgattaaaa agtattgcta tggaagggaa tcttctgcac taatcagtct
     8221 ctgttagcta gtgacgaaat tactatccat ctctctctct ttctctttct ctccctctct
     8281 ctaggcctgt tttctctaac ctcctctccc agaataaagt gatgagggca gctatagtgt
     8341 tgcaattagg aacatgaatc ttttatcgtt tggacaagga agggaaaatg ccattactgt
     8401 caactgaaat gtcctacttg ggttttttgc tcctacttcc ctgccaaagc ccattgctgc
     8461 tgctgaaatt gtataacatt cacagctgtt cttgatggct tgattcttaa cacagccaga
     8521 aatgtagccc gggagatgct taagacagtt tatggaaaat aatagatttc cttgcagaga
     8581 caccaatgca tcgagaaggg ccttgagtca cgttagcccc agccaagatc accaattttc
     8641 tctctatctg gcttcagtta caaaggctat gcctt
//
