LOCUS       NM_014412               2869 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens calcyclin binding protein (CACYBP), transcript variant
            1, mRNA.
ACCESSION   NM_014412
VERSION     NM_014412.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2869)
  AUTHORS   Bai,M., Lu,K., Che,Y. and Fu,L.
  TITLE     CacyBP promotes the development of lung adenocarcinoma by
            regulating OTUD5
  JOURNAL   Carcinogenesis 45 (8), 595-606 (2024)
   PUBMED   38558058
  REMARK    GeneRIF: CacyBP promotes the development of lung adenocarcinoma by
            regulating OTUD5.
REFERENCE   2  (bases 1 to 2869)
  AUTHORS   Li,Q., Liu,Z., Ma,L., Yin,W. and Zhang,K.
  TITLE     CACYBP knockdown inhibits progression of prostate cancer via p53
  JOURNAL   J Cancer Res Clin Oncol 149 (9), 5761-5772 (2023)
   PUBMED   36576589
  REMARK    GeneRIF: CACYBP knockdown inhibits progression of prostate cancer
            via p53.
REFERENCE   3  (bases 1 to 2869)
  AUTHORS   Smereczanska,M., Domian,N., Mlynarczyk,G. and Kasacka,I.
  TITLE     The Effect of CacyBP/SIP on the Phosphorylation of ERK1/2 and p38
            Kinases in Clear Cell Renal Cell Carcinoma
  JOURNAL   Int J Mol Sci 24 (12), 10362 (2023)
   PUBMED   37373509
  REMARK    GeneRIF: The Effect of CacyBP/SIP on the Phosphorylation of ERK1/2
            and p38 Kinases in Clear Cell Renal Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2869)
  AUTHORS   Lesniak,W., Bohush,A., Maksymowicz,M., Piwowarczyk,C.,
            Karolak,N.K., Jurewicz,E. and Filipek,A.
  TITLE     Involvement of CacyBP/SIP in differentiation and the immune
            response of HaCaT keratinocytes
  JOURNAL   Immunobiology 228 (3), 152385 (2023)
   PUBMED   37156124
  REMARK    GeneRIF: Involvement of CacyBP/SIP in differentiation and the
            immune response of HaCaT keratinocytes.
REFERENCE   5  (bases 1 to 2869)
  AUTHORS   Kanno,M., Suzuki,M., Tanikawa,K., Numakura,C., Matsuzawa,S.I.,
            Niihori,T., Aoki,Y., Matsubara,Y., Makino,S., Tamiya,G., Nakano,S.,
            Funayama,R., Shirota,M., Nakayama,K., Mitsui,T. and Hayasaka,K.
  TITLE     Heterozygous calcyclin-binding protein/Siah1-interacting protein
            (CACYBP/SIP) gene pathogenic variant linked to a dominant family
            with paucity of interlobular bile duct
  JOURNAL   J Hum Genet 67 (7), 393-397 (2022)
   PUBMED   35087201
  REMARK    GeneRIF: Heterozygous calcyclin-binding protein/Siah1-interacting
            protein (CACYBP/SIP) gene pathogenic variant linked to a dominant
            family with paucity of interlobular bile duct.
REFERENCE   6  (bases 1 to 2869)
  AUTHORS   Matsuzawa,S., Li,C., Ni,C.Z., Takayama,S., Reed,J.C. and Ely,K.R.
  TITLE     Structural analysis of Siah1 and its interactions with
            Siah-interacting protein (SIP)
  JOURNAL   J Biol Chem 278 (3), 1837-1840 (2003)
   PUBMED   12421809
  REMARK    GeneRIF: investigation of interaction with Siah1
REFERENCE   7  (bases 1 to 2869)
  AUTHORS   Filipek,A., Jastrzebska,B., Nowotny,M. and Kuznicki,J.
  TITLE     CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds
            EF-hand proteins of the S100 family
  JOURNAL   J Biol Chem 277 (32), 28848-28852 (2002)
   PUBMED   12042313
REFERENCE   8  (bases 1 to 2869)
  AUTHORS   Filipek,A., Jastrzebska,B., Nowotny,M., Kwiatkowska,K., Hetman,M.,
            Surmacz,L., Wyroba,E. and Kuznicki,J.
  TITLE     Ca2+-dependent translocation of the calcyclin-binding protein in
            neurons and neuroblastoma NB-2a cells
  JOURNAL   J Biol Chem 277 (23), 21103-21109 (2002)
   PUBMED   11927578
REFERENCE   9  (bases 1 to 2869)
  AUTHORS   Liu,W.X., Wu,J., Zhao,Z., Zhou,Y., Peng,X.Z., Yuan,J.G. and
            Qiang,B.Q.
  TITLE     [Cloning and expression of human calcyclin binding protein
            (hCacyBP) gene]
  JOURNAL   Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34 (2),
            181-186 (2002)
   PUBMED   12006993
REFERENCE   10 (bases 1 to 2869)
  AUTHORS   Matsuzawa,S.I. and Reed,J.C.
  TITLE     Siah-1, SIP, and Ebi collaborate in a novel pathway for
            beta-catenin degradation linked to p53 responses
  JOURNAL   Mol Cell 7 (5), 915-926 (2001)
   PUBMED   11389839
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CA951015.1, AL035305.1 and
            AW300675.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_014412.2.
            
            Summary: The protein encoded by this gene is a calcyclin binding
            protein. It may be involved in calcium-dependent ubiquitination and
            subsequent proteosomal degradation of target proteins. It probably
            serves as a molecular bridge in ubiquitin E3 complexes and
            participates in the ubiquitin-mediated degradation of beta-catenin.
            Two alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.28890.1,
                                           SRR1803615.238333.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367679.7/ ENSP00000356652.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               CA951015.1         192-308
            118-2552            AL035305.1         1-2435
            2553-2869           AW300675.1         178-494
FEATURES             Location/Qualifiers
     source          1..2869
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.1"
     gene            1..2869
                     /gene="CACYBP"
                     /gene_synonym="GIG5; PNAS-107; S100A6BP; SIP"
                     /note="calcyclin binding protein"
                     /db_xref="GeneID:27101"
                     /db_xref="HGNC:HGNC:30423"
                     /db_xref="MIM:606186"
     exon            1..249
                     /gene="CACYBP"
                     /gene_synonym="GIG5; PNAS-107; S100A6BP; SIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..921
                     /gene="CACYBP"
                     /gene_synonym="GIG5; PNAS-107; S100A6BP; SIP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     growth-inhibiting gene 5 protein; Siah-interacting protein
                     (SIP); hCacyBP; S100A6-binding protein"
                     /codon_start=1
                     /product="calcyclin-binding protein isoform 1"
                     /protein_id="NP_055227.1"
                     /db_xref="CCDS:CCDS1315.1"
                     /db_xref="GeneID:27101"
                     /db_xref="HGNC:HGNC:30423"
                     /db_xref="MIM:606186"
                     /translation="MASEELQKDLEEVKVLLEKATRKRVRDALTAEKSKIETEIKNKM
                     QQKSQKKAELLDNEKPAAVVAPITTGYTVKISNYGWDQSDKFVKIYITLTGVHQVPTE
                     NVQVHFTERSFDLLVKNLNGKSYSMIVNNLLKPISVEGSSKKVKTDTVLILCRKKVEN
                     TRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKRTINKAWVESR
                     EKQAKGDTEF"
     exon            250..469
                     /gene="CACYBP"
                     /gene_synonym="GIG5; PNAS-107; S100A6BP; SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            470..566
                     /gene="CACYBP"
                     /gene_synonym="GIG5; PNAS-107; S100A6BP; SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            567..666
                     /gene="CACYBP"
                     /gene_synonym="GIG5; PNAS-107; S100A6BP; SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            667..764
                     /gene="CACYBP"
                     /gene_synonym="GIG5; PNAS-107; S100A6BP; SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            765..2869
                     /gene="CACYBP"
                     /gene_synonym="GIG5; PNAS-107; S100A6BP; SIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1085..1090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACYBP"
                     /gene_synonym="GIG5; PNAS-107; S100A6BP; SIP"
                     /note="hexamer: AATAAA"
     polyA_site      1106
                     /gene="CACYBP"
                     /gene_synonym="GIG5; PNAS-107; S100A6BP; SIP"
     regulatory      1203..1208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACYBP"
                     /gene_synonym="GIG5; PNAS-107; S100A6BP; SIP"
                     /note="hexamer: AATAAA"
     polyA_site      1210
                     /gene="CACYBP"
                     /gene_synonym="GIG5; PNAS-107; S100A6BP; SIP"
                     /note="major polyA site"
     regulatory      1619..1624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACYBP"
                     /gene_synonym="GIG5; PNAS-107; S100A6BP; SIP"
                     /note="hexamer: AATAAA"
     polyA_site      1643
                     /gene="CACYBP"
                     /gene_synonym="GIG5; PNAS-107; S100A6BP; SIP"
                     /note="major polyA site"
     regulatory      2529..2534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACYBP"
                     /gene_synonym="GIG5; PNAS-107; S100A6BP; SIP"
                     /note="hexamer: AATAAA"
     polyA_site      2562
                     /gene="CACYBP"
                     /gene_synonym="GIG5; PNAS-107; S100A6BP; SIP"
ORIGIN      
        1 ggcgggctgt gcgtgctcgc ggtgggcggt ggcggcggct gcctcgcgaa ggttcgagat
       61 ccgtcgcgtg cgggaggcgg gccgcgatct tgcgcagggt cggtgtgggc gcaggctgca
      121 gcgccgcgac tcgtgcgggt aggcgtctgc gctcggtttg agggctcggc gcggggtttc
      181 ctgttcctcc ttctgcgcgg ctgcagctcg ggacttcggc ctgacccagc ccccatggct
      241 tcagaagagc tacagaaaga tctagaagag gtaaaggtgt tgctggaaaa ggctactagg
      301 aaaagagtac gtgatgccct tacagctgaa aaatccaaga ttgagacaga aatcaagaac
      361 aagatgcaac agaaatcaca gaagaaagca gaacttcttg ataatgaaaa accagctgct
      421 gtggttgctc ccattacaac gggctatacg gtgaaaatca gtaattatgg atgggatcag
      481 tcagataagt ttgtgaaaat ctacattacc ttaactggag ttcatcaagt tcccactgag
      541 aatgtgcagg tgcatttcac agagaggtca tttgatcttt tggtaaagaa tctaaatggg
      601 aagagttact ccatgattgt gaacaatctc ttgaaaccca tctctgtgga aggcagttca
      661 aaaaaagtca agactgatac agttcttata ttgtgtagaa agaaagtgga aaacacaagg
      721 tgggattacc tgacccaggt tgaaaaggag tgcaaagaaa aagagaagcc ctcctatgac
      781 actgaaacag atcctagtga gggattgatg aatgttctaa agaaaattta tgaagatgga
      841 gacgatgata tgaagcgaac cattaataaa gcctgggtgg aatcaagaga gaagcaagcc
      901 aaaggagaca cggaattttg agactttaaa gtcgttttgg gaactgtgat gtgatgtgga
      961 aatactgatg tttccagtaa gggaatattg gtgagctgca tatataaatt tgacagatag
     1021 ctatttacat agccttctaa gtaaaggcaa tgaattctcc atttcctact ggaggattta
     1081 tttaaataaa atatgcttat taaacactcc tgcaaagatg gttttattag taccctggtc
     1141 attttgttca aggaagggtt atattgcatt ctcacgtgaa atataaaaag caagtcttgc
     1201 ccaataaaaa cgctacattg tgtgtatttt ttgttcagct aagaattgga aaagtatttg
     1261 cttgcctttt aagttactga catcagcttc caccagtgta aaaattgagt aaaacctgaa
     1321 gttttgcata aaatgcaaat cggtgcctgt gcttgaaggt tgctgtagag catctgaccc
     1381 cttattacca ccttaagcaa tgtatatgcc atgcattacc atgcactaat tcaatcacag
     1441 gtgtttctat ctagatttaa atatatttgt caatgaatgt ggaatagaaa atctaaacat
     1501 gacaataata gacatatctt tgtatggtac cagttagttt tgccgtggat cagatggttt
     1561 ataaaagtaa taaccataaa gcaaaaaata atttgaaagc ccgtctattc ctatgctcaa
     1621 taaagttaag tttttcttca ttagaacagt tttatgattt atttgtctag gagtatgtca
     1681 gaaaaatcag gcttttagta ggaattactc ctattccccc tgaagtcagg accagtgcct
     1741 gtgatctcca ttactttatt ttcctggagg tattagccaa cacagttaga tcagagaaag
     1801 caattgaagc caggcatgaa ggctggcgcc cgtaatccca gctactaagg ctggaggatc
     1861 acttcagccc aggagtttaa ggctgcagtg agctatgatg atgccactgt actgcagctt
     1921 gggtaacaga ttgagaacct gtctcattaa aaaaaaaaaa aaaaaaaaag ccgttagaca
     1981 cacaggaaaa atccagaagg gtaaactaaa ctaaagctac aattaatatg ggaatttgga
     2041 agaagtggta ggatttaaaa tacagaaaca gtttatgtat aggatagcta taagtaaata
     2101 ctgaaacaca ttatgcctct gtaattgggg ttgacacatg aacagaatag cagacacaat
     2161 gcatatgaaa gttacagaat atggtaaaag tggggtaaag atgggttttt aatgatacta
     2221 agataactga aaataggcat atagatatat tccaagccgc ctgacgatct aattgtaaaa
     2281 agtaaagcat acaaatacta gaagaaaatg gaggaaaacg acattatatg tgacttaaaa
     2341 cctagaagaa ataaataaaa ctattgatca attttaacta cataaaaatg tttataggac
     2401 aagaaaaacc ccaccataac ccaaggcaaa caatgtattg acaggattcc aataattaag
     2461 aatacttcat acaaaaagaa atgtaaatga cctttaacat gtaaagatgc tcaccttgtt
     2521 cagaagagaa taaaccagtg tttttacctt tcacttgaaa aagaagtata aaaacaactg
     2581 tattgagttg aggctgtgga gaaataagga cacatatatg ggaatggaat gcaaaagtta
     2641 aactttggtt aacaagaata tttgggcagg tgcagtggct cacacctgta atcccaacac
     2701 cttgggaggc caaggtgggc ggatcacttg aggtcaggag ttcaagacca tctggccaac
     2761 atggtgaaac cctgtctcta ctgaaaataa aaaaaactag ctgggcatgg tggcagatgc
     2821 ctgtaactcc agctactcgg gagactgaag gacaagaatc acttgaacc
//
