LOCUS       NM_001080543            3583 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens cactin, spliceosome C complex subunit (CACTIN),
            transcript variant 1, mRNA.
ACCESSION   NM_001080543 XM_933013
VERSION     NM_001080543.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3583)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3583)
  AUTHORS   Zanini,I.M., Soneson,C., Lorenzi,L.E. and Azzalin,C.M.
  TITLE     Human cactin interacts with DHX8 and SRRM2 to assure efficient
            pre-mRNA splicing and sister chromatid cohesion
  JOURNAL   J Cell Sci 130 (4), 767-778 (2017)
   PUBMED   28062851
  REMARK    GeneRIF: cellular complexes comprising cactin, DHX8 and SRRM2
            sustain precise chromosome segregation, genome stability and cell
            proliferation by allowing faithful splicing of specific pre-mRNAs.
REFERENCE   3  (bases 1 to 3583)
  AUTHORS   Suzuki,M., Watanabe,M., Nakamaru,Y., Takagi,D., Takahashi,H.,
            Fukuda,S. and Hatakeyama,S.
  TITLE     TRIM39 negatively regulates the NFkappaB-mediated signaling pathway
            through stabilization of Cactin
  JOURNAL   Cell Mol Life Sci 73 (5), 1085-1101 (2016)
   PUBMED   26363554
  REMARK    GeneRIF: TRIM39 negatively regulates the NFkappaB signaling pathway
            possibly via stabilization of cactin.
REFERENCE   4  (bases 1 to 3583)
  AUTHORS   Yamada,H., Kikuchi,T., Masumoto,T., Wei,F.Y., Abe,T., Takeda,T.,
            Nishiki,T., Tomizawa,K., Watanabe,M., Matsui,H. and Takei,K.
  TITLE     Possible role of cortactin phosphorylation by protein kinase Calpha
            in actin-bundle formation at growth cone
  JOURNAL   Biol Cell 107 (9), 319-330 (2015)
   PUBMED   26033110
  REMARK    GeneRIF: results indicate that PKC-mediated cortactin
            phosphorylation might be implicated in the maintenance of growth
            cone
REFERENCE   5  (bases 1 to 3583)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 3583)
  AUTHORS   Sogayar,M.C., Camargo,A.A., Bettoni,F., Carraro,D.M., Pires,L.C.,
            Parmigiani,R.B., Ferreira,E.N., de Sa Moreira,E., do Rosario D de O
            Latorre,M., Simpson,A.J., Cruz,L.O., Degaki,T.L., Festa,F.,
            Massirer,K.B., Sogayar,M.C., Filho,F.C., Camargo,L.P., Cunha,M.A.,
            De Souza,S.J., Faria,M. Jr., Giuliatti,S., Kopp,L., de
            Oliveira,P.S., Paiva,P.B., Pereira,A.A., Pinheiro,D.G., Puga,R.D.,
            S de Souza,J.E., Albuquerque,D.M., Andrade,L.E., Baia,G.S.,
            Briones,M.R., Cavaleiro-Luna,A.M., Cerutti,J.M., Costa,F.F.,
            Costanzi-Strauss,E., Espreafico,E.M., Ferrasi,A.C., Ferro,E.S.,
            Fortes,M.A., Furchi,J.R., Giannella-Neto,D., Goldman,G.H.,
            Goldman,M.H., Gruber,A., Guimaraes,G.S., Hackel,C.,
            Henrique-Silva,F., Kimura,E.T., Leoni,S.G., Macedo,C., Malnic,B.,
            Manzini,B. CV, Marie,S.K., Martinez-Rossi,N.M., Menossi,M.,
            Miracca,E.C., Nagai,M.A., Nobrega,F.G., Nobrega,M.P.,
            Oba-Shinjo,S.M., Oliveira,M.K., Orabona,G.M., Otsuka,A.Y.,
            Paco-Larson,M.L., Paixao,B.M., Pandolfi,J.R., Pardini,M.I., Passos
            Bueno,M.R., Passos,G.A., Pesquero,J.B., Pessoa,J.G., Rahal,P.,
            Rainho,C.A., Reis,C.P., Ricca,T.I., Rodrigues,V., Rogatto,S.R.,
            Romano,C.M., Romeiro,J.G., Rossi,A., Sa,R.G., Sales,M.M.,
            Sant'Anna,S.C., Santarosa,P.L., Segato,F., Silva,W.A. Jr.,
            Silva,I.D., Silva,N.P., Soares-Costa,A., Sonati,M.F., Strauss,B.E.,
            Tajara,E.H., Valentini,S.R., Villanova,F.E., Ward,L.S. and
            Zanette,D.L.
  CONSRTM   Ludwig-FAPESP Transcript Finishing Initiative
  TITLE     A transcript finishing initiative for closing gaps in the human
            transcriptome
  JOURNAL   Genome Res 14 (7), 1413-1423 (2004)
   PUBMED   15197164
REFERENCE   7  (bases 1 to 3583)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   8  (bases 1 to 3583)
  AUTHORS   Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
            Sanderson,C.M.
  TITLE     Analysis of a high-throughput yeast two-hybrid system and its use
            to predict the function of intracellular proteins encoded within
            the human MHC class III region
  JOURNAL   Genomics 83 (1), 153-167 (2004)
   PUBMED   14667819
REFERENCE   9  (bases 1 to 3583)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   10 (bases 1 to 3583)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN305928.1, BF196424.1, CO248922.1, AW027691.1, CF272634.1 and
            AC005175.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001080543.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY917150.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2151119, SAMEA2155371 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429344.7/ ENSP00000415078.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               CN305928.1         28-155
            129-419             BF196424.1         1-291               c
            420-766             CO248922.1         214-560
            767-981             AW027691.1         324-538
            982-1190            CF272634.1         114-322
            1191-1383           AC005175.1         30743-30935         c
            1384-1506           AC005175.1         29810-29932         c
            1507-1814           AC005175.1         29404-29711         c
            1815-3583           AC005175.1         26991-28759         c
FEATURES             Location/Qualifiers
     source          1..3583
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3583
                     /gene="CACTIN"
                     /gene_synonym="C19orf29; fSAPc; NY-REN-24"
                     /note="cactin, spliceosome C complex subunit"
                     /db_xref="GeneID:58509"
                     /db_xref="HGNC:HGNC:29938"
                     /db_xref="MIM:618536"
     exon            1..195
                     /gene="CACTIN"
                     /gene_synonym="C19orf29; fSAPc; NY-REN-24"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..2305
                     /gene="CACTIN"
                     /gene_synonym="C19orf29; fSAPc; NY-REN-24"
                     /note="functional spliceosome-associated protein c; NY REN
                     24 antigen; renal carcinoma antigen NY-REN-24"
                     /codon_start=1
                     /product="splicing factor Cactin"
                     /protein_id="NP_001074012.1"
                     /db_xref="CCDS:CCDS45920.1"
                     /db_xref="GeneID:58509"
                     /db_xref="HGNC:HGNC:29938"
                     /db_xref="MIM:618536"
                     /translation="MGRDTRSRSRSAGRRGRRRQSQSGSRSRSRSHGRRNRRRREDEG
                     RRRRRRRSRERRSDSEEERWQRSGMRSRSPPRPKWHSRDGSSQSDSGEEQSRGQWARR
                     RRRARSWSPSSSASSSASPGRSQSPRAAAAALSQQQSLQERLRLREERKQQEELMKAF
                     ETPEEKRARRLAKKEAKERKKREKMGWGEEYMGYTNTDNPFGDNNLLGTFIWNKALEK
                     KGISHLEEKELKERNKRIQEDNRLELQKVKQLRLEREREKAMREQELEMLQREKEAEH
                     FKTWEEQEDNFHLQQAKLRSKIRIRDGRAKPIDLLAKYISAEDDDLAVEMHEPYTFLN
                     GLTVADMEDLLEDIQVYMELEQGKNADFWRDMTTITEDEISKLRKLEASGKGPGERRE
                     GVNASVSSDVQSVFKGKTYNQLQVIFQGIEGKIRAGGPNLDMGYWESLLQQLRAHMAR
                     ARLRERHQDVLRQKLYKLKQEQGVESEPLFPILKQEPQSPSRSLEPEDAAPTPPGPSS
                     EGGPAEAEVDGATPTEGDGDGDGEGEGEGEAVLMEEDLIQQSLDDYDAGRYSPRLLTA
                     HELPLDAHVLEPDEDLQRLQLSRQQLQVTGDASESAEDIFFRRAKEGMGQDEAQFSVE
                     MPLTGKAYLWADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNPPPKIVQGYKFNIFY
                     PDLIDKRSTPEYFLEACADNKDFAILRFHAGPPYEDIAFKIVNREWEYSHRHGFRCQF
                     ANGIFQLWFHFKRYRYRR"
     exon            196..670
                     /gene="CACTIN"
                     /gene_synonym="C19orf29; fSAPc; NY-REN-24"
                     /inference="alignment:Splign:2.1.0"
     exon            671..766
                     /gene="CACTIN"
                     /gene_synonym="C19orf29; fSAPc; NY-REN-24"
                     /inference="alignment:Splign:2.1.0"
     exon            767..912
                     /gene="CACTIN"
                     /gene_synonym="C19orf29; fSAPc; NY-REN-24"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1075
                     /gene="CACTIN"
                     /gene_synonym="C19orf29; fSAPc; NY-REN-24"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1190
                     /gene="CACTIN"
                     /gene_synonym="C19orf29; fSAPc; NY-REN-24"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1383
                     /gene="CACTIN"
                     /gene_synonym="C19orf29; fSAPc; NY-REN-24"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1506
                     /gene="CACTIN"
                     /gene_synonym="C19orf29; fSAPc; NY-REN-24"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1814
                     /gene="CACTIN"
                     /gene_synonym="C19orf29; fSAPc; NY-REN-24"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..3583
                     /gene="CACTIN"
                     /gene_synonym="C19orf29; fSAPc; NY-REN-24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3560..3565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACTIN"
                     /gene_synonym="C19orf29; fSAPc; NY-REN-24"
                     /note="hexamer: AATAAA"
     polyA_site      3583
                     /gene="CACTIN"
                     /gene_synonym="C19orf29; fSAPc; NY-REN-24"
                     /note="major polyA site"
ORIGIN      
        1 gttggtgccg cggccactgg cccagccgat gggtcgggac acacgctcgc gctcgcggtc
       61 cgcgggtcgc cggggccgaa ggcggcagag tcagagcggg agccgaagtc ggagcaggag
      121 ccatgggcgg cgaaaccgac ggcgccggga ggacgaggga cggcgcagac ggaggcggcg
      181 gagccgggag cgcaggtcag attcagagga agagcggtgg cagcgctcag ggatgcgaag
      241 ccggagcccc ccgcggccca agtggcactc aagagatggg tcctctcagt cggactcagg
      301 agaggagcag tcacggggcc agtgggctcg ccggcgacgg cgcgcacgct cgtggtctcc
      361 tagctcctca gcatccagct ccgcgtctcc agggcgatcc cagagccccc gggcggccgc
      421 ggctgccctg agccagcagc agagcctgca ggagcggctg cggctgcggg aggagcggaa
      481 gcagcaggag gagctgatga aggccttcga gacgcccgag gagaagcgcg cacggcggct
      541 ggccaagaag gaggccaagg agcgcaagaa gcgggagaag atgggctggg gtgaggagta
      601 catgggctac accaacaccg acaacccctt cggagacaac aacctgctgg gcaccttcat
      661 ctggaataag gccctggaga agaaggggat cagccacctg gaggagaagg agctgaagga
      721 gcggaacaag aggatccagg aggacaaccg gctggagctg cagaaggtga agcagctgcg
      781 gctggagcgg gagcgggaga aggccatgcg cgagcaggag ctggagatgc tgcagcgcga
      841 gaaggaggca gagcacttca agacatggga ggagcaggag gacaacttcc acctccagca
      901 ggccaagctg cgttccaaga tccgcatccg ggacgggcgg gccaagccca tcgacctgct
      961 ggccaagtac atcagcgctg aggatgacga tctggccgtg gagatgcatg agccctacac
     1021 gttcctcaac ggcctcaccg tggccgacat ggaggacctg ctggaggata tccaggtcta
     1081 catggagctg gagcagggca agaacgccga cttctggcgg gacatgacca ccatcaccga
     1141 ggacgagatc tccaagctcc gcaagctgga ggcctcgggc aaggggccag gtgagcgccg
     1201 cgagggggtc aacgcctccg tcagctctga tgtgcagtcg gtgttcaagg ggaagacata
     1261 caaccagctg caggtcatct tccagggcat cgagggcaaa atccgcgctg gtggccccaa
     1321 cctggacatg ggctactggg agagcctcct gcagcagctt cgtgcccaca tggcacgggc
     1381 ccggctgcgt gagcgccacc aggacgtgct gcggcagaag ctgtacaaac tgaagcagga
     1441 gcagggcgtg gagagcgagc cgctgttccc catcctcaag caggagcccc agtcccccag
     1501 ccgcagcctg gagcctgagg acgcggcgcc caccccgccc gggccctcct cggagggcgg
     1561 ccccgcggag gccgaggtgg acggcgcgac cccgacagag ggcgacggcg acggggacgg
     1621 tgagggcgag ggcgagggcg aggcggtgct catggaggag gacctgatcc agcagagcct
     1681 ggacgactac gacgccggca ggtacagccc gcggctgctc acggcgcacg agctgccact
     1741 ggacgcgcac gtgctggaac cggatgagga cctgcagcgc ctgcagctct cgcgccagca
     1801 gctccaggtc acgggagacg ccagcgagag cgccgaggac atcttcttcc ggcgggccaa
     1861 ggagggcatg ggccaggacg aggcgcagtt cagcgtggag atgccactca ccggcaaggc
     1921 ctacctgtgg gccgacaagt accggccacg caagccgcgc ttcttcaacc gcgtgcacac
     1981 gggcttcgag tggaacaagt acaaccagac gcactacgac tttgacaacc caccgcccaa
     2041 gatcgtgcag ggatacaagt tcaacatctt ctaccccgac ctcatcgaca agcgctccac
     2101 gcccgagtac ttcctggagg cctgcgccga caacaaggat ttcgccatcc tgcgcttcca
     2161 cgcggggccg ccctacgagg acatcgcttt caagatcgtc aaccgcgagt gggaatactc
     2221 gcaccgccac ggcttccgct gccagtttgc caacggcatc ttccagctgt ggtttcactt
     2281 caagcgctac cgctatcggc ggtgacggcc ctggggaacg gcaggcaggt gtcctcgggg
     2341 gcacagtaaa ggggcttcgg tgaagctggt ggtcactccg gggccgctgt ctgggctgca
     2401 gggccgcggg ttcacgtccc acctcaggcc gcatctttct ttcgccaggc ctcagtttcc
     2461 tcctatataa aaggggggtc accattgagc ctgccatggt gagctgagga gacactggga
     2521 caggctggcc tagggtcctg atgcaacgga gggggcgcta ggggcatctt tcgagcacga
     2581 gggtggccag cagccgccag ctgacctcac cgtccaggcg gacactctcc accgcccctc
     2641 agccaggctg ggtggggccc acagggcctg ccccaagtgg cggccacaca gggtgttgtg
     2701 gagatgggcc agaggggcct gggcttggcg gtgccaggct cgtgagaagc aggaaactca
     2761 aggccagccc tgccacatca cggggcaccc actgggcgtg aggcagagcc cgcggctgtg
     2821 gggcagctcc agccctgccc acaggccacc ctcgcccgca caggcagcac tgaggccggg
     2881 accctgctgg cgcccgatcc gccactgcag aagagaccct ctgtggacac ccacactctg
     2941 cagggactgg cccccaactc accccgtgct ggctggtggg gtccatttcc ccgcagcggg
     3001 tatggaggat gcgtcgaggt ccctgtctct gtcaaggtcg tgggaaccaa aagtcactga
     3061 gccgtcctcc ccccacctct gagcacaggg cctggagggc aggggctccc cgaaggctgg
     3121 gggttggaga agggtgaggg gcttccccca gggatccccc cacctggcct gctcacgggg
     3181 ccttggagca tgagaccagt gaccccgagt tttgcccata tcaggacagt ggctccttct
     3241 cactcccctt tctcaggcca ggagggccga gggccacacg ggtgccacag cccaggtcgg
     3301 agtggcccag ccggcaggct tgttcttcag catccgacgg gaacatctcc aacagaagca
     3361 aaacggaaag tgcctcccgg acccccagag ggccacccaa cctcaccagt caccagcccc
     3421 agaccaccca cagcccctcc cagacacccc gcctcatctg gaaatagttc cgtttgtttc
     3481 tctaaaaaga cttgtaggtg ggaaaaaaaa tcttttgttc tcatggaatt ggcctattgg
     3541 caagatcgca tgttttttta ataaacgttg tattttagaa taa
//
